Amino acid dipepetide frequency for Bifidobacterium choerinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.015AlaAla: 15.015 ± 0.261	1.269AlaCys: 1.269 ± 0.051	8.808AlaAsp: 8.808 ± 0.173	5.895AlaGlu: 5.895 ± 0.121	3.576AlaPhe: 3.576 ± 0.088	8.679AlaGly: 8.679 ± 0.125	2.808AlaHis: 2.808 ± 0.082	5.599AlaIle: 5.599 ± 0.111	4.641AlaLys: 4.641 ± 0.117	10.801AlaLeu: 10.801 ± 0.169	3.397AlaMet: 3.397 ± 0.066	3.402AlaAsn: 3.402 ± 0.074	4.569AlaPro: 4.569 ± 0.092	4.969AlaGln: 4.969 ± 0.111	7.578AlaArg: 7.578 ± 0.153	6.193AlaSer: 6.193 ± 0.109	6.247AlaThr: 6.247 ± 0.103	8.694AlaVal: 8.694 ± 0.137	1.519AlaTrp: 1.519 ± 0.057	2.729AlaTyr: 2.729 ± 0.065	0.002AlaXaa: 0.002 ± 0.002
Cys	1.331CysAla: 1.331 ± 0.053	0.149CysCys: 0.149 ± 0.02	0.653CysAsp: 0.653 ± 0.036	0.522CysGlu: 0.522 ± 0.027	0.29CysPhe: 0.29 ± 0.024	1.072CysGly: 1.072 ± 0.046	0.201CysHis: 0.201 ± 0.018	0.482CysIle: 0.482 ± 0.029	0.244CysLys: 0.244 ± 0.022	0.723CysLeu: 0.723 ± 0.04	0.251CysMet: 0.251 ± 0.024	0.214CysAsn: 0.214 ± 0.018	0.497CysPro: 0.497 ± 0.035	0.174CysGln: 0.174 ± 0.018	0.579CysArg: 0.579 ± 0.032	0.571CysSer: 0.571 ± 0.034	0.574CysThr: 0.574 ± 0.032	0.844CysVal: 0.844 ± 0.04	0.142CysTrp: 0.142 ± 0.015	0.273CysTyr: 0.273 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	9.746AspAla: 9.746 ± 0.157	0.601AspCys: 0.601 ± 0.035	6.518AspAsp: 6.518 ± 0.16	5.836AspGlu: 5.836 ± 0.104	2.404AspPhe: 2.404 ± 0.061	7.26AspGly: 7.26 ± 0.132	1.42AspHis: 1.42 ± 0.054	3.151AspIle: 3.151 ± 0.078	2.136AspLys: 2.136 ± 0.073	5.214AspLeu: 5.214 ± 0.1	2.064AspMet: 2.064 ± 0.058	1.629AspAsn: 1.629 ± 0.054	3.745AspPro: 3.745 ± 0.079	1.544AspGln: 1.544 ± 0.051	3.613AspArg: 3.613 ± 0.094	2.863AspSer: 2.863 ± 0.083	3.33AspThr: 3.33 ± 0.088	6.448AspVal: 6.448 ± 0.122	1.051AspTrp: 1.051 ± 0.049	2.044AspTyr: 2.044 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	6.314GluAla: 6.314 ± 0.13	0.452GluCys: 0.452 ± 0.027	3.454GluAsp: 3.454 ± 0.084	3.563GluGlu: 3.563 ± 0.088	1.728GluPhe: 1.728 ± 0.054	3.894GluGly: 3.894 ± 0.086	2.014GluHis: 2.014 ± 0.071	2.685GluIle: 2.685 ± 0.069	1.914GluLys: 1.914 ± 0.068	5.456GluLeu: 5.456 ± 0.123	1.39GluMet: 1.39 ± 0.044	1.488GluAsn: 1.488 ± 0.053	2.727GluPro: 2.727 ± 0.072	2.912GluGln: 2.912 ± 0.076	5.178GluArg: 5.178 ± 0.119	2.878GluSer: 2.878 ± 0.069	3.333GluThr: 3.333 ± 0.073	3.554GluVal: 3.554 ± 0.08	0.633GluTrp: 0.633 ± 0.031	1.569GluTyr: 1.569 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	4.07PheAla: 4.07 ± 0.092	0.335PheCys: 0.335 ± 0.026	2.734PheAsp: 2.734 ± 0.071	1.76PheGlu: 1.76 ± 0.06	1.128PhePhe: 1.128 ± 0.047	3.176PheGly: 3.176 ± 0.085	0.75PheHis: 0.75 ± 0.039	1.663PheIle: 1.663 ± 0.066	0.981PheLys: 0.981 ± 0.048	2.707PheLeu: 2.707 ± 0.085	0.747PheMet: 0.747 ± 0.038	1.144PheAsn: 1.144 ± 0.046	1.329PhePro: 1.329 ± 0.049	0.774PheGln: 0.774 ± 0.039	1.728PheArg: 1.728 ± 0.06	1.977PheSer: 1.977 ± 0.059	2.188PheThr: 2.188 ± 0.072	2.771PheVal: 2.771 ± 0.075	0.403PheTrp: 0.403 ± 0.028	0.892PheTyr: 0.892 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	8.837GlyAla: 8.837 ± 0.159	0.83GlyCys: 0.83 ± 0.044	5.59GlyAsp: 5.59 ± 0.106	4.676GlyGlu: 4.676 ± 0.105	2.935GlyPhe: 2.935 ± 0.071	6.352GlyGly: 6.352 ± 0.134	1.75GlyHis: 1.75 ± 0.057	4.248GlyIle: 4.248 ± 0.1	3.27GlyLys: 3.27 ± 0.1	6.439GlyLeu: 6.439 ± 0.11	2.403GlyMet: 2.403 ± 0.07	2.361GlyAsn: 2.361 ± 0.077	2.595GlyPro: 2.595 ± 0.063	2.332GlyGln: 2.332 ± 0.065	5.147GlyArg: 5.147 ± 0.105	4.502GlySer: 4.502 ± 0.098	4.849GlyThr: 4.849 ± 0.104	6.829GlyVal: 6.829 ± 0.109	1.207GlyTrp: 1.207 ± 0.049	2.548GlyTyr: 2.548 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.563HisAla: 2.563 ± 0.083	0.223HisCys: 0.223 ± 0.02	2.019HisAsp: 2.019 ± 0.064	1.375HisGlu: 1.375 ± 0.051	0.573HisPhe: 0.573 ± 0.033	2.259HisGly: 2.259 ± 0.056	0.541HisHis: 0.541 ± 0.033	1.108HisIle: 1.108 ± 0.046	0.583HisLys: 0.583 ± 0.032	1.587HisLeu: 1.587 ± 0.054	0.68HisMet: 0.68 ± 0.032	0.563HisAsn: 0.563 ± 0.032	1.368HisPro: 1.368 ± 0.046	0.554HisGln: 0.554 ± 0.028	1.663HisArg: 1.663 ± 0.054	0.912HisSer: 0.912 ± 0.04	1.279HisThr: 1.279 ± 0.048	2.177HisVal: 2.177 ± 0.069	0.328HisTrp: 0.328 ± 0.023	0.643HisTyr: 0.643 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.583IleAla: 6.583 ± 0.108	0.609IleCys: 0.609 ± 0.033	4.455IleAsp: 4.455 ± 0.092	3.26IleGlu: 3.26 ± 0.078	1.359IlePhe: 1.359 ± 0.051	4.569IleGly: 4.569 ± 0.101	0.926IleHis: 0.926 ± 0.043	2.689IleIle: 2.689 ± 0.093	1.41IleLys: 1.41 ± 0.049	3.591IleLeu: 3.591 ± 0.096	1.172IleMet: 1.172 ± 0.053	1.542IleAsn: 1.542 ± 0.055	2.424IlePro: 2.424 ± 0.068	1.092IleGln: 1.092 ± 0.049	3.049IleArg: 3.049 ± 0.074	2.49IleSer: 2.49 ± 0.072	2.853IleThr: 2.853 ± 0.077	5.078IleVal: 5.078 ± 0.103	0.583IleTrp: 0.583 ± 0.036	1.154IleTyr: 1.154 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.038LysAla: 4.038 ± 0.109	0.151LysCys: 0.151 ± 0.016	2.597LysAsp: 2.597 ± 0.086	2.136LysGlu: 2.136 ± 0.079	0.854LysPhe: 0.854 ± 0.038	2.408LysGly: 2.408 ± 0.085	0.77LysHis: 0.77 ± 0.038	1.594LysIle: 1.594 ± 0.051	1.634LysLys: 1.634 ± 0.065	2.796LysLeu: 2.796 ± 0.076	0.774LysMet: 0.774 ± 0.036	1.2LysAsn: 1.2 ± 0.056	2.1LysPro: 2.1 ± 0.065	1.403LysGln: 1.403 ± 0.05	2.351LysArg: 2.351 ± 0.074	1.925LysSer: 1.925 ± 0.058	2.321LysThr: 2.321 ± 0.066	2.423LysVal: 2.423 ± 0.075	0.385LysTrp: 0.385 ± 0.03	0.978LysTyr: 0.978 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	10.206LeuAla: 10.206 ± 0.157	1.046LeuCys: 1.046 ± 0.046	6.484LeuAsp: 6.484 ± 0.106	4.551LeuGlu: 4.551 ± 0.087	2.963LeuPhe: 2.963 ± 0.083	6.823LeuGly: 6.823 ± 0.129	1.944LeuHis: 1.944 ± 0.055	4.288LeuIle: 4.288 ± 0.099	2.905LeuLys: 2.905 ± 0.077	7.564LeuLeu: 7.564 ± 0.134	2.173LeuMet: 2.173 ± 0.058	2.647LeuAsn: 2.647 ± 0.077	4.335LeuPro: 4.335 ± 0.087	2.379LeuGln: 2.379 ± 0.069	5.788LeuArg: 5.788 ± 0.112	4.765LeuSer: 4.765 ± 0.099	5.341LeuThr: 5.341 ± 0.098	6.551LeuVal: 6.551 ± 0.128	1.051LeuTrp: 1.051 ± 0.053	2.026LeuTyr: 2.026 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.967MetAla: 2.967 ± 0.074	0.285MetCys: 0.285 ± 0.02	1.507MetAsp: 1.507 ± 0.052	1.125MetGlu: 1.125 ± 0.048	0.943MetPhe: 0.943 ± 0.04	1.83MetGly: 1.83 ± 0.061	0.725MetHis: 0.725 ± 0.037	1.264MetIle: 1.264 ± 0.05	0.919MetLys: 0.919 ± 0.043	2.736MetLeu: 2.736 ± 0.077	0.787MetMet: 0.787 ± 0.047	0.923MetAsn: 0.923 ± 0.042	1.678MetPro: 1.678 ± 0.052	0.963MetGln: 0.963 ± 0.044	2.218MetArg: 2.218 ± 0.066	1.755MetSer: 1.755 ± 0.058	2.1MetThr: 2.1 ± 0.059	1.562MetVal: 1.562 ± 0.049	0.281MetTrp: 0.281 ± 0.022	0.579MetTyr: 0.579 ± 0.031	0.002MetXaa: 0.002 ± 0.002
Asn	3.583AsnAla: 3.583 ± 0.078	0.218AsnCys: 0.218 ± 0.022	2.116AsnAsp: 2.116 ± 0.07	1.755AsnGlu: 1.755 ± 0.061	0.822AsnPhe: 0.822 ± 0.037	2.978AsnGly: 2.978 ± 0.094	0.609AsnHis: 0.609 ± 0.037	1.457AsnIle: 1.457 ± 0.053	1.072AsnLys: 1.072 ± 0.046	2.322AsnLeu: 2.322 ± 0.065	0.79AsnMet: 0.79 ± 0.041	0.968AsnAsn: 0.968 ± 0.051	1.9AsnPro: 1.9 ± 0.056	0.817AsnGln: 0.817 ± 0.043	1.701AsnArg: 1.701 ± 0.056	1.371AsnSer: 1.371 ± 0.056	1.701AsnThr: 1.701 ± 0.065	2.339AsnVal: 2.339 ± 0.058	0.417AsnTrp: 0.417 ± 0.032	0.827AsnTyr: 0.827 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	5.18ProAla: 5.18 ± 0.112	0.345ProCys: 0.345 ± 0.025	3.638ProAsp: 3.638 ± 0.083	3.255ProGlu: 3.255 ± 0.075	1.592ProPhe: 1.592 ± 0.058	3.528ProGly: 3.528 ± 0.073	1.055ProHis: 1.055 ± 0.049	2.419ProIle: 2.419 ± 0.069	1.847ProLys: 1.847 ± 0.068	3.755ProLeu: 3.755 ± 0.087	1.234ProMet: 1.234 ± 0.053	1.478ProAsn: 1.478 ± 0.06	1.537ProPro: 1.537 ± 0.064	2.029ProGln: 2.029 ± 0.066	2.771ProArg: 2.771 ± 0.082	3.007ProSer: 3.007 ± 0.083	3.131ProThr: 3.131 ± 0.089	3.553ProVal: 3.553 ± 0.081	0.718ProTrp: 0.718 ± 0.035	1.358ProTyr: 1.358 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	3.578GlnAla: 3.578 ± 0.095	0.26GlnCys: 0.26 ± 0.022	1.604GlnAsp: 1.604 ± 0.048	1.631GlnGlu: 1.631 ± 0.052	1.013GlnPhe: 1.013 ± 0.041	2.121GlnGly: 2.121 ± 0.059	0.762GlnHis: 0.762 ± 0.035	2.131GlnIle: 2.131 ± 0.058	0.983GlnLys: 0.983 ± 0.039	3.337GlnLeu: 3.337 ± 0.069	1.055GlnMet: 1.055 ± 0.043	0.857GlnAsn: 0.857 ± 0.046	1.929GlnPro: 1.929 ± 0.077	1.791GlnGln: 1.791 ± 0.072	2.433GlnArg: 2.433 ± 0.067	1.673GlnSer: 1.673 ± 0.054	2.011GlnThr: 2.011 ± 0.071	2.317GlnVal: 2.317 ± 0.069	0.554GlnTrp: 0.554 ± 0.033	1.056GlnTyr: 1.056 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	6.953ArgAla: 6.953 ± 0.13	0.551ArgCys: 0.551 ± 0.032	4.226ArgAsp: 4.226 ± 0.095	3.896ArgGlu: 3.896 ± 0.097	2.647ArgPhe: 2.647 ± 0.073	4.298ArgGly: 4.298 ± 0.094	1.847ArgHis: 1.847 ± 0.063	3.765ArgIle: 3.765 ± 0.081	2.359ArgLys: 2.359 ± 0.067	5.9ArgLeu: 5.9 ± 0.113	2.071ArgMet: 2.071 ± 0.061	2.039ArgAsn: 2.039 ± 0.058	2.999ArgPro: 2.999 ± 0.074	2.299ArgGln: 2.299 ± 0.068	6.096ArgArg: 6.096 ± 0.196	3.076ArgSer: 3.076 ± 0.078	3.878ArgThr: 3.878 ± 0.093	4.505ArgVal: 4.505 ± 0.099	0.976ArgTrp: 0.976 ± 0.044	2.014ArgTyr: 2.014 ± 0.059	0.002ArgXaa: 0.002 ± 0.002
Ser	5.736SerAla: 5.736 ± 0.112	0.475SerCys: 0.475 ± 0.032	3.486SerAsp: 3.486 ± 0.081	2.635SerGlu: 2.635 ± 0.068	1.9SerPhe: 1.9 ± 0.068	4.758SerGly: 4.758 ± 0.089	1.065SerHis: 1.065 ± 0.046	2.98SerIle: 2.98 ± 0.082	1.798SerLys: 1.798 ± 0.063	4.634SerLeu: 4.634 ± 0.09	1.622SerMet: 1.622 ± 0.053	1.644SerAsn: 1.644 ± 0.061	2.439SerPro: 2.439 ± 0.063	1.698SerGln: 1.698 ± 0.049	3.245SerArg: 3.245 ± 0.089	3.501SerSer: 3.501 ± 0.1	3.385SerThr: 3.385 ± 0.091	4.179SerVal: 4.179 ± 0.091	0.809SerTrp: 0.809 ± 0.039	1.515SerTyr: 1.515 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	6.453ThrAla: 6.453 ± 0.129	0.506ThrCys: 0.506 ± 0.03	3.779ThrAsp: 3.779 ± 0.087	2.603ThrGlu: 2.603 ± 0.056	2.108ThrPhe: 2.108 ± 0.07	4.695ThrGly: 4.695 ± 0.097	1.314ThrHis: 1.314 ± 0.048	3.389ThrIle: 3.389 ± 0.073	2.285ThrLys: 2.285 ± 0.059	5.694ThrLeu: 5.694 ± 0.108	1.676ThrMet: 1.676 ± 0.06	1.935ThrAsn: 1.935 ± 0.064	3.62ThrPro: 3.62 ± 0.086	1.939ThrGln: 1.939 ± 0.062	3.305ThrArg: 3.305 ± 0.088	3.395ThrSer: 3.395 ± 0.076	3.983ThrThr: 3.983 ± 0.101	5.127ThrVal: 5.127 ± 0.113	0.693ThrTrp: 0.693 ± 0.038	1.505ThrTyr: 1.505 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	8.877ValAla: 8.877 ± 0.145	0.958ValCys: 0.958 ± 0.043	6.056ValAsp: 6.056 ± 0.116	4.561ValGlu: 4.561 ± 0.106	2.86ValPhe: 2.86 ± 0.073	5.547ValGly: 5.547 ± 0.107	1.704ValHis: 1.704 ± 0.052	3.961ValIle: 3.961 ± 0.086	2.505ValLys: 2.505 ± 0.075	6.938ValLeu: 6.938 ± 0.118	1.833ValMet: 1.833 ± 0.056	2.317ValAsn: 2.317 ± 0.068	3.847ValPro: 3.847 ± 0.087	2.113ValGln: 2.113 ± 0.058	5.039ValArg: 5.039 ± 0.095	4.559ValSer: 4.559 ± 0.096	5.148ValThr: 5.148 ± 0.11	7.002ValVal: 7.002 ± 0.147	1.102ValTrp: 1.102 ± 0.05	1.92ValTyr: 1.92 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	1.224TrpAla: 1.224 ± 0.052	0.198TrpCys: 0.198 ± 0.019	0.876TrpAsp: 0.876 ± 0.04	0.536TrpGlu: 0.536 ± 0.035	0.586TrpPhe: 0.586 ± 0.029	0.871TrpGly: 0.871 ± 0.04	0.291TrpHis: 0.291 ± 0.023	0.804TrpIle: 0.804 ± 0.036	0.558TrpLys: 0.558 ± 0.034	1.398TrpLeu: 1.398 ± 0.052	0.398TrpMet: 0.398 ± 0.028	0.563TrpAsn: 0.563 ± 0.036	0.551TrpPro: 0.551 ± 0.035	0.524TrpGln: 0.524 ± 0.033	1.028TrpArg: 1.028 ± 0.051	0.77TrpSer: 0.77 ± 0.035	0.83TrpThr: 0.83 ± 0.043	0.835TrpVal: 0.835 ± 0.037	0.285TrpTrp: 0.285 ± 0.022	0.414TrpTyr: 0.414 ± 0.028	0.002TrpXaa: 0.002 ± 0.002
Tyr	3.136TyrAla: 3.136 ± 0.071	0.328TyrCys: 0.328 ± 0.024	2.017TyrAsp: 2.017 ± 0.064	1.567TyrGlu: 1.567 ± 0.06	0.976TyrPhe: 0.976 ± 0.04	2.583TyrGly: 2.583 ± 0.065	0.501TyrHis: 0.501 ± 0.026	1.21TyrIle: 1.21 ± 0.045	0.794TyrLys: 0.794 ± 0.043	2.237TyrLeu: 2.237 ± 0.062	0.628TyrMet: 0.628 ± 0.036	0.849TyrAsn: 0.849 ± 0.04	1.237TyrPro: 1.237 ± 0.051	0.79TyrGln: 0.79 ± 0.037	1.885TyrArg: 1.885 ± 0.059	1.323TyrSer: 1.323 ± 0.047	1.522TyrThr: 1.522 ± 0.057	2.059TyrVal: 2.059 ± 0.062	0.402TyrTrp: 0.402 ± 0.027	0.789TyrTyr: 0.789 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.003	0.0XaaGln: 0.0 ± 0.0	0.003XaaArg: 0.003 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1672 proteins (597285 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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