Amino acid dipepetide frequency for Amazon lily mild mottle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.091AlaAla: 8.091 ± 1.975
0.952AlaCys: 0.952 ± 0.328
5.712AlaAsp: 5.712 ± 1.494
5.712AlaGlu: 5.712 ± 1.502
4.76AlaPhe: 4.76 ± 1.102
5.712AlaGly: 5.712 ± 1.884
2.38AlaHis: 2.38 ± 1.077
3.808AlaIle: 3.808 ± 1.598
2.856AlaLys: 2.856 ± 1.098
8.567AlaLeu: 8.567 ± 2.165
0.476AlaMet: 0.476 ± 0.315
1.904AlaAsn: 1.904 ± 0.558
2.856AlaPro: 2.856 ± 1.467
2.38AlaGln: 2.38 ± 1.449
2.38AlaArg: 2.38 ± 0.698
2.856AlaSer: 2.856 ± 0.928
1.904AlaThr: 1.904 ± 0.782
5.236AlaVal: 5.236 ± 1.642
1.428AlaTrp: 1.428 ± 0.782
2.856AlaTyr: 2.856 ± 1.02
0.0AlaXaa: 0.0 ± 0.0
Cys
1.428CysAla: 1.428 ± 0.51
0.952CysCys: 0.952 ± 0.328
2.856CysAsp: 2.856 ± 0.474
1.428CysGlu: 1.428 ± 0.651
2.38CysPhe: 2.38 ± 0.798
0.952CysGly: 0.952 ± 0.63
0.476CysHis: 0.476 ± 0.315
2.856CysIle: 2.856 ± 1.02
1.428CysLys: 1.428 ± 0.945
2.856CysLeu: 2.856 ± 0.474
0.0CysMet: 0.0 ± 0.0
0.476CysAsn: 0.476 ± 0.61
1.904CysPro: 1.904 ± 0.782
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
2.856CysSer: 2.856 ± 1.793
1.428CysThr: 1.428 ± 0.429
4.284CysVal: 4.284 ± 0.747
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
6.663AspAla: 6.663 ± 1.494
3.808AspCys: 3.808 ± 2.075
3.808AspAsp: 3.808 ± 2.045
2.856AspGlu: 2.856 ± 1.382
4.284AspPhe: 4.284 ± 0.194
2.856AspGly: 2.856 ± 0.984
0.0AspHis: 0.0 ± 0.0
2.856AspIle: 2.856 ± 1.31
4.284AspLys: 4.284 ± 0.887
6.188AspLeu: 6.188 ± 0.772
1.904AspMet: 1.904 ± 0.833
2.856AspAsn: 2.856 ± 0.762
3.808AspPro: 3.808 ± 1.867
3.332AspGln: 3.332 ± 1.108
2.856AspArg: 2.856 ± 0.762
3.808AspSer: 3.808 ± 0.923
3.332AspThr: 3.332 ± 1.0
4.284AspVal: 4.284 ± 1.351
0.952AspTrp: 0.952 ± 0.328
2.38AspTyr: 2.38 ± 1.114
0.0AspXaa: 0.0 ± 0.0
Glu
3.332GluAla: 3.332 ± 1.197
2.38GluCys: 2.38 ± 0.798
1.904GluAsp: 1.904 ± 1.199
5.712GluGlu: 5.712 ± 1.667
3.808GluPhe: 3.808 ± 1.254
2.38GluGly: 2.38 ± 1.077
0.952GluHis: 0.952 ± 0.699
2.38GluIle: 2.38 ± 1.077
4.76GluLys: 4.76 ± 2.155
5.236GluLeu: 5.236 ± 0.878
2.38GluMet: 2.38 ± 1.053
2.856GluAsn: 2.856 ± 0.864
0.476GluPro: 0.476 ± 0.392
0.952GluGln: 0.952 ± 0.328
5.236GluArg: 5.236 ± 0.892
4.76GluSer: 4.76 ± 0.89
2.38GluThr: 2.38 ± 1.222
4.76GluVal: 4.76 ± 1.015
0.476GluTrp: 0.476 ± 0.392
1.428GluTyr: 1.428 ± 0.623
0.0GluXaa: 0.0 ± 0.0
Phe
2.38PheAla: 2.38 ± 1.053
0.952PheCys: 0.952 ± 0.328
5.712PheAsp: 5.712 ± 1.586
4.284PheGlu: 4.284 ± 1.052
0.952PhePhe: 0.952 ± 0.328
2.856PheGly: 2.856 ± 1.02
1.904PheHis: 1.904 ± 0.656
3.332PheIle: 3.332 ± 0.76
2.856PheLys: 2.856 ± 0.474
3.332PheLeu: 3.332 ± 0.954
1.428PheMet: 1.428 ± 0.69
2.856PheAsn: 2.856 ± 0.816
1.904PhePro: 1.904 ± 0.833
2.856PheGln: 2.856 ± 0.796
3.332PheArg: 3.332 ± 1.185
2.856PheSer: 2.856 ± 0.474
2.38PheThr: 2.38 ± 1.406
5.236PheVal: 5.236 ± 1.301
0.0PheTrp: 0.0 ± 0.0
0.476PheTyr: 0.476 ± 0.392
0.0PheXaa: 0.0 ± 0.0
Gly
3.332GlyAla: 3.332 ± 1.215
1.904GlyCys: 1.904 ± 0.656
5.236GlyAsp: 5.236 ± 0.878
4.284GlyGlu: 4.284 ± 1.052
3.808GlyPhe: 3.808 ± 1.002
4.284GlyGly: 4.284 ± 0.638
0.0GlyHis: 0.0 ± 0.0
2.38GlyIle: 2.38 ± 0.565
2.856GlyLys: 2.856 ± 0.474
6.188GlyLeu: 6.188 ± 2.669
0.952GlyMet: 0.952 ± 0.328
2.38GlyAsn: 2.38 ± 1.406
1.904GlyPro: 1.904 ± 1.301
0.476GlyGln: 0.476 ± 0.315
1.428GlyArg: 1.428 ± 0.429
4.76GlySer: 4.76 ± 0.468
2.856GlyThr: 2.856 ± 1.805
3.332GlyVal: 3.332 ± 0.957
1.428GlyTrp: 1.428 ± 0.623
1.428GlyTyr: 1.428 ± 1.099
0.0GlyXaa: 0.0 ± 0.0
His
0.952HisAla: 0.952 ± 0.784
1.904HisCys: 1.904 ± 0.782
1.428HisAsp: 1.428 ± 0.51
0.476HisGlu: 0.476 ± 0.315
1.428HisPhe: 1.428 ± 0.651
0.952HisGly: 0.952 ± 0.63
0.0HisHis: 0.0 ± 0.0
0.952HisIle: 0.952 ± 0.328
2.38HisLys: 2.38 ± 1.575
2.38HisLeu: 2.38 ± 0.954
0.952HisMet: 0.952 ± 0.328
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.476HisGln: 0.476 ± 0.392
0.952HisArg: 0.952 ± 0.699
2.38HisSer: 2.38 ± 1.077
0.476HisThr: 0.476 ± 0.315
1.428HisVal: 1.428 ± 0.903
0.476HisTrp: 0.476 ± 0.315
0.952HisTyr: 0.952 ± 0.328
0.0HisXaa: 0.0 ± 0.0
Ile
3.808IleAla: 3.808 ± 2.0
1.428IleCys: 1.428 ± 0.51
3.332IleAsp: 3.332 ± 1.669
2.856IleGlu: 2.856 ± 0.796
0.0IlePhe: 0.0 ± 0.0
0.952IleGly: 0.952 ± 0.63
0.476IleHis: 0.476 ± 0.315
1.428IleIle: 1.428 ± 0.945
2.856IleLys: 2.856 ± 0.762
5.236IleLeu: 5.236 ± 1.429
0.476IleMet: 0.476 ± 0.315
2.856IleAsn: 2.856 ± 0.816
4.284IlePro: 4.284 ± 1.943
0.952IleGln: 0.952 ± 0.784
4.76IleArg: 4.76 ± 1.595
2.856IleSer: 2.856 ± 1.301
1.904IleThr: 1.904 ± 1.199
2.38IleVal: 2.38 ± 1.205
1.428IleTrp: 1.428 ± 0.903
1.428IleTyr: 1.428 ± 0.51
0.0IleXaa: 0.0 ± 0.0
Lys
3.332LysAla: 3.332 ± 1.106
0.952LysCys: 0.952 ± 0.63
3.332LysAsp: 3.332 ± 0.957
4.284LysGlu: 4.284 ± 1.713
1.904LysPhe: 1.904 ± 0.656
3.808LysGly: 3.808 ± 2.327
0.952LysHis: 0.952 ± 0.328
4.284LysIle: 4.284 ± 2.312
2.856LysLys: 2.856 ± 0.474
6.663LysLeu: 6.663 ± 1.597
0.952LysMet: 0.952 ± 0.784
2.38LysAsn: 2.38 ± 0.798
2.38LysPro: 2.38 ± 0.798
0.476LysGln: 0.476 ± 0.392
4.284LysArg: 4.284 ± 1.856
6.663LysSer: 6.663 ± 1.643
3.808LysThr: 3.808 ± 1.407
5.712LysVal: 5.712 ± 2.176
0.952LysTrp: 0.952 ± 0.648
1.904LysTyr: 1.904 ± 1.023
0.0LysXaa: 0.0 ± 0.0
Leu
5.236LeuAla: 5.236 ± 1.119
1.428LeuCys: 1.428 ± 0.945
8.091LeuAsp: 8.091 ± 2.368
5.236LeuGlu: 5.236 ± 1.911
7.139LeuPhe: 7.139 ± 1.744
7.139LeuGly: 7.139 ± 2.311
2.38LeuHis: 2.38 ± 0.798
3.808LeuIle: 3.808 ± 0.721
5.236LeuLys: 5.236 ± 1.613
5.712LeuLeu: 5.712 ± 1.951
1.428LeuMet: 1.428 ± 0.936
3.808LeuAsn: 3.808 ± 1.218
4.76LeuPro: 4.76 ± 2.091
2.856LeuGln: 2.856 ± 0.984
3.332LeuArg: 3.332 ± 0.76
7.139LeuSer: 7.139 ± 3.213
4.76LeuThr: 4.76 ± 1.981
12.375LeuVal: 12.375 ± 1.42
0.476LeuTrp: 0.476 ± 0.315
0.476LeuTyr: 0.476 ± 0.315
0.0LeuXaa: 0.0 ± 0.0
Met
2.38MetAla: 2.38 ± 0.953
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
2.38MetGlu: 2.38 ± 0.953
0.952MetPhe: 0.952 ± 0.53
0.952MetGly: 0.952 ± 0.63
1.904MetHis: 1.904 ± 0.382
0.952MetIle: 0.952 ± 0.784
1.904MetLys: 1.904 ± 1.023
1.428MetLeu: 1.428 ± 0.51
1.428MetMet: 1.428 ± 0.51
0.476MetAsn: 0.476 ± 0.392
0.0MetPro: 0.0 ± 0.0
0.476MetGln: 0.476 ± 0.752
1.904MetArg: 1.904 ± 2.08
2.856MetSer: 2.856 ± 0.864
0.476MetThr: 0.476 ± 0.315
1.904MetVal: 1.904 ± 0.627
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.904AsnAla: 1.904 ± 0.656
1.428AsnCys: 1.428 ± 0.945
0.952AsnAsp: 0.952 ± 0.784
1.904AsnGlu: 1.904 ± 1.003
3.808AsnPhe: 3.808 ± 1.598
1.904AsnGly: 1.904 ± 0.833
1.904AsnHis: 1.904 ± 0.656
0.952AsnIle: 0.952 ± 0.328
2.856AsnLys: 2.856 ± 0.857
3.332AsnLeu: 3.332 ± 1.282
0.476AsnMet: 0.476 ± 0.392
1.904AsnAsn: 1.904 ± 0.864
0.952AsnPro: 0.952 ± 0.746
0.952AsnGln: 0.952 ± 1.04
3.332AsnArg: 3.332 ± 2.933
3.332AsnSer: 3.332 ± 1.496
0.952AsnThr: 0.952 ± 0.328
3.332AsnVal: 3.332 ± 1.092
0.476AsnTrp: 0.476 ± 0.392
1.428AsnTyr: 1.428 ± 0.623
0.0AsnXaa: 0.0 ± 0.0
Pro
1.904ProAla: 1.904 ± 1.199
0.476ProCys: 0.476 ± 0.61
2.856ProAsp: 2.856 ± 0.474
3.332ProGlu: 3.332 ± 1.75
1.428ProPhe: 1.428 ± 1.446
3.808ProGly: 3.808 ± 2.147
0.476ProHis: 0.476 ± 0.315
5.236ProIle: 5.236 ± 1.163
1.428ProLys: 1.428 ± 0.429
3.332ProLeu: 3.332 ± 1.496
0.476ProMet: 0.476 ± 0.5
0.952ProAsn: 0.952 ± 0.699
0.476ProPro: 0.476 ± 0.752
0.952ProGln: 0.952 ± 1.04
2.856ProArg: 2.856 ± 0.864
3.332ProSer: 3.332 ± 1.185
2.38ProThr: 2.38 ± 1.297
2.856ProVal: 2.856 ± 1.407
0.952ProTrp: 0.952 ± 0.328
0.952ProTyr: 0.952 ± 0.328
0.0ProXaa: 0.0 ± 0.0
Gln
4.284GlnAla: 4.284 ± 1.046
0.952GlnCys: 0.952 ± 0.328
0.952GlnAsp: 0.952 ± 0.699
0.952GlnGlu: 0.952 ± 0.63
1.904GlnPhe: 1.904 ± 0.656
1.904GlnGly: 1.904 ± 0.656
0.476GlnHis: 0.476 ± 0.392
2.38GlnIle: 2.38 ± 0.698
0.952GlnLys: 0.952 ± 0.784
2.38GlnLeu: 2.38 ± 1.077
0.0GlnMet: 0.0 ± 0.0
1.428GlnAsn: 1.428 ± 1.709
0.476GlnPro: 0.476 ± 0.392
2.38GlnGln: 2.38 ± 0.583
3.332GlnArg: 3.332 ± 1.608
0.476GlnSer: 0.476 ± 0.61
0.952GlnThr: 0.952 ± 0.328
1.428GlnVal: 1.428 ± 0.924
0.476GlnTrp: 0.476 ± 0.752
1.428GlnTyr: 1.428 ± 0.651
0.0GlnXaa: 0.0 ± 0.0
Arg
3.332ArgAla: 3.332 ± 1.092
2.38ArgCys: 2.38 ± 1.095
3.808ArgAsp: 3.808 ± 1.564
1.904ArgGlu: 1.904 ± 1.301
1.428ArgPhe: 1.428 ± 0.429
2.38ArgGly: 2.38 ± 0.553
2.38ArgHis: 2.38 ± 0.698
1.428ArgIle: 1.428 ± 0.651
3.808ArgLys: 3.808 ± 2.0
7.615ArgLeu: 7.615 ± 1.672
2.38ArgMet: 2.38 ± 0.583
0.952ArgAsn: 0.952 ± 0.746
0.952ArgPro: 0.952 ± 0.699
2.38ArgGln: 2.38 ± 1.495
2.856ArgArg: 2.856 ± 2.306
5.712ArgSer: 5.712 ± 3.15
4.76ArgThr: 4.76 ± 1.766
5.236ArgVal: 5.236 ± 2.066
0.476ArgTrp: 0.476 ± 0.61
0.952ArgTyr: 0.952 ± 0.648
0.0ArgXaa: 0.0 ± 0.0
Ser
4.284SerAla: 4.284 ± 2.091
1.904SerCys: 1.904 ± 1.003
4.76SerAsp: 4.76 ± 1.266
3.332SerGlu: 3.332 ± 1.197
6.188SerPhe: 6.188 ± 1.651
3.808SerGly: 3.808 ± 0.748
0.952SerHis: 0.952 ± 0.648
1.428SerIle: 1.428 ± 0.945
7.615SerLys: 7.615 ± 1.845
8.091SerLeu: 8.091 ± 2.848
1.428SerMet: 1.428 ± 0.51
1.904SerAsn: 1.904 ± 0.656
2.856SerPro: 2.856 ± 1.793
2.38SerGln: 2.38 ± 0.954
3.332SerArg: 3.332 ± 1.46
7.615SerSer: 7.615 ± 5.675
5.236SerThr: 5.236 ± 1.642
8.091SerVal: 8.091 ± 1.352
0.952SerTrp: 0.952 ± 0.63
2.38SerTyr: 2.38 ± 0.458
0.0SerXaa: 0.0 ± 0.0
Thr
6.188ThrAla: 6.188 ± 1.014
0.952ThrCys: 0.952 ± 0.63
2.856ThrAsp: 2.856 ± 1.603
0.952ThrGlu: 0.952 ± 0.784
1.904ThrPhe: 1.904 ± 1.023
2.856ThrGly: 2.856 ± 1.393
0.476ThrHis: 0.476 ± 0.392
1.904ThrIle: 1.904 ± 0.627
2.38ThrLys: 2.38 ± 1.095
6.663ThrLeu: 6.663 ± 0.816
1.904ThrMet: 1.904 ± 0.558
1.904ThrAsn: 1.904 ± 0.656
2.856ThrPro: 2.856 ± 2.835
1.428ThrGln: 1.428 ± 0.945
4.284ThrArg: 4.284 ± 2.091
4.76ThrSer: 4.76 ± 2.105
4.284ThrThr: 4.284 ± 1.209
2.38ThrVal: 2.38 ± 1.222
0.0ThrTrp: 0.0 ± 0.0
1.428ThrTyr: 1.428 ± 0.945
0.0ThrXaa: 0.0 ± 0.0
Val
7.615ValAla: 7.615 ± 1.391
2.856ValCys: 2.856 ± 1.317
7.139ValAsp: 7.139 ± 1.463
4.284ValGlu: 4.284 ± 1.209
2.38ValPhe: 2.38 ± 0.936
4.284ValGly: 4.284 ± 0.719
1.428ValHis: 1.428 ± 0.945
1.904ValIle: 1.904 ± 1.399
5.236ValLys: 5.236 ± 1.358
4.76ValLeu: 4.76 ± 0.796
1.904ValMet: 1.904 ± 0.631
4.284ValAsn: 4.284 ± 1.965
7.615ValPro: 7.615 ± 3.631
1.428ValGln: 1.428 ± 0.578
5.236ValArg: 5.236 ± 1.797
5.712ValSer: 5.712 ± 1.525
6.663ValThr: 6.663 ± 3.493
9.519ValVal: 9.519 ± 1.918
1.428ValTrp: 1.428 ± 0.782
1.428ValTyr: 1.428 ± 0.51
0.0ValXaa: 0.0 ± 0.0
Trp
0.476TrpAla: 0.476 ± 0.392
0.476TrpCys: 0.476 ± 0.392
0.476TrpAsp: 0.476 ± 0.61
0.476TrpGlu: 0.476 ± 0.315
0.952TrpPhe: 0.952 ± 0.328
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.428TrpLys: 1.428 ± 0.623
0.952TrpLeu: 0.952 ± 0.699
0.0TrpMet: 0.0 ± 0.0
0.476TrpAsn: 0.476 ± 0.315
0.0TrpPro: 0.0 ± 0.0
0.476TrpGln: 0.476 ± 0.315
0.476TrpArg: 0.476 ± 0.315
2.856TrpSer: 2.856 ± 0.57
0.952TrpThr: 0.952 ± 0.699
1.428TrpVal: 1.428 ± 0.903
1.428TrpTrp: 1.428 ± 0.51
0.476TrpTyr: 0.476 ± 0.392
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.904TyrAla: 1.904 ± 0.656
0.476TyrCys: 0.476 ± 0.315
1.904TyrAsp: 1.904 ± 1.061
1.904TyrGlu: 1.904 ± 0.382
0.476TyrPhe: 0.476 ± 0.392
1.428TyrGly: 1.428 ± 0.88
1.428TyrHis: 1.428 ± 0.51
1.428TyrIle: 1.428 ± 0.51
1.904TyrLys: 1.904 ± 1.26
2.38TyrLeu: 2.38 ± 0.553
0.952TyrMet: 0.952 ± 0.648
1.428TyrAsn: 1.428 ± 0.429
0.0TyrPro: 0.0 ± 0.0
1.904TyrGln: 1.904 ± 1.023
0.952TyrArg: 0.952 ± 0.328
0.952TyrSer: 0.952 ± 0.63
0.476TyrThr: 0.476 ± 0.315
1.904TyrVal: 1.904 ± 0.382
0.0TyrTrp: 0.0 ± 0.0
1.428TyrTyr: 1.428 ± 0.651
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (2102 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski