Amino acid dipepetide frequency for Streptomyces afghaniensis 772

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.798AlaAla: 19.798 ± 0.146	1.121AlaCys: 1.121 ± 0.021	8.039AlaAsp: 8.039 ± 0.064	8.466AlaGlu: 8.466 ± 0.075	3.496AlaPhe: 3.496 ± 0.039	12.797AlaGly: 12.797 ± 0.083	2.884AlaHis: 2.884 ± 0.036	3.455AlaIle: 3.455 ± 0.038	2.826AlaLys: 2.826 ± 0.043	14.283AlaLeu: 14.283 ± 0.094	2.52AlaMet: 2.52 ± 0.031	1.847AlaAsn: 1.847 ± 0.026	6.64AlaPro: 6.64 ± 0.058	3.69AlaGln: 3.69 ± 0.042	10.332AlaArg: 10.332 ± 0.08	5.841AlaSer: 5.841 ± 0.053	6.722AlaThr: 6.722 ± 0.05	11.937AlaVal: 11.937 ± 0.086	1.884AlaTrp: 1.884 ± 0.028	2.813AlaTyr: 2.813 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.119CysAla: 1.119 ± 0.023	0.135CysCys: 0.135 ± 0.009	0.458CysAsp: 0.458 ± 0.014	0.438CysGlu: 0.438 ± 0.015	0.231CysPhe: 0.231 ± 0.01	1.012CysGly: 1.012 ± 0.021	0.197CysHis: 0.197 ± 0.01	0.171CysIle: 0.171 ± 0.009	0.123CysLys: 0.123 ± 0.007	0.791CysLeu: 0.791 ± 0.017	0.149CysMet: 0.149 ± 0.008	0.125CysAsn: 0.125 ± 0.007	0.536CysPro: 0.536 ± 0.015	0.161CysGln: 0.161 ± 0.009	0.706CysArg: 0.706 ± 0.017	0.484CysSer: 0.484 ± 0.013	0.511CysThr: 0.511 ± 0.013	0.706CysVal: 0.706 ± 0.015	0.149CysTrp: 0.149 ± 0.008	0.154CysTyr: 0.154 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.407AspAla: 7.407 ± 0.054	0.426AspCys: 0.426 ± 0.013	3.676AspAsp: 3.676 ± 0.044	3.908AspGlu: 3.908 ± 0.049	1.681AspPhe: 1.681 ± 0.03	6.407AspGly: 6.407 ± 0.06	1.467AspHis: 1.467 ± 0.023	1.955AspIle: 1.955 ± 0.032	1.239AspLys: 1.239 ± 0.025	6.138AspLeu: 6.138 ± 0.05	0.843AspMet: 0.843 ± 0.019	0.999AspAsn: 0.999 ± 0.02	4.481AspPro: 4.481 ± 0.049	1.556AspGln: 1.556 ± 0.027	4.959AspArg: 4.959 ± 0.052	2.59AspSer: 2.59 ± 0.036	3.241AspThr: 3.241 ± 0.039	4.875AspVal: 4.875 ± 0.048	1.045AspTrp: 1.045 ± 0.02	1.118AspTyr: 1.118 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.309GluAla: 7.309 ± 0.063	0.358GluCys: 0.358 ± 0.013	2.872GluAsp: 2.872 ± 0.038	3.667GluGlu: 3.667 ± 0.054	1.478GluPhe: 1.478 ± 0.025	4.352GluGly: 4.352 ± 0.041	1.572GluHis: 1.572 ± 0.026	2.228GluIle: 2.228 ± 0.033	1.523GluLys: 1.523 ± 0.029	6.713GluLeu: 6.713 ± 0.061	0.89GluMet: 0.89 ± 0.02	1.063GluAsn: 1.063 ± 0.022	3.467GluPro: 3.467 ± 0.044	2.377GluGln: 2.377 ± 0.035	5.463GluArg: 5.463 ± 0.055	2.579GluSer: 2.579 ± 0.033	2.939GluThr: 2.939 ± 0.035	4.49GluVal: 4.49 ± 0.05	0.777GluTrp: 0.777 ± 0.02	1.135GluTyr: 1.135 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.62PheAla: 3.62 ± 0.044	0.271PheCys: 0.271 ± 0.012	1.976PheAsp: 1.976 ± 0.031	1.469PheGlu: 1.469 ± 0.025	0.912PhePhe: 0.912 ± 0.022	2.976PheGly: 2.976 ± 0.037	0.631PheHis: 0.631 ± 0.015	0.689PheIle: 0.689 ± 0.016	0.537PheLys: 0.537 ± 0.017	2.641PheLeu: 2.641 ± 0.036	0.425PheMet: 0.425 ± 0.013	0.589PheAsn: 0.589 ± 0.015	1.407PhePro: 1.407 ± 0.023	0.729PheGln: 0.729 ± 0.018	1.918PheArg: 1.918 ± 0.026	1.503PheSer: 1.503 ± 0.028	2.053PheThr: 2.053 ± 0.03	2.278PheVal: 2.278 ± 0.029	0.439PheTrp: 0.439 ± 0.013	0.597PheTyr: 0.597 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.532GlyAla: 10.532 ± 0.076	0.897GlyCys: 0.897 ± 0.018	5.269GlyAsp: 5.269 ± 0.046	5.198GlyGlu: 5.198 ± 0.045	2.875GlyPhe: 2.875 ± 0.037	8.689GlyGly: 8.689 ± 0.071	2.39GlyHis: 2.39 ± 0.034	3.432GlyIle: 3.432 ± 0.038	2.537GlyLys: 2.537 ± 0.039	9.53GlyLeu: 9.53 ± 0.073	2.041GlyMet: 2.041 ± 0.028	1.742GlyAsn: 1.742 ± 0.03	5.162GlyPro: 5.162 ± 0.05	2.758GlyGln: 2.758 ± 0.04	8.008GlyArg: 8.008 ± 0.071	5.325GlySer: 5.325 ± 0.048	6.412GlyThr: 6.412 ± 0.056	7.592GlyVal: 7.592 ± 0.063	1.714GlyTrp: 1.714 ± 0.029	2.295GlyTyr: 2.295 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	2.676HisAla: 2.676 ± 0.036	0.22HisCys: 0.22 ± 0.009	1.408HisAsp: 1.408 ± 0.025	1.27HisGlu: 1.27 ± 0.022	0.655HisPhe: 0.655 ± 0.015	2.491HisGly: 2.491 ± 0.034	0.709HisHis: 0.709 ± 0.02	0.695HisIle: 0.695 ± 0.017	0.376HisLys: 0.376 ± 0.011	2.458HisLeu: 2.458 ± 0.035	0.336HisMet: 0.336 ± 0.011	0.385HisAsn: 0.385 ± 0.014	1.879HisPro: 1.879 ± 0.028	0.656HisGln: 0.656 ± 0.017	2.24HisArg: 2.24 ± 0.037	1.007HisSer: 1.007 ± 0.021	1.373HisThr: 1.373 ± 0.025	1.779HisVal: 1.779 ± 0.027	0.384HisTrp: 0.384 ± 0.013	0.488HisTyr: 0.488 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.67IleAla: 4.67 ± 0.049	0.284IleCys: 0.284 ± 0.011	2.23IleAsp: 2.23 ± 0.034	1.921IleGlu: 1.921 ± 0.027	0.717IlePhe: 0.717 ± 0.018	3.503IleGly: 3.503 ± 0.042	0.628IleHis: 0.628 ± 0.014	0.865IleIle: 0.865 ± 0.022	0.736IleLys: 0.736 ± 0.02	2.425IleLeu: 2.425 ± 0.036	0.478IleMet: 0.478 ± 0.014	0.689IleAsn: 0.689 ± 0.015	1.811IlePro: 1.811 ± 0.024	0.726IleGln: 0.726 ± 0.019	2.231IleArg: 2.231 ± 0.033	1.637IleSer: 1.637 ± 0.03	2.257IleThr: 2.257 ± 0.033	2.727IleVal: 2.727 ± 0.039	0.363IleTrp: 0.363 ± 0.012	0.522IleTyr: 0.522 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.025LysAla: 3.025 ± 0.045	0.13LysCys: 0.13 ± 0.007	1.382LysAsp: 1.382 ± 0.027	1.27LysGlu: 1.27 ± 0.026	0.472LysPhe: 0.472 ± 0.015	1.955LysGly: 1.955 ± 0.038	0.441LysHis: 0.441 ± 0.014	0.859LysIle: 0.859 ± 0.024	0.944LysLys: 0.944 ± 0.031	2.051LysLeu: 2.051 ± 0.029	0.414LysMet: 0.414 ± 0.012	0.553LysAsn: 0.553 ± 0.017	1.421LysPro: 1.421 ± 0.027	0.75LysGln: 0.75 ± 0.018	1.43LysArg: 1.43 ± 0.028	1.197LysSer: 1.197 ± 0.026	1.334LysThr: 1.334 ± 0.026	1.992LysVal: 1.992 ± 0.034	0.285LysTrp: 0.285 ± 0.011	0.492LysTyr: 0.492 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.744LeuAla: 14.744 ± 0.102	0.856LeuCys: 0.856 ± 0.019	6.67LeuAsp: 6.67 ± 0.058	4.74LeuGlu: 4.74 ± 0.052	2.704LeuPhe: 2.704 ± 0.041	9.279LeuGly: 9.279 ± 0.073	2.31LeuHis: 2.31 ± 0.035	3.155LeuIle: 3.155 ± 0.042	2.172LeuLys: 2.172 ± 0.033	11.244LeuLeu: 11.244 ± 0.097	1.67LeuMet: 1.67 ± 0.029	1.682LeuAsn: 1.682 ± 0.027	6.533LeuPro: 6.533 ± 0.057	2.228LeuGln: 2.228 ± 0.029	8.721LeuArg: 8.721 ± 0.068	5.263LeuSer: 5.263 ± 0.047	6.909LeuThr: 6.909 ± 0.046	8.887LeuVal: 8.887 ± 0.078	1.336LeuTrp: 1.336 ± 0.03	1.893LeuTyr: 1.893 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.324MetAla: 2.324 ± 0.029	0.149MetCys: 0.149 ± 0.008	0.901MetAsp: 0.901 ± 0.017	0.789MetGlu: 0.789 ± 0.018	0.489MetPhe: 0.489 ± 0.014	1.34MetGly: 1.34 ± 0.023	0.369MetHis: 0.369 ± 0.012	0.704MetIle: 0.704 ± 0.019	0.437MetLys: 0.437 ± 0.013	1.756MetLeu: 1.756 ± 0.029	0.337MetMet: 0.337 ± 0.012	0.434MetAsn: 0.434 ± 0.012	1.143MetPro: 1.143 ± 0.023	0.449MetGln: 0.449 ± 0.014	1.478MetArg: 1.478 ± 0.024	1.281MetSer: 1.281 ± 0.02	1.605MetThr: 1.605 ± 0.024	1.314MetVal: 1.314 ± 0.021	0.242MetTrp: 0.242 ± 0.009	0.344MetTyr: 0.344 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.152AsnAla: 2.152 ± 0.028	0.178AsnCys: 0.178 ± 0.009	0.993AsnAsp: 0.993 ± 0.021	0.812AsnGlu: 0.812 ± 0.018	0.503AsnPhe: 0.503 ± 0.013	1.852AsnGly: 1.852 ± 0.03	0.401AsnHis: 0.401 ± 0.014	0.654AsnIle: 0.654 ± 0.016	0.439AsnLys: 0.439 ± 0.014	1.65AsnLeu: 1.65 ± 0.026	0.305AsnMet: 0.305 ± 0.01	0.438AsnAsn: 0.438 ± 0.015	1.358AsnPro: 1.358 ± 0.021	0.553AsnGln: 0.553 ± 0.013	1.274AsnArg: 1.274 ± 0.023	0.939AsnSer: 0.939 ± 0.019	1.115AsnThr: 1.115 ± 0.023	1.378AsnVal: 1.378 ± 0.024	0.307AsnTrp: 0.307 ± 0.01	0.419AsnTyr: 0.419 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.306ProAla: 8.306 ± 0.069	0.397ProCys: 0.397 ± 0.013	4.542ProAsp: 4.542 ± 0.046	4.454ProGlu: 4.454 ± 0.048	1.585ProPhe: 1.585 ± 0.026	6.734ProGly: 6.734 ± 0.059	1.504ProHis: 1.504 ± 0.029	1.237ProIle: 1.237 ± 0.022	1.243ProLys: 1.243 ± 0.027	5.386ProLeu: 5.386 ± 0.046	1.014ProMet: 1.014 ± 0.018	0.883ProAsn: 0.883 ± 0.02	3.587ProPro: 3.587 ± 0.051	1.762ProGln: 1.762 ± 0.027	4.165ProArg: 4.165 ± 0.051	3.299ProSer: 3.299 ± 0.039	3.121ProThr: 3.121 ± 0.039	5.515ProVal: 5.515 ± 0.047	0.944ProTrp: 0.944 ± 0.021	1.437ProTyr: 1.437 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.735GlnAla: 3.735 ± 0.041	0.17GlnCys: 0.17 ± 0.009	1.513GlnAsp: 1.513 ± 0.024	1.574GlnGlu: 1.574 ± 0.028	0.686GlnPhe: 0.686 ± 0.015	2.385GlnGly: 2.385 ± 0.033	0.692GlnHis: 0.692 ± 0.017	1.069GlnIle: 1.069 ± 0.022	0.647GlnLys: 0.647 ± 0.019	3.021GlnLeu: 3.021 ± 0.038	0.508GlnMet: 0.508 ± 0.015	0.496GlnAsn: 0.496 ± 0.015	1.75GlnPro: 1.75 ± 0.034	1.226GlnGln: 1.226 ± 0.029	2.395GlnArg: 2.395 ± 0.034	1.253GlnSer: 1.253 ± 0.022	1.363GlnThr: 1.363 ± 0.025	2.389GlnVal: 2.389 ± 0.029	0.479GlnTrp: 0.479 ± 0.013	0.631GlnTyr: 0.631 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.85ArgAla: 9.85 ± 0.089	0.68ArgCys: 0.68 ± 0.018	4.327ArgAsp: 4.327 ± 0.045	4.818ArgGlu: 4.818 ± 0.051	2.311ArgPhe: 2.311 ± 0.031	5.955ArgGly: 5.955 ± 0.062	2.276ArgHis: 2.276 ± 0.038	3.222ArgIle: 3.222 ± 0.036	1.695ArgLys: 1.695 ± 0.026	8.988ArgLeu: 8.988 ± 0.073	1.814ArgMet: 1.814 ± 0.028	1.401ArgAsn: 1.401 ± 0.025	5.253ArgPro: 5.253 ± 0.068	2.357ArgGln: 2.357 ± 0.035	8.164ArgArg: 8.164 ± 0.105	4.175ArgSer: 4.175 ± 0.046	5.447ArgThr: 5.447 ± 0.055	5.931ArgVal: 5.931 ± 0.045	1.417ArgTrp: 1.417 ± 0.024	1.793ArgTyr: 1.793 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.498SerAla: 6.498 ± 0.051	0.468SerCys: 0.468 ± 0.014	2.738SerAsp: 2.738 ± 0.034	2.436SerGlu: 2.436 ± 0.033	1.53SerPhe: 1.53 ± 0.023	5.991SerGly: 5.991 ± 0.05	1.022SerHis: 1.022 ± 0.018	1.39SerIle: 1.39 ± 0.024	1.074SerLys: 1.074 ± 0.023	4.772SerLeu: 4.772 ± 0.043	1.136SerMet: 1.136 ± 0.021	0.864SerAsn: 0.864 ± 0.019	3.327SerPro: 3.327 ± 0.041	1.243SerGln: 1.243 ± 0.021	3.838SerArg: 3.838 ± 0.045	2.973SerSer: 2.973 ± 0.044	3.118SerThr: 3.118 ± 0.039	4.303SerVal: 4.303 ± 0.04	0.943SerTrp: 0.943 ± 0.02	1.227SerTyr: 1.227 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	8.735ThrAla: 8.735 ± 0.06	0.474ThrCys: 0.474 ± 0.014	3.664ThrAsp: 3.664 ± 0.042	3.234ThrGlu: 3.234 ± 0.041	1.657ThrPhe: 1.657 ± 0.024	6.704ThrGly: 6.704 ± 0.056	1.23ThrHis: 1.23 ± 0.021	1.726ThrIle: 1.726 ± 0.026	1.24ThrLys: 1.24 ± 0.028	5.656ThrLeu: 5.656 ± 0.049	0.985ThrMet: 0.985 ± 0.019	1.007ThrAsn: 1.007 ± 0.022	4.18ThrPro: 4.18 ± 0.049	1.349ThrGln: 1.349 ± 0.025	3.999ThrArg: 3.999 ± 0.044	3.284ThrSer: 3.284 ± 0.035	3.908ThrThr: 3.908 ± 0.047	6.043ThrVal: 6.043 ± 0.045	0.953ThrTrp: 0.953 ± 0.022	1.412ThrTyr: 1.412 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.455ValAla: 10.455 ± 0.068	0.812ValCys: 0.812 ± 0.017	4.925ValAsp: 4.925 ± 0.039	4.726ValGlu: 4.726 ± 0.049	2.468ValPhe: 2.468 ± 0.033	6.548ValGly: 6.548 ± 0.054	1.995ValHis: 1.995 ± 0.028	2.838ValIle: 2.838 ± 0.038	1.777ValLys: 1.777 ± 0.031	9.583ValLeu: 9.583 ± 0.075	1.442ValMet: 1.442 ± 0.025	1.672ValAsn: 1.672 ± 0.023	5.28ValPro: 5.28 ± 0.048	2.144ValGln: 2.144 ± 0.028	7.317ValArg: 7.317 ± 0.055	4.322ValSer: 4.322 ± 0.045	5.72ValThr: 5.72 ± 0.053	8.001ValVal: 8.001 ± 0.079	1.173ValTrp: 1.173 ± 0.02	1.665ValTyr: 1.665 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.677TrpAla: 1.677 ± 0.028	0.161TrpCys: 0.161 ± 0.008	0.842TrpAsp: 0.842 ± 0.019	0.765TrpGlu: 0.765 ± 0.018	0.526TrpPhe: 0.526 ± 0.014	1.05TrpGly: 1.05 ± 0.023	0.374TrpHis: 0.374 ± 0.012	0.562TrpIle: 0.562 ± 0.015	0.398TrpLys: 0.398 ± 0.012	1.807TrpLeu: 1.807 ± 0.03	0.315TrpMet: 0.315 ± 0.01	0.423TrpAsn: 0.423 ± 0.013	0.833TrpPro: 0.833 ± 0.021	0.647TrpGln: 0.647 ± 0.017	1.403TrpArg: 1.403 ± 0.025	0.969TrpSer: 0.969 ± 0.022	1.086TrpThr: 1.086 ± 0.021	0.99TrpVal: 0.99 ± 0.018	0.346TrpTrp: 0.346 ± 0.012	0.388TrpTyr: 0.388 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.763TyrAla: 2.763 ± 0.032	0.169TyrCys: 0.169 ± 0.008	1.583TyrAsp: 1.583 ± 0.026	1.299TyrGlu: 1.299 ± 0.023	0.684TyrPhe: 0.684 ± 0.017	2.379TyrGly: 2.379 ± 0.031	0.395TyrHis: 0.395 ± 0.011	0.511TyrIle: 0.511 ± 0.015	0.435TyrLys: 0.435 ± 0.014	2.104TyrLeu: 2.104 ± 0.034	0.263TyrMet: 0.263 ± 0.009	0.429TyrAsn: 0.429 ± 0.015	1.066TyrPro: 1.066 ± 0.022	0.619TyrGln: 0.619 ± 0.014	1.833TyrArg: 1.833 ± 0.023	0.969TyrSer: 0.969 ± 0.019	1.205TyrThr: 1.205 ± 0.023	1.736TyrVal: 1.736 ± 0.029	0.382TyrTrp: 0.382 ± 0.013	0.471TyrTyr: 0.471 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9009 proteins (2641689 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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