Amino acid dipepetide frequency for Planctomycetes bacterium SV_7m_r

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.033AlaAla: 11.033 ± 0.105	1.117AlaCys: 1.117 ± 0.029	6.331AlaAsp: 6.331 ± 0.077	6.17AlaGlu: 6.17 ± 0.069	3.26AlaPhe: 3.26 ± 0.045	7.698AlaGly: 7.698 ± 0.079	1.486AlaHis: 1.486 ± 0.03	5.571AlaIle: 5.571 ± 0.066	4.468AlaLys: 4.468 ± 0.074	8.422AlaLeu: 8.422 ± 0.073	2.704AlaMet: 2.704 ± 0.044	3.376AlaAsn: 3.376 ± 0.059	4.021AlaPro: 4.021 ± 0.059	3.874AlaGln: 3.874 ± 0.055	4.737AlaArg: 4.737 ± 0.054	6.86AlaSer: 6.86 ± 0.07	5.771AlaThr: 5.771 ± 0.076	6.661AlaVal: 6.661 ± 0.071	1.25AlaTrp: 1.25 ± 0.025	1.899AlaTyr: 1.899 ± 0.03	0.0AlaXaa: 0.0 ± 0.001
Cys	0.787CysAla: 0.787 ± 0.02	0.252CysCys: 0.252 ± 0.012	0.745CysAsp: 0.745 ± 0.022	0.615CysGlu: 0.615 ± 0.021	0.483CysPhe: 0.483 ± 0.017	1.047CysGly: 1.047 ± 0.029	0.504CysHis: 0.504 ± 0.02	0.444CysIle: 0.444 ± 0.016	0.348CysLys: 0.348 ± 0.018	1.242CysLeu: 1.242 ± 0.033	0.223CysMet: 0.223 ± 0.011	0.372CysAsn: 0.372 ± 0.014	0.589CysPro: 0.589 ± 0.02	0.615CysGln: 0.615 ± 0.018	0.711CysArg: 0.711 ± 0.02	0.741CysSer: 0.741 ± 0.021	0.504CysThr: 0.504 ± 0.018	0.864CysVal: 0.864 ± 0.027	0.196CysTrp: 0.196 ± 0.01	0.324CysTyr: 0.324 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.177AspAla: 6.177 ± 0.077	0.685AspCys: 0.685 ± 0.02	4.148AspAsp: 4.148 ± 0.073	3.778AspGlu: 3.778 ± 0.059	2.363AspPhe: 2.363 ± 0.038	5.247AspGly: 5.247 ± 0.098	1.644AspHis: 1.644 ± 0.034	2.264AspIle: 2.264 ± 0.045	1.89AspLys: 1.89 ± 0.035	6.169AspLeu: 6.169 ± 0.068	0.997AspMet: 0.997 ± 0.025	1.831AspAsn: 1.831 ± 0.045	3.885AspPro: 3.885 ± 0.054	4.041AspGln: 4.041 ± 0.064	4.249AspArg: 4.249 ± 0.047	4.142AspSer: 4.142 ± 0.057	2.472AspThr: 2.472 ± 0.055	4.132AspVal: 4.132 ± 0.054	1.107AspTrp: 1.107 ± 0.024	1.61AspTyr: 1.61 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	5.348GluAla: 5.348 ± 0.068	0.487GluCys: 0.487 ± 0.018	2.672GluAsp: 2.672 ± 0.043	2.821GluGlu: 2.821 ± 0.055	2.132GluPhe: 2.132 ± 0.035	3.392GluGly: 3.392 ± 0.053	1.285GluHis: 1.285 ± 0.028	3.251GluIle: 3.251 ± 0.044	2.424GluLys: 2.424 ± 0.043	6.346GluLeu: 6.346 ± 0.061	1.477GluMet: 1.477 ± 0.028	1.947GluAsn: 1.947 ± 0.033	2.632GluPro: 2.632 ± 0.046	3.258GluGln: 3.258 ± 0.051	3.599GluArg: 3.599 ± 0.052	4.379GluSer: 4.379 ± 0.059	3.833GluThr: 3.833 ± 0.05	3.756GluVal: 3.756 ± 0.043	0.534GluTrp: 0.534 ± 0.019	1.206GluTyr: 1.206 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.631PheAla: 3.631 ± 0.041	0.485PheCys: 0.485 ± 0.014	2.725PheAsp: 2.725 ± 0.043	2.061PheGlu: 2.061 ± 0.033	1.366PhePhe: 1.366 ± 0.027	3.124PheGly: 3.124 ± 0.044	0.802PheHis: 0.802 ± 0.021	1.506PheIle: 1.506 ± 0.029	1.098PheLys: 1.098 ± 0.026	3.327PheLeu: 3.327 ± 0.048	0.649PheMet: 0.649 ± 0.018	1.233PheAsn: 1.233 ± 0.028	1.613PhePro: 1.613 ± 0.028	1.59PheGln: 1.59 ± 0.026	2.16PheArg: 2.16 ± 0.033	2.435PheSer: 2.435 ± 0.038	1.891PheThr: 1.891 ± 0.035	2.618PheVal: 2.618 ± 0.042	0.496PheTrp: 0.496 ± 0.017	0.934PheTyr: 0.934 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	5.637GlyAla: 5.637 ± 0.092	0.987GlyCys: 0.987 ± 0.026	4.855GlyAsp: 4.855 ± 0.091	4.022GlyGlu: 4.022 ± 0.051	3.029GlyPhe: 3.029 ± 0.039	6.209GlyGly: 6.209 ± 0.106	1.644GlyHis: 1.644 ± 0.032	3.799GlyIle: 3.799 ± 0.048	3.843GlyLys: 3.843 ± 0.068	6.929GlyLeu: 6.929 ± 0.066	1.933GlyMet: 1.933 ± 0.034	2.852GlyAsn: 2.852 ± 0.064	3.143GlyPro: 3.143 ± 0.052	3.922GlyGln: 3.922 ± 0.058	4.666GlyArg: 4.666 ± 0.054	4.942GlySer: 4.942 ± 0.079	4.341GlyThr: 4.341 ± 0.073	5.025GlyVal: 5.025 ± 0.065	1.223GlyTrp: 1.223 ± 0.027	2.057GlyTyr: 2.057 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.04HisAla: 2.04 ± 0.035	0.434HisCys: 0.434 ± 0.016	1.334HisAsp: 1.334 ± 0.029	1.072HisGlu: 1.072 ± 0.025	0.926HisPhe: 0.926 ± 0.023	1.819HisGly: 1.819 ± 0.035	0.75HisHis: 0.75 ± 0.021	0.714HisIle: 0.714 ± 0.017	0.529HisLys: 0.529 ± 0.018	2.333HisLeu: 2.333 ± 0.04	0.38HisMet: 0.38 ± 0.014	0.6HisAsn: 0.6 ± 0.019	1.468HisPro: 1.468 ± 0.031	1.341HisGln: 1.341 ± 0.029	1.706HisArg: 1.706 ± 0.035	1.44HisSer: 1.44 ± 0.028	0.938HisThr: 0.938 ± 0.025	1.491HisVal: 1.491 ± 0.03	0.512HisTrp: 0.512 ± 0.016	0.678HisTyr: 0.678 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.718IleAla: 5.718 ± 0.056	0.637IleCys: 0.637 ± 0.02	4.297IleAsp: 4.297 ± 0.067	3.801IleGlu: 3.801 ± 0.053	1.263IlePhe: 1.263 ± 0.027	4.091IleGly: 4.091 ± 0.054	1.085IleHis: 1.085 ± 0.024	1.889IleIle: 1.889 ± 0.031	1.792IleLys: 1.792 ± 0.026	3.708IleLeu: 3.708 ± 0.054	0.784IleMet: 0.784 ± 0.021	1.836IleAsn: 1.836 ± 0.044	2.383IlePro: 2.383 ± 0.039	2.025IleGln: 2.025 ± 0.032	3.128IleArg: 3.128 ± 0.042	3.083IleSer: 3.083 ± 0.054	2.632IleThr: 2.632 ± 0.055	3.59IleVal: 3.59 ± 0.048	0.578IleTrp: 0.578 ± 0.018	1.088IleTyr: 1.088 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.402LysAla: 3.402 ± 0.056	0.288LysCys: 0.288 ± 0.013	1.93LysAsp: 1.93 ± 0.035	1.949LysGlu: 1.949 ± 0.044	1.11LysPhe: 1.11 ± 0.023	2.22LysGly: 2.22 ± 0.041	1.008LysHis: 1.008 ± 0.025	1.823LysIle: 1.823 ± 0.033	1.699LysLys: 1.699 ± 0.045	3.978LysLeu: 3.978 ± 0.06	0.892LysMet: 0.892 ± 0.024	1.189LysAsn: 1.189 ± 0.027	2.567LysPro: 2.567 ± 0.044	2.393LysGln: 2.393 ± 0.043	2.892LysArg: 2.892 ± 0.046	2.441LysSer: 2.441 ± 0.039	2.427LysThr: 2.427 ± 0.043	2.461LysVal: 2.461 ± 0.043	0.538LysTrp: 0.538 ± 0.018	0.82LysTyr: 0.82 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	10.44LeuAla: 10.44 ± 0.092	1.184LeuCys: 1.184 ± 0.029	6.036LeuAsp: 6.036 ± 0.064	5.234LeuGlu: 5.234 ± 0.053	3.316LeuPhe: 3.316 ± 0.048	6.825LeuGly: 6.825 ± 0.069	2.061LeuHis: 2.061 ± 0.037	5.126LeuIle: 5.126 ± 0.055	3.729LeuLys: 3.729 ± 0.056	9.589LeuLeu: 9.589 ± 0.099	2.136LeuMet: 2.136 ± 0.038	3.13LeuAsn: 3.13 ± 0.048	5.71LeuPro: 5.71 ± 0.055	4.71LeuGln: 4.71 ± 0.061	5.941LeuArg: 5.941 ± 0.078	6.66LeuSer: 6.66 ± 0.078	5.565LeuThr: 5.565 ± 0.066	6.707LeuVal: 6.707 ± 0.066	1.236LeuTrp: 1.236 ± 0.036	2.067LeuTyr: 2.067 ± 0.032	0.001LeuXaa: 0.001 ± 0.001
Met	2.117MetAla: 2.117 ± 0.033	0.2MetCys: 0.2 ± 0.01	1.105MetAsp: 1.105 ± 0.028	1.074MetGlu: 1.074 ± 0.027	0.705MetPhe: 0.705 ± 0.021	1.465MetGly: 1.465 ± 0.032	0.495MetHis: 0.495 ± 0.018	1.331MetIle: 1.331 ± 0.03	0.993MetLys: 0.993 ± 0.027	2.384MetLeu: 2.384 ± 0.041	0.633MetMet: 0.633 ± 0.019	0.939MetAsn: 0.939 ± 0.024	1.441MetPro: 1.441 ± 0.027	1.155MetGln: 1.155 ± 0.022	1.419MetArg: 1.419 ± 0.029	1.505MetSer: 1.505 ± 0.028	1.476MetThr: 1.476 ± 0.028	1.615MetVal: 1.615 ± 0.034	0.209MetTrp: 0.209 ± 0.012	0.384MetTyr: 0.384 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.315AsnAla: 3.315 ± 0.052	0.371AsnCys: 0.371 ± 0.016	2.18AsnAsp: 2.18 ± 0.054	1.936AsnGlu: 1.936 ± 0.036	1.061AsnPhe: 1.061 ± 0.026	2.784AsnGly: 2.784 ± 0.052	0.891AsnHis: 0.891 ± 0.021	1.285AsnIle: 1.285 ± 0.04	0.996AsnLys: 0.996 ± 0.028	3.222AsnLeu: 3.222 ± 0.043	0.601AsnMet: 0.601 ± 0.018	1.109AsnAsn: 1.109 ± 0.038	2.164AsnPro: 2.164 ± 0.042	2.008AsnGln: 2.008 ± 0.046	2.49AsnArg: 2.49 ± 0.04	1.934AsnSer: 1.934 ± 0.043	1.65AsnThr: 1.65 ± 0.037	2.368AsnVal: 2.368 ± 0.047	0.546AsnTrp: 0.546 ± 0.016	0.773AsnTyr: 0.773 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	5.766ProAla: 5.766 ± 0.082	0.411ProCys: 0.411 ± 0.015	3.416ProAsp: 3.416 ± 0.053	3.79ProGlu: 3.79 ± 0.046	1.793ProPhe: 1.793 ± 0.031	3.907ProGly: 3.907 ± 0.052	1.112ProHis: 1.112 ± 0.023	2.577ProIle: 2.577 ± 0.039	2.148ProLys: 2.148 ± 0.042	4.589ProLeu: 4.589 ± 0.056	1.158ProMet: 1.158 ± 0.027	2.053ProAsn: 2.053 ± 0.039	2.855ProPro: 2.855 ± 0.054	2.392ProGln: 2.392 ± 0.04	2.557ProArg: 2.557 ± 0.044	3.804ProSer: 3.804 ± 0.063	3.097ProThr: 3.097 ± 0.046	3.898ProVal: 3.898 ± 0.058	0.717ProTrp: 0.717 ± 0.02	1.093ProTyr: 1.093 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.316GlnAla: 5.316 ± 0.073	0.561GlnCys: 0.561 ± 0.016	2.313GlnAsp: 2.313 ± 0.038	2.305GlnGlu: 2.305 ± 0.041	1.77GlnPhe: 1.77 ± 0.028	3.059GlnGly: 3.059 ± 0.042	1.255GlnHis: 1.255 ± 0.026	2.539GlnIle: 2.539 ± 0.048	1.53GlnLys: 1.53 ± 0.033	5.33GlnLeu: 5.33 ± 0.061	1.123GlnMet: 1.123 ± 0.028	1.416GlnAsn: 1.416 ± 0.034	3.115GlnPro: 3.115 ± 0.048	3.761GlnGln: 3.761 ± 0.073	3.905GlnArg: 3.905 ± 0.054	3.655GlnSer: 3.655 ± 0.058	3.073GlnThr: 3.073 ± 0.053	3.285GlnVal: 3.285 ± 0.049	0.966GlnTrp: 0.966 ± 0.023	1.113GlnTyr: 1.113 ± 0.027	0.0GlnXaa: 0.0 ± 0.001
Arg	4.378ArgAla: 4.378 ± 0.055	0.837ArgCys: 0.837 ± 0.026	3.636ArgAsp: 3.636 ± 0.044	3.359ArgGlu: 3.359 ± 0.055	2.873ArgPhe: 2.873 ± 0.038	3.924ArgGly: 3.924 ± 0.064	1.448ArgHis: 1.448 ± 0.03	3.263ArgIle: 3.263 ± 0.046	2.353ArgLys: 2.353 ± 0.044	6.938ArgLeu: 6.938 ± 0.066	1.731ArgMet: 1.731 ± 0.032	2.064ArgAsn: 2.064 ± 0.03	3.121ArgPro: 3.121 ± 0.046	3.452ArgGln: 3.452 ± 0.051	4.782ArgArg: 4.782 ± 0.074	4.338ArgSer: 4.338 ± 0.06	3.032ArgThr: 3.032 ± 0.04	4.174ArgVal: 4.174 ± 0.057	1.229ArgTrp: 1.229 ± 0.029	1.928ArgTyr: 1.928 ± 0.032	0.001ArgXaa: 0.001 ± 0.001
Ser	6.027SerAla: 6.027 ± 0.068	0.701SerCys: 0.701 ± 0.023	4.567SerAsp: 4.567 ± 0.06	3.921SerGlu: 3.921 ± 0.058	2.43SerPhe: 2.43 ± 0.035	5.882SerGly: 5.882 ± 0.079	1.456SerHis: 1.456 ± 0.032	3.432SerIle: 3.432 ± 0.05	2.464SerLys: 2.464 ± 0.038	6.74SerLeu: 6.74 ± 0.068	1.638SerMet: 1.638 ± 0.032	2.327SerAsn: 2.327 ± 0.041	3.723SerPro: 3.723 ± 0.053	3.199SerGln: 3.199 ± 0.049	3.85SerArg: 3.85 ± 0.051	4.605SerSer: 4.605 ± 0.071	3.592SerThr: 3.592 ± 0.055	4.81SerVal: 4.81 ± 0.06	0.875SerTrp: 0.875 ± 0.025	1.402SerTyr: 1.402 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.467ThrAla: 5.467 ± 0.065	0.549ThrCys: 0.549 ± 0.019	3.468ThrAsp: 3.468 ± 0.055	3.191ThrGlu: 3.191 ± 0.047	1.914ThrPhe: 1.914 ± 0.035	4.664ThrGly: 4.664 ± 0.075	1.156ThrHis: 1.156 ± 0.025	3.108ThrIle: 3.108 ± 0.054	2.004ThrLys: 2.004 ± 0.035	5.713ThrLeu: 5.713 ± 0.07	1.164ThrMet: 1.164 ± 0.026	1.806ThrAsn: 1.806 ± 0.038	3.336ThrPro: 3.336 ± 0.047	2.179ThrGln: 2.179 ± 0.039	2.967ThrArg: 2.967 ± 0.044	3.513ThrSer: 3.513 ± 0.055	3.168ThrThr: 3.168 ± 0.07	4.146ThrVal: 4.146 ± 0.066	0.692ThrTrp: 0.692 ± 0.019	1.221ThrTyr: 1.221 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	7.105ValAla: 7.105 ± 0.065	0.916ValCys: 0.916 ± 0.027	4.695ValAsp: 4.695 ± 0.076	3.758ValGlu: 3.758 ± 0.049	2.442ValPhe: 2.442 ± 0.042	4.964ValGly: 4.964 ± 0.061	1.396ValHis: 1.396 ± 0.027	3.845ValIle: 3.845 ± 0.053	2.359ValLys: 2.359 ± 0.038	6.391ValLeu: 6.391 ± 0.066	1.616ValMet: 1.616 ± 0.029	2.314ValAsn: 2.314 ± 0.047	3.55ValPro: 3.55 ± 0.046	3.029ValGln: 3.029 ± 0.042	4.173ValArg: 4.173 ± 0.049	4.789ValSer: 4.789 ± 0.057	4.172ValThr: 4.172 ± 0.068	5.347ValVal: 5.347 ± 0.066	0.914ValTrp: 0.914 ± 0.026	1.612ValTyr: 1.612 ± 0.032	0.001ValXaa: 0.001 ± 0.001
Trp	1.042TrpAla: 1.042 ± 0.024	0.185TrpCys: 0.185 ± 0.011	0.831TrpAsp: 0.831 ± 0.023	0.62TrpGlu: 0.62 ± 0.017	0.529TrpPhe: 0.529 ± 0.017	0.862TrpGly: 0.862 ± 0.024	0.414TrpHis: 0.414 ± 0.015	0.857TrpIle: 0.857 ± 0.02	0.68TrpLys: 0.68 ± 0.02	1.7TrpLeu: 1.7 ± 0.033	0.425TrpMet: 0.425 ± 0.014	0.554TrpAsn: 0.554 ± 0.019	0.66TrpPro: 0.66 ± 0.02	0.9TrpGln: 0.9 ± 0.021	0.921TrpArg: 0.921 ± 0.023	0.982TrpSer: 0.982 ± 0.024	0.76TrpThr: 0.76 ± 0.023	0.937TrpVal: 0.937 ± 0.026	0.244TrpTrp: 0.244 ± 0.012	0.36TrpTyr: 0.36 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.961TyrAla: 1.961 ± 0.033	0.322TyrCys: 0.322 ± 0.013	1.548TyrAsp: 1.548 ± 0.028	1.304TyrGlu: 1.304 ± 0.027	0.979TyrPhe: 0.979 ± 0.023	1.873TyrGly: 1.873 ± 0.033	0.61TyrHis: 0.61 ± 0.017	0.783TyrIle: 0.783 ± 0.019	0.678TyrLys: 0.678 ± 0.02	2.352TyrLeu: 2.352 ± 0.041	0.38TyrMet: 0.38 ± 0.015	0.737TyrAsn: 0.737 ± 0.022	1.155TyrPro: 1.155 ± 0.029	1.548TyrGln: 1.548 ± 0.034	2.009TyrArg: 2.009 ± 0.031	1.394TyrSer: 1.394 ± 0.025	1.032TyrThr: 1.032 ± 0.032	1.503TyrVal: 1.503 ± 0.03	0.403TyrTrp: 0.403 ± 0.014	0.705TyrTyr: 0.705 ± 0.02	0.0TyrXaa: 0.0 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.01XaaXaa: 0.01 ± 0.004

Statistics based on 5245 proteins (2028258 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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