Amino acid dipepetide frequency for Richelia intracellularis HM01

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.822AlaAla: 5.822 ± 0.141
0.909AlaCys: 0.909 ± 0.052
3.158AlaAsp: 3.158 ± 0.096
4.215AlaGlu: 4.215 ± 0.107
2.543AlaPhe: 2.543 ± 0.099
4.758AlaGly: 4.758 ± 0.119
1.364AlaHis: 1.364 ± 0.064
6.476AlaIle: 6.476 ± 0.164
4.037AlaLys: 4.037 ± 0.12
7.295AlaLeu: 7.295 ± 0.163
1.721AlaMet: 1.721 ± 0.079
3.294AlaAsn: 3.294 ± 0.121
2.033AlaPro: 2.033 ± 0.078
3.043AlaGln: 3.043 ± 0.095
3.44AlaArg: 3.44 ± 0.106
4.309AlaSer: 4.309 ± 0.126
3.643AlaThr: 3.643 ± 0.098
4.9AlaVal: 4.9 ± 0.139
0.876AlaTrp: 0.876 ± 0.056
2.346AlaTyr: 2.346 ± 0.09
0.0AlaXaa: 0.0 ± 0.0
Cys
0.679CysAla: 0.679 ± 0.044
0.212CysCys: 0.212 ± 0.025
0.649CysAsp: 0.649 ± 0.043
0.506CysGlu: 0.506 ± 0.034
0.455CysPhe: 0.455 ± 0.037
0.933CysGly: 0.933 ± 0.053
0.349CysHis: 0.349 ± 0.033
0.9CysIle: 0.9 ± 0.051
0.594CysLys: 0.594 ± 0.044
1.288CysLeu: 1.288 ± 0.062
0.3CysMet: 0.3 ± 0.03
0.582CysAsn: 0.582 ± 0.04
0.609CysPro: 0.609 ± 0.046
0.709CysGln: 0.709 ± 0.043
0.615CysArg: 0.615 ± 0.044
0.821CysSer: 0.821 ± 0.052
0.582CysThr: 0.582 ± 0.041
0.539CysVal: 0.539 ± 0.043
0.212CysTrp: 0.212 ± 0.027
0.445CysTyr: 0.445 ± 0.037
0.003CysXaa: 0.003 ± 0.003
Asp
2.679AspAla: 2.679 ± 0.093
0.661AspCys: 0.661 ± 0.043
1.873AspAsp: 1.873 ± 0.09
2.579AspGlu: 2.579 ± 0.085
2.112AspPhe: 2.112 ± 0.084
2.743AspGly: 2.743 ± 0.096
0.706AspHis: 0.706 ± 0.05
4.112AspIle: 4.112 ± 0.107
2.64AspLys: 2.64 ± 0.087
5.3AspLeu: 5.3 ± 0.144
1.052AspMet: 1.052 ± 0.06
2.4AspAsn: 2.4 ± 0.085
1.912AspPro: 1.912 ± 0.07
1.412AspGln: 1.412 ± 0.062
2.237AspArg: 2.237 ± 0.082
2.8AspSer: 2.8 ± 0.101
2.346AspThr: 2.346 ± 0.079
2.691AspVal: 2.691 ± 0.102
0.733AspTrp: 0.733 ± 0.049
1.988AspTyr: 1.988 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
4.349GluAla: 4.349 ± 0.117
0.536GluCys: 0.536 ± 0.041
2.637GluAsp: 2.637 ± 0.093
3.946GluGlu: 3.946 ± 0.116
2.194GluPhe: 2.194 ± 0.076
2.906GluGly: 2.906 ± 0.099
1.067GluHis: 1.067 ± 0.057
5.564GluIle: 5.564 ± 0.122
4.167GluLys: 4.167 ± 0.127
6.846GluLeu: 6.846 ± 0.19
1.579GluMet: 1.579 ± 0.066
3.112GluAsn: 3.112 ± 0.103
1.997GluPro: 1.997 ± 0.088
2.824GluGln: 2.824 ± 0.107
2.834GluArg: 2.834 ± 0.105
3.221GluSer: 3.221 ± 0.097
3.088GluThr: 3.088 ± 0.1
4.079GluVal: 4.079 ± 0.132
0.773GluTrp: 0.773 ± 0.047
1.961GluTyr: 1.961 ± 0.079
0.0GluXaa: 0.0 ± 0.0
Phe
2.794PheAla: 2.794 ± 0.087
0.682PheCys: 0.682 ± 0.041
1.985PheAsp: 1.985 ± 0.076
1.812PheGlu: 1.812 ± 0.076
1.57PhePhe: 1.57 ± 0.063
2.785PheGly: 2.785 ± 0.088
0.827PheHis: 0.827 ± 0.053
2.988PheIle: 2.988 ± 0.107
1.773PheLys: 1.773 ± 0.07
4.27PheLeu: 4.27 ± 0.126
0.909PheMet: 0.909 ± 0.051
1.721PheAsn: 1.721 ± 0.07
1.812PhePro: 1.812 ± 0.063
1.712PheGln: 1.712 ± 0.07
1.679PheArg: 1.679 ± 0.076
2.876PheSer: 2.876 ± 0.097
2.146PheThr: 2.146 ± 0.078
2.209PheVal: 2.209 ± 0.086
0.661PheTrp: 0.661 ± 0.053
1.449PheTyr: 1.449 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.409GlyAla: 4.409 ± 0.163
0.918GlyCys: 0.918 ± 0.053
3.149GlyAsp: 3.149 ± 0.107
3.879GlyGlu: 3.879 ± 0.132
2.891GlyPhe: 2.891 ± 0.085
4.706GlyGly: 4.706 ± 0.137
1.315GlyHis: 1.315 ± 0.076
5.964GlyIle: 5.964 ± 0.123
4.831GlyLys: 4.831 ± 0.128
6.861GlyLeu: 6.861 ± 0.138
1.779GlyMet: 1.779 ± 0.084
3.225GlyAsn: 3.225 ± 0.088
1.579GlyPro: 1.579 ± 0.069
2.443GlyGln: 2.443 ± 0.097
3.194GlyArg: 3.194 ± 0.101
3.958GlySer: 3.958 ± 0.117
3.267GlyThr: 3.267 ± 0.11
4.725GlyVal: 4.725 ± 0.137
1.015GlyTrp: 1.015 ± 0.053
2.479GlyTyr: 2.479 ± 0.103
0.0GlyXaa: 0.0 ± 0.0
His
1.07HisAla: 1.07 ± 0.066
0.249HisCys: 0.249 ± 0.028
0.667HisAsp: 0.667 ± 0.044
0.903HisGlu: 0.903 ± 0.048
0.949HisPhe: 0.949 ± 0.055
1.388HisGly: 1.388 ± 0.08
0.639HisHis: 0.639 ± 0.046
1.53HisIle: 1.53 ± 0.068
1.194HisLys: 1.194 ± 0.063
2.315HisLeu: 2.315 ± 0.079
0.409HisMet: 0.409 ± 0.035
1.097HisAsn: 1.097 ± 0.056
1.227HisPro: 1.227 ± 0.065
1.164HisGln: 1.164 ± 0.061
1.036HisArg: 1.036 ± 0.054
1.4HisSer: 1.4 ± 0.066
1.085HisThr: 1.085 ± 0.059
0.991HisVal: 0.991 ± 0.053
0.33HisTrp: 0.33 ± 0.037
0.788HisTyr: 0.788 ± 0.048
0.0HisXaa: 0.0 ± 0.0
Ile
6.895IleAla: 6.895 ± 0.149
1.106IleCys: 1.106 ± 0.058
4.049IleAsp: 4.049 ± 0.096
4.564IleGlu: 4.564 ± 0.138
3.164IlePhe: 3.164 ± 0.095
5.237IleGly: 5.237 ± 0.142
1.618IleHis: 1.618 ± 0.08
6.34IleIle: 6.34 ± 0.164
4.088IleLys: 4.088 ± 0.123
8.595IleLeu: 8.595 ± 0.169
1.473IleMet: 1.473 ± 0.072
4.452IleAsn: 4.452 ± 0.129
4.3IlePro: 4.3 ± 0.122
3.461IleGln: 3.461 ± 0.111
3.688IleArg: 3.688 ± 0.1
5.87IleSer: 5.87 ± 0.135
4.752IleThr: 4.752 ± 0.132
4.646IleVal: 4.646 ± 0.132
1.024IleTrp: 1.024 ± 0.058
2.415IleTyr: 2.415 ± 0.088
0.0IleXaa: 0.0 ± 0.0
Lys
3.803LysAla: 3.803 ± 0.11
0.473LysCys: 0.473 ± 0.039
2.249LysAsp: 2.249 ± 0.091
3.418LysGlu: 3.418 ± 0.094
2.2LysPhe: 2.2 ± 0.09
3.1LysGly: 3.1 ± 0.105
1.012LysHis: 1.012 ± 0.055
4.782LysIle: 4.782 ± 0.115
3.079LysLys: 3.079 ± 0.118
6.625LysLeu: 6.625 ± 0.151
1.315LysMet: 1.315 ± 0.063
2.785LysAsn: 2.785 ± 0.094
2.382LysPro: 2.382 ± 0.095
2.9LysGln: 2.9 ± 0.109
2.597LysArg: 2.597 ± 0.087
3.615LysSer: 3.615 ± 0.103
3.303LysThr: 3.303 ± 0.104
4.055LysVal: 4.055 ± 0.118
0.506LysTrp: 0.506 ± 0.038
1.985LysTyr: 1.985 ± 0.08
0.0LysXaa: 0.0 ± 0.0
Leu
8.207LeuAla: 8.207 ± 0.167
1.167LeuCys: 1.167 ± 0.058
4.955LeuAsp: 4.955 ± 0.136
7.722LeuGlu: 7.722 ± 0.173
3.797LeuPhe: 3.797 ± 0.122
7.792LeuGly: 7.792 ± 0.173
2.085LeuHis: 2.085 ± 0.082
8.004LeuIle: 8.004 ± 0.167
6.037LeuLys: 6.037 ± 0.132
11.274LeuLeu: 11.274 ± 0.248
2.397LeuMet: 2.397 ± 0.104
4.749LeuAsn: 4.749 ± 0.127
5.525LeuPro: 5.525 ± 0.14
5.531LeuGln: 5.531 ± 0.16
5.116LeuArg: 5.116 ± 0.134
7.455LeuSer: 7.455 ± 0.19
5.849LeuThr: 5.849 ± 0.111
7.488LeuVal: 7.488 ± 0.16
1.276LeuTrp: 1.276 ± 0.074
2.894LeuTyr: 2.894 ± 0.108
0.0LeuXaa: 0.0 ± 0.0
Met
2.055MetAla: 2.055 ± 0.082
0.17MetCys: 0.17 ± 0.021
0.955MetAsp: 0.955 ± 0.058
1.397MetGlu: 1.397 ± 0.059
0.685MetPhe: 0.685 ± 0.05
2.009MetGly: 2.009 ± 0.084
0.397MetHis: 0.397 ± 0.036
1.682MetIle: 1.682 ± 0.073
1.215MetLys: 1.215 ± 0.06
2.361MetLeu: 2.361 ± 0.084
0.524MetMet: 0.524 ± 0.042
1.109MetAsn: 1.109 ± 0.059
0.991MetPro: 0.991 ± 0.053
0.997MetGln: 0.997 ± 0.056
1.036MetArg: 1.036 ± 0.062
1.682MetSer: 1.682 ± 0.064
1.379MetThr: 1.379 ± 0.073
1.652MetVal: 1.652 ± 0.073
0.188MetTrp: 0.188 ± 0.023
0.539MetTyr: 0.539 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.985AsnAla: 2.985 ± 0.106
0.642AsnCys: 0.642 ± 0.045
1.803AsnAsp: 1.803 ± 0.079
1.697AsnGlu: 1.697 ± 0.066
2.085AsnPhe: 2.085 ± 0.07
2.594AsnGly: 2.594 ± 0.109
1.224AsnHis: 1.224 ± 0.059
4.197AsnIle: 4.197 ± 0.128
2.491AsnLys: 2.491 ± 0.086
5.973AsnLeu: 5.973 ± 0.16
1.073AsnMet: 1.073 ± 0.051
2.749AsnAsn: 2.749 ± 0.11
2.679AsnPro: 2.679 ± 0.075
2.706AsnGln: 2.706 ± 0.104
2.382AsnArg: 2.382 ± 0.087
3.567AsnSer: 3.567 ± 0.119
2.8AsnThr: 2.8 ± 0.1
2.294AsnVal: 2.294 ± 0.086
0.818AsnTrp: 0.818 ± 0.051
1.861AsnTyr: 1.861 ± 0.073
0.0AsnXaa: 0.0 ± 0.0
Pro
2.349ProAla: 2.349 ± 0.081
0.406ProCys: 0.406 ± 0.03
2.218ProAsp: 2.218 ± 0.076
3.343ProGlu: 3.343 ± 0.084
1.549ProPhe: 1.549 ± 0.069
2.912ProGly: 2.912 ± 0.091
1.052ProHis: 1.052 ± 0.053
3.515ProIle: 3.515 ± 0.103
2.343ProLys: 2.343 ± 0.098
4.361ProLeu: 4.361 ± 0.13
0.879ProMet: 0.879 ± 0.046
2.258ProAsn: 2.258 ± 0.095
1.652ProPro: 1.652 ± 0.07
2.249ProGln: 2.249 ± 0.079
1.761ProArg: 1.761 ± 0.066
2.64ProSer: 2.64 ± 0.088
2.23ProThr: 2.23 ± 0.084
2.761ProVal: 2.761 ± 0.095
0.545ProTrp: 0.545 ± 0.042
1.47ProTyr: 1.47 ± 0.076
0.0ProXaa: 0.0 ± 0.0
Gln
3.491GlnAla: 3.491 ± 0.113
0.385GlnCys: 0.385 ± 0.031
1.961GlnAsp: 1.961 ± 0.068
3.612GlnGlu: 3.612 ± 0.127
1.521GlnPhe: 1.521 ± 0.065
3.103GlnGly: 3.103 ± 0.092
0.873GlnHis: 0.873 ± 0.05
3.909GlnIle: 3.909 ± 0.114
3.155GlnLys: 3.155 ± 0.109
5.306GlnLeu: 5.306 ± 0.141
1.146GlnMet: 1.146 ± 0.058
2.094GlnAsn: 2.094 ± 0.082
1.909GlnPro: 1.909 ± 0.068
2.809GlnGln: 2.809 ± 0.132
2.394GlnArg: 2.394 ± 0.082
2.655GlnSer: 2.655 ± 0.09
2.54GlnThr: 2.54 ± 0.095
3.509GlnVal: 3.509 ± 0.115
0.536GlnTrp: 0.536 ± 0.04
1.403GlnTyr: 1.403 ± 0.068
0.0GlnXaa: 0.0 ± 0.0
Arg
2.918ArgAla: 2.918 ± 0.103
0.567ArgCys: 0.567 ± 0.042
2.194ArgAsp: 2.194 ± 0.074
2.982ArgGlu: 2.982 ± 0.098
1.87ArgPhe: 1.87 ± 0.076
2.912ArgGly: 2.912 ± 0.119
0.955ArgHis: 0.955 ± 0.055
3.667ArgIle: 3.667 ± 0.108
2.661ArgLys: 2.661 ± 0.101
5.473ArgLeu: 5.473 ± 0.158
1.194ArgMet: 1.194 ± 0.06
2.349ArgAsn: 2.349 ± 0.094
1.761ArgPro: 1.761 ± 0.067
2.727ArgGln: 2.727 ± 0.1
2.821ArgArg: 2.821 ± 0.118
2.743ArgSer: 2.743 ± 0.099
2.27ArgThr: 2.27 ± 0.074
3.315ArgVal: 3.315 ± 0.101
0.685ArgTrp: 0.685 ± 0.047
1.724ArgTyr: 1.724 ± 0.082
0.0ArgXaa: 0.0 ± 0.0
Ser
4.046SerAla: 4.046 ± 0.104
0.827SerCys: 0.827 ± 0.048
2.8SerAsp: 2.8 ± 0.1
3.503SerGlu: 3.503 ± 0.114
2.449SerPhe: 2.449 ± 0.089
4.719SerGly: 4.719 ± 0.139
1.555SerHis: 1.555 ± 0.072
4.973SerIle: 4.973 ± 0.149
3.443SerLys: 3.443 ± 0.1
7.555SerLeu: 7.555 ± 0.141
1.555SerMet: 1.555 ± 0.08
3.167SerAsn: 3.167 ± 0.106
3.031SerPro: 3.031 ± 0.094
3.773SerGln: 3.773 ± 0.11
3.149SerArg: 3.149 ± 0.1
4.982SerSer: 4.982 ± 0.135
3.412SerThr: 3.412 ± 0.106
3.652SerVal: 3.652 ± 0.108
0.973SerTrp: 0.973 ± 0.054
2.221SerTyr: 2.221 ± 0.086
0.0SerXaa: 0.0 ± 0.0
Thr
3.988ThrAla: 3.988 ± 0.095
0.633ThrCys: 0.633 ± 0.039
2.34ThrAsp: 2.34 ± 0.096
2.879ThrGlu: 2.879 ± 0.097
1.885ThrPhe: 1.885 ± 0.075
4.219ThrGly: 4.219 ± 0.104
1.136ThrHis: 1.136 ± 0.053
4.488ThrIle: 4.488 ± 0.122
2.658ThrLys: 2.658 ± 0.104
5.685ThrLeu: 5.685 ± 0.129
1.073ThrMet: 1.073 ± 0.055
2.321ThrAsn: 2.321 ± 0.09
2.749ThrPro: 2.749 ± 0.098
2.373ThrGln: 2.373 ± 0.078
2.415ThrArg: 2.415 ± 0.083
3.837ThrSer: 3.837 ± 0.092
2.979ThrThr: 2.979 ± 0.096
3.482ThrVal: 3.482 ± 0.116
0.636ThrTrp: 0.636 ± 0.045
1.752ThrTyr: 1.752 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
5.076ValAla: 5.076 ± 0.16
0.812ValCys: 0.812 ± 0.054
3.358ValAsp: 3.358 ± 0.116
4.125ValGlu: 4.125 ± 0.13
2.634ValPhe: 2.634 ± 0.098
4.6ValGly: 4.6 ± 0.135
1.085ValHis: 1.085 ± 0.059
5.394ValIle: 5.394 ± 0.146
3.525ValLys: 3.525 ± 0.106
6.194ValLeu: 6.194 ± 0.136
1.6ValMet: 1.6 ± 0.069
3.028ValAsn: 3.028 ± 0.103
2.367ValPro: 2.367 ± 0.092
2.285ValGln: 2.285 ± 0.09
2.961ValArg: 2.961 ± 0.097
4.085ValSer: 4.085 ± 0.118
3.603ValThr: 3.603 ± 0.103
4.479ValVal: 4.479 ± 0.128
0.83ValTrp: 0.83 ± 0.054
1.888ValTyr: 1.888 ± 0.076
0.0ValXaa: 0.0 ± 0.0
Trp
0.752TrpAla: 0.752 ± 0.048
0.158TrpCys: 0.158 ± 0.021
0.518TrpAsp: 0.518 ± 0.041
0.882TrpGlu: 0.882 ± 0.047
0.579TrpPhe: 0.579 ± 0.043
1.033TrpGly: 1.033 ± 0.055
0.345TrpHis: 0.345 ± 0.036
0.906TrpIle: 0.906 ± 0.054
0.585TrpLys: 0.585 ± 0.044
1.767TrpLeu: 1.767 ± 0.08
0.349TrpMet: 0.349 ± 0.033
0.624TrpAsn: 0.624 ± 0.045
0.242TrpPro: 0.242 ± 0.026
1.221TrpGln: 1.221 ± 0.066
0.655TrpArg: 0.655 ± 0.048
0.864TrpSer: 0.864 ± 0.049
0.452TrpThr: 0.452 ± 0.04
0.833TrpVal: 0.833 ± 0.049
0.209TrpTrp: 0.209 ± 0.026
0.467TrpTyr: 0.467 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.815TyrAla: 1.815 ± 0.072
0.47TyrCys: 0.47 ± 0.04
1.461TyrAsp: 1.461 ± 0.066
1.715TyrGlu: 1.715 ± 0.084
1.533TyrPhe: 1.533 ± 0.07
2.137TyrGly: 2.137 ± 0.075
0.827TyrHis: 0.827 ± 0.054
2.343TyrIle: 2.343 ± 0.089
1.673TyrLys: 1.673 ± 0.082
3.973TyrLeu: 3.973 ± 0.116
0.694TyrMet: 0.694 ± 0.046
1.506TyrAsn: 1.506 ± 0.069
1.733TyrPro: 1.733 ± 0.066
1.973TyrGln: 1.973 ± 0.081
1.779TyrArg: 1.779 ± 0.078
2.403TyrSer: 2.403 ± 0.096
1.803TyrThr: 1.803 ± 0.074
1.624TyrVal: 1.624 ± 0.074
0.612TyrTrp: 0.612 ± 0.042
1.258TyrTyr: 1.258 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.003XaaVal: 0.003 ± 0.003
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1674 proteins (329974 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski