Amino acid dipepetide frequency for Croceicoccus ponticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.604AlaAla: 16.604 ± 0.165	1.135AlaCys: 1.135 ± 0.038	7.726AlaAsp: 7.726 ± 0.095	7.663AlaGlu: 7.663 ± 0.113	4.149AlaPhe: 4.149 ± 0.069	10.698AlaGly: 10.698 ± 0.117	2.293AlaHis: 2.293 ± 0.051	7.264AlaIle: 7.264 ± 0.09	4.381AlaLys: 4.381 ± 0.082	12.831AlaLeu: 12.831 ± 0.126	4.337AlaMet: 4.337 ± 0.066	3.385AlaAsn: 3.385 ± 0.063	5.573AlaPro: 5.573 ± 0.081	4.215AlaGln: 4.215 ± 0.065	8.962AlaArg: 8.962 ± 0.122	6.411AlaSer: 6.411 ± 0.086	6.314AlaThr: 6.314 ± 0.086	8.31AlaVal: 8.31 ± 0.111	1.54AlaTrp: 1.54 ± 0.042	2.497AlaTyr: 2.497 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.046CysAla: 1.046 ± 0.034	0.095CysCys: 0.095 ± 0.01	0.653CysAsp: 0.653 ± 0.032	0.519CysGlu: 0.519 ± 0.024	0.31CysPhe: 0.31 ± 0.018	0.969CysGly: 0.969 ± 0.031	0.29CysHis: 0.29 ± 0.023	0.4CysIle: 0.4 ± 0.022	0.218CysLys: 0.218 ± 0.014	0.683CysLeu: 0.683 ± 0.026	0.168CysMet: 0.168 ± 0.012	0.237CysAsn: 0.237 ± 0.016	0.474CysPro: 0.474 ± 0.024	0.234CysGln: 0.234 ± 0.015	0.612CysArg: 0.612 ± 0.025	0.507CysSer: 0.507 ± 0.024	0.415CysThr: 0.415 ± 0.02	0.619CysVal: 0.619 ± 0.023	0.132CysTrp: 0.132 ± 0.011	0.195CysTyr: 0.195 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.127AspAla: 8.127 ± 0.104	0.59AspCys: 0.59 ± 0.023	3.998AspAsp: 3.998 ± 0.081	3.916AspGlu: 3.916 ± 0.074	2.418AspPhe: 2.418 ± 0.05	6.188AspGly: 6.188 ± 0.096	1.285AspHis: 1.285 ± 0.039	3.264AspIle: 3.264 ± 0.056	1.92AspLys: 1.92 ± 0.044	5.839AspLeu: 5.839 ± 0.075	1.666AspMet: 1.666 ± 0.044	1.508AspAsn: 1.508 ± 0.039	3.808AspPro: 3.808 ± 0.072	1.78AspGln: 1.78 ± 0.044	4.986AspArg: 4.986 ± 0.073	2.48AspSer: 2.48 ± 0.053	2.869AspThr: 2.869 ± 0.055	4.378AspVal: 4.378 ± 0.071	1.117AspTrp: 1.117 ± 0.035	1.633AspTyr: 1.633 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.52GluAla: 7.52 ± 0.109	0.403GluCys: 0.403 ± 0.021	3.178GluAsp: 3.178 ± 0.059	3.189GluGlu: 3.189 ± 0.065	1.811GluPhe: 1.811 ± 0.044	4.675GluGly: 4.675 ± 0.07	1.24GluHis: 1.24 ± 0.038	3.24GluIle: 3.24 ± 0.057	2.232GluLys: 2.232 ± 0.052	5.421GluLeu: 5.421 ± 0.074	1.716GluMet: 1.716 ± 0.041	1.668GluAsn: 1.668 ± 0.046	2.796GluPro: 2.796 ± 0.056	2.115GluGln: 2.115 ± 0.049	5.097GluArg: 5.097 ± 0.083	2.556GluSer: 2.556 ± 0.061	3.365GluThr: 3.365 ± 0.059	3.844GluVal: 3.844 ± 0.064	0.939GluTrp: 0.939 ± 0.031	1.192GluTyr: 1.192 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	5.003PheAla: 5.003 ± 0.076	0.344PheCys: 0.344 ± 0.017	2.871PheAsp: 2.871 ± 0.058	2.198PheGlu: 2.198 ± 0.05	1.305PhePhe: 1.305 ± 0.046	3.687PheGly: 3.687 ± 0.071	0.78PheHis: 0.78 ± 0.028	1.425PheIle: 1.425 ± 0.036	0.897PheLys: 0.897 ± 0.03	3.029PheLeu: 3.029 ± 0.059	0.77PheMet: 0.77 ± 0.028	1.02PheAsn: 1.02 ± 0.036	1.548PhePro: 1.548 ± 0.036	0.844PheGln: 0.844 ± 0.032	2.259PheArg: 2.259 ± 0.046	2.033PheSer: 2.033 ± 0.051	1.961PheThr: 1.961 ± 0.046	2.857PheVal: 2.857 ± 0.055	0.506PheTrp: 0.506 ± 0.022	0.944PheTyr: 0.944 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.493GlyAla: 9.493 ± 0.105	0.913GlyCys: 0.913 ± 0.032	5.144GlyAsp: 5.144 ± 0.077	5.326GlyGlu: 5.326 ± 0.075	3.594GlyPhe: 3.594 ± 0.069	7.806GlyGly: 7.806 ± 0.123	1.931GlyHis: 1.931 ± 0.056	4.639GlyIle: 4.639 ± 0.078	3.626GlyLys: 3.626 ± 0.069	8.26GlyLeu: 8.26 ± 0.096	2.642GlyMet: 2.642 ± 0.057	2.518GlyAsn: 2.518 ± 0.059	3.754GlyPro: 3.754 ± 0.057	2.854GlyGln: 2.854 ± 0.055	6.09GlyArg: 6.09 ± 0.089	4.913GlySer: 4.913 ± 0.075	4.811GlyThr: 4.811 ± 0.07	5.949GlyVal: 5.949 ± 0.1	1.605GlyTrp: 1.605 ± 0.045	2.273GlyTyr: 2.273 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.436HisAla: 2.436 ± 0.053	0.248HisCys: 0.248 ± 0.015	1.339HisAsp: 1.339 ± 0.039	1.158HisGlu: 1.158 ± 0.037	0.876HisPhe: 0.876 ± 0.033	1.946HisGly: 1.946 ± 0.044	0.531HisHis: 0.531 ± 0.022	0.918HisIle: 0.918 ± 0.029	0.515HisLys: 0.515 ± 0.024	1.882HisLeu: 1.882 ± 0.047	0.464HisMet: 0.464 ± 0.022	0.441HisAsn: 0.441 ± 0.023	1.306HisPro: 1.306 ± 0.037	0.521HisGln: 0.521 ± 0.022	1.514HisArg: 1.514 ± 0.038	0.985HisSer: 0.985 ± 0.032	0.745HisThr: 0.745 ± 0.024	1.498HisVal: 1.498 ± 0.048	0.321HisTrp: 0.321 ± 0.019	0.596HisTyr: 0.596 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	8.021IleAla: 8.021 ± 0.104	0.499IleCys: 0.499 ± 0.024	4.237IleAsp: 4.237 ± 0.065	3.849IleGlu: 3.849 ± 0.064	1.579IlePhe: 1.579 ± 0.039	5.188IleGly: 5.188 ± 0.083	0.881IleHis: 0.881 ± 0.03	2.008IleIle: 2.008 ± 0.05	1.167IleLys: 1.167 ± 0.031	3.853IleLeu: 3.853 ± 0.069	1.06IleMet: 1.06 ± 0.038	1.302IleAsn: 1.302 ± 0.042	2.326IlePro: 2.326 ± 0.057	1.07IleGln: 1.07 ± 0.038	3.222IleArg: 3.222 ± 0.057	2.79IleSer: 2.79 ± 0.066	2.564IleThr: 2.564 ± 0.055	4.542IleVal: 4.542 ± 0.073	0.599IleTrp: 0.599 ± 0.028	1.06IleTyr: 1.06 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.096LysAla: 4.096 ± 0.083	0.198LysCys: 0.198 ± 0.013	1.708LysAsp: 1.708 ± 0.048	1.371LysGlu: 1.371 ± 0.043	1.0LysPhe: 1.0 ± 0.031	2.885LysGly: 2.885 ± 0.052	0.586LysHis: 0.586 ± 0.021	1.588LysIle: 1.588 ± 0.041	1.244LysLys: 1.244 ± 0.046	3.203LysLeu: 3.203 ± 0.059	0.797LysMet: 0.797 ± 0.032	0.843LysAsn: 0.843 ± 0.031	1.954LysPro: 1.954 ± 0.043	0.983LysGln: 0.983 ± 0.034	2.313LysArg: 2.313 ± 0.051	1.779LysSer: 1.779 ± 0.043	1.748LysThr: 1.748 ± 0.046	2.435LysVal: 2.435 ± 0.052	0.436LysTrp: 0.436 ± 0.022	0.667LysTyr: 0.667 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.542LeuAla: 13.542 ± 0.132	0.799LeuCys: 0.799 ± 0.03	6.238LeuAsp: 6.238 ± 0.09	4.724LeuGlu: 4.724 ± 0.078	3.439LeuPhe: 3.439 ± 0.073	7.788LeuGly: 7.788 ± 0.096	1.79LeuHis: 1.79 ± 0.046	4.701LeuIle: 4.701 ± 0.075	2.979LeuLys: 2.979 ± 0.055	8.727LeuLeu: 8.727 ± 0.134	2.266LeuMet: 2.266 ± 0.051	2.429LeuAsn: 2.429 ± 0.058	5.292LeuPro: 5.292 ± 0.077	2.431LeuGln: 2.431 ± 0.048	6.417LeuArg: 6.417 ± 0.09	5.905LeuSer: 5.905 ± 0.081	5.417LeuThr: 5.417 ± 0.076	6.924LeuVal: 6.924 ± 0.086	1.097LeuTrp: 1.097 ± 0.033	1.836LeuTyr: 1.836 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.597MetAla: 3.597 ± 0.063	0.175MetCys: 0.175 ± 0.014	1.325MetAsp: 1.325 ± 0.036	1.322MetGlu: 1.322 ± 0.041	0.776MetPhe: 0.776 ± 0.025	2.186MetGly: 2.186 ± 0.049	0.533MetHis: 0.533 ± 0.027	1.478MetIle: 1.478 ± 0.045	1.023MetLys: 1.023 ± 0.033	2.754MetLeu: 2.754 ± 0.059	0.71MetMet: 0.71 ± 0.032	0.783MetAsn: 0.783 ± 0.031	1.629MetPro: 1.629 ± 0.04	0.887MetGln: 0.887 ± 0.03	2.021MetArg: 2.021 ± 0.043	1.512MetSer: 1.512 ± 0.044	1.883MetThr: 1.883 ± 0.042	1.825MetVal: 1.825 ± 0.041	0.265MetTrp: 0.265 ± 0.016	0.3MetTyr: 0.3 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.402AsnAla: 3.402 ± 0.066	0.315AsnCys: 0.315 ± 0.018	1.61AsnAsp: 1.61 ± 0.041	1.387AsnGlu: 1.387 ± 0.042	1.026AsnPhe: 1.026 ± 0.032	2.473AsnGly: 2.473 ± 0.053	0.502AsnHis: 0.502 ± 0.024	1.34AsnIle: 1.34 ± 0.037	0.66AsnLys: 0.66 ± 0.029	2.483AsnLeu: 2.483 ± 0.06	0.623AsnMet: 0.623 ± 0.028	0.68AsnAsn: 0.68 ± 0.029	1.842AsnPro: 1.842 ± 0.044	0.677AsnGln: 0.677 ± 0.026	1.965AsnArg: 1.965 ± 0.046	1.343AsnSer: 1.343 ± 0.045	1.225AsnThr: 1.225 ± 0.043	2.085AsnVal: 2.085 ± 0.046	0.461AsnTrp: 0.461 ± 0.025	0.708AsnTyr: 0.708 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	6.275ProAla: 6.275 ± 0.087	0.378ProCys: 0.378 ± 0.018	4.084ProAsp: 4.084 ± 0.062	3.663ProGlu: 3.663 ± 0.071	1.945ProPhe: 1.945 ± 0.05	4.604ProGly: 4.604 ± 0.076	1.079ProHis: 1.079 ± 0.038	2.451ProIle: 2.451 ± 0.049	1.494ProLys: 1.494 ± 0.047	4.582ProLeu: 4.582 ± 0.069	1.354ProMet: 1.354 ± 0.035	1.277ProAsn: 1.277 ± 0.042	2.526ProPro: 2.526 ± 0.075	1.592ProGln: 1.592 ± 0.038	2.853ProArg: 2.853 ± 0.066	2.567ProSer: 2.567 ± 0.051	2.506ProThr: 2.506 ± 0.052	4.291ProVal: 4.291 ± 0.075	0.651ProTrp: 0.651 ± 0.03	1.087ProTyr: 1.087 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.679GlnAla: 3.679 ± 0.067	0.229GlnCys: 0.229 ± 0.015	1.598GlnAsp: 1.598 ± 0.038	1.378GlnGlu: 1.378 ± 0.04	1.086GlnPhe: 1.086 ± 0.031	2.305GlnGly: 2.305 ± 0.044	0.584GlnHis: 0.584 ± 0.021	1.744GlnIle: 1.744 ± 0.045	0.951GlnLys: 0.951 ± 0.034	2.782GlnLeu: 2.782 ± 0.054	0.89GlnMet: 0.89 ± 0.033	0.764GlnAsn: 0.764 ± 0.031	1.629GlnPro: 1.629 ± 0.043	1.118GlnGln: 1.118 ± 0.04	2.298GlnArg: 2.298 ± 0.047	1.732GlnSer: 1.732 ± 0.048	1.643GlnThr: 1.643 ± 0.038	2.323GlnVal: 2.323 ± 0.051	0.454GlnTrp: 0.454 ± 0.022	0.664GlnTyr: 0.664 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	7.89ArgAla: 7.89 ± 0.108	0.545ArgCys: 0.545 ± 0.025	4.505ArgAsp: 4.505 ± 0.08	4.564ArgGlu: 4.564 ± 0.073	3.097ArgPhe: 3.097 ± 0.065	4.995ArgGly: 4.995 ± 0.08	1.694ArgHis: 1.694 ± 0.043	4.204ArgIle: 4.204 ± 0.08	2.368ArgLys: 2.368 ± 0.053	7.46ArgLeu: 7.46 ± 0.099	2.094ArgMet: 2.094 ± 0.046	1.987ArgAsn: 1.987 ± 0.051	3.38ArgPro: 3.38 ± 0.053	2.354ArgGln: 2.354 ± 0.054	5.445ArgArg: 5.445 ± 0.09	3.67ArgSer: 3.67 ± 0.067	3.424ArgThr: 3.424 ± 0.058	4.66ArgVal: 4.66 ± 0.067	1.128ArgTrp: 1.128 ± 0.039	1.855ArgTyr: 1.855 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	6.215SerAla: 6.215 ± 0.099	0.455SerCys: 0.455 ± 0.023	3.332SerAsp: 3.332 ± 0.055	2.924SerGlu: 2.924 ± 0.06	2.071SerPhe: 2.071 ± 0.042	5.603SerGly: 5.603 ± 0.086	1.04SerHis: 1.04 ± 0.034	2.713SerIle: 2.713 ± 0.056	1.5SerLys: 1.5 ± 0.044	5.046SerLeu: 5.046 ± 0.082	1.265SerMet: 1.265 ± 0.033	1.416SerAsn: 1.416 ± 0.041	2.71SerPro: 2.71 ± 0.054	1.606SerGln: 1.606 ± 0.041	3.731SerArg: 3.731 ± 0.062	2.664SerSer: 2.664 ± 0.057	2.462SerThr: 2.462 ± 0.053	3.848SerVal: 3.848 ± 0.062	0.742SerTrp: 0.742 ± 0.03	1.353SerTyr: 1.353 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.055ThrAla: 6.055 ± 0.088	0.465ThrCys: 0.465 ± 0.024	3.187ThrAsp: 3.187 ± 0.055	2.597ThrGlu: 2.597 ± 0.059	1.915ThrPhe: 1.915 ± 0.049	5.465ThrGly: 5.465 ± 0.082	0.969ThrHis: 0.969 ± 0.032	2.996ThrIle: 2.996 ± 0.05	1.455ThrLys: 1.455 ± 0.039	5.304ThrLeu: 5.304 ± 0.082	1.397ThrMet: 1.397 ± 0.034	1.361ThrAsn: 1.361 ± 0.043	3.012ThrPro: 3.012 ± 0.059	1.417ThrGln: 1.417 ± 0.044	3.383ThrArg: 3.383 ± 0.061	2.748ThrSer: 2.748 ± 0.055	2.685ThrThr: 2.685 ± 0.058	4.134ThrVal: 4.134 ± 0.059	0.603ThrTrp: 0.603 ± 0.026	1.147ThrTyr: 1.147 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.487ValAla: 9.487 ± 0.111	0.6ValCys: 0.6 ± 0.026	4.548ValAsp: 4.548 ± 0.069	4.582ValGlu: 4.582 ± 0.067	2.392ValPhe: 2.392 ± 0.053	5.625ValGly: 5.625 ± 0.079	1.319ValHis: 1.319 ± 0.038	3.88ValIle: 3.88 ± 0.066	2.1ValLys: 2.1 ± 0.056	6.872ValLeu: 6.872 ± 0.087	1.879ValMet: 1.879 ± 0.047	2.023ValAsn: 2.023 ± 0.049	3.938ValPro: 3.938 ± 0.06	1.862ValGln: 1.862 ± 0.042	5.033ValArg: 5.033 ± 0.081	4.023ValSer: 4.023 ± 0.065	4.481ValThr: 4.481 ± 0.086	5.437ValVal: 5.437 ± 0.078	0.943ValTrp: 0.943 ± 0.036	1.322ValTyr: 1.322 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.29TrpAla: 1.29 ± 0.041	0.131TrpCys: 0.131 ± 0.011	0.796TrpAsp: 0.796 ± 0.034	0.61TrpGlu: 0.61 ± 0.025	0.589TrpPhe: 0.589 ± 0.026	0.935TrpGly: 0.935 ± 0.03	0.385TrpHis: 0.385 ± 0.021	0.683TrpIle: 0.683 ± 0.028	0.507TrpLys: 0.507 ± 0.027	1.687TrpLeu: 1.687 ± 0.045	0.413TrpMet: 0.413 ± 0.02	0.515TrpAsn: 0.515 ± 0.026	0.708TrpPro: 0.708 ± 0.03	0.659TrpGln: 0.659 ± 0.022	1.272TrpArg: 1.272 ± 0.036	0.897TrpSer: 0.897 ± 0.033	0.729TrpThr: 0.729 ± 0.03	0.778TrpVal: 0.778 ± 0.028	0.247TrpTrp: 0.247 ± 0.015	0.282TrpTyr: 0.282 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.51TyrAla: 2.51 ± 0.054	0.259TyrCys: 0.259 ± 0.016	1.694TyrAsp: 1.694 ± 0.042	1.256TyrGlu: 1.256 ± 0.036	0.903TyrPhe: 0.903 ± 0.025	2.118TyrGly: 2.118 ± 0.053	0.528TyrHis: 0.528 ± 0.026	0.88TyrIle: 0.88 ± 0.034	0.594TyrLys: 0.594 ± 0.026	2.044TyrLeu: 2.044 ± 0.055	0.474TyrMet: 0.474 ± 0.02	0.65TyrAsn: 0.65 ± 0.026	1.055TyrPro: 1.055 ± 0.032	0.634TyrGln: 0.634 ± 0.027	1.844TyrArg: 1.844 ± 0.05	1.182TyrSer: 1.182 ± 0.037	1.049TyrThr: 1.049 ± 0.038	1.61TyrVal: 1.61 ± 0.042	0.329TyrTrp: 0.329 ± 0.02	0.628TyrTyr: 0.628 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2986 proteins (958650 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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