Amino acid dipepetide frequency for Sporobacter termitidis DSM 10068

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.593AlaAla: 12.593 ± 0.159	1.369AlaCys: 1.369 ± 0.035	5.522AlaAsp: 5.522 ± 0.08	5.958AlaGlu: 5.958 ± 0.075	3.695AlaPhe: 3.695 ± 0.057	8.953AlaGly: 8.953 ± 0.124	1.402AlaHis: 1.402 ± 0.039	5.253AlaIle: 5.253 ± 0.077	4.227AlaLys: 4.227 ± 0.058	10.706AlaLeu: 10.706 ± 0.104	2.538AlaMet: 2.538 ± 0.052	2.468AlaAsn: 2.468 ± 0.049	3.641AlaPro: 3.641 ± 0.065	2.813AlaGln: 2.813 ± 0.055	4.804AlaArg: 4.804 ± 0.069	5.254AlaSer: 5.254 ± 0.075	3.952AlaThr: 3.952 ± 0.066	8.932AlaVal: 8.932 ± 0.103	0.816AlaTrp: 0.816 ± 0.027	3.014AlaTyr: 3.014 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.54CysAla: 1.54 ± 0.04	0.254CysCys: 0.254 ± 0.014	0.846CysAsp: 0.846 ± 0.027	0.686CysGlu: 0.686 ± 0.024	0.603CysPhe: 0.603 ± 0.024	1.628CysGly: 1.628 ± 0.043	0.272CysHis: 0.272 ± 0.016	0.783CysIle: 0.783 ± 0.028	0.535CysLys: 0.535 ± 0.023	1.207CysLeu: 1.207 ± 0.034	0.35CysMet: 0.35 ± 0.018	0.415CysAsn: 0.415 ± 0.02	0.689CysPro: 0.689 ± 0.026	0.354CysGln: 0.354 ± 0.016	0.898CysArg: 0.898 ± 0.024	0.755CysSer: 0.755 ± 0.027	0.742CysThr: 0.742 ± 0.029	1.07CysVal: 1.07 ± 0.035	0.122CysTrp: 0.122 ± 0.01	0.417CysTyr: 0.417 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	5.52AspAla: 5.52 ± 0.081	0.738AspCys: 0.738 ± 0.029	3.012AspAsp: 3.012 ± 0.056	3.598AspGlu: 3.598 ± 0.055	2.543AspPhe: 2.543 ± 0.048	4.956AspGly: 4.956 ± 0.072	0.743AspHis: 0.743 ± 0.028	4.606AspIle: 4.606 ± 0.065	3.235AspLys: 3.235 ± 0.047	4.471AspLeu: 4.471 ± 0.059	1.721AspMet: 1.721 ± 0.041	2.084AspAsn: 2.084 ± 0.047	2.284AspPro: 2.284 ± 0.047	1.152AspGln: 1.152 ± 0.032	2.716AspArg: 2.716 ± 0.053	2.811AspSer: 2.811 ± 0.054	3.302AspThr: 3.302 ± 0.086	4.09AspVal: 4.09 ± 0.065	0.666AspTrp: 0.666 ± 0.028	2.361AspTyr: 2.361 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.592GluAla: 5.592 ± 0.074	0.578GluCys: 0.578 ± 0.023	3.073GluAsp: 3.073 ± 0.059	4.234GluGlu: 4.234 ± 0.071	2.121GluPhe: 2.121 ± 0.04	3.559GluGly: 3.559 ± 0.062	1.06GluHis: 1.06 ± 0.032	4.163GluIle: 4.163 ± 0.065	4.466GluLys: 4.466 ± 0.065	6.234GluLeu: 6.234 ± 0.089	1.713GluMet: 1.713 ± 0.04	2.964GluAsn: 2.964 ± 0.052	2.005GluPro: 2.005 ± 0.052	2.028GluGln: 2.028 ± 0.043	3.199GluArg: 3.199 ± 0.058	2.983GluSer: 2.983 ± 0.046	3.531GluThr: 3.531 ± 0.054	3.394GluVal: 3.394 ± 0.055	0.488GluTrp: 0.488 ± 0.02	2.035GluTyr: 2.035 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.399PheAla: 3.399 ± 0.055	0.598PheCys: 0.598 ± 0.023	2.593PheAsp: 2.593 ± 0.052	2.429PheGlu: 2.429 ± 0.046	1.794PhePhe: 1.794 ± 0.043	3.31PheGly: 3.31 ± 0.054	0.653PheHis: 0.653 ± 0.023	2.776PheIle: 2.776 ± 0.053	1.97PheLys: 1.97 ± 0.038	3.64PheLeu: 3.64 ± 0.065	1.062PheMet: 1.062 ± 0.031	1.582PheAsn: 1.582 ± 0.036	1.478PhePro: 1.478 ± 0.038	0.993PheGln: 0.993 ± 0.026	1.731PheArg: 1.731 ± 0.047	3.152PheSer: 3.152 ± 0.056	2.506PheThr: 2.506 ± 0.051	2.752PheVal: 2.752 ± 0.054	0.393PheTrp: 0.393 ± 0.021	1.507PheTyr: 1.507 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	7.976GlyAla: 7.976 ± 0.115	1.401GlyCys: 1.401 ± 0.04	4.407GlyAsp: 4.407 ± 0.087	4.412GlyGlu: 4.412 ± 0.065	3.431GlyPhe: 3.431 ± 0.06	7.456GlyGly: 7.456 ± 0.145	1.335GlyHis: 1.335 ± 0.036	5.654GlyIle: 5.654 ± 0.071	4.656GlyLys: 4.656 ± 0.072	7.316GlyLeu: 7.316 ± 0.088	2.264GlyMet: 2.264 ± 0.047	2.756GlyAsn: 2.756 ± 0.068	2.207GlyPro: 2.207 ± 0.091	2.279GlyGln: 2.279 ± 0.046	4.335GlyArg: 4.335 ± 0.069	4.59GlySer: 4.59 ± 0.078	4.954GlyThr: 4.954 ± 0.086	6.11GlyVal: 6.11 ± 0.078	0.767GlyTrp: 0.767 ± 0.027	3.173GlyTyr: 3.173 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.292HisAla: 1.292 ± 0.034	0.298HisCys: 0.298 ± 0.015	0.946HisAsp: 0.946 ± 0.026	0.924HisGlu: 0.924 ± 0.032	0.735HisPhe: 0.735 ± 0.027	1.342HisGly: 1.342 ± 0.032	0.379HisHis: 0.379 ± 0.019	1.175HisIle: 1.175 ± 0.037	0.704HisLys: 0.704 ± 0.022	1.407HisLeu: 1.407 ± 0.037	0.463HisMet: 0.463 ± 0.022	0.571HisAsn: 0.571 ± 0.023	0.903HisPro: 0.903 ± 0.031	0.447HisGln: 0.447 ± 0.02	0.892HisArg: 0.892 ± 0.029	0.846HisSer: 0.846 ± 0.029	0.884HisThr: 0.884 ± 0.029	1.051HisVal: 1.051 ± 0.035	0.178HisTrp: 0.178 ± 0.012	0.6HisTyr: 0.6 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.222IleAla: 6.222 ± 0.083	1.033IleCys: 1.033 ± 0.035	3.865IleAsp: 3.865 ± 0.061	3.593IleGlu: 3.593 ± 0.065	2.664IlePhe: 2.664 ± 0.054	5.275IleGly: 5.275 ± 0.081	1.015IleHis: 1.015 ± 0.032	4.359IleIle: 4.359 ± 0.075	3.236IleLys: 3.236 ± 0.067	6.282IleLeu: 6.282 ± 0.087	1.633IleMet: 1.633 ± 0.039	2.393IleAsn: 2.393 ± 0.049	2.926IlePro: 2.926 ± 0.049	1.571IleGln: 1.571 ± 0.037	3.371IleArg: 3.371 ± 0.052	4.697IleSer: 4.697 ± 0.076	4.001IleThr: 4.001 ± 0.061	4.969IleVal: 4.969 ± 0.078	0.461IleTrp: 0.461 ± 0.02	2.14IleTyr: 2.14 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	5.065LysAla: 5.065 ± 0.073	0.612LysCys: 0.612 ± 0.023	2.946LysAsp: 2.946 ± 0.054	3.271LysGlu: 3.271 ± 0.045	1.571LysPhe: 1.571 ± 0.036	3.374LysGly: 3.374 ± 0.051	0.832LysHis: 0.832 ± 0.028	3.753LysIle: 3.753 ± 0.057	4.092LysLys: 4.092 ± 0.061	4.946LysLeu: 4.946 ± 0.067	1.569LysMet: 1.569 ± 0.037	2.761LysAsn: 2.761 ± 0.051	2.039LysPro: 2.039 ± 0.041	1.532LysGln: 1.532 ± 0.038	2.755LysArg: 2.755 ± 0.054	3.229LysSer: 3.229 ± 0.051	3.663LysThr: 3.663 ± 0.059	3.201LysVal: 3.201 ± 0.053	0.495LysTrp: 0.495 ± 0.019	2.214LysTyr: 2.214 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	8.736LeuAla: 8.736 ± 0.109	1.571LeuCys: 1.571 ± 0.039	5.34LeuAsp: 5.34 ± 0.07	5.492LeuGlu: 5.492 ± 0.074	3.935LeuPhe: 3.935 ± 0.067	7.06LeuGly: 7.06 ± 0.093	1.474LeuHis: 1.474 ± 0.035	6.016LeuIle: 6.016 ± 0.089	5.443LeuLys: 5.443 ± 0.069	9.836LeuLeu: 9.836 ± 0.114	2.542LeuMet: 2.542 ± 0.05	3.657LeuAsn: 3.657 ± 0.06	4.288LeuPro: 4.288 ± 0.078	2.623LeuGln: 2.623 ± 0.05	5.176LeuArg: 5.176 ± 0.081	7.218LeuSer: 7.218 ± 0.093	5.982LeuThr: 5.982 ± 0.067	6.186LeuVal: 6.186 ± 0.072	0.787LeuTrp: 0.787 ± 0.032	3.072LeuTyr: 3.072 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.578MetAla: 2.578 ± 0.049	0.29MetCys: 0.29 ± 0.015	1.522MetAsp: 1.522 ± 0.034	1.562MetGlu: 1.562 ± 0.039	0.878MetPhe: 0.878 ± 0.029	1.897MetGly: 1.897 ± 0.04	0.408MetHis: 0.408 ± 0.022	1.585MetIle: 1.585 ± 0.039	1.891MetLys: 1.891 ± 0.039	2.756MetLeu: 2.756 ± 0.053	0.695MetMet: 0.695 ± 0.024	1.234MetAsn: 1.234 ± 0.031	1.279MetPro: 1.279 ± 0.036	0.811MetGln: 0.811 ± 0.029	1.317MetArg: 1.317 ± 0.036	1.826MetSer: 1.826 ± 0.049	1.882MetThr: 1.882 ± 0.038	1.55MetVal: 1.55 ± 0.037	0.182MetTrp: 0.182 ± 0.014	0.732MetTyr: 0.732 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.595AsnAla: 3.595 ± 0.059	0.497AsnCys: 0.497 ± 0.022	1.883AsnAsp: 1.883 ± 0.041	1.916AsnGlu: 1.916 ± 0.044	1.387AsnPhe: 1.387 ± 0.038	3.177AsnGly: 3.177 ± 0.058	0.544AsnHis: 0.544 ± 0.02	3.113AsnIle: 3.113 ± 0.053	1.886AsnLys: 1.886 ± 0.041	3.225AsnLeu: 3.225 ± 0.055	1.04AsnMet: 1.04 ± 0.032	1.411AsnAsn: 1.411 ± 0.04	1.938AsnPro: 1.938 ± 0.042	0.946AsnGln: 0.946 ± 0.031	1.749AsnArg: 1.749 ± 0.041	2.05AsnSer: 2.05 ± 0.052	2.212AsnThr: 2.212 ± 0.046	2.553AsnVal: 2.553 ± 0.051	0.367AsnTrp: 0.367 ± 0.015	1.434AsnTyr: 1.434 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.322ProAla: 4.322 ± 0.065	0.507ProCys: 0.507 ± 0.023	2.979ProAsp: 2.979 ± 0.057	3.424ProGlu: 3.424 ± 0.068	1.62ProPhe: 1.62 ± 0.039	3.423ProGly: 3.423 ± 0.062	0.669ProHis: 0.669 ± 0.024	1.966ProIle: 1.966 ± 0.036	1.782ProLys: 1.782 ± 0.041	3.477ProLeu: 3.477 ± 0.057	0.982ProMet: 0.982 ± 0.025	1.284ProAsn: 1.284 ± 0.04	1.547ProPro: 1.547 ± 0.043	1.16ProGln: 1.16 ± 0.031	1.65ProArg: 1.65 ± 0.045	2.395ProSer: 2.395 ± 0.06	1.983ProThr: 1.983 ± 0.074	3.517ProVal: 3.517 ± 0.057	0.373ProTrp: 0.373 ± 0.02	1.532ProTyr: 1.532 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.638GlnAla: 2.638 ± 0.055	0.297GlnCys: 0.297 ± 0.015	1.312GlnAsp: 1.312 ± 0.033	1.589GlnGlu: 1.589 ± 0.04	1.048GlnPhe: 1.048 ± 0.027	1.831GlnGly: 1.831 ± 0.044	0.419GlnHis: 0.419 ± 0.019	1.906GlnIle: 1.906 ± 0.045	1.801GlnLys: 1.801 ± 0.04	2.771GlnLeu: 2.771 ± 0.051	0.912GlnMet: 0.912 ± 0.029	1.356GlnAsn: 1.356 ± 0.036	1.036GlnPro: 1.036 ± 0.027	1.003GlnGln: 1.003 ± 0.032	1.397GlnArg: 1.397 ± 0.035	1.722GlnSer: 1.722 ± 0.041	1.646GlnThr: 1.646 ± 0.038	1.679GlnVal: 1.679 ± 0.04	0.288GlnTrp: 0.288 ± 0.016	1.144GlnTyr: 1.144 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.391ArgAla: 4.391 ± 0.066	0.72ArgCys: 0.72 ± 0.028	2.964ArgAsp: 2.964 ± 0.056	3.778ArgGlu: 3.778 ± 0.07	2.2ArgPhe: 2.2 ± 0.043	3.409ArgGly: 3.409 ± 0.054	1.033ArgHis: 1.033 ± 0.026	3.395ArgIle: 3.395 ± 0.052	2.683ArgLys: 2.683 ± 0.046	5.603ArgLeu: 5.603 ± 0.09	1.393ArgMet: 1.393 ± 0.032	1.677ArgAsn: 1.677 ± 0.039	1.937ArgPro: 1.937 ± 0.048	1.885ArgGln: 1.885 ± 0.041	3.366ArgArg: 3.366 ± 0.07	2.387ArgSer: 2.387 ± 0.05	2.481ArgThr: 2.481 ± 0.045	3.163ArgVal: 3.163 ± 0.061	0.426ArgTrp: 0.426 ± 0.021	1.969ArgTyr: 1.969 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.253SerAla: 6.253 ± 0.077	0.842SerCys: 0.842 ± 0.027	3.415SerAsp: 3.415 ± 0.054	3.305SerGlu: 3.305 ± 0.053	2.658SerPhe: 2.658 ± 0.051	6.337SerGly: 6.337 ± 0.096	0.942SerHis: 0.942 ± 0.031	3.618SerIle: 3.618 ± 0.06	2.729SerLys: 2.729 ± 0.047	5.405SerLeu: 5.405 ± 0.077	1.628SerMet: 1.628 ± 0.033	1.927SerAsn: 1.927 ± 0.041	2.669SerPro: 2.669 ± 0.063	1.681SerGln: 1.681 ± 0.044	3.003SerArg: 3.003 ± 0.053	3.659SerSer: 3.659 ± 0.084	2.955SerThr: 2.955 ± 0.061	4.838SerVal: 4.838 ± 0.078	0.603SerTrp: 0.603 ± 0.027	2.155SerTyr: 2.155 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	6.294ThrAla: 6.294 ± 0.091	0.634ThrCys: 0.634 ± 0.023	3.214ThrAsp: 3.214 ± 0.055	3.164ThrGlu: 3.164 ± 0.054	2.092ThrPhe: 2.092 ± 0.043	5.809ThrGly: 5.809 ± 0.165	0.964ThrHis: 0.964 ± 0.026	3.546ThrIle: 3.546 ± 0.065	2.511ThrLys: 2.511 ± 0.048	5.526ThrLeu: 5.526 ± 0.077	1.338ThrMet: 1.338 ± 0.033	1.805ThrAsn: 1.805 ± 0.042	2.863ThrPro: 2.863 ± 0.052	1.42ThrGln: 1.42 ± 0.035	2.318ThrArg: 2.318 ± 0.041	3.131ThrSer: 3.131 ± 0.06	2.98ThrThr: 2.98 ± 0.062	5.225ThrVal: 5.225 ± 0.089	0.467ThrTrp: 0.467 ± 0.02	2.007ThrTyr: 2.007 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	5.965ValAla: 5.965 ± 0.08	1.227ValCys: 1.227 ± 0.035	3.829ValAsp: 3.829 ± 0.066	3.487ValGlu: 3.487 ± 0.05	3.289ValPhe: 3.289 ± 0.06	5.065ValGly: 5.065 ± 0.084	1.043ValHis: 1.043 ± 0.027	5.058ValIle: 5.058 ± 0.074	3.842ValLys: 3.842 ± 0.06	7.365ValLeu: 7.365 ± 0.101	1.968ValMet: 1.968 ± 0.042	2.652ValAsn: 2.652 ± 0.058	3.139ValPro: 3.139 ± 0.051	1.771ValGln: 1.771 ± 0.031	3.84ValArg: 3.84 ± 0.067	5.303ValSer: 5.303 ± 0.077	5.045ValThr: 5.045 ± 0.093	5.381ValVal: 5.381 ± 0.078	0.62ValTrp: 0.62 ± 0.024	2.449ValTyr: 2.449 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.743TrpAla: 0.743 ± 0.027	0.134TrpCys: 0.134 ± 0.011	0.551TrpAsp: 0.551 ± 0.023	0.551TrpGlu: 0.551 ± 0.025	0.444TrpPhe: 0.444 ± 0.022	0.685TrpGly: 0.685 ± 0.024	0.206TrpHis: 0.206 ± 0.013	0.477TrpIle: 0.477 ± 0.018	0.448TrpLys: 0.448 ± 0.024	0.985TrpLeu: 0.985 ± 0.034	0.24TrpMet: 0.24 ± 0.015	0.387TrpAsn: 0.387 ± 0.017	0.31TrpPro: 0.31 ± 0.018	0.334TrpGln: 0.334 ± 0.018	0.491TrpArg: 0.491 ± 0.021	0.53TrpSer: 0.53 ± 0.023	0.446TrpThr: 0.446 ± 0.017	0.524TrpVal: 0.524 ± 0.021	0.108TrpTrp: 0.108 ± 0.01	0.358TrpTyr: 0.358 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.194TyrAla: 3.194 ± 0.053	0.564TyrCys: 0.564 ± 0.02	2.389TyrAsp: 2.389 ± 0.055	2.047TyrGlu: 2.047 ± 0.038	1.607TyrPhe: 1.607 ± 0.04	2.937TyrGly: 2.937 ± 0.061	0.645TyrHis: 0.645 ± 0.022	2.502TyrIle: 2.502 ± 0.043	1.781TyrLys: 1.781 ± 0.043	3.274TyrLeu: 3.274 ± 0.062	0.823TyrMet: 0.823 ± 0.025	1.537TyrAsn: 1.537 ± 0.043	1.417TyrPro: 1.417 ± 0.036	0.992TyrGln: 0.992 ± 0.03	1.854TyrArg: 1.854 ± 0.043	2.086TyrSer: 2.086 ± 0.041	2.161TyrThr: 2.161 ± 0.045	2.156TyrVal: 2.156 ± 0.048	0.346TyrTrp: 0.346 ± 0.019	1.425TyrTyr: 1.425 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3771 proteins (1206611 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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