Amino acid dipepetide frequency for Eubacterium ventriosum ATCC 27560

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.708AlaAla: 4.708 ± 0.097	0.814AlaCys: 0.814 ± 0.034	3.837AlaAsp: 3.837 ± 0.082	4.229AlaGlu: 4.229 ± 0.083	2.708AlaPhe: 2.708 ± 0.062	4.778AlaGly: 4.778 ± 0.087	0.882AlaHis: 0.882 ± 0.039	5.32AlaIle: 5.32 ± 0.106	5.436AlaLys: 5.436 ± 0.094	5.517AlaLeu: 5.517 ± 0.102	1.975AlaMet: 1.975 ± 0.055	2.919AlaAsn: 2.919 ± 0.072	1.769AlaPro: 1.769 ± 0.074	1.623AlaGln: 1.623 ± 0.049	2.156AlaArg: 2.156 ± 0.057	3.558AlaSer: 3.558 ± 0.064	4.006AlaThr: 4.006 ± 0.089	5.039AlaVal: 5.039 ± 0.097	0.539AlaTrp: 0.539 ± 0.029	2.67AlaTyr: 2.67 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.805CysAla: 0.805 ± 0.032	0.263CysCys: 0.263 ± 0.019	0.776CysAsp: 0.776 ± 0.031	0.791CysGlu: 0.791 ± 0.028	0.621CysPhe: 0.621 ± 0.028	1.298CysGly: 1.298 ± 0.049	0.257CysHis: 0.257 ± 0.02	1.147CysIle: 1.147 ± 0.038	1.091CysLys: 1.091 ± 0.033	0.972CysLeu: 0.972 ± 0.036	0.406CysMet: 0.406 ± 0.026	0.811CysAsn: 0.811 ± 0.035	0.523CysPro: 0.523 ± 0.025	0.353CysGln: 0.353 ± 0.024	0.481CysArg: 0.481 ± 0.027	0.848CysSer: 0.848 ± 0.035	0.755CysThr: 0.755 ± 0.037	0.999CysVal: 0.999 ± 0.033	0.118CysTrp: 0.118 ± 0.012	0.574CysTyr: 0.574 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	3.371AspAla: 3.371 ± 0.068	0.755AspCys: 0.755 ± 0.032	3.276AspAsp: 3.276 ± 0.076	4.744AspGlu: 4.744 ± 0.087	2.767AspPhe: 2.767 ± 0.06	4.344AspGly: 4.344 ± 0.093	0.634AspHis: 0.634 ± 0.027	4.904AspIle: 4.904 ± 0.076	4.935AspLys: 4.935 ± 0.089	4.064AspLeu: 4.064 ± 0.08	1.875AspMet: 1.875 ± 0.045	3.301AspAsn: 3.301 ± 0.073	1.304AspPro: 1.304 ± 0.036	1.172AspGln: 1.172 ± 0.04	1.972AspArg: 1.972 ± 0.053	3.446AspSer: 3.446 ± 0.082	3.012AspThr: 3.012 ± 0.069	3.864AspVal: 3.864 ± 0.077	0.561AspTrp: 0.561 ± 0.026	3.075AspTyr: 3.075 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	4.456GluAla: 4.456 ± 0.086	0.839GluCys: 0.839 ± 0.036	4.001GluAsp: 4.001 ± 0.077	6.162GluGlu: 6.162 ± 0.135	2.616GluPhe: 2.616 ± 0.06	3.835GluGly: 3.835 ± 0.069	1.134GluHis: 1.134 ± 0.034	5.86GluIle: 5.86 ± 0.094	7.508GluLys: 7.508 ± 0.111	5.842GluLeu: 5.842 ± 0.097	2.239GluMet: 2.239 ± 0.059	5.085GluAsn: 5.085 ± 0.097	1.658GluPro: 1.658 ± 0.054	2.608GluGln: 2.608 ± 0.064	2.673GluArg: 2.673 ± 0.07	3.471GluSer: 3.471 ± 0.059	3.659GluThr: 3.659 ± 0.082	4.261GluVal: 4.261 ± 0.089	0.559GluTrp: 0.559 ± 0.03	3.453GluTyr: 3.453 ± 0.073	0.0GluXaa: 0.0 ± 0.0
Phe	2.603PheAla: 2.603 ± 0.06	0.696PheCys: 0.696 ± 0.03	2.585PheAsp: 2.585 ± 0.058	2.764PheGlu: 2.764 ± 0.065	1.829PhePhe: 1.829 ± 0.054	2.989PheGly: 2.989 ± 0.072	0.621PheHis: 0.621 ± 0.025	3.273PheIle: 3.273 ± 0.07	3.049PheLys: 3.049 ± 0.065	3.407PheLeu: 3.407 ± 0.085	1.194PheMet: 1.194 ± 0.036	2.26PheAsn: 2.26 ± 0.049	1.181PhePro: 1.181 ± 0.043	1.062PheGln: 1.062 ± 0.037	1.371PheArg: 1.371 ± 0.041	2.918PheSer: 2.918 ± 0.072	2.38PheThr: 2.38 ± 0.055	2.931PheVal: 2.931 ± 0.071	0.398PheTrp: 0.398 ± 0.023	1.743PheTyr: 1.743 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	4.269GlyAla: 4.269 ± 0.093	1.052GlyCys: 1.052 ± 0.039	3.383GlyAsp: 3.383 ± 0.07	4.11GlyGlu: 4.11 ± 0.075	2.844GlyPhe: 2.844 ± 0.059	4.229GlyGly: 4.229 ± 0.098	1.072GlyHis: 1.072 ± 0.039	6.105GlyIle: 6.105 ± 0.102	6.3GlyLys: 6.3 ± 0.101	4.998GlyLeu: 4.998 ± 0.076	2.103GlyMet: 2.103 ± 0.056	3.553GlyAsn: 3.553 ± 0.082	1.097GlyPro: 1.097 ± 0.04	1.917GlyGln: 1.917 ± 0.046	2.504GlyArg: 2.504 ± 0.058	3.863GlySer: 3.863 ± 0.075	4.267GlyThr: 4.267 ± 0.099	4.646GlyVal: 4.646 ± 0.092	0.684GlyTrp: 0.684 ± 0.033	3.27GlyTyr: 3.27 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	0.785HisAla: 0.785 ± 0.033	0.271HisCys: 0.271 ± 0.017	0.665HisAsp: 0.665 ± 0.032	0.784HisGlu: 0.784 ± 0.03	0.734HisPhe: 0.734 ± 0.028	1.092HisGly: 1.092 ± 0.039	0.37HisHis: 0.37 ± 0.03	1.365HisIle: 1.365 ± 0.043	1.079HisLys: 1.079 ± 0.034	1.139HisLeu: 1.139 ± 0.038	0.455HisMet: 0.455 ± 0.022	0.863HisAsn: 0.863 ± 0.033	0.61HisPro: 0.61 ± 0.034	0.416HisGln: 0.416 ± 0.021	0.629HisArg: 0.629 ± 0.031	0.905HisSer: 0.905 ± 0.03	0.839HisThr: 0.839 ± 0.031	0.81HisVal: 0.81 ± 0.032	0.151HisTrp: 0.151 ± 0.011	0.64HisTyr: 0.64 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.449IleAla: 5.449 ± 0.092	1.336IleCys: 1.336 ± 0.037	4.713IleAsp: 4.713 ± 0.074	5.63IleGlu: 5.63 ± 0.103	3.449IlePhe: 3.449 ± 0.093	5.27IleGly: 5.27 ± 0.078	1.165IleHis: 1.165 ± 0.038	6.841IleIle: 6.841 ± 0.118	7.023IleLys: 7.023 ± 0.109	6.542IleLeu: 6.542 ± 0.116	2.142IleMet: 2.142 ± 0.056	4.599IleAsn: 4.599 ± 0.085	2.956IlePro: 2.956 ± 0.061	2.025IleGln: 2.025 ± 0.044	2.88IleArg: 2.88 ± 0.068	5.716IleSer: 5.716 ± 0.094	4.92IleThr: 4.92 ± 0.089	5.827IleVal: 5.827 ± 0.088	0.672IleTrp: 0.672 ± 0.029	3.262IleTyr: 3.262 ± 0.07	0.0IleXaa: 0.0 ± 0.0
Lys	5.687LysAla: 5.687 ± 0.092	0.95LysCys: 0.95 ± 0.032	5.153LysAsp: 5.153 ± 0.086	7.519LysGlu: 7.519 ± 0.127	2.616LysPhe: 2.616 ± 0.066	4.983LysGly: 4.983 ± 0.088	1.142LysHis: 1.142 ± 0.034	7.024LysIle: 7.024 ± 0.09	9.296LysLys: 9.296 ± 0.161	6.404LysLeu: 6.404 ± 0.105	2.824LysMet: 2.824 ± 0.058	5.639LysAsn: 5.639 ± 0.093	2.27LysPro: 2.27 ± 0.049	2.649LysGln: 2.649 ± 0.06	2.937LysArg: 2.937 ± 0.058	4.724LysSer: 4.724 ± 0.086	4.866LysThr: 4.866 ± 0.104	5.958LysVal: 5.958 ± 0.108	0.773LysTrp: 0.773 ± 0.034	4.191LysTyr: 4.191 ± 0.088	0.0LysXaa: 0.0 ± 0.0
Leu	5.312LeuAla: 5.312 ± 0.087	1.236LeuCys: 1.236 ± 0.036	4.549LeuAsp: 4.549 ± 0.083	5.536LeuGlu: 5.536 ± 0.092	3.421LeuPhe: 3.421 ± 0.074	5.084LeuGly: 5.084 ± 0.086	1.189LeuHis: 1.189 ± 0.046	5.965LeuIle: 5.965 ± 0.102	7.002LeuLys: 7.002 ± 0.113	6.415LeuLeu: 6.415 ± 0.118	2.4LeuMet: 2.4 ± 0.062	4.29LeuAsn: 4.29 ± 0.086	2.776LeuPro: 2.776 ± 0.066	2.181LeuGln: 2.181 ± 0.05	2.766LeuArg: 2.766 ± 0.067	5.532LeuSer: 5.532 ± 0.094	4.543LeuThr: 4.543 ± 0.086	5.113LeuVal: 5.113 ± 0.091	0.647LeuTrp: 0.647 ± 0.03	3.098LeuTyr: 3.098 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.387MetAla: 2.387 ± 0.055	0.414MetCys: 0.414 ± 0.022	1.833MetAsp: 1.833 ± 0.05	2.42MetGlu: 2.42 ± 0.053	1.18MetPhe: 1.18 ± 0.037	1.876MetGly: 1.876 ± 0.045	0.397MetHis: 0.397 ± 0.025	2.197MetIle: 2.197 ± 0.059	2.593MetLys: 2.593 ± 0.055	2.471MetLeu: 2.471 ± 0.058	0.787MetMet: 0.787 ± 0.033	1.587MetAsn: 1.587 ± 0.045	1.071MetPro: 1.071 ± 0.041	0.798MetGln: 0.798 ± 0.031	1.02MetArg: 1.02 ± 0.039	1.945MetSer: 1.945 ± 0.049	1.535MetThr: 1.535 ± 0.041	1.925MetVal: 1.925 ± 0.058	0.206MetTrp: 0.206 ± 0.016	1.068MetTyr: 1.068 ± 0.039	0.0MetXaa: 0.0 ± 0.0
Asn	3.227AsnAla: 3.227 ± 0.073	0.767AsnCys: 0.767 ± 0.031	2.885AsnAsp: 2.885 ± 0.066	3.66AsnGlu: 3.66 ± 0.075	2.043AsnPhe: 2.043 ± 0.048	4.165AsnGly: 4.165 ± 0.092	0.895AsnHis: 0.895 ± 0.034	5.227AsnIle: 5.227 ± 0.079	4.879AsnLys: 4.879 ± 0.083	4.229AsnLeu: 4.229 ± 0.076	1.706AsnMet: 1.706 ± 0.046	3.692AsnAsn: 3.692 ± 0.079	2.172AsnPro: 2.172 ± 0.047	1.812AsnGln: 1.812 ± 0.054	2.035AsnArg: 2.035 ± 0.055	3.365AsnSer: 3.365 ± 0.08	3.074AsnThr: 3.074 ± 0.063	3.941AsnVal: 3.941 ± 0.083	0.511AsnTrp: 0.511 ± 0.027	2.465AsnTyr: 2.465 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	1.833ProAla: 1.833 ± 0.056	0.422ProCys: 0.422 ± 0.022	1.974ProAsp: 1.974 ± 0.057	2.587ProGlu: 2.587 ± 0.07	1.371ProPhe: 1.371 ± 0.043	1.855ProGly: 1.855 ± 0.053	0.491ProHis: 0.491 ± 0.025	2.244ProIle: 2.244 ± 0.054	2.146ProLys: 2.146 ± 0.049	2.192ProLeu: 2.192 ± 0.063	0.822ProMet: 0.822 ± 0.031	1.466ProAsn: 1.466 ± 0.043	0.582ProPro: 0.582 ± 0.027	0.803ProGln: 0.803 ± 0.033	0.819ProArg: 0.819 ± 0.034	1.642ProSer: 1.642 ± 0.048	1.869ProThr: 1.869 ± 0.081	2.369ProVal: 2.369 ± 0.052	0.257ProTrp: 0.257 ± 0.019	1.308ProTyr: 1.308 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.894GlnAla: 1.894 ± 0.06	0.358GlnCys: 0.358 ± 0.021	1.277GlnAsp: 1.277 ± 0.041	1.781GlnGlu: 1.781 ± 0.053	1.073GlnPhe: 1.073 ± 0.039	1.716GlnGly: 1.716 ± 0.049	0.377GlnHis: 0.377 ± 0.024	2.535GlnIle: 2.535 ± 0.063	2.394GlnLys: 2.394 ± 0.066	2.549GlnLeu: 2.549 ± 0.062	0.944GlnMet: 0.944 ± 0.036	1.529GlnAsn: 1.529 ± 0.045	0.792GlnPro: 0.792 ± 0.034	0.962GlnGln: 0.962 ± 0.045	1.078GlnArg: 1.078 ± 0.034	1.473GlnSer: 1.473 ± 0.044	1.491GlnThr: 1.491 ± 0.044	2.0GlnVal: 2.0 ± 0.048	0.311GlnTrp: 0.311 ± 0.019	1.344GlnTyr: 1.344 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	1.977ArgAla: 1.977 ± 0.048	0.457ArgCys: 0.457 ± 0.022	1.843ArgAsp: 1.843 ± 0.05	2.862ArgGlu: 2.862 ± 0.066	1.546ArgPhe: 1.546 ± 0.039	1.892ArgGly: 1.892 ± 0.047	0.562ArgHis: 0.562 ± 0.027	3.012ArgIle: 3.012 ± 0.062	3.337ArgLys: 3.337 ± 0.064	2.939ArgLeu: 2.939 ± 0.071	1.239ArgMet: 1.239 ± 0.038	2.06ArgAsn: 2.06 ± 0.053	0.973ArgPro: 0.973 ± 0.037	1.225ArgGln: 1.225 ± 0.042	1.631ArgArg: 1.631 ± 0.046	1.705ArgSer: 1.705 ± 0.047	1.982ArgThr: 1.982 ± 0.049	2.248ArgVal: 2.248 ± 0.057	0.299ArgTrp: 0.299 ± 0.021	1.527ArgTyr: 1.527 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.731SerAla: 3.731 ± 0.075	0.71SerCys: 0.71 ± 0.031	3.776SerAsp: 3.776 ± 0.083	4.079SerGlu: 4.079 ± 0.081	2.751SerPhe: 2.751 ± 0.053	4.592SerGly: 4.592 ± 0.096	0.881SerHis: 0.881 ± 0.036	4.885SerIle: 4.885 ± 0.093	5.074SerLys: 5.074 ± 0.089	4.836SerLeu: 4.836 ± 0.09	1.646SerMet: 1.646 ± 0.053	3.282SerAsn: 3.282 ± 0.074	1.505SerPro: 1.505 ± 0.045	1.728SerGln: 1.728 ± 0.049	2.216SerArg: 2.216 ± 0.048	3.978SerSer: 3.978 ± 0.1	3.385SerThr: 3.385 ± 0.084	4.508SerVal: 4.508 ± 0.084	0.536SerTrp: 0.536 ± 0.027	2.649SerTyr: 2.649 ± 0.07	0.0SerXaa: 0.0 ± 0.0
Thr	3.899ThrAla: 3.899 ± 0.091	0.64ThrCys: 0.64 ± 0.033	3.476ThrAsp: 3.476 ± 0.063	3.815ThrGlu: 3.815 ± 0.08	2.374ThrPhe: 2.374 ± 0.056	4.356ThrGly: 4.356 ± 0.094	0.786ThrHis: 0.786 ± 0.03	4.743ThrIle: 4.743 ± 0.087	4.527ThrLys: 4.527 ± 0.096	4.572ThrLeu: 4.572 ± 0.073	1.521ThrMet: 1.521 ± 0.045	2.776ThrAsn: 2.776 ± 0.063	2.064ThrPro: 2.064 ± 0.056	1.324ThrGln: 1.324 ± 0.048	1.712ThrArg: 1.712 ± 0.054	3.449ThrSer: 3.449 ± 0.074	4.359ThrThr: 4.359 ± 0.182	5.031ThrVal: 5.031 ± 0.121	0.522ThrTrp: 0.522 ± 0.025	2.499ThrTyr: 2.499 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	5.006ValAla: 5.006 ± 0.091	1.103ValCys: 1.103 ± 0.04	4.088ValAsp: 4.088 ± 0.074	4.803ValGlu: 4.803 ± 0.082	2.967ValPhe: 2.967 ± 0.069	4.218ValGly: 4.218 ± 0.079	0.884ValHis: 0.884 ± 0.032	5.677ValIle: 5.677 ± 0.104	5.698ValLys: 5.698 ± 0.119	5.936ValLeu: 5.936 ± 0.096	1.989ValMet: 1.989 ± 0.051	3.628ValAsn: 3.628 ± 0.068	2.263ValPro: 2.263 ± 0.055	1.752ValGln: 1.752 ± 0.054	2.383ValArg: 2.383 ± 0.052	4.661ValSer: 4.661 ± 0.084	4.476ValThr: 4.476 ± 0.098	5.047ValVal: 5.047 ± 0.096	0.612ValTrp: 0.612 ± 0.031	2.883ValTyr: 2.883 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.515TrpAla: 0.515 ± 0.028	0.124TrpCys: 0.124 ± 0.013	0.511TrpAsp: 0.511 ± 0.026	0.617TrpGlu: 0.617 ± 0.028	0.4TrpPhe: 0.4 ± 0.022	0.655TrpGly: 0.655 ± 0.033	0.165TrpHis: 0.165 ± 0.014	0.678TrpIle: 0.678 ± 0.031	0.719TrpLys: 0.719 ± 0.03	0.684TrpLeu: 0.684 ± 0.033	0.268TrpMet: 0.268 ± 0.019	0.61TrpAsn: 0.61 ± 0.031	0.189TrpPro: 0.189 ± 0.018	0.322TrpGln: 0.322 ± 0.022	0.307TrpArg: 0.307 ± 0.019	0.597TrpSer: 0.597 ± 0.029	0.482TrpThr: 0.482 ± 0.029	0.486TrpVal: 0.486 ± 0.025	0.113TrpTrp: 0.113 ± 0.013	0.376TrpTyr: 0.376 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.569TyrAla: 2.569 ± 0.062	0.684TyrCys: 0.684 ± 0.028	2.774TyrAsp: 2.774 ± 0.061	3.027TyrGlu: 3.027 ± 0.068	1.942TyrPhe: 1.942 ± 0.053	3.039TyrGly: 3.039 ± 0.067	0.7TyrHis: 0.7 ± 0.031	3.414TyrIle: 3.414 ± 0.066	3.516TyrLys: 3.516 ± 0.072	3.349TyrLeu: 3.349 ± 0.069	1.174TyrMet: 1.174 ± 0.044	2.803TyrAsn: 2.803 ± 0.066	1.294TyrPro: 1.294 ± 0.037	1.148TyrGln: 1.148 ± 0.037	1.747TyrArg: 1.747 ± 0.043	2.953TyrSer: 2.953 ± 0.068	2.545TyrThr: 2.545 ± 0.065	3.071TyrVal: 3.071 ± 0.066	0.348TyrTrp: 0.348 ± 0.023	2.248TyrTyr: 2.248 ± 0.071	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2776 proteins (829464 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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