Amino acid dipepetide frequency for Candidatus Cytomitobacter primus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.128AlaAla: 3.128 ± 0.221
0.812AlaCys: 0.812 ± 0.069
2.854AlaAsp: 2.854 ± 0.181
3.18AlaGlu: 3.18 ± 0.208
2.499AlaPhe: 2.499 ± 0.13
2.848AlaGly: 2.848 ± 0.164
1.195AlaHis: 1.195 ± 0.085
4.878AlaIle: 4.878 ± 0.21
4.941AlaLys: 4.941 ± 0.198
5.387AlaLeu: 5.387 ± 0.165
1.699AlaMet: 1.699 ± 0.097
3.5AlaAsn: 3.5 ± 0.175
1.361AlaPro: 1.361 ± 0.101
2.162AlaGln: 2.162 ± 0.128
1.87AlaArg: 1.87 ± 0.137
4.032AlaSer: 4.032 ± 0.177
2.03AlaThr: 2.03 ± 0.091
3.128AlaVal: 3.128 ± 0.148
0.4AlaTrp: 0.4 ± 0.051
2.259AlaTyr: 2.259 ± 0.116
0.0AlaXaa: 0.0 ± 0.0
Cys
0.726CysAla: 0.726 ± 0.058
0.217CysCys: 0.217 ± 0.037
0.784CysAsp: 0.784 ± 0.067
0.841CysGlu: 0.841 ± 0.059
0.652CysPhe: 0.652 ± 0.058
0.972CysGly: 0.972 ± 0.067
0.189CysHis: 0.189 ± 0.032
1.636CysIle: 1.636 ± 0.106
1.018CysLys: 1.018 ± 0.084
1.144CysLeu: 1.144 ± 0.081
0.475CysMet: 0.475 ± 0.053
0.938CysAsn: 0.938 ± 0.074
0.36CysPro: 0.36 ± 0.042
0.292CysGln: 0.292 ± 0.039
0.349CysArg: 0.349 ± 0.047
0.961CysSer: 0.961 ± 0.082
0.681CysThr: 0.681 ± 0.062
0.755CysVal: 0.755 ± 0.06
0.074CysTrp: 0.074 ± 0.019
0.435CysTyr: 0.435 ± 0.05
0.0CysXaa: 0.0 ± 0.0
Asp
2.934AspAla: 2.934 ± 0.137
0.629AspCys: 0.629 ± 0.055
2.734AspAsp: 2.734 ± 0.156
3.506AspGlu: 3.506 ± 0.162
2.493AspPhe: 2.493 ± 0.115
2.911AspGly: 2.911 ± 0.141
1.35AspHis: 1.35 ± 0.094
5.456AspIle: 5.456 ± 0.189
5.25AspLys: 5.25 ± 0.212
5.862AspLeu: 5.862 ± 0.252
1.573AspMet: 1.573 ± 0.105
3.34AspAsn: 3.34 ± 0.139
1.447AspPro: 1.447 ± 0.101
2.219AspGln: 2.219 ± 0.108
1.956AspArg: 1.956 ± 0.114
4.078AspSer: 4.078 ± 0.176
2.242AspThr: 2.242 ± 0.128
2.962AspVal: 2.962 ± 0.142
0.475AspTrp: 0.475 ± 0.06
2.168AspTyr: 2.168 ± 0.1
0.0AspXaa: 0.0 ± 0.0
Glu
3.208GluAla: 3.208 ± 0.212
0.709GluCys: 0.709 ± 0.07
3.128GluAsp: 3.128 ± 0.165
4.398GluGlu: 4.398 ± 0.231
2.619GluPhe: 2.619 ± 0.124
2.391GluGly: 2.391 ± 0.115
1.413GluHis: 1.413 ± 0.102
6.034GluIle: 6.034 ± 0.222
5.753GluLys: 5.753 ± 0.288
5.839GluLeu: 5.839 ± 0.319
1.801GluMet: 1.801 ± 0.103
4.89GluAsn: 4.89 ± 0.193
1.018GluPro: 1.018 ± 0.077
2.356GluGln: 2.356 ± 0.164
1.893GluArg: 1.893 ± 0.107
4.77GluSer: 4.77 ± 0.211
2.282GluThr: 2.282 ± 0.127
3.386GluVal: 3.386 ± 0.178
0.538GluTrp: 0.538 ± 0.059
2.665GluTyr: 2.665 ± 0.13
0.0GluXaa: 0.0 ± 0.0
Phe
2.825PheAla: 2.825 ± 0.137
0.726PheCys: 0.726 ± 0.059
2.928PheAsp: 2.928 ± 0.131
2.499PheGlu: 2.499 ± 0.108
2.139PhePhe: 2.139 ± 0.121
2.842PheGly: 2.842 ± 0.161
0.898PheHis: 0.898 ± 0.075
4.501PheIle: 4.501 ± 0.204
3.294PheLys: 3.294 ± 0.166
4.129PheLeu: 4.129 ± 0.187
1.321PheMet: 1.321 ± 0.087
2.968PheAsn: 2.968 ± 0.138
1.224PhePro: 1.224 ± 0.083
1.367PheGln: 1.367 ± 0.087
1.464PheArg: 1.464 ± 0.101
3.426PheSer: 3.426 ± 0.154
2.122PheThr: 2.122 ± 0.11
2.453PheVal: 2.453 ± 0.119
0.417PheTrp: 0.417 ± 0.049
1.538PheTyr: 1.538 ± 0.109
0.0PheXaa: 0.0 ± 0.0
Gly
2.534GlyAla: 2.534 ± 0.145
0.778GlyCys: 0.778 ± 0.075
2.86GlyAsp: 2.86 ± 0.141
2.808GlyGlu: 2.808 ± 0.15
2.762GlyPhe: 2.762 ± 0.136
3.002GlyGly: 3.002 ± 0.163
1.161GlyHis: 1.161 ± 0.087
4.936GlyIle: 4.936 ± 0.201
4.833GlyLys: 4.833 ± 0.171
4.787GlyLeu: 4.787 ± 0.201
1.704GlyMet: 1.704 ± 0.118
3.031GlyAsn: 3.031 ± 0.156
1.207GlyPro: 1.207 ± 0.084
1.447GlyGln: 1.447 ± 0.086
1.824GlyArg: 1.824 ± 0.11
4.215GlySer: 4.215 ± 0.157
2.288GlyThr: 2.288 ± 0.098
3.3GlyVal: 3.3 ± 0.146
0.463GlyTrp: 0.463 ± 0.051
2.093GlyTyr: 2.093 ± 0.122
0.0GlyXaa: 0.0 ± 0.0
His
1.27HisAla: 1.27 ± 0.076
0.229HisCys: 0.229 ± 0.037
1.378HisAsp: 1.378 ± 0.079
1.407HisGlu: 1.407 ± 0.086
0.921HisPhe: 0.921 ± 0.074
1.578HisGly: 1.578 ± 0.091
0.663HisHis: 0.663 ± 0.067
2.551HisIle: 2.551 ± 0.125
1.985HisLys: 1.985 ± 0.119
1.779HisLeu: 1.779 ± 0.103
0.652HisMet: 0.652 ± 0.058
1.944HisAsn: 1.944 ± 0.118
0.795HisPro: 0.795 ± 0.061
0.743HisGln: 0.743 ± 0.067
0.669HisArg: 0.669 ± 0.066
1.395HisSer: 1.395 ± 0.1
1.081HisThr: 1.081 ± 0.09
1.247HisVal: 1.247 ± 0.089
0.177HisTrp: 0.177 ± 0.03
0.938HisTyr: 0.938 ± 0.078
0.0HisXaa: 0.0 ± 0.0
Ile
5.971IleAla: 5.971 ± 0.184
1.521IleCys: 1.521 ± 0.106
5.908IleAsp: 5.908 ± 0.221
6.096IleGlu: 6.096 ± 0.221
4.083IlePhe: 4.083 ± 0.183
5.502IleGly: 5.502 ± 0.211
1.87IleHis: 1.87 ± 0.117
8.413IleIle: 8.413 ± 0.322
8.905IleLys: 8.905 ± 0.24
8.27IleLeu: 8.27 ± 0.267
2.677IleMet: 2.677 ± 0.119
6.834IleAsn: 6.834 ± 0.206
3.134IlePro: 3.134 ± 0.143
3.226IleGln: 3.226 ± 0.156
3.1IleArg: 3.1 ± 0.137
8.081IleSer: 8.081 ± 0.277
4.472IleThr: 4.472 ± 0.16
4.61IleVal: 4.61 ± 0.163
0.818IleTrp: 0.818 ± 0.062
3.197IleTyr: 3.197 ± 0.136
0.0IleXaa: 0.0 ± 0.0
Lys
4.587LysAla: 4.587 ± 0.244
1.075LysCys: 1.075 ± 0.082
4.867LysAsp: 4.867 ± 0.198
5.725LysGlu: 5.725 ± 0.215
3.729LysPhe: 3.729 ± 0.162
3.563LysGly: 3.563 ± 0.151
2.368LysHis: 2.368 ± 0.127
8.498LysIle: 8.498 ± 0.243
7.789LysLys: 7.789 ± 0.251
7.989LysLeu: 7.989 ± 0.35
2.322LysMet: 2.322 ± 0.111
7.109LysAsn: 7.109 ± 0.228
2.156LysPro: 2.156 ± 0.111
3.357LysGln: 3.357 ± 0.171
2.877LysArg: 2.877 ± 0.156
7.595LysSer: 7.595 ± 0.245
3.643LysThr: 3.643 ± 0.166
4.461LysVal: 4.461 ± 0.146
0.972LysTrp: 0.972 ± 0.077
4.095LysTyr: 4.095 ± 0.168
0.0LysXaa: 0.0 ± 0.0
Leu
4.478LeuAla: 4.478 ± 0.18
1.584LeuCys: 1.584 ± 0.102
5.021LeuAsp: 5.021 ± 0.249
5.65LeuGlu: 5.65 ± 0.222
4.392LeuPhe: 4.392 ± 0.187
4.747LeuGly: 4.747 ± 0.187
2.356LeuHis: 2.356 ± 0.119
7.44LeuIle: 7.44 ± 0.256
7.143LeuLys: 7.143 ± 0.214
7.521LeuLeu: 7.521 ± 0.272
2.013LeuMet: 2.013 ± 0.099
6.726LeuAsn: 6.726 ± 0.261
3.443LeuPro: 3.443 ± 0.277
3.58LeuGln: 3.58 ± 0.149
3.3LeuArg: 3.3 ± 0.163
8.081LeuSer: 8.081 ± 0.286
4.009LeuThr: 4.009 ± 0.3
4.02LeuVal: 4.02 ± 0.151
0.795LeuTrp: 0.795 ± 0.067
3.717LeuTyr: 3.717 ± 0.216
0.0LeuXaa: 0.0 ± 0.0
Met
1.092MetAla: 1.092 ± 0.089
0.343MetCys: 0.343 ± 0.044
1.167MetAsp: 1.167 ± 0.091
1.207MetGlu: 1.207 ± 0.095
1.161MetPhe: 1.161 ± 0.085
1.275MetGly: 1.275 ± 0.078
1.178MetHis: 1.178 ± 0.071
2.528MetIle: 2.528 ± 0.122
2.579MetLys: 2.579 ± 0.126
2.688MetLeu: 2.688 ± 0.122
0.778MetMet: 0.778 ± 0.069
2.505MetAsn: 2.505 ± 0.117
0.932MetPro: 0.932 ± 0.075
1.544MetGln: 1.544 ± 0.113
1.081MetArg: 1.081 ± 0.083
2.282MetSer: 2.282 ± 0.119
1.018MetThr: 1.018 ± 0.08
1.31MetVal: 1.31 ± 0.089
0.154MetTrp: 0.154 ± 0.031
0.932MetTyr: 0.932 ± 0.081
0.0MetXaa: 0.0 ± 0.0
Asn
4.306AsnAla: 4.306 ± 0.177
0.732AsnCys: 0.732 ± 0.066
3.706AsnAsp: 3.706 ± 0.164
4.038AsnGlu: 4.038 ± 0.18
2.396AsnPhe: 2.396 ± 0.121
3.369AsnGly: 3.369 ± 0.139
1.847AsnHis: 1.847 ± 0.118
8.247AsnIle: 8.247 ± 0.277
6.485AsnLys: 6.485 ± 0.233
6.857AsnLeu: 6.857 ± 0.333
2.145AsnMet: 2.145 ± 0.113
5.467AsnAsn: 5.467 ± 0.265
2.082AsnPro: 2.082 ± 0.112
3.231AsnGln: 3.231 ± 0.25
2.316AsnArg: 2.316 ± 0.122
5.119AsnSer: 5.119 ± 0.173
3.197AsnThr: 3.197 ± 0.158
3.763AsnVal: 3.763 ± 0.16
0.623AsnTrp: 0.623 ± 0.063
2.465AsnTyr: 2.465 ± 0.12
0.0AsnXaa: 0.0 ± 0.0
Pro
1.258ProAla: 1.258 ± 0.098
0.423ProCys: 0.423 ± 0.05
1.664ProAsp: 1.664 ± 0.121
2.025ProGlu: 2.025 ± 0.127
1.441ProPhe: 1.441 ± 0.097
1.727ProGly: 1.727 ± 0.142
0.658ProHis: 0.658 ± 0.055
2.682ProIle: 2.682 ± 0.128
2.276ProLys: 2.276 ± 0.119
2.196ProLeu: 2.196 ± 0.12
0.566ProMet: 0.566 ± 0.058
1.922ProAsn: 1.922 ± 0.111
0.635ProPro: 0.635 ± 0.059
0.932ProGln: 0.932 ± 0.079
0.778ProArg: 0.778 ± 0.066
2.23ProSer: 2.23 ± 0.12
1.212ProThr: 1.212 ± 0.075
1.618ProVal: 1.618 ± 0.109
0.252ProTrp: 0.252 ± 0.035
1.304ProTyr: 1.304 ± 0.101
0.0ProXaa: 0.0 ± 0.0
Gln
1.779GlnAla: 1.779 ± 0.108
0.395GlnCys: 0.395 ± 0.044
1.904GlnAsp: 1.904 ± 0.096
2.322GlnGlu: 2.322 ± 0.14
1.624GlnPhe: 1.624 ± 0.116
1.435GlnGly: 1.435 ± 0.08
0.858GlnHis: 0.858 ± 0.07
3.529GlnIle: 3.529 ± 0.136
3.42GlnLys: 3.42 ± 0.149
3.168GlnLeu: 3.168 ± 0.226
0.904GlnMet: 0.904 ± 0.067
3.374GlnAsn: 3.374 ± 0.147
0.726GlnPro: 0.726 ± 0.08
1.144GlnGln: 1.144 ± 0.107
1.064GlnArg: 1.064 ± 0.088
3.043GlnSer: 3.043 ± 0.137
1.527GlnThr: 1.527 ± 0.095
1.487GlnVal: 1.487 ± 0.106
0.309GlnTrp: 0.309 ± 0.038
1.996GlnTyr: 1.996 ± 0.221
0.0GlnXaa: 0.0 ± 0.0
Arg
1.578ArgAla: 1.578 ± 0.097
0.395ArgCys: 0.395 ± 0.043
1.653ArgAsp: 1.653 ± 0.097
2.002ArgGlu: 2.002 ± 0.112
1.733ArgPhe: 1.733 ± 0.108
1.624ArgGly: 1.624 ± 0.108
0.606ArgHis: 0.606 ± 0.056
3.037ArgIle: 3.037 ± 0.123
3.494ArgLys: 3.494 ± 0.13
2.9ArgLeu: 2.9 ± 0.15
1.035ArgMet: 1.035 ± 0.089
2.516ArgAsn: 2.516 ± 0.116
0.881ArgPro: 0.881 ± 0.117
0.898ArgGln: 0.898 ± 0.075
1.453ArgArg: 1.453 ± 0.1
2.608ArgSer: 2.608 ± 0.119
1.258ArgThr: 1.258 ± 0.089
1.996ArgVal: 1.996 ± 0.149
0.286ArgTrp: 0.286 ± 0.046
1.292ArgTyr: 1.292 ± 0.102
0.0ArgXaa: 0.0 ± 0.0
Ser
4.341SerAla: 4.341 ± 0.179
0.967SerCys: 0.967 ± 0.07
4.838SerAsp: 4.838 ± 0.169
4.753SerGlu: 4.753 ± 0.197
3.837SerPhe: 3.837 ± 0.171
4.306SerGly: 4.306 ± 0.176
1.641SerHis: 1.641 ± 0.102
8.556SerIle: 8.556 ± 0.278
6.68SerLys: 6.68 ± 0.199
6.565SerLeu: 6.565 ± 0.224
2.31SerMet: 2.31 ± 0.133
5.181SerAsn: 5.181 ± 0.204
1.927SerPro: 1.927 ± 0.12
2.659SerGln: 2.659 ± 0.123
2.288SerArg: 2.288 ± 0.126
5.988SerSer: 5.988 ± 0.187
3.3SerThr: 3.3 ± 0.136
4.661SerVal: 4.661 ± 0.201
0.715SerTrp: 0.715 ± 0.057
3.197SerTyr: 3.197 ± 0.126
0.0SerXaa: 0.0 ± 0.0
Thr
2.356ThrAla: 2.356 ± 0.126
0.595ThrCys: 0.595 ± 0.06
2.087ThrAsp: 2.087 ± 0.133
2.402ThrGlu: 2.402 ± 0.16
1.796ThrPhe: 1.796 ± 0.098
2.396ThrGly: 2.396 ± 0.125
0.949ThrHis: 0.949 ± 0.063
3.883ThrIle: 3.883 ± 0.142
3.803ThrLys: 3.803 ± 0.141
4.049ThrLeu: 4.049 ± 0.151
1.007ThrMet: 1.007 ± 0.079
3.226ThrAsn: 3.226 ± 0.161
1.464ThrPro: 1.464 ± 0.096
1.521ThrGln: 1.521 ± 0.089
1.155ThrArg: 1.155 ± 0.088
3.111ThrSer: 3.111 ± 0.156
1.91ThrThr: 1.91 ± 0.12
2.282ThrVal: 2.282 ± 0.098
0.366ThrTrp: 0.366 ± 0.047
1.819ThrTyr: 1.819 ± 0.101
0.0ThrXaa: 0.0 ± 0.0
Val
2.974ValAla: 2.974 ± 0.141
0.732ValCys: 0.732 ± 0.06
3.128ValAsp: 3.128 ± 0.172
3.254ValGlu: 3.254 ± 0.15
2.768ValPhe: 2.768 ± 0.15
2.894ValGly: 2.894 ± 0.144
1.235ValHis: 1.235 ± 0.081
4.804ValIle: 4.804 ± 0.194
4.547ValLys: 4.547 ± 0.197
4.867ValLeu: 4.867 ± 0.173
1.533ValMet: 1.533 ± 0.119
3.237ValAsn: 3.237 ± 0.136
1.67ValPro: 1.67 ± 0.108
2.059ValGln: 2.059 ± 0.112
2.19ValArg: 2.19 ± 0.121
4.106ValSer: 4.106 ± 0.174
1.859ValThr: 1.859 ± 0.109
3.105ValVal: 3.105 ± 0.154
0.486ValTrp: 0.486 ± 0.051
1.767ValTyr: 1.767 ± 0.096
0.0ValXaa: 0.0 ± 0.0
Trp
0.435TrpAla: 0.435 ± 0.05
0.109TrpCys: 0.109 ± 0.022
0.583TrpAsp: 0.583 ± 0.063
0.395TrpGlu: 0.395 ± 0.051
0.412TrpPhe: 0.412 ± 0.051
0.4TrpGly: 0.4 ± 0.05
0.297TrpHis: 0.297 ± 0.045
0.955TrpIle: 0.955 ± 0.075
0.795TrpLys: 0.795 ± 0.068
0.755TrpLeu: 0.755 ± 0.073
0.252TrpMet: 0.252 ± 0.039
0.738TrpAsn: 0.738 ± 0.075
0.189TrpPro: 0.189 ± 0.032
0.24TrpGln: 0.24 ± 0.033
0.332TrpArg: 0.332 ± 0.049
0.715TrpSer: 0.715 ± 0.072
0.372TrpThr: 0.372 ± 0.046
0.486TrpVal: 0.486 ± 0.055
0.092TrpTrp: 0.092 ± 0.024
0.212TrpTyr: 0.212 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.385TyrAla: 2.385 ± 0.116
0.526TyrCys: 0.526 ± 0.057
2.391TyrAsp: 2.391 ± 0.108
2.585TyrGlu: 2.585 ± 0.169
1.624TyrPhe: 1.624 ± 0.114
2.253TyrGly: 2.253 ± 0.137
0.669TyrHis: 0.669 ± 0.068
4.123TyrIle: 4.123 ± 0.187
3.786TyrLys: 3.786 ± 0.165
3.266TyrLeu: 3.266 ± 0.134
0.984TyrMet: 0.984 ± 0.074
2.945TyrAsn: 2.945 ± 0.139
1.15TyrPro: 1.15 ± 0.094
1.029TyrGln: 1.029 ± 0.083
1.287TyrArg: 1.287 ± 0.097
2.877TyrSer: 2.877 ± 0.13
1.676TyrThr: 1.676 ± 0.104
2.185TyrVal: 2.185 ± 0.13
0.349TyrTrp: 0.349 ± 0.045
1.516TyrTyr: 1.516 ± 0.107
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 519 proteins (174856 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski