Amino acid dipepetide frequency for Burkholderia phage vB_BceS_KL1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.248AlaAla: 16.248 ± 3.046
0.874AlaCys: 0.874 ± 0.291
5.61AlaAsp: 5.61 ± 0.674
6.485AlaGlu: 6.485 ± 0.991
3.934AlaPhe: 3.934 ± 0.423
7.942AlaGly: 7.942 ± 0.686
1.749AlaHis: 1.749 ± 0.437
6.193AlaIle: 6.193 ± 1.144
7.286AlaLys: 7.286 ± 0.997
9.545AlaLeu: 9.545 ± 1.112
2.404AlaMet: 2.404 ± 0.353
6.047AlaAsn: 6.047 ± 0.751
5.027AlaPro: 5.027 ± 0.822
5.027AlaGln: 5.027 ± 1.107
5.537AlaArg: 5.537 ± 0.562
6.266AlaSer: 6.266 ± 0.756
7.796AlaThr: 7.796 ± 1.231
6.922AlaVal: 6.922 ± 0.881
1.53AlaTrp: 1.53 ± 0.394
2.987AlaTyr: 2.987 ± 0.404
0.0AlaXaa: 0.0 ± 0.0
Cys
1.02CysAla: 1.02 ± 0.285
0.146CysCys: 0.146 ± 0.098
0.874CysAsp: 0.874 ± 0.257
0.729CysGlu: 0.729 ± 0.265
0.437CysPhe: 0.437 ± 0.183
0.947CysGly: 0.947 ± 0.328
0.364CysHis: 0.364 ± 0.161
0.437CysIle: 0.437 ± 0.215
0.729CysLys: 0.729 ± 0.255
0.583CysLeu: 0.583 ± 0.209
0.073CysMet: 0.073 ± 0.073
0.364CysAsn: 0.364 ± 0.141
0.437CysPro: 0.437 ± 0.205
0.073CysGln: 0.073 ± 0.077
0.51CysArg: 0.51 ± 0.173
0.073CysSer: 0.073 ± 0.073
0.51CysThr: 0.51 ± 0.183
0.656CysVal: 0.656 ± 0.189
0.0CysTrp: 0.0 ± 0.0
0.437CysTyr: 0.437 ± 0.177
0.0CysXaa: 0.0 ± 0.0
Asp
6.849AspAla: 6.849 ± 0.714
0.437AspCys: 0.437 ± 0.169
2.914AspAsp: 2.914 ± 0.476
4.882AspGlu: 4.882 ± 0.565
2.914AspPhe: 2.914 ± 0.53
5.756AspGly: 5.756 ± 0.706
0.437AspHis: 0.437 ± 0.183
2.259AspIle: 2.259 ± 0.393
2.914AspLys: 2.914 ± 0.531
4.663AspLeu: 4.663 ± 0.463
0.729AspMet: 0.729 ± 0.231
2.842AspAsn: 2.842 ± 0.345
2.623AspPro: 2.623 ± 0.411
1.311AspGln: 1.311 ± 0.382
2.914AspArg: 2.914 ± 0.433
2.842AspSer: 2.842 ± 0.471
2.987AspThr: 2.987 ± 0.415
3.206AspVal: 3.206 ± 0.355
1.239AspTrp: 1.239 ± 0.266
2.477AspTyr: 2.477 ± 0.405
0.0AspXaa: 0.0 ± 0.0
Glu
6.339GluAla: 6.339 ± 0.833
0.947GluCys: 0.947 ± 0.217
3.206GluAsp: 3.206 ± 0.576
3.424GluGlu: 3.424 ± 0.702
2.04GluPhe: 2.04 ± 0.353
4.007GluGly: 4.007 ± 0.633
0.656GluHis: 0.656 ± 0.229
3.57GluIle: 3.57 ± 0.644
2.842GluLys: 2.842 ± 0.527
5.392GluLeu: 5.392 ± 0.726
1.603GluMet: 1.603 ± 0.347
2.404GluAsn: 2.404 ± 0.351
1.967GluPro: 1.967 ± 0.509
2.769GluGln: 2.769 ± 0.47
3.206GluArg: 3.206 ± 0.49
1.967GluSer: 1.967 ± 0.441
3.934GluThr: 3.934 ± 0.587
4.226GluVal: 4.226 ± 0.522
1.093GluTrp: 1.093 ± 0.285
2.259GluTyr: 2.259 ± 0.385
0.0GluXaa: 0.0 ± 0.0
Phe
3.497PheAla: 3.497 ± 0.485
0.364PheCys: 0.364 ± 0.161
3.57PheAsp: 3.57 ± 0.483
2.113PheGlu: 2.113 ± 0.4
1.821PhePhe: 1.821 ± 0.352
3.352PheGly: 3.352 ± 0.489
0.437PheHis: 0.437 ± 0.222
3.06PheIle: 3.06 ± 0.416
1.311PheLys: 1.311 ± 0.339
2.113PheLeu: 2.113 ± 0.393
1.239PheMet: 1.239 ± 0.327
2.04PheAsn: 2.04 ± 0.385
1.384PhePro: 1.384 ± 0.293
1.02PheGln: 1.02 ± 0.268
1.967PheArg: 1.967 ± 0.354
2.332PheSer: 2.332 ± 0.455
2.113PheThr: 2.113 ± 0.509
3.06PheVal: 3.06 ± 0.524
0.51PheTrp: 0.51 ± 0.176
1.457PheTyr: 1.457 ± 0.251
0.0PheXaa: 0.0 ± 0.0
Gly
8.015GlyAla: 8.015 ± 0.979
0.801GlyCys: 0.801 ± 0.249
4.736GlyAsp: 4.736 ± 0.615
4.954GlyGlu: 4.954 ± 0.626
3.57GlyPhe: 3.57 ± 0.516
7.14GlyGly: 7.14 ± 1.201
0.874GlyHis: 0.874 ± 0.329
3.789GlyIle: 3.789 ± 0.437
5.173GlyLys: 5.173 ± 0.751
6.922GlyLeu: 6.922 ± 0.898
1.53GlyMet: 1.53 ± 0.304
2.769GlyAsn: 2.769 ± 0.374
2.769GlyPro: 2.769 ± 0.453
3.424GlyGln: 3.424 ± 0.7
2.477GlyArg: 2.477 ± 0.428
4.517GlySer: 4.517 ± 0.516
4.882GlyThr: 4.882 ± 0.649
5.246GlyVal: 5.246 ± 0.454
1.311GlyTrp: 1.311 ± 0.311
2.55GlyTyr: 2.55 ± 0.478
0.0GlyXaa: 0.0 ± 0.0
His
1.239HisAla: 1.239 ± 0.348
0.437HisCys: 0.437 ± 0.165
0.364HisAsp: 0.364 ± 0.148
0.729HisGlu: 0.729 ± 0.243
0.51HisPhe: 0.51 ± 0.208
1.457HisGly: 1.457 ± 0.381
0.219HisHis: 0.219 ± 0.14
1.093HisIle: 1.093 ± 0.266
0.583HisLys: 0.583 ± 0.239
1.311HisLeu: 1.311 ± 0.372
0.291HisMet: 0.291 ± 0.146
0.656HisAsn: 0.656 ± 0.197
0.656HisPro: 0.656 ± 0.218
0.146HisGln: 0.146 ± 0.094
0.656HisArg: 0.656 ± 0.235
0.801HisSer: 0.801 ± 0.25
0.51HisThr: 0.51 ± 0.181
1.239HisVal: 1.239 ± 0.319
0.146HisTrp: 0.146 ± 0.1
0.291HisTyr: 0.291 ± 0.151
0.0HisXaa: 0.0 ± 0.0
Ile
6.849IleAla: 6.849 ± 0.65
0.729IleCys: 0.729 ± 0.264
3.57IleAsp: 3.57 ± 0.451
4.226IleGlu: 4.226 ± 0.591
1.821IlePhe: 1.821 ± 0.381
3.206IleGly: 3.206 ± 0.496
0.874IleHis: 0.874 ± 0.209
2.769IleIle: 2.769 ± 0.423
3.643IleLys: 3.643 ± 0.533
2.55IleLeu: 2.55 ± 0.427
1.239IleMet: 1.239 ± 0.298
2.55IleAsn: 2.55 ± 0.453
3.424IlePro: 3.424 ± 0.561
1.53IleGln: 1.53 ± 0.407
2.55IleArg: 2.55 ± 0.412
3.206IleSer: 3.206 ± 0.475
3.352IleThr: 3.352 ± 0.506
3.862IleVal: 3.862 ± 0.505
0.729IleTrp: 0.729 ± 0.196
1.53IleTyr: 1.53 ± 0.434
0.0IleXaa: 0.0 ± 0.0
Lys
6.995LysAla: 6.995 ± 0.911
0.583LysCys: 0.583 ± 0.215
2.696LysAsp: 2.696 ± 0.346
2.332LysGlu: 2.332 ± 0.599
1.821LysPhe: 1.821 ± 0.367
3.206LysGly: 3.206 ± 0.451
0.583LysHis: 0.583 ± 0.212
2.477LysIle: 2.477 ± 0.406
4.226LysLys: 4.226 ± 0.674
5.902LysLeu: 5.902 ± 0.836
0.874LysMet: 0.874 ± 0.229
2.404LysAsn: 2.404 ± 0.462
2.55LysPro: 2.55 ± 0.509
1.967LysGln: 1.967 ± 0.442
2.404LysArg: 2.404 ± 0.328
3.133LysSer: 3.133 ± 0.495
3.279LysThr: 3.279 ± 0.48
4.444LysVal: 4.444 ± 0.495
0.656LysTrp: 0.656 ± 0.19
2.04LysTyr: 2.04 ± 0.453
0.0LysXaa: 0.0 ± 0.0
Leu
9.107LeuAla: 9.107 ± 1.158
0.364LeuCys: 0.364 ± 0.172
4.517LeuAsp: 4.517 ± 0.579
3.643LeuGlu: 3.643 ± 0.584
3.279LeuPhe: 3.279 ± 0.447
4.59LeuGly: 4.59 ± 0.646
1.093LeuHis: 1.093 ± 0.31
3.643LeuIle: 3.643 ± 0.475
4.226LeuLys: 4.226 ± 0.596
6.339LeuLeu: 6.339 ± 0.569
1.311LeuMet: 1.311 ± 0.379
3.789LeuAsn: 3.789 ± 0.536
4.299LeuPro: 4.299 ± 0.444
4.226LeuGln: 4.226 ± 1.073
5.1LeuArg: 5.1 ± 0.633
5.902LeuSer: 5.902 ± 0.509
4.809LeuThr: 4.809 ± 0.653
4.08LeuVal: 4.08 ± 0.466
1.02LeuTrp: 1.02 ± 0.254
2.987LeuTyr: 2.987 ± 0.512
0.0LeuXaa: 0.0 ± 0.0
Met
3.133MetAla: 3.133 ± 0.444
0.146MetCys: 0.146 ± 0.118
1.093MetAsp: 1.093 ± 0.284
0.583MetGlu: 0.583 ± 0.263
0.583MetPhe: 0.583 ± 0.172
1.603MetGly: 1.603 ± 0.33
0.219MetHis: 0.219 ± 0.132
0.947MetIle: 0.947 ± 0.289
1.02MetLys: 1.02 ± 0.306
2.04MetLeu: 2.04 ± 0.503
0.437MetMet: 0.437 ± 0.203
0.729MetAsn: 0.729 ± 0.222
1.384MetPro: 1.384 ± 0.26
1.166MetGln: 1.166 ± 0.291
0.874MetArg: 0.874 ± 0.269
1.821MetSer: 1.821 ± 0.305
1.676MetThr: 1.676 ± 0.378
1.239MetVal: 1.239 ± 0.298
0.219MetTrp: 0.219 ± 0.121
0.291MetTyr: 0.291 ± 0.126
0.0MetXaa: 0.0 ± 0.0
Asn
4.954AsnAla: 4.954 ± 0.959
0.656AsnCys: 0.656 ± 0.28
2.914AsnAsp: 2.914 ± 0.462
2.477AsnGlu: 2.477 ± 0.398
1.603AsnPhe: 1.603 ± 0.315
4.59AsnGly: 4.59 ± 0.528
0.583AsnHis: 0.583 ± 0.232
3.206AsnIle: 3.206 ± 0.623
2.987AsnLys: 2.987 ± 0.423
2.769AsnLeu: 2.769 ± 0.457
0.947AsnMet: 0.947 ± 0.259
2.113AsnAsn: 2.113 ± 0.507
2.914AsnPro: 2.914 ± 0.383
1.166AsnGln: 1.166 ± 0.32
2.259AsnArg: 2.259 ± 0.378
2.696AsnSer: 2.696 ± 0.431
2.987AsnThr: 2.987 ± 0.427
4.226AsnVal: 4.226 ± 0.614
0.583AsnTrp: 0.583 ± 0.186
0.801AsnTyr: 0.801 ± 0.211
0.0AsnXaa: 0.0 ± 0.0
Pro
5.1ProAla: 5.1 ± 0.936
0.51ProCys: 0.51 ± 0.203
3.206ProAsp: 3.206 ± 0.471
2.842ProGlu: 2.842 ± 0.48
2.04ProPhe: 2.04 ± 0.446
3.57ProGly: 3.57 ± 0.825
0.874ProHis: 0.874 ± 0.257
2.477ProIle: 2.477 ± 0.415
1.676ProLys: 1.676 ± 0.322
2.914ProLeu: 2.914 ± 0.582
1.239ProMet: 1.239 ± 0.33
3.06ProAsn: 3.06 ± 0.468
2.332ProPro: 2.332 ± 0.438
2.987ProGln: 2.987 ± 1.097
2.04ProArg: 2.04 ± 0.365
2.987ProSer: 2.987 ± 0.564
3.352ProThr: 3.352 ± 0.501
3.424ProVal: 3.424 ± 0.593
0.729ProTrp: 0.729 ± 0.233
1.603ProTyr: 1.603 ± 0.342
0.0ProXaa: 0.0 ± 0.0
Gln
4.954GlnAla: 4.954 ± 0.622
0.146GlnCys: 0.146 ± 0.097
1.894GlnAsp: 1.894 ± 0.516
1.311GlnGlu: 1.311 ± 0.33
1.384GlnPhe: 1.384 ± 0.301
3.352GlnGly: 3.352 ± 0.731
0.583GlnHis: 0.583 ± 0.207
2.404GlnIle: 2.404 ± 0.448
2.04GlnLys: 2.04 ± 0.541
3.934GlnLeu: 3.934 ± 0.868
0.947GlnMet: 0.947 ± 0.276
2.259GlnAsn: 2.259 ± 0.445
2.696GlnPro: 2.696 ± 1.1
3.643GlnGln: 3.643 ± 1.213
1.894GlnArg: 1.894 ± 0.415
2.04GlnSer: 2.04 ± 0.499
3.06GlnThr: 3.06 ± 0.619
2.332GlnVal: 2.332 ± 0.489
0.291GlnTrp: 0.291 ± 0.159
1.239GlnTyr: 1.239 ± 0.312
0.0GlnXaa: 0.0 ± 0.0
Arg
5.027ArgAla: 5.027 ± 0.658
0.219ArgCys: 0.219 ± 0.105
2.987ArgAsp: 2.987 ± 0.37
2.842ArgGlu: 2.842 ± 0.395
1.894ArgPhe: 1.894 ± 0.377
3.279ArgGly: 3.279 ± 0.363
0.656ArgHis: 0.656 ± 0.216
3.643ArgIle: 3.643 ± 0.46
2.477ArgLys: 2.477 ± 0.504
4.809ArgLeu: 4.809 ± 0.351
1.457ArgMet: 1.457 ± 0.292
1.749ArgAsn: 1.749 ± 0.285
2.477ArgPro: 2.477 ± 0.485
2.113ArgGln: 2.113 ± 0.324
3.206ArgArg: 3.206 ± 0.501
2.477ArgSer: 2.477 ± 0.307
3.279ArgThr: 3.279 ± 0.619
2.186ArgVal: 2.186 ± 0.448
0.656ArgTrp: 0.656 ± 0.236
2.186ArgTyr: 2.186 ± 0.404
0.0ArgXaa: 0.0 ± 0.0
Ser
6.412SerAla: 6.412 ± 0.742
0.219SerCys: 0.219 ± 0.115
3.57SerAsp: 3.57 ± 0.43
3.133SerGlu: 3.133 ± 0.434
2.55SerPhe: 2.55 ± 0.468
4.809SerGly: 4.809 ± 0.464
0.729SerHis: 0.729 ± 0.223
2.914SerIle: 2.914 ± 0.497
2.914SerLys: 2.914 ± 0.531
4.226SerLeu: 4.226 ± 0.497
0.729SerMet: 0.729 ± 0.189
2.623SerAsn: 2.623 ± 0.483
2.404SerPro: 2.404 ± 0.422
2.914SerGln: 2.914 ± 0.595
3.133SerArg: 3.133 ± 0.44
3.862SerSer: 3.862 ± 0.584
3.934SerThr: 3.934 ± 0.501
3.643SerVal: 3.643 ± 0.511
0.656SerTrp: 0.656 ± 0.261
1.749SerTyr: 1.749 ± 0.414
0.0SerXaa: 0.0 ± 0.0
Thr
7.723ThrAla: 7.723 ± 1.398
0.291ThrCys: 0.291 ± 0.136
3.497ThrAsp: 3.497 ± 0.482
4.299ThrGlu: 4.299 ± 0.589
2.259ThrPhe: 2.259 ± 0.392
5.464ThrGly: 5.464 ± 0.675
0.51ThrHis: 0.51 ± 0.178
3.57ThrIle: 3.57 ± 0.822
3.716ThrLys: 3.716 ± 0.608
5.027ThrLeu: 5.027 ± 0.542
1.384ThrMet: 1.384 ± 0.321
3.206ThrAsn: 3.206 ± 0.506
3.497ThrPro: 3.497 ± 0.587
2.259ThrGln: 2.259 ± 0.625
2.332ThrArg: 2.332 ± 0.425
3.352ThrSer: 3.352 ± 0.442
5.027ThrThr: 5.027 ± 0.928
3.862ThrVal: 3.862 ± 0.669
0.729ThrTrp: 0.729 ± 0.219
2.332ThrTyr: 2.332 ± 0.37
0.0ThrXaa: 0.0 ± 0.0
Val
8.087ValAla: 8.087 ± 0.965
0.437ValCys: 0.437 ± 0.175
2.842ValAsp: 2.842 ± 0.476
4.59ValGlu: 4.59 ± 0.661
2.769ValPhe: 2.769 ± 0.48
5.829ValGly: 5.829 ± 0.815
1.02ValHis: 1.02 ± 0.222
3.279ValIle: 3.279 ± 0.405
2.696ValLys: 2.696 ± 0.475
4.372ValLeu: 4.372 ± 0.435
1.384ValMet: 1.384 ± 0.278
2.842ValAsn: 2.842 ± 0.417
3.862ValPro: 3.862 ± 0.485
2.259ValGln: 2.259 ± 0.404
3.352ValArg: 3.352 ± 0.55
3.934ValSer: 3.934 ± 0.477
4.08ValThr: 4.08 ± 0.592
4.663ValVal: 4.663 ± 0.549
1.311ValTrp: 1.311 ± 0.337
1.821ValTyr: 1.821 ± 0.401
0.0ValXaa: 0.0 ± 0.0
Trp
1.02TrpAla: 1.02 ± 0.261
0.291TrpCys: 0.291 ± 0.136
0.583TrpAsp: 0.583 ± 0.196
0.437TrpGlu: 0.437 ± 0.17
0.437TrpPhe: 0.437 ± 0.178
0.656TrpGly: 0.656 ± 0.323
0.437TrpHis: 0.437 ± 0.166
0.656TrpIle: 0.656 ± 0.244
0.656TrpLys: 0.656 ± 0.179
0.656TrpLeu: 0.656 ± 0.222
0.291TrpMet: 0.291 ± 0.115
1.093TrpAsn: 1.093 ± 0.258
1.02TrpPro: 1.02 ± 0.249
1.311TrpGln: 1.311 ± 0.293
1.166TrpArg: 1.166 ± 0.269
0.583TrpSer: 0.583 ± 0.157
0.583TrpThr: 0.583 ± 0.228
0.801TrpVal: 0.801 ± 0.218
0.291TrpTrp: 0.291 ± 0.137
1.166TrpTyr: 1.166 ± 0.29
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.842TyrAla: 2.842 ± 0.511
0.801TyrCys: 0.801 ± 0.34
2.55TyrAsp: 2.55 ± 0.517
1.821TyrGlu: 1.821 ± 0.346
1.093TyrPhe: 1.093 ± 0.304
2.696TyrGly: 2.696 ± 0.45
0.437TyrHis: 0.437 ± 0.174
1.821TyrIle: 1.821 ± 0.351
1.53TyrLys: 1.53 ± 0.369
2.259TyrLeu: 2.259 ± 0.339
1.02TyrMet: 1.02 ± 0.371
1.894TyrAsn: 1.894 ± 0.332
1.239TyrPro: 1.239 ± 0.3
1.093TyrGln: 1.093 ± 0.294
2.04TyrArg: 2.04 ± 0.39
2.332TyrSer: 2.332 ± 0.5
2.186TyrThr: 2.186 ± 0.436
2.113TyrVal: 2.113 ± 0.399
0.437TyrTrp: 0.437 ± 0.193
0.656TyrTyr: 0.656 ± 0.271
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (13726 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski