Amino acid dipepetide frequency for Coprococcus sp. CAG:782

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.572AlaAla: 6.572 ± 0.129	1.064AlaCys: 1.064 ± 0.043	5.204AlaAsp: 5.204 ± 0.093	5.083AlaGlu: 5.083 ± 0.103	2.778AlaPhe: 2.778 ± 0.075	6.321AlaGly: 6.321 ± 0.129	1.086AlaHis: 1.086 ± 0.046	5.407AlaIle: 5.407 ± 0.108	4.523AlaLys: 4.523 ± 0.104	6.07AlaLeu: 6.07 ± 0.111	2.373AlaMet: 2.373 ± 0.068	2.887AlaAsn: 2.887 ± 0.063	1.833AlaPro: 1.833 ± 0.062	1.575AlaGln: 1.575 ± 0.043	2.993AlaArg: 2.993 ± 0.073	3.87AlaSer: 3.87 ± 0.082	3.488AlaThr: 3.488 ± 0.076	6.249AlaVal: 6.249 ± 0.109	0.489AlaTrp: 0.489 ± 0.028	2.987AlaTyr: 2.987 ± 0.066	0.003AlaXaa: 0.003 ± 0.002
Cys	0.95CysAla: 0.95 ± 0.039	0.259CysCys: 0.259 ± 0.024	1.032CysAsp: 1.032 ± 0.044	0.821CysGlu: 0.821 ± 0.041	0.555CysPhe: 0.555 ± 0.033	1.576CysGly: 1.576 ± 0.043	0.29CysHis: 0.29 ± 0.025	1.261CysIle: 1.261 ± 0.044	0.775CysLys: 0.775 ± 0.039	1.012CysLeu: 1.012 ± 0.035	0.49CysMet: 0.49 ± 0.027	0.675CysAsn: 0.675 ± 0.031	0.558CysPro: 0.558 ± 0.033	0.314CysGln: 0.314 ± 0.024	0.677CysArg: 0.677 ± 0.035	0.891CysSer: 0.891 ± 0.037	0.701CysThr: 0.701 ± 0.035	1.065CysVal: 1.065 ± 0.037	0.085CysTrp: 0.085 ± 0.011	0.672CysTyr: 0.672 ± 0.03	0.0CysXaa: 0.0 ± 0.0
Asp	4.011AspAla: 4.011 ± 0.096	0.848AspCys: 0.848 ± 0.037	4.247AspAsp: 4.247 ± 0.113	5.507AspGlu: 5.507 ± 0.1	2.698AspPhe: 2.698 ± 0.072	4.951AspGly: 4.951 ± 0.099	0.959AspHis: 0.959 ± 0.038	6.079AspIle: 6.079 ± 0.104	4.946AspLys: 4.946 ± 0.091	4.336AspLeu: 4.336 ± 0.085	2.52AspMet: 2.52 ± 0.08	3.364AspAsn: 3.364 ± 0.08	1.827AspPro: 1.827 ± 0.056	1.235AspGln: 1.235 ± 0.046	3.016AspArg: 3.016 ± 0.078	3.69AspSer: 3.69 ± 0.086	3.794AspThr: 3.794 ± 0.091	4.866AspVal: 4.866 ± 0.1	0.505AspTrp: 0.505 ± 0.029	3.257AspTyr: 3.257 ± 0.075	0.003AspXaa: 0.003 ± 0.002
Glu	5.607GluAla: 5.607 ± 0.112	0.844GluCys: 0.844 ± 0.035	4.755GluAsp: 4.755 ± 0.085	5.987GluGlu: 5.987 ± 0.121	2.541GluPhe: 2.541 ± 0.065	3.925GluGly: 3.925 ± 0.077	1.349GluHis: 1.349 ± 0.052	5.513GluIle: 5.513 ± 0.105	5.962GluLys: 5.962 ± 0.113	6.676GluLeu: 6.676 ± 0.115	2.132GluMet: 2.132 ± 0.059	4.09GluAsn: 4.09 ± 0.086	1.784GluPro: 1.784 ± 0.054	2.186GluGln: 2.186 ± 0.051	2.784GluArg: 2.784 ± 0.071	3.136GluSer: 3.136 ± 0.066	3.596GluThr: 3.596 ± 0.083	4.212GluVal: 4.212 ± 0.089	0.507GluTrp: 0.507 ± 0.027	3.552GluTyr: 3.552 ± 0.077	0.002GluXaa: 0.002 ± 0.002
Phe	3.092PheAla: 3.092 ± 0.079	0.625PheCys: 0.625 ± 0.028	2.863PheAsp: 2.863 ± 0.063	2.312PheGlu: 2.312 ± 0.061	1.658PhePhe: 1.658 ± 0.06	2.831PheGly: 2.831 ± 0.072	0.586PheHis: 0.586 ± 0.033	2.989PheIle: 2.989 ± 0.074	2.552PheLys: 2.552 ± 0.07	3.171PheLeu: 3.171 ± 0.074	1.141PheMet: 1.141 ± 0.04	1.936PheAsn: 1.936 ± 0.06	1.174PhePro: 1.174 ± 0.043	0.83PheGln: 0.83 ± 0.037	1.449PheArg: 1.449 ± 0.047	2.552PheSer: 2.552 ± 0.065	2.16PheThr: 2.16 ± 0.067	2.981PheVal: 2.981 ± 0.078	0.273PheTrp: 0.273 ± 0.024	1.654PheTyr: 1.654 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	5.031GlyAla: 5.031 ± 0.109	1.233GlyCys: 1.233 ± 0.046	4.363GlyAsp: 4.363 ± 0.086	4.476GlyGlu: 4.476 ± 0.083	2.937GlyPhe: 2.937 ± 0.068	4.834GlyGly: 4.834 ± 0.1	1.256GlyHis: 1.256 ± 0.052	6.313GlyIle: 6.313 ± 0.095	5.175GlyLys: 5.175 ± 0.099	5.489GlyLeu: 5.489 ± 0.093	2.476GlyMet: 2.476 ± 0.061	3.561GlyAsn: 3.561 ± 0.09	1.189GlyPro: 1.189 ± 0.045	1.839GlyGln: 1.839 ± 0.049	3.389GlyArg: 3.389 ± 0.078	4.515GlySer: 4.515 ± 0.099	4.353GlyThr: 4.353 ± 0.12	5.336GlyVal: 5.336 ± 0.107	0.537GlyTrp: 0.537 ± 0.03	3.734GlyTyr: 3.734 ± 0.082	0.003GlyXaa: 0.003 ± 0.002
His	0.892HisAla: 0.892 ± 0.03	0.225HisCys: 0.225 ± 0.017	0.968HisAsp: 0.968 ± 0.046	0.96HisGlu: 0.96 ± 0.04	0.652HisPhe: 0.652 ± 0.03	1.25HisGly: 1.25 ± 0.047	0.332HisHis: 0.332 ± 0.026	1.393HisIle: 1.393 ± 0.044	1.038HisLys: 1.038 ± 0.05	1.129HisLeu: 1.129 ± 0.045	0.56HisMet: 0.56 ± 0.031	0.81HisAsn: 0.81 ± 0.035	0.651HisPro: 0.651 ± 0.033	0.413HisGln: 0.413 ± 0.029	0.722HisArg: 0.722 ± 0.035	0.93HisSer: 0.93 ± 0.031	0.863HisThr: 0.863 ± 0.036	1.047HisVal: 1.047 ± 0.035	0.1HisTrp: 0.1 ± 0.013	0.718HisTyr: 0.718 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.771IleAla: 5.771 ± 0.115	1.428IleCys: 1.428 ± 0.048	5.133IleAsp: 5.133 ± 0.091	5.125IleGlu: 5.125 ± 0.101	3.074IlePhe: 3.074 ± 0.085	5.198IleGly: 5.198 ± 0.104	1.156IleHis: 1.156 ± 0.043	6.368IleIle: 6.368 ± 0.137	5.706IleLys: 5.706 ± 0.105	6.446IleLeu: 6.446 ± 0.129	2.265IleMet: 2.265 ± 0.064	4.004IleAsn: 4.004 ± 0.086	2.846IlePro: 2.846 ± 0.066	1.702IleGln: 1.702 ± 0.051	3.191IleArg: 3.191 ± 0.083	5.441IleSer: 5.441 ± 0.097	4.527IleThr: 4.527 ± 0.089	5.668IleVal: 5.668 ± 0.096	0.537IleTrp: 0.537 ± 0.027	3.16IleTyr: 3.16 ± 0.074	0.002IleXaa: 0.002 ± 0.001
Lys	5.395LysAla: 5.395 ± 0.101	0.889LysCys: 0.889 ± 0.036	4.691LysAsp: 4.691 ± 0.101	5.975LysGlu: 5.975 ± 0.115	2.027LysPhe: 2.027 ± 0.056	4.319LysGly: 4.319 ± 0.088	1.082LysHis: 1.082 ± 0.044	4.988LysIle: 4.988 ± 0.081	6.398LysLys: 6.398 ± 0.134	6.172LysLeu: 6.172 ± 0.102	2.13LysMet: 2.13 ± 0.063	4.332LysAsn: 4.332 ± 0.083	2.028LysPro: 2.028 ± 0.066	2.098LysGln: 2.098 ± 0.056	3.062LysArg: 3.062 ± 0.066	3.688LysSer: 3.688 ± 0.09	3.863LysThr: 3.863 ± 0.082	4.841LysVal: 4.841 ± 0.079	0.551LysTrp: 0.551 ± 0.027	3.406LysTyr: 3.406 ± 0.079	0.0LysXaa: 0.0 ± 0.0
Leu	6.044LeuAla: 6.044 ± 0.092	1.343LeuCys: 1.343 ± 0.048	5.211LeuAsp: 5.211 ± 0.089	5.098LeuGlu: 5.098 ± 0.091	3.42LeuPhe: 3.42 ± 0.094	5.568LeuGly: 5.568 ± 0.106	1.177LeuHis: 1.177 ± 0.042	5.94LeuIle: 5.94 ± 0.13	6.202LeuLys: 6.202 ± 0.103	6.733LeuLeu: 6.733 ± 0.129	2.679LeuMet: 2.679 ± 0.076	3.797LeuAsn: 3.797 ± 0.072	2.779LeuPro: 2.779 ± 0.074	1.787LeuGln: 1.787 ± 0.053	3.168LeuArg: 3.168 ± 0.072	5.542LeuSer: 5.542 ± 0.101	4.544LeuThr: 4.544 ± 0.097	5.803LeuVal: 5.803 ± 0.094	0.561LeuTrp: 0.561 ± 0.029	3.292LeuTyr: 3.292 ± 0.075	0.002LeuXaa: 0.002 ± 0.001
Met	2.713MetAla: 2.713 ± 0.067	0.44MetCys: 0.44 ± 0.027	2.154MetAsp: 2.154 ± 0.057	2.204MetGlu: 2.204 ± 0.065	1.176MetPhe: 1.176 ± 0.043	2.151MetGly: 2.151 ± 0.064	0.391MetHis: 0.391 ± 0.024	2.32MetIle: 2.32 ± 0.063	2.606MetLys: 2.606 ± 0.073	2.696MetLeu: 2.696 ± 0.076	0.973MetMet: 0.973 ± 0.042	1.651MetAsn: 1.651 ± 0.053	1.051MetPro: 1.051 ± 0.04	0.731MetGln: 0.731 ± 0.036	1.108MetArg: 1.108 ± 0.043	1.971MetSer: 1.971 ± 0.056	1.727MetThr: 1.727 ± 0.053	2.16MetVal: 2.16 ± 0.06	0.217MetTrp: 0.217 ± 0.016	1.183MetTyr: 1.183 ± 0.047	0.002MetXaa: 0.002 ± 0.002
Asn	3.194AsnAla: 3.194 ± 0.072	0.678AsnCys: 0.678 ± 0.034	3.113AsnAsp: 3.113 ± 0.075	3.266AsnGlu: 3.266 ± 0.07	1.578AsnPhe: 1.578 ± 0.052	3.951AsnGly: 3.951 ± 0.101	0.736AsnHis: 0.736 ± 0.034	4.36AsnIle: 4.36 ± 0.087	3.612AsnLys: 3.612 ± 0.081	3.48AsnLeu: 3.48 ± 0.072	1.648AsnMet: 1.648 ± 0.049	2.769AsnAsn: 2.769 ± 0.092	1.805AsnPro: 1.805 ± 0.056	1.161AsnGln: 1.161 ± 0.048	2.16AsnArg: 2.16 ± 0.066	3.024AsnSer: 3.024 ± 0.067	2.773AsnThr: 2.773 ± 0.07	3.673AsnVal: 3.673 ± 0.072	0.376AsnTrp: 0.376 ± 0.027	2.224AsnTyr: 2.224 ± 0.071	0.0AsnXaa: 0.0 ± 0.0
Pro	2.121ProAla: 2.121 ± 0.057	0.416ProCys: 0.416 ± 0.023	2.478ProAsp: 2.478 ± 0.059	3.06ProGlu: 3.06 ± 0.07	1.297ProPhe: 1.297 ± 0.046	2.318ProGly: 2.318 ± 0.063	0.529ProHis: 0.529 ± 0.027	1.815ProIle: 1.815 ± 0.06	1.684ProLys: 1.684 ± 0.048	2.28ProLeu: 2.28 ± 0.057	0.821ProMet: 0.821 ± 0.032	1.06ProAsn: 1.06 ± 0.043	0.572ProPro: 0.572 ± 0.029	0.725ProGln: 0.725 ± 0.037	0.872ProArg: 0.872 ± 0.033	1.491ProSer: 1.491 ± 0.05	1.362ProThr: 1.362 ± 0.046	2.927ProVal: 2.927 ± 0.065	0.272ProTrp: 0.272 ± 0.022	1.367ProTyr: 1.367 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	1.863GlnAla: 1.863 ± 0.058	0.279GlnCys: 0.279 ± 0.021	1.28GlnAsp: 1.28 ± 0.047	1.555GlnGlu: 1.555 ± 0.049	0.91GlnPhe: 0.91 ± 0.034	1.508GlnGly: 1.508 ± 0.053	0.331GlnHis: 0.331 ± 0.023	1.998GlnIle: 1.998 ± 0.056	1.739GlnLys: 1.739 ± 0.056	2.024GlnLeu: 2.024 ± 0.06	0.886GlnMet: 0.886 ± 0.032	1.293GlnAsn: 1.293 ± 0.049	0.637GlnPro: 0.637 ± 0.031	0.687GlnGln: 0.687 ± 0.042	0.977GlnArg: 0.977 ± 0.038	1.303GlnSer: 1.303 ± 0.043	1.288GlnThr: 1.288 ± 0.042	1.839GlnVal: 1.839 ± 0.054	0.182GlnTrp: 0.182 ± 0.016	1.246GlnTyr: 1.246 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	2.579ArgAla: 2.579 ± 0.061	0.537ArgCys: 0.537 ± 0.028	2.465ArgAsp: 2.465 ± 0.065	3.221ArgGlu: 3.221 ± 0.075	1.643ArgPhe: 1.643 ± 0.053	2.259ArgGly: 2.259 ± 0.065	0.736ArgHis: 0.736 ± 0.035	3.496ArgIle: 3.496 ± 0.078	3.377ArgLys: 3.377 ± 0.071	3.65ArgLeu: 3.65 ± 0.087	1.416ArgMet: 1.416 ± 0.051	2.241ArgAsn: 2.241 ± 0.064	1.226ArgPro: 1.226 ± 0.049	1.352ArgGln: 1.352 ± 0.051	2.197ArgArg: 2.197 ± 0.071	2.045ArgSer: 2.045 ± 0.065	2.165ArgThr: 2.165 ± 0.057	2.735ArgVal: 2.735 ± 0.074	0.284ArgTrp: 0.284 ± 0.023	2.112ArgTyr: 2.112 ± 0.054	0.002ArgXaa: 0.002 ± 0.001
Ser	4.157SerAla: 4.157 ± 0.083	0.783SerCys: 0.783 ± 0.037	4.055SerAsp: 4.055 ± 0.088	4.069SerGlu: 4.069 ± 0.086	2.514SerPhe: 2.514 ± 0.062	5.384SerGly: 5.384 ± 0.124	0.985SerHis: 0.985 ± 0.042	4.268SerIle: 4.268 ± 0.083	3.787SerLys: 3.787 ± 0.078	4.68SerLeu: 4.68 ± 0.095	1.751SerMet: 1.751 ± 0.051	2.485SerAsn: 2.485 ± 0.058	1.472SerPro: 1.472 ± 0.044	1.387SerGln: 1.387 ± 0.051	2.732SerArg: 2.732 ± 0.066	3.55SerSer: 3.55 ± 0.101	3.093SerThr: 3.093 ± 0.069	4.427SerVal: 4.427 ± 0.077	0.434SerTrp: 0.434 ± 0.03	2.83SerTyr: 2.83 ± 0.069	0.0SerXaa: 0.0 ± 0.0
Thr	4.119ThrAla: 4.119 ± 0.102	0.733ThrCys: 0.733 ± 0.036	3.864ThrAsp: 3.864 ± 0.089	4.118ThrGlu: 4.118 ± 0.089	2.103ThrPhe: 2.103 ± 0.054	5.246ThrGly: 5.246 ± 0.113	0.777ThrHis: 0.777 ± 0.033	4.122ThrIle: 4.122 ± 0.082	3.031ThrLys: 3.031 ± 0.064	4.429ThrLeu: 4.429 ± 0.089	1.488ThrMet: 1.488 ± 0.047	2.132ThrAsn: 2.132 ± 0.064	2.027ThrPro: 2.027 ± 0.061	1.123ThrGln: 1.123 ± 0.04	2.004ThrArg: 2.004 ± 0.052	2.984ThrSer: 2.984 ± 0.08	3.175ThrThr: 3.175 ± 0.093	4.526ThrVal: 4.526 ± 0.096	0.44ThrTrp: 0.44 ± 0.026	2.426ThrTyr: 2.426 ± 0.082	0.0ThrXaa: 0.0 ± 0.0
Val	5.372ValAla: 5.372 ± 0.11	1.268ValCys: 1.268 ± 0.04	4.872ValAsp: 4.872 ± 0.088	4.644ValGlu: 4.644 ± 0.091	3.063ValPhe: 3.063 ± 0.081	4.571ValGly: 4.571 ± 0.086	1.023ValHis: 1.023 ± 0.037	5.887ValIle: 5.887 ± 0.114	5.378ValLys: 5.378 ± 0.094	6.29ValLeu: 6.29 ± 0.111	2.264ValMet: 2.264 ± 0.061	3.474ValAsn: 3.474 ± 0.085	2.517ValPro: 2.517 ± 0.061	1.408ValGln: 1.408 ± 0.048	2.842ValArg: 2.842 ± 0.072	5.01ValSer: 5.01 ± 0.097	4.527ValThr: 4.527 ± 0.102	5.689ValVal: 5.689 ± 0.104	0.507ValTrp: 0.507 ± 0.03	3.212ValTyr: 3.212 ± 0.078	0.002ValXaa: 0.002 ± 0.001
Trp	0.422TrpAla: 0.422 ± 0.025	0.12TrpCys: 0.12 ± 0.014	0.467TrpAsp: 0.467 ± 0.028	0.417TrpGlu: 0.417 ± 0.026	0.335TrpPhe: 0.335 ± 0.024	0.54TrpGly: 0.54 ± 0.033	0.167TrpHis: 0.167 ± 0.017	0.552TrpIle: 0.552 ± 0.03	0.543TrpLys: 0.543 ± 0.03	0.655TrpLeu: 0.655 ± 0.033	0.228TrpMet: 0.228 ± 0.021	0.431TrpAsn: 0.431 ± 0.026	0.159TrpPro: 0.159 ± 0.015	0.249TrpGln: 0.249 ± 0.02	0.262TrpArg: 0.262 ± 0.024	0.396TrpSer: 0.396 ± 0.024	0.364TrpThr: 0.364 ± 0.022	0.423TrpVal: 0.423 ± 0.027	0.061TrpTrp: 0.061 ± 0.009	0.44TrpTyr: 0.44 ± 0.044	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.946TyrAla: 2.946 ± 0.076	0.648TyrCys: 0.648 ± 0.028	3.441TyrAsp: 3.441 ± 0.078	3.241TyrGlu: 3.241 ± 0.078	1.868TyrPhe: 1.868 ± 0.053	3.335TyrGly: 3.335 ± 0.074	0.704TyrHis: 0.704 ± 0.033	3.681TyrIle: 3.681 ± 0.077	2.898TyrLys: 2.898 ± 0.075	3.271TyrLeu: 3.271 ± 0.078	1.384TyrMet: 1.384 ± 0.047	2.591TyrAsn: 2.591 ± 0.063	1.329TyrPro: 1.329 ± 0.048	1.024TyrGln: 1.024 ± 0.039	2.132TyrArg: 2.132 ± 0.068	2.813TyrSer: 2.813 ± 0.075	2.5TyrThr: 2.5 ± 0.097	3.351TyrVal: 3.351 ± 0.077	0.316TyrTrp: 0.316 ± 0.022	2.282TyrTyr: 2.282 ± 0.092	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.002	0.003XaaGly: 0.003 ± 0.002	0.002XaaHis: 0.002 ± 0.002	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.002	0.002XaaLeu: 0.002 ± 0.001	0.002XaaMet: 0.002 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.002XaaSer: 0.002 ± 0.002	0.002XaaThr: 0.002 ± 0.002	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.024XaaXaa: 0.024 ± 0.008

Statistics based on 1959 proteins (659125 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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