Amino acid dipepetide frequency for Hubei toti-like virus 19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.197AlaAla: 8.197 ± 2.931
1.726AlaCys: 1.726 ± 0.903
4.745AlaAsp: 4.745 ± 1.124
6.04AlaGlu: 6.04 ± 1.121
2.157AlaPhe: 2.157 ± 0.449
4.745AlaGly: 4.745 ± 1.124
1.294AlaHis: 1.294 ± 0.683
5.608AlaIle: 5.608 ± 2.256
5.608AlaLys: 5.608 ± 0.895
6.471AlaLeu: 6.471 ± 0.666
3.451AlaMet: 3.451 ± 0.234
1.726AlaAsn: 1.726 ± 0.903
3.02AlaPro: 3.02 ± 0.901
2.588AlaGln: 2.588 ± 0.686
4.745AlaArg: 4.745 ± 0.237
4.745AlaSer: 4.745 ± 1.124
6.04AlaThr: 6.04 ± 0.441
5.177AlaVal: 5.177 ± 0.011
1.726AlaTrp: 1.726 ± 0.903
2.157AlaTyr: 2.157 ± 1.592
0.0AlaXaa: 0.0 ± 0.0
Cys
0.863CysAla: 0.863 ± 0.452
0.431CysCys: 0.431 ± 0.226
0.863CysAsp: 0.863 ± 0.229
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.431CysGly: 0.431 ± 0.455
0.431CysHis: 0.431 ± 0.226
0.0CysIle: 0.0 ± 0.0
0.431CysLys: 0.431 ± 0.455
0.431CysLeu: 0.431 ± 0.226
0.431CysMet: 0.431 ± 0.226
2.157CysAsn: 2.157 ± 1.129
0.863CysPro: 0.863 ± 0.909
1.294CysGln: 1.294 ± 0.683
0.0CysArg: 0.0 ± 0.0
0.431CysSer: 0.431 ± 0.226
0.431CysThr: 0.431 ± 0.226
1.726CysVal: 1.726 ± 0.223
0.0CysTrp: 0.0 ± 0.0
2.588CysTyr: 2.588 ± 0.686
0.0CysXaa: 0.0 ± 0.0
Asp
5.177AspAla: 5.177 ± 0.669
0.863AspCys: 0.863 ± 0.229
3.02AspAsp: 3.02 ± 0.901
3.883AspGlu: 3.883 ± 1.352
0.863AspPhe: 0.863 ± 0.229
3.02AspGly: 3.02 ± 0.22
1.726AspHis: 1.726 ± 0.903
5.177AspIle: 5.177 ± 1.372
2.588AspLys: 2.588 ± 1.355
4.745AspLeu: 4.745 ± 1.804
0.0AspMet: 0.0 ± 0.0
3.451AspAsn: 3.451 ± 0.446
2.588AspPro: 2.588 ± 1.355
1.726AspGln: 1.726 ± 1.138
1.726AspArg: 1.726 ± 0.903
2.588AspSer: 2.588 ± 0.675
4.745AspThr: 4.745 ± 1.124
4.745AspVal: 4.745 ± 0.443
1.726AspTrp: 1.726 ± 0.457
3.883AspTyr: 3.883 ± 1.352
0.0AspXaa: 0.0 ± 0.0
Glu
6.903GluAla: 6.903 ± 0.892
0.0GluCys: 0.0 ± 0.0
1.294GluAsp: 1.294 ± 0.003
8.197GluGlu: 8.197 ± 0.209
1.294GluPhe: 1.294 ± 1.364
6.471GluGly: 6.471 ± 0.014
1.726GluHis: 1.726 ± 0.457
6.04GluIle: 6.04 ± 0.441
7.334GluLys: 7.334 ± 0.243
3.451GluLeu: 3.451 ± 0.446
3.451GluMet: 3.451 ± 0.915
2.588GluAsn: 2.588 ± 0.686
2.588GluPro: 2.588 ± 0.006
3.02GluGln: 3.02 ± 0.22
6.471GluArg: 6.471 ± 2.055
3.02GluSer: 3.02 ± 0.901
3.883GluThr: 3.883 ± 1.352
3.883GluVal: 3.883 ± 1.352
2.157GluTrp: 2.157 ± 1.592
2.157GluTyr: 2.157 ± 0.912
0.0GluXaa: 0.0 ± 0.0
Phe
2.157PheAla: 2.157 ± 0.231
1.294PheCys: 1.294 ± 0.003
1.294PheAsp: 1.294 ± 0.003
1.726PheGlu: 1.726 ± 0.457
0.863PhePhe: 0.863 ± 0.452
3.451PheGly: 3.451 ± 0.446
0.863PheHis: 0.863 ± 0.229
2.157PheIle: 2.157 ± 0.912
1.726PheLys: 1.726 ± 1.138
2.588PheLeu: 2.588 ± 0.006
0.863PheMet: 0.863 ± 0.452
1.294PheAsn: 1.294 ± 0.003
0.431PhePro: 0.431 ± 0.226
0.863PheGln: 0.863 ± 0.452
2.157PheArg: 2.157 ± 0.231
1.726PheSer: 1.726 ± 0.457
2.157PheThr: 2.157 ± 1.129
0.863PheVal: 0.863 ± 0.229
0.0PheTrp: 0.0 ± 0.0
0.431PheTyr: 0.431 ± 0.455
0.0PheXaa: 0.0 ± 0.0
Gly
3.883GlyAla: 3.883 ± 1.369
0.863GlyCys: 0.863 ± 0.909
8.197GlyAsp: 8.197 ± 1.57
5.177GlyGlu: 5.177 ± 0.011
3.883GlyPhe: 3.883 ± 0.672
6.471GlyGly: 6.471 ± 0.014
1.294GlyHis: 1.294 ± 0.678
7.334GlyIle: 7.334 ± 0.243
3.883GlyLys: 3.883 ± 0.689
5.608GlyLeu: 5.608 ± 0.466
0.431GlyMet: 0.431 ± 0.226
1.726GlyAsn: 1.726 ± 0.223
1.726GlyPro: 1.726 ± 0.457
1.294GlyGln: 1.294 ± 0.678
4.314GlyArg: 4.314 ± 0.463
3.451GlySer: 3.451 ± 1.127
5.177GlyThr: 5.177 ± 1.35
6.04GlyVal: 6.04 ± 0.441
1.294GlyTrp: 1.294 ± 0.678
2.588GlyTyr: 2.588 ± 1.366
0.0GlyXaa: 0.0 ± 0.0
His
1.294HisAla: 1.294 ± 0.003
0.0HisCys: 0.0 ± 0.0
0.863HisAsp: 0.863 ± 0.452
0.431HisGlu: 0.431 ± 0.226
0.431HisPhe: 0.431 ± 0.226
1.294HisGly: 1.294 ± 0.003
0.863HisHis: 0.863 ± 0.229
1.726HisIle: 1.726 ± 1.138
1.726HisLys: 1.726 ± 0.223
1.726HisLeu: 1.726 ± 0.457
0.863HisMet: 0.863 ± 0.229
1.726HisAsn: 1.726 ± 0.903
1.294HisPro: 1.294 ± 0.683
0.863HisGln: 0.863 ± 0.229
2.588HisArg: 2.588 ± 0.006
1.726HisSer: 1.726 ± 0.903
0.431HisThr: 0.431 ± 0.226
1.726HisVal: 1.726 ± 1.138
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
6.04IleAla: 6.04 ± 1.121
0.0IleCys: 0.0 ± 0.0
4.314IleAsp: 4.314 ± 0.218
3.451IleGlu: 3.451 ± 0.446
2.157IlePhe: 2.157 ± 0.449
2.588IleGly: 2.588 ± 0.006
3.02IleHis: 3.02 ± 0.46
1.726IleIle: 1.726 ± 1.138
6.04IleLys: 6.04 ± 0.92
5.608IleLeu: 5.608 ± 1.826
1.294IleMet: 1.294 ± 1.364
4.745IleAsn: 4.745 ± 0.443
3.02IlePro: 3.02 ± 1.821
2.157IleGln: 2.157 ± 0.912
5.608IleArg: 5.608 ± 0.215
4.314IleSer: 4.314 ± 1.143
3.02IleThr: 3.02 ± 0.22
3.02IleVal: 3.02 ± 0.901
0.431IleTrp: 0.431 ± 0.455
0.863IleTyr: 0.863 ± 0.909
0.0IleXaa: 0.0 ± 0.0
Lys
4.745LysAla: 4.745 ± 0.443
1.726LysCys: 1.726 ± 0.457
5.608LysAsp: 5.608 ± 0.895
7.765LysGlu: 7.765 ± 0.664
0.863LysPhe: 0.863 ± 0.229
7.334LysGly: 7.334 ± 0.243
0.863LysHis: 0.863 ± 0.229
3.883LysIle: 3.883 ± 1.352
8.197LysLys: 8.197 ± 0.89
3.02LysLeu: 3.02 ± 0.22
1.294LysMet: 1.294 ± 0.683
1.726LysAsn: 1.726 ± 0.457
3.883LysPro: 3.883 ± 0.672
0.431LysGln: 0.431 ± 0.226
3.02LysArg: 3.02 ± 0.46
3.02LysSer: 3.02 ± 2.501
4.745LysThr: 4.745 ± 2.278
4.314LysVal: 4.314 ± 0.218
0.863LysTrp: 0.863 ± 0.229
2.157LysTyr: 2.157 ± 0.231
0.0LysXaa: 0.0 ± 0.0
Leu
6.903LeuAla: 6.903 ± 0.468
1.726LeuCys: 1.726 ± 0.457
6.471LeuAsp: 6.471 ± 1.347
8.628LeuGlu: 8.628 ± 2.967
3.02LeuPhe: 3.02 ± 0.46
3.451LeuGly: 3.451 ± 1.595
0.863LeuHis: 0.863 ± 0.229
4.314LeuIle: 4.314 ± 0.463
4.745LeuLys: 4.745 ± 1.124
3.883LeuLeu: 3.883 ± 1.369
1.294LeuMet: 1.294 ± 0.678
2.588LeuAsn: 2.588 ± 0.006
3.451LeuPro: 3.451 ± 0.915
0.863LeuGln: 0.863 ± 0.909
3.451LeuArg: 3.451 ± 0.915
6.04LeuSer: 6.04 ± 1.801
2.588LeuThr: 2.588 ± 0.675
4.314LeuVal: 4.314 ± 1.578
0.863LeuTrp: 0.863 ± 0.452
3.451LeuTyr: 3.451 ± 1.595
0.0LeuXaa: 0.0 ± 0.0
Met
3.451MetAla: 3.451 ± 0.915
0.0MetCys: 0.0 ± 0.0
0.863MetAsp: 0.863 ± 0.909
2.157MetGlu: 2.157 ± 0.449
0.863MetPhe: 0.863 ± 0.229
2.588MetGly: 2.588 ± 0.675
1.294MetHis: 1.294 ± 0.678
0.431MetIle: 0.431 ± 0.455
1.294MetLys: 1.294 ± 0.003
3.883MetLeu: 3.883 ± 2.73
1.294MetMet: 1.294 ± 0.678
0.431MetAsn: 0.431 ± 0.226
0.863MetPro: 0.863 ± 0.229
0.431MetGln: 0.431 ± 0.455
1.726MetArg: 1.726 ± 0.457
1.726MetSer: 1.726 ± 0.223
1.726MetThr: 1.726 ± 0.903
1.294MetVal: 1.294 ± 0.003
1.294MetTrp: 1.294 ± 0.683
0.431MetTyr: 0.431 ± 0.226
0.0MetXaa: 0.0 ± 0.0
Asn
3.02AsnAla: 3.02 ± 1.581
0.431AsnCys: 0.431 ± 0.226
1.726AsnAsp: 1.726 ± 0.223
0.863AsnGlu: 0.863 ± 0.229
0.863AsnPhe: 0.863 ± 0.229
2.588AsnGly: 2.588 ± 0.675
0.0AsnHis: 0.0 ± 0.0
3.883AsnIle: 3.883 ± 0.008
2.588AsnLys: 2.588 ± 0.006
3.02AsnLeu: 3.02 ± 0.22
1.294AsnMet: 1.294 ± 0.683
0.431AsnAsn: 0.431 ± 0.226
1.294AsnPro: 1.294 ± 0.003
1.294AsnGln: 1.294 ± 0.683
2.588AsnArg: 2.588 ± 0.006
3.02AsnSer: 3.02 ± 0.22
3.451AsnThr: 3.451 ± 1.127
3.451AsnVal: 3.451 ± 0.915
0.863AsnTrp: 0.863 ± 0.229
3.883AsnTyr: 3.883 ± 1.352
0.0AsnXaa: 0.0 ± 0.0
Pro
4.314ProAla: 4.314 ± 0.898
0.431ProCys: 0.431 ± 0.226
2.588ProAsp: 2.588 ± 0.686
5.608ProGlu: 5.608 ± 0.215
0.863ProPhe: 0.863 ± 0.909
3.883ProGly: 3.883 ± 2.033
0.431ProHis: 0.431 ± 0.455
1.294ProIle: 1.294 ± 1.364
0.431ProLys: 0.431 ± 0.226
3.02ProLeu: 3.02 ± 0.46
0.863ProMet: 0.863 ± 0.909
1.726ProAsn: 1.726 ± 0.223
3.02ProPro: 3.02 ± 0.46
0.0ProGln: 0.0 ± 0.0
2.157ProArg: 2.157 ± 0.449
1.726ProSer: 1.726 ± 1.138
2.157ProThr: 2.157 ± 0.449
4.745ProVal: 4.745 ± 0.917
0.0ProTrp: 0.0 ± 0.0
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
1.726GlnAla: 1.726 ± 0.223
0.431GlnCys: 0.431 ± 0.455
0.863GlnAsp: 0.863 ± 0.452
2.588GlnGlu: 2.588 ± 1.366
0.863GlnPhe: 0.863 ± 0.229
2.588GlnGly: 2.588 ± 0.686
0.863GlnHis: 0.863 ± 0.229
2.588GlnIle: 2.588 ± 0.006
0.863GlnLys: 0.863 ± 0.909
1.726GlnLeu: 1.726 ± 0.223
2.157GlnMet: 2.157 ± 0.449
1.726GlnAsn: 1.726 ± 0.223
1.726GlnPro: 1.726 ± 0.223
0.431GlnGln: 0.431 ± 0.226
0.863GlnArg: 0.863 ± 0.229
0.863GlnSer: 0.863 ± 0.229
1.294GlnThr: 1.294 ± 0.003
0.863GlnVal: 0.863 ± 0.229
0.863GlnTrp: 0.863 ± 0.909
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
6.471ArgAla: 6.471 ± 1.347
0.431ArgCys: 0.431 ± 0.455
2.157ArgAsp: 2.157 ± 0.449
2.588ArgGlu: 2.588 ± 0.006
2.588ArgPhe: 2.588 ± 0.006
3.451ArgGly: 3.451 ± 0.234
1.294ArgHis: 1.294 ± 0.003
4.745ArgIle: 4.745 ± 0.917
5.608ArgLys: 5.608 ± 0.466
6.471ArgLeu: 6.471 ± 0.694
1.726ArgMet: 1.726 ± 0.903
2.157ArgAsn: 2.157 ± 0.449
1.294ArgPro: 1.294 ± 0.683
0.431ArgGln: 0.431 ± 0.226
5.177ArgArg: 5.177 ± 0.692
3.883ArgSer: 3.883 ± 0.672
4.314ArgThr: 4.314 ± 1.824
5.608ArgVal: 5.608 ± 0.466
1.726ArgTrp: 1.726 ± 0.457
3.02ArgTyr: 3.02 ± 0.46
0.0ArgXaa: 0.0 ± 0.0
Ser
4.314SerAla: 4.314 ± 2.259
0.863SerCys: 0.863 ± 0.229
3.02SerAsp: 3.02 ± 1.581
3.02SerGlu: 3.02 ± 0.22
3.02SerPhe: 3.02 ± 0.22
3.451SerGly: 3.451 ± 0.446
0.863SerHis: 0.863 ± 0.229
3.02SerIle: 3.02 ± 0.46
3.883SerLys: 3.883 ± 0.008
4.745SerLeu: 4.745 ± 1.124
2.588SerMet: 2.588 ± 0.686
2.588SerAsn: 2.588 ± 0.006
1.726SerPro: 1.726 ± 0.457
3.02SerGln: 3.02 ± 0.46
4.745SerArg: 4.745 ± 0.443
6.471SerSer: 6.471 ± 0.666
4.314SerThr: 4.314 ± 1.578
2.588SerVal: 2.588 ± 1.355
1.726SerTrp: 1.726 ± 1.138
1.726SerTyr: 1.726 ± 0.457
0.0SerXaa: 0.0 ± 0.0
Thr
3.883ThrAla: 3.883 ± 1.352
0.0ThrCys: 0.0 ± 0.0
4.745ThrAsp: 4.745 ± 1.124
4.745ThrGlu: 4.745 ± 0.443
0.863ThrPhe: 0.863 ± 0.229
6.903ThrGly: 6.903 ± 0.468
2.157ThrHis: 2.157 ± 0.449
3.451ThrIle: 3.451 ± 1.595
4.745ThrLys: 4.745 ± 1.804
4.745ThrLeu: 4.745 ± 1.804
0.863ThrMet: 0.863 ± 0.193
1.726ThrAsn: 1.726 ± 0.223
2.157ThrPro: 2.157 ± 0.449
1.726ThrGln: 1.726 ± 0.903
5.177ThrArg: 5.177 ± 0.669
3.451ThrSer: 3.451 ± 1.127
4.314ThrThr: 4.314 ± 0.218
3.451ThrVal: 3.451 ± 0.234
1.294ThrTrp: 1.294 ± 0.003
1.726ThrTyr: 1.726 ± 0.457
0.0ThrXaa: 0.0 ± 0.0
Val
3.451ValAla: 3.451 ± 1.127
0.431ValCys: 0.431 ± 0.226
1.294ValAsp: 1.294 ± 0.678
6.471ValGlu: 6.471 ± 0.694
3.02ValPhe: 3.02 ± 0.901
3.883ValGly: 3.883 ± 0.672
0.431ValHis: 0.431 ± 0.226
2.588ValIle: 2.588 ± 0.006
4.314ValLys: 4.314 ± 3.184
3.451ValLeu: 3.451 ± 1.595
1.726ValMet: 1.726 ± 0.476
3.02ValAsn: 3.02 ± 0.46
3.451ValPro: 3.451 ± 0.446
2.588ValGln: 2.588 ± 0.675
5.177ValArg: 5.177 ± 0.669
5.608ValSer: 5.608 ± 0.895
4.745ValThr: 4.745 ± 0.443
4.314ValVal: 4.314 ± 0.218
0.863ValTrp: 0.863 ± 0.229
2.588ValTyr: 2.588 ± 0.675
0.0ValXaa: 0.0 ± 0.0
Trp
1.726TrpAla: 1.726 ± 0.223
0.431TrpCys: 0.431 ± 0.226
1.294TrpAsp: 1.294 ± 0.003
0.863TrpGlu: 0.863 ± 0.909
0.0TrpPhe: 0.0 ± 0.0
3.451TrpGly: 3.451 ± 0.234
0.863TrpHis: 0.863 ± 0.909
0.863TrpIle: 0.863 ± 0.909
0.431TrpLys: 0.431 ± 0.455
0.863TrpLeu: 0.863 ± 0.909
0.431TrpMet: 0.431 ± 0.455
0.863TrpAsn: 0.863 ± 0.229
0.863TrpPro: 0.863 ± 0.229
0.0TrpGln: 0.0 ± 0.0
0.863TrpArg: 0.863 ± 0.909
1.726TrpSer: 1.726 ± 0.903
1.294TrpThr: 1.294 ± 0.003
0.863TrpVal: 0.863 ± 0.229
0.0TrpTrp: 0.0 ± 0.0
0.431TrpTyr: 0.431 ± 0.226
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.451TyrAla: 3.451 ± 0.234
1.726TyrCys: 1.726 ± 0.903
3.02TyrAsp: 3.02 ± 0.901
1.726TyrGlu: 1.726 ± 1.138
0.431TyrPhe: 0.431 ± 0.455
2.588TyrGly: 2.588 ± 0.686
0.431TyrHis: 0.431 ± 0.226
2.588TyrIle: 2.588 ± 0.006
3.02TyrLys: 3.02 ± 0.46
3.451TyrLeu: 3.451 ± 0.915
1.294TyrMet: 1.294 ± 0.683
2.157TyrAsn: 2.157 ± 0.912
0.0TyrPro: 0.0 ± 0.0
0.863TyrGln: 0.863 ± 0.909
2.588TyrArg: 2.588 ± 0.006
2.157TyrSer: 2.157 ± 0.231
1.726TyrThr: 1.726 ± 0.223
0.431TyrVal: 0.431 ± 0.455
0.431TyrTrp: 0.431 ± 0.455
0.863TyrTyr: 0.863 ± 0.909
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2319 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski