Amino acid dipepetide frequency for Mycoplasma wenyonii (strain Massachusetts) (Eperythrozoon wenyonii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.397AlaAla: 1.397 ± 0.108
0.636AlaCys: 0.636 ± 0.053
1.548AlaAsp: 1.548 ± 0.087
3.246AlaGlu: 3.246 ± 0.129
2.265AlaPhe: 2.265 ± 0.117
3.468AlaGly: 3.468 ± 0.143
0.728AlaHis: 0.728 ± 0.066
3.78AlaIle: 3.78 ± 0.166
4.26AlaLys: 4.26 ± 0.16
5.182AlaLeu: 5.182 ± 0.158
0.593AlaMet: 0.593 ± 0.062
1.931AlaAsn: 1.931 ± 0.105
1.478AlaPro: 1.478 ± 0.099
1.807AlaGln: 1.807 ± 0.099
2.173AlaArg: 2.173 ± 0.108
3.441AlaSer: 3.441 ± 0.143
2.551AlaThr: 2.551 ± 0.12
2.783AlaVal: 2.783 ± 0.147
0.653AlaTrp: 0.653 ± 0.073
1.456AlaTyr: 1.456 ± 0.098
0.0AlaXaa: 0.0 ± 0.0
Cys
0.475CysAla: 0.475 ± 0.052
0.28CysCys: 0.28 ± 0.073
0.582CysAsp: 0.582 ± 0.056
0.938CysGlu: 0.938 ± 0.068
0.992CysPhe: 0.992 ± 0.075
0.739CysGly: 0.739 ± 0.058
0.162CysHis: 0.162 ± 0.031
0.485CysIle: 0.485 ± 0.05
1.262CysLys: 1.262 ± 0.081
1.041CysLeu: 1.041 ± 0.072
0.097CysMet: 0.097 ± 0.021
0.642CysAsn: 0.642 ± 0.056
0.307CysPro: 0.307 ± 0.05
0.523CysGln: 0.523 ± 0.056
0.421CysArg: 0.421 ± 0.048
1.424CysSer: 1.424 ± 0.089
0.609CysThr: 0.609 ± 0.056
0.555CysVal: 0.555 ± 0.057
0.264CysTrp: 0.264 ± 0.038
0.453CysTyr: 0.453 ± 0.048
0.0CysXaa: 0.0 ± 0.0
Asp
1.316AspAla: 1.316 ± 0.09
0.658AspCys: 0.658 ± 0.057
1.434AspAsp: 1.434 ± 0.081
2.756AspGlu: 2.756 ± 0.152
2.335AspPhe: 2.335 ± 0.135
2.788AspGly: 2.788 ± 0.145
0.615AspHis: 0.615 ± 0.06
2.826AspIle: 2.826 ± 0.133
4.713AspLys: 4.713 ± 0.165
4.411AspLeu: 4.411 ± 0.148
0.599AspMet: 0.599 ± 0.053
2.179AspAsn: 2.179 ± 0.127
1.537AspPro: 1.537 ± 0.086
1.634AspGln: 1.634 ± 0.087
1.731AspArg: 1.731 ± 0.092
4.449AspSer: 4.449 ± 0.14
1.936AspThr: 1.936 ± 0.115
1.823AspVal: 1.823 ± 0.103
1.008AspTrp: 1.008 ± 0.078
2.038AspTyr: 2.038 ± 0.095
0.0AspXaa: 0.0 ± 0.0
Glu
3.193GluAla: 3.193 ± 0.144
0.836GluCys: 0.836 ± 0.067
3.624GluAsp: 3.624 ± 0.131
8.122GluGlu: 8.122 ± 0.291
3.279GluPhe: 3.279 ± 0.143
5.188GluGly: 5.188 ± 0.185
1.181GluHis: 1.181 ± 0.075
6.169GluIle: 6.169 ± 0.201
8.887GluLys: 8.887 ± 0.236
9.286GluLeu: 9.286 ± 0.258
1.165GluMet: 1.165 ± 0.095
3.888GluAsn: 3.888 ± 0.142
1.494GluPro: 1.494 ± 0.109
2.858GluGln: 2.858 ± 0.137
3.775GluArg: 3.775 ± 0.154
5.269GluSer: 5.269 ± 0.16
3.716GluThr: 3.716 ± 0.152
4.417GluVal: 4.417 ± 0.185
1.208GluTrp: 1.208 ± 0.077
2.373GluTyr: 2.373 ± 0.108
0.0GluXaa: 0.0 ± 0.0
Phe
2.438PheAla: 2.438 ± 0.115
0.793PheCys: 0.793 ± 0.06
2.2PheAsp: 2.2 ± 0.108
3.36PheGlu: 3.36 ± 0.161
3.624PhePhe: 3.624 ± 0.185
3.031PheGly: 3.031 ± 0.136
0.825PheHis: 0.825 ± 0.072
3.025PheIle: 3.025 ± 0.124
4.708PheLys: 4.708 ± 0.156
5.857PheLeu: 5.857 ± 0.215
0.626PheMet: 0.626 ± 0.073
2.68PheAsn: 2.68 ± 0.114
1.731PhePro: 1.731 ± 0.104
1.855PheGln: 1.855 ± 0.108
1.661PheArg: 1.661 ± 0.083
5.226PheSer: 5.226 ± 0.166
2.491PheThr: 2.491 ± 0.125
2.583PheVal: 2.583 ± 0.125
1.132PheTrp: 1.132 ± 0.07
2.119PheTyr: 2.119 ± 0.107
0.0PheXaa: 0.0 ± 0.0
Gly
3.473GlyAla: 3.473 ± 0.142
0.857GlyCys: 0.857 ± 0.06
3.187GlyAsp: 3.187 ± 0.135
5.188GlyGlu: 5.188 ± 0.179
2.842GlyPhe: 2.842 ± 0.114
6.347GlyGly: 6.347 ± 0.299
0.917GlyHis: 0.917 ± 0.071
4.622GlyIle: 4.622 ± 0.176
5.738GlyLys: 5.738 ± 0.179
5.258GlyLeu: 5.258 ± 0.169
1.035GlyMet: 1.035 ± 0.073
3.176GlyAsn: 3.176 ± 0.153
1.257GlyPro: 1.257 ± 0.071
2.092GlyGln: 2.092 ± 0.126
2.626GlyArg: 2.626 ± 0.137
5.139GlySer: 5.139 ± 0.223
3.36GlyThr: 3.36 ± 0.149
3.748GlyVal: 3.748 ± 0.156
1.213GlyTrp: 1.213 ± 0.083
2.055GlyTyr: 2.055 ± 0.1
0.0GlyXaa: 0.0 ± 0.0
His
0.469HisAla: 0.469 ± 0.049
0.253HisCys: 0.253 ± 0.037
0.507HisAsp: 0.507 ± 0.044
0.577HisGlu: 0.577 ± 0.056
0.857HisPhe: 0.857 ± 0.075
0.626HisGly: 0.626 ± 0.067
0.28HisHis: 0.28 ± 0.04
1.165HisIle: 1.165 ± 0.094
1.424HisLys: 1.424 ± 0.085
1.887HisLeu: 1.887 ± 0.096
0.178HisMet: 0.178 ± 0.03
0.965HisAsn: 0.965 ± 0.07
0.426HisPro: 0.426 ± 0.051
0.502HisGln: 0.502 ± 0.054
0.534HisArg: 0.534 ± 0.054
1.316HisSer: 1.316 ± 0.088
0.766HisThr: 0.766 ± 0.066
0.523HisVal: 0.523 ± 0.061
0.318HisTrp: 0.318 ± 0.038
0.836HisTyr: 0.836 ± 0.066
0.0HisXaa: 0.0 ± 0.0
Ile
3.84IleAla: 3.84 ± 0.173
0.906IleCys: 0.906 ± 0.074
3.246IleAsp: 3.246 ± 0.142
5.333IleGlu: 5.333 ± 0.168
3.915IlePhe: 3.915 ± 0.139
3.845IleGly: 3.845 ± 0.174
0.944IleHis: 0.944 ± 0.078
4.293IleIle: 4.293 ± 0.173
6.574IleLys: 6.574 ± 0.2
5.91IleLeu: 5.91 ± 0.209
0.938IleMet: 0.938 ± 0.069
3.629IleAsn: 3.629 ± 0.164
2.998IlePro: 2.998 ± 0.124
2.637IleGln: 2.637 ± 0.115
2.378IleArg: 2.378 ± 0.103
6.315IleSer: 6.315 ± 0.167
3.699IleThr: 3.699 ± 0.156
4.336IleVal: 4.336 ± 0.186
0.868IleTrp: 0.868 ± 0.061
2.707IleTyr: 2.707 ± 0.125
0.0IleXaa: 0.0 ± 0.0
Lys
4.341LysAla: 4.341 ± 0.152
1.149LysCys: 1.149 ± 0.085
5.069LysAsp: 5.069 ± 0.171
9.729LysGlu: 9.729 ± 0.287
4.287LysPhe: 4.287 ± 0.151
5.722LysGly: 5.722 ± 0.22
1.359LysHis: 1.359 ± 0.089
6.552LysIle: 6.552 ± 0.187
9.987LysLys: 9.987 ± 0.244
9.971LysLeu: 9.971 ± 0.236
1.823LysMet: 1.823 ± 0.106
5.797LysAsn: 5.797 ± 0.199
2.394LysPro: 2.394 ± 0.122
3.397LysGln: 3.397 ± 0.147
3.915LysArg: 3.915 ± 0.164
6.288LysSer: 6.288 ± 0.175
4.929LysThr: 4.929 ± 0.182
5.355LysVal: 5.355 ± 0.159
2.017LysTrp: 2.017 ± 0.134
3.726LysTyr: 3.726 ± 0.155
0.0LysXaa: 0.0 ± 0.0
Leu
5.258LeuAla: 5.258 ± 0.171
0.879LeuCys: 0.879 ± 0.073
4.503LeuAsp: 4.503 ± 0.16
7.976LeuGlu: 7.976 ± 0.248
6.218LeuPhe: 6.218 ± 0.21
6.035LeuGly: 6.035 ± 0.207
1.321LeuHis: 1.321 ± 0.073
7.598LeuIle: 7.598 ± 0.182
10.807LeuLys: 10.807 ± 0.264
10.413LeuLeu: 10.413 ± 0.277
1.467LeuMet: 1.467 ± 0.081
5.457LeuAsn: 5.457 ± 0.161
3.5LeuPro: 3.5 ± 0.136
3.403LeuGln: 3.403 ± 0.137
3.672LeuArg: 3.672 ± 0.138
9.772LeuSer: 9.772 ± 0.28
5.824LeuThr: 5.824 ± 0.188
6.498LeuVal: 6.498 ± 0.195
1.305LeuTrp: 1.305 ± 0.092
2.917LeuTyr: 2.917 ± 0.121
0.0LeuXaa: 0.0 ± 0.0
Met
0.911MetAla: 0.911 ± 0.067
0.178MetCys: 0.178 ± 0.033
0.534MetAsp: 0.534 ± 0.055
1.062MetGlu: 1.062 ± 0.077
0.647MetPhe: 0.647 ± 0.052
0.965MetGly: 0.965 ± 0.071
0.232MetHis: 0.232 ± 0.034
0.906MetIle: 0.906 ± 0.067
1.257MetLys: 1.257 ± 0.088
1.3MetLeu: 1.3 ± 0.074
0.162MetMet: 0.162 ± 0.027
0.75MetAsn: 0.75 ± 0.067
0.631MetPro: 0.631 ± 0.071
0.415MetGln: 0.415 ± 0.05
0.701MetArg: 0.701 ± 0.058
1.596MetSer: 1.596 ± 0.109
0.744MetThr: 0.744 ± 0.062
0.836MetVal: 0.836 ± 0.07
0.178MetTrp: 0.178 ± 0.031
0.399MetTyr: 0.399 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
1.78AsnAla: 1.78 ± 0.087
0.857AsnCys: 0.857 ± 0.064
1.537AsnAsp: 1.537 ± 0.089
2.966AsnGlu: 2.966 ± 0.139
2.729AsnPhe: 2.729 ± 0.128
3.112AsnGly: 3.112 ± 0.18
0.782AsnHis: 0.782 ± 0.07
3.268AsnIle: 3.268 ± 0.148
5.371AsnLys: 5.371 ± 0.166
5.77AsnLeu: 5.77 ± 0.199
0.663AsnMet: 0.663 ± 0.059
3.284AsnAsn: 3.284 ± 0.155
2.055AsnPro: 2.055 ± 0.118
2.184AsnGln: 2.184 ± 0.122
2.06AsnArg: 2.06 ± 0.099
5.129AsnSer: 5.129 ± 0.17
2.578AsnThr: 2.578 ± 0.128
2.087AsnVal: 2.087 ± 0.124
1.138AsnTrp: 1.138 ± 0.092
2.917AsnTyr: 2.917 ± 0.133
0.0AsnXaa: 0.0 ± 0.0
Pro
1.736ProAla: 1.736 ± 0.097
0.28ProCys: 0.28 ± 0.036
1.154ProAsp: 1.154 ± 0.093
2.966ProGlu: 2.966 ± 0.134
1.585ProPhe: 1.585 ± 0.097
0.981ProGly: 0.981 ± 0.071
0.485ProHis: 0.485 ± 0.049
2.454ProIle: 2.454 ± 0.124
2.939ProLys: 2.939 ± 0.123
3.166ProLeu: 3.166 ± 0.13
0.377ProMet: 0.377 ± 0.045
1.478ProAsn: 1.478 ± 0.092
1.019ProPro: 1.019 ± 0.087
0.901ProGln: 0.901 ± 0.067
1.143ProArg: 1.143 ± 0.068
2.675ProSer: 2.675 ± 0.129
1.887ProThr: 1.887 ± 0.108
1.861ProVal: 1.861 ± 0.111
0.577ProTrp: 0.577 ± 0.06
1.008ProTyr: 1.008 ± 0.078
0.0ProXaa: 0.0 ± 0.0
Gln
1.666GlnAla: 1.666 ± 0.099
0.313GlnCys: 0.313 ± 0.04
1.564GlnAsp: 1.564 ± 0.086
3.775GlnGlu: 3.775 ± 0.138
1.278GlnPhe: 1.278 ± 0.093
1.941GlnGly: 1.941 ± 0.116
0.534GlnHis: 0.534 ± 0.064
2.642GlnIle: 2.642 ± 0.116
3.516GlnLys: 3.516 ± 0.14
4.907GlnLeu: 4.907 ± 0.177
0.545GlnMet: 0.545 ± 0.056
1.715GlnAsn: 1.715 ± 0.102
0.879GlnPro: 0.879 ± 0.077
1.494GlnGln: 1.494 ± 0.102
1.375GlnArg: 1.375 ± 0.085
2.109GlnSer: 2.109 ± 0.105
1.887GlnThr: 1.887 ± 0.115
1.952GlnVal: 1.952 ± 0.107
0.507GlnTrp: 0.507 ± 0.051
0.96GlnTyr: 0.96 ± 0.076
0.0GlnXaa: 0.0 ± 0.0
Arg
2.049ArgAla: 2.049 ± 0.108
0.399ArgCys: 0.399 ± 0.056
2.001ArgAsp: 2.001 ± 0.107
4.411ArgGlu: 4.411 ± 0.155
1.537ArgPhe: 1.537 ± 0.099
2.82ArgGly: 2.82 ± 0.132
0.561ArgHis: 0.561 ± 0.064
2.459ArgIle: 2.459 ± 0.133
3.608ArgLys: 3.608 ± 0.145
4.066ArgLeu: 4.066 ± 0.132
0.75ArgMet: 0.75 ± 0.062
2.243ArgAsn: 2.243 ± 0.116
0.847ArgPro: 0.847 ± 0.066
1.267ArgGln: 1.267 ± 0.106
1.65ArgArg: 1.65 ± 0.104
2.249ArgSer: 2.249 ± 0.116
1.909ArgThr: 1.909 ± 0.104
2.475ArgVal: 2.475 ± 0.114
0.685ArgTrp: 0.685 ± 0.061
1.461ArgTyr: 1.461 ± 0.097
0.0ArgXaa: 0.0 ± 0.0
Ser
3.516SerAla: 3.516 ± 0.145
1.095SerCys: 1.095 ± 0.077
3.5SerAsp: 3.5 ± 0.157
6.644SerGlu: 6.644 ± 0.187
4.821SerPhe: 4.821 ± 0.183
5.781SerGly: 5.781 ± 0.186
1.132SerHis: 1.132 ± 0.072
5.77SerIle: 5.77 ± 0.183
7.329SerLys: 7.329 ± 0.195
9.168SerLeu: 9.168 ± 0.277
1.224SerMet: 1.224 ± 0.09
4.535SerAsn: 4.535 ± 0.142
2.702SerPro: 2.702 ± 0.133
3.112SerGln: 3.112 ± 0.15
3.338SerArg: 3.338 ± 0.112
8.758SerSer: 8.758 ± 0.283
3.818SerThr: 3.818 ± 0.149
3.926SerVal: 3.926 ± 0.169
1.72SerTrp: 1.72 ± 0.088
3.133SerTyr: 3.133 ± 0.126
0.0SerXaa: 0.0 ± 0.0
Thr
2.287ThrAla: 2.287 ± 0.117
0.631ThrCys: 0.631 ± 0.058
2.033ThrAsp: 2.033 ± 0.106
3.397ThrGlu: 3.397 ± 0.124
2.303ThrPhe: 2.303 ± 0.111
3.527ThrGly: 3.527 ± 0.142
0.83ThrHis: 0.83 ± 0.084
3.807ThrIle: 3.807 ± 0.133
5.333ThrLys: 5.333 ± 0.209
5.587ThrLeu: 5.587 ± 0.149
0.663ThrMet: 0.663 ± 0.06
2.928ThrAsn: 2.928 ± 0.132
2.189ThrPro: 2.189 ± 0.124
2.028ThrGln: 2.028 ± 0.11
1.947ThrArg: 1.947 ± 0.108
4.206ThrSer: 4.206 ± 0.152
3.117ThrThr: 3.117 ± 0.163
2.615ThrVal: 2.615 ± 0.129
0.863ThrTrp: 0.863 ± 0.08
1.607ThrTyr: 1.607 ± 0.097
0.0ThrXaa: 0.0 ± 0.0
Val
3.117ValAla: 3.117 ± 0.14
0.696ValCys: 0.696 ± 0.066
2.168ValAsp: 2.168 ± 0.107
4.142ValGlu: 4.142 ± 0.164
2.944ValPhe: 2.944 ± 0.12
3.942ValGly: 3.942 ± 0.142
0.728ValHis: 0.728 ± 0.056
4.282ValIle: 4.282 ± 0.174
4.762ValLys: 4.762 ± 0.138
4.848ValLeu: 4.848 ± 0.173
0.733ValMet: 0.733 ± 0.06
2.648ValAsn: 2.648 ± 0.11
1.817ValPro: 1.817 ± 0.092
1.424ValGln: 1.424 ± 0.083
1.931ValArg: 1.931 ± 0.116
4.934ValSer: 4.934 ± 0.193
3.295ValThr: 3.295 ± 0.138
3.646ValVal: 3.646 ± 0.142
0.895ValTrp: 0.895 ± 0.069
1.569ValTyr: 1.569 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.949TrpAla: 0.949 ± 0.078
0.097TrpCys: 0.097 ± 0.023
1.025TrpAsp: 1.025 ± 0.072
1.348TrpGlu: 1.348 ± 0.091
0.944TrpPhe: 0.944 ± 0.075
1.348TrpGly: 1.348 ± 0.088
0.2TrpHis: 0.2 ± 0.036
1.24TrpIle: 1.24 ± 0.075
1.931TrpLys: 1.931 ± 0.102
1.467TrpLeu: 1.467 ± 0.089
0.351TrpMet: 0.351 ± 0.039
0.987TrpAsn: 0.987 ± 0.08
0.372TrpPro: 0.372 ± 0.047
0.518TrpGln: 0.518 ± 0.062
0.841TrpArg: 0.841 ± 0.063
1.025TrpSer: 1.025 ± 0.078
1.186TrpThr: 1.186 ± 0.088
0.938TrpVal: 0.938 ± 0.069
0.324TrpTrp: 0.324 ± 0.047
0.48TrpTyr: 0.48 ± 0.051
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.165TyrAla: 1.165 ± 0.08
0.458TyrCys: 0.458 ± 0.053
1.37TyrAsp: 1.37 ± 0.089
1.99TyrGlu: 1.99 ± 0.101
2.562TyrPhe: 2.562 ± 0.115
1.925TyrGly: 1.925 ± 0.094
0.593TyrHis: 0.593 ± 0.058
1.968TyrIle: 1.968 ± 0.092
3.403TyrLys: 3.403 ± 0.139
5.328TyrLeu: 5.328 ± 0.201
0.41TyrMet: 0.41 ± 0.048
1.354TyrAsn: 1.354 ± 0.087
1.041TyrPro: 1.041 ± 0.066
1.51TyrGln: 1.51 ± 0.089
1.58TyrArg: 1.58 ± 0.099
3.705TyrSer: 3.705 ± 0.131
1.596TyrThr: 1.596 ± 0.104
1.564TyrVal: 1.564 ± 0.104
0.696TyrTrp: 0.696 ± 0.058
1.623TyrTyr: 1.623 ± 0.1
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 651 proteins (185434 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski