Amino acid dipepetide frequency for Synechococcus phage ACG-2014e

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.872AlaAla: 5.872 ± 0.568
0.604AlaCys: 0.604 ± 0.12
4.144AlaAsp: 4.144 ± 0.263
3.523AlaGlu: 3.523 ± 0.263
2.684AlaPhe: 2.684 ± 0.219
6.694AlaGly: 6.694 ± 0.632
0.755AlaHis: 0.755 ± 0.132
4.06AlaIle: 4.06 ± 0.259
3.64AlaLys: 3.64 ± 0.36
4.664AlaLeu: 4.664 ± 0.368
1.325AlaMet: 1.325 ± 0.189
4.546AlaAsn: 4.546 ± 0.4
2.785AlaPro: 2.785 ± 0.262
2.198AlaGln: 2.198 ± 0.239
2.181AlaArg: 2.181 ± 0.165
4.966AlaSer: 4.966 ± 0.394
5.754AlaThr: 5.754 ± 0.437
4.228AlaVal: 4.228 ± 0.277
0.587AlaTrp: 0.587 ± 0.102
2.298AlaTyr: 2.298 ± 0.198
0.0AlaXaa: 0.0 ± 0.0
Cys
0.453CysAla: 0.453 ± 0.09
0.084CysCys: 0.084 ± 0.036
0.621CysAsp: 0.621 ± 0.116
0.52CysGlu: 0.52 ± 0.109
0.403CysPhe: 0.403 ± 0.088
0.537CysGly: 0.537 ± 0.108
0.201CysHis: 0.201 ± 0.065
0.487CysIle: 0.487 ± 0.09
0.621CysLys: 0.621 ± 0.104
0.52CysLeu: 0.52 ± 0.098
0.168CysMet: 0.168 ± 0.061
0.403CysAsn: 0.403 ± 0.078
0.369CysPro: 0.369 ± 0.091
0.369CysGln: 0.369 ± 0.083
0.369CysArg: 0.369 ± 0.081
0.587CysSer: 0.587 ± 0.1
0.52CysThr: 0.52 ± 0.086
0.721CysVal: 0.721 ± 0.12
0.151CysTrp: 0.151 ± 0.06
0.369CysTyr: 0.369 ± 0.081
0.0CysXaa: 0.0 ± 0.0
Asp
4.613AspAla: 4.613 ± 0.386
0.57AspCys: 0.57 ± 0.094
4.345AspAsp: 4.345 ± 0.308
3.858AspGlu: 3.858 ± 0.345
3.238AspPhe: 3.238 ± 0.231
5.419AspGly: 5.419 ± 0.42
0.939AspHis: 0.939 ± 0.13
4.211AspIle: 4.211 ± 0.345
3.523AspLys: 3.523 ± 0.387
5.083AspLeu: 5.083 ± 0.37
1.342AspMet: 1.342 ± 0.176
3.942AspAsn: 3.942 ± 0.289
2.818AspPro: 2.818 ± 0.262
2.198AspGln: 2.198 ± 0.191
2.382AspArg: 2.382 ± 0.204
4.462AspSer: 4.462 ± 0.335
4.915AspThr: 4.915 ± 0.338
4.546AspVal: 4.546 ± 0.267
1.074AspTrp: 1.074 ± 0.163
3.187AspTyr: 3.187 ± 0.231
0.0AspXaa: 0.0 ± 0.0
Glu
3.104GluAla: 3.104 ± 0.276
0.52GluCys: 0.52 ± 0.088
3.758GluAsp: 3.758 ± 0.253
4.496GluGlu: 4.496 ± 0.491
3.087GluPhe: 3.087 ± 0.286
4.06GluGly: 4.06 ± 0.241
0.872GluHis: 0.872 ± 0.145
4.194GluIle: 4.194 ± 0.298
3.406GluLys: 3.406 ± 0.386
4.831GluLeu: 4.831 ± 0.372
1.661GluMet: 1.661 ± 0.245
2.902GluAsn: 2.902 ± 0.257
1.745GluPro: 1.745 ± 0.208
2.131GluGln: 2.131 ± 0.219
2.147GluArg: 2.147 ± 0.203
3.322GluSer: 3.322 ± 0.234
4.177GluThr: 4.177 ± 0.248
4.026GluVal: 4.026 ± 0.249
1.057GluTrp: 1.057 ± 0.16
2.785GluTyr: 2.785 ± 0.247
0.0GluXaa: 0.0 ± 0.0
Phe
3.137PheAla: 3.137 ± 0.217
0.554PheCys: 0.554 ± 0.111
3.422PheAsp: 3.422 ± 0.243
2.584PheGlu: 2.584 ± 0.218
1.644PhePhe: 1.644 ± 0.159
3.02PheGly: 3.02 ± 0.253
0.621PheHis: 0.621 ± 0.126
2.416PheIle: 2.416 ± 0.22
2.282PheLys: 2.282 ± 0.216
3.137PheLeu: 3.137 ± 0.266
0.755PheMet: 0.755 ± 0.135
2.902PheAsn: 2.902 ± 0.201
1.443PhePro: 1.443 ± 0.199
1.694PheGln: 1.694 ± 0.177
1.694PheArg: 1.694 ± 0.196
3.171PheSer: 3.171 ± 0.234
3.557PheThr: 3.557 ± 0.277
3.036PheVal: 3.036 ± 0.28
0.503PheTrp: 0.503 ± 0.118
1.829PheTyr: 1.829 ± 0.199
0.0PheXaa: 0.0 ± 0.0
Gly
5.821GlyAla: 5.821 ± 0.502
0.52GlyCys: 0.52 ± 0.086
5.721GlyAsp: 5.721 ± 0.465
4.261GlyGlu: 4.261 ± 0.261
2.953GlyPhe: 2.953 ± 0.266
9.663GlyGly: 9.663 ± 1.395
1.107GlyHis: 1.107 ± 0.154
4.194GlyIle: 4.194 ± 0.319
3.557GlyLys: 3.557 ± 0.33
4.345GlyLeu: 4.345 ± 0.315
1.443GlyMet: 1.443 ± 0.201
5.603GlyAsn: 5.603 ± 0.501
2.147GlyPro: 2.147 ± 0.196
2.852GlyGln: 2.852 ± 0.279
2.869GlyArg: 2.869 ± 0.199
7.784GlySer: 7.784 ± 0.627
7.281GlyThr: 7.281 ± 0.652
5.62GlyVal: 5.62 ± 0.326
0.822GlyTrp: 0.822 ± 0.12
3.137GlyTyr: 3.137 ± 0.226
0.0GlyXaa: 0.0 ± 0.0
His
0.705HisAla: 0.705 ± 0.14
0.185HisCys: 0.185 ± 0.056
0.872HisAsp: 0.872 ± 0.149
0.939HisGlu: 0.939 ± 0.154
0.671HisPhe: 0.671 ± 0.1
0.973HisGly: 0.973 ± 0.133
0.268HisHis: 0.268 ± 0.085
0.738HisIle: 0.738 ± 0.118
0.939HisLys: 0.939 ± 0.151
1.023HisLeu: 1.023 ± 0.167
0.235HisMet: 0.235 ± 0.065
0.805HisAsn: 0.805 ± 0.12
0.772HisPro: 0.772 ± 0.134
0.453HisGln: 0.453 ± 0.083
0.654HisArg: 0.654 ± 0.112
0.822HisSer: 0.822 ± 0.143
0.889HisThr: 0.889 ± 0.132
0.738HisVal: 0.738 ± 0.151
0.134HisTrp: 0.134 ± 0.054
0.721HisTyr: 0.721 ± 0.116
0.0HisXaa: 0.0 ± 0.0
Ile
4.026IleAla: 4.026 ± 0.328
0.554IleCys: 0.554 ± 0.106
4.949IleAsp: 4.949 ± 0.307
4.597IleGlu: 4.597 ± 0.306
2.282IlePhe: 2.282 ± 0.185
4.53IleGly: 4.53 ± 0.36
0.772IleHis: 0.772 ± 0.131
4.228IleIle: 4.228 ± 0.313
3.758IleLys: 3.758 ± 0.313
4.261IleLeu: 4.261 ± 0.243
0.856IleMet: 0.856 ± 0.139
4.06IleAsn: 4.06 ± 0.292
2.416IlePro: 2.416 ± 0.194
2.6IleGln: 2.6 ± 0.254
2.466IleArg: 2.466 ± 0.183
5.1IleSer: 5.1 ± 0.391
6.123IleThr: 6.123 ± 0.443
4.295IleVal: 4.295 ± 0.328
0.52IleTrp: 0.52 ± 0.089
1.879IleTyr: 1.879 ± 0.213
0.0IleXaa: 0.0 ± 0.0
Lys
2.852LysAla: 2.852 ± 0.363
0.487LysCys: 0.487 ± 0.089
3.104LysAsp: 3.104 ± 0.289
3.59LysGlu: 3.59 ± 0.395
2.567LysPhe: 2.567 ± 0.26
2.986LysGly: 2.986 ± 0.28
0.956LysHis: 0.956 ± 0.173
4.328LysIle: 4.328 ± 0.332
4.093LysLys: 4.093 ± 0.571
4.462LysLeu: 4.462 ± 0.355
1.426LysMet: 1.426 ± 0.245
2.802LysAsn: 2.802 ± 0.279
1.778LysPro: 1.778 ± 0.234
2.198LysGln: 2.198 ± 0.229
2.382LysArg: 2.382 ± 0.253
3.54LysSer: 3.54 ± 0.315
3.959LysThr: 3.959 ± 0.342
3.322LysVal: 3.322 ± 0.281
0.621LysTrp: 0.621 ± 0.131
2.734LysTyr: 2.734 ± 0.254
0.0LysXaa: 0.0 ± 0.0
Leu
4.328LeuAla: 4.328 ± 0.335
0.637LeuCys: 0.637 ± 0.103
5.234LeuAsp: 5.234 ± 0.348
4.563LeuGlu: 4.563 ± 0.333
2.55LeuPhe: 2.55 ± 0.238
4.697LeuGly: 4.697 ± 0.312
0.99LeuHis: 0.99 ± 0.147
3.959LeuIle: 3.959 ± 0.286
4.261LeuLys: 4.261 ± 0.392
4.697LeuLeu: 4.697 ± 0.451
1.426LeuMet: 1.426 ± 0.181
4.815LeuAsn: 4.815 ± 0.297
3.238LeuPro: 3.238 ± 0.228
2.617LeuGln: 2.617 ± 0.248
3.221LeuArg: 3.221 ± 0.228
5.637LeuSer: 5.637 ± 0.3
6.492LeuThr: 6.492 ± 0.434
4.043LeuVal: 4.043 ± 0.249
0.621LeuTrp: 0.621 ± 0.096
3.036LeuTyr: 3.036 ± 0.209
0.0LeuXaa: 0.0 ± 0.0
Met
1.409MetAla: 1.409 ± 0.196
0.201MetCys: 0.201 ± 0.065
1.057MetAsp: 1.057 ± 0.164
0.738MetGlu: 0.738 ± 0.137
0.671MetPhe: 0.671 ± 0.125
0.939MetGly: 0.939 ± 0.15
0.302MetHis: 0.302 ± 0.082
0.872MetIle: 0.872 ± 0.156
1.527MetLys: 1.527 ± 0.228
1.795MetLeu: 1.795 ± 0.22
0.671MetMet: 0.671 ± 0.132
1.292MetAsn: 1.292 ± 0.185
1.074MetPro: 1.074 ± 0.137
0.788MetGln: 0.788 ± 0.124
0.956MetArg: 0.956 ± 0.168
1.342MetSer: 1.342 ± 0.234
1.476MetThr: 1.476 ± 0.158
1.124MetVal: 1.124 ± 0.133
0.268MetTrp: 0.268 ± 0.071
0.755MetTyr: 0.755 ± 0.128
0.0MetXaa: 0.0 ± 0.0
Asn
3.741AsnAla: 3.741 ± 0.354
0.503AsnCys: 0.503 ± 0.089
3.775AsnAsp: 3.775 ± 0.256
3.305AsnGlu: 3.305 ± 0.282
3.02AsnPhe: 3.02 ± 0.265
5.402AsnGly: 5.402 ± 0.483
0.872AsnHis: 0.872 ± 0.123
4.379AsnIle: 4.379 ± 0.41
2.969AsnLys: 2.969 ± 0.251
4.194AsnLeu: 4.194 ± 0.25
0.856AsnMet: 0.856 ± 0.156
3.741AsnAsn: 3.741 ± 0.265
3.305AsnPro: 3.305 ± 0.254
2.164AsnGln: 2.164 ± 0.172
2.382AsnArg: 2.382 ± 0.227
4.831AsnSer: 4.831 ± 0.445
5.15AsnThr: 5.15 ± 0.416
4.261AsnVal: 4.261 ± 0.31
0.788AsnTrp: 0.788 ± 0.144
2.533AsnTyr: 2.533 ± 0.274
0.0AsnXaa: 0.0 ± 0.0
Pro
2.701ProAla: 2.701 ± 0.205
0.201ProCys: 0.201 ± 0.075
2.852ProAsp: 2.852 ± 0.233
2.5ProGlu: 2.5 ± 0.289
1.795ProPhe: 1.795 ± 0.177
3.406ProGly: 3.406 ± 0.259
0.47ProHis: 0.47 ± 0.106
1.946ProIle: 1.946 ± 0.234
1.661ProLys: 1.661 ± 0.206
2.416ProLeu: 2.416 ± 0.242
0.637ProMet: 0.637 ± 0.124
2.332ProAsn: 2.332 ± 0.195
2.097ProPro: 2.097 ± 0.251
1.359ProGln: 1.359 ± 0.134
1.443ProArg: 1.443 ± 0.165
3.322ProSer: 3.322 ± 0.221
3.842ProThr: 3.842 ± 0.267
2.701ProVal: 2.701 ± 0.189
0.419ProTrp: 0.419 ± 0.08
1.761ProTyr: 1.761 ± 0.173
0.0ProXaa: 0.0 ± 0.0
Gln
2.298GlnAla: 2.298 ± 0.228
0.201GlnCys: 0.201 ± 0.057
1.963GlnAsp: 1.963 ± 0.19
2.516GlnGlu: 2.516 ± 0.274
1.661GlnPhe: 1.661 ± 0.177
2.332GlnGly: 2.332 ± 0.185
0.705GlnHis: 0.705 ± 0.121
2.651GlnIle: 2.651 ± 0.247
1.98GlnLys: 1.98 ± 0.227
2.6GlnLeu: 2.6 ± 0.216
0.889GlnMet: 0.889 ± 0.165
2.063GlnAsn: 2.063 ± 0.213
1.241GlnPro: 1.241 ± 0.182
1.342GlnGln: 1.342 ± 0.177
1.443GlnArg: 1.443 ± 0.141
2.399GlnSer: 2.399 ± 0.253
2.198GlnThr: 2.198 ± 0.26
2.634GlnVal: 2.634 ± 0.263
0.738GlnTrp: 0.738 ± 0.112
1.745GlnTyr: 1.745 ± 0.173
0.0GlnXaa: 0.0 ± 0.0
Arg
2.298ArgAla: 2.298 ± 0.183
0.419ArgCys: 0.419 ± 0.077
2.349ArgAsp: 2.349 ± 0.197
1.912ArgGlu: 1.912 ± 0.211
1.627ArgPhe: 1.627 ± 0.198
2.718ArgGly: 2.718 ± 0.201
0.537ArgHis: 0.537 ± 0.115
2.818ArgIle: 2.818 ± 0.18
2.55ArgLys: 2.55 ± 0.266
3.54ArgLeu: 3.54 ± 0.248
0.906ArgMet: 0.906 ± 0.129
1.896ArgAsn: 1.896 ± 0.19
1.342ArgPro: 1.342 ± 0.148
1.426ArgGln: 1.426 ± 0.157
1.795ArgArg: 1.795 ± 0.209
2.147ArgSer: 2.147 ± 0.156
2.349ArgThr: 2.349 ± 0.225
2.231ArgVal: 2.231 ± 0.237
0.487ArgTrp: 0.487 ± 0.1
2.131ArgTyr: 2.131 ± 0.17
0.0ArgXaa: 0.0 ± 0.0
Ser
5.855SerAla: 5.855 ± 0.37
0.487SerCys: 0.487 ± 0.1
4.395SerAsp: 4.395 ± 0.277
3.305SerGlu: 3.305 ± 0.246
3.406SerPhe: 3.406 ± 0.277
8.791SerGly: 8.791 ± 0.701
0.755SerHis: 0.755 ± 0.116
5.251SerIle: 5.251 ± 0.459
3.523SerLys: 3.523 ± 0.344
5.419SerLeu: 5.419 ± 0.352
1.225SerMet: 1.225 ± 0.185
5.083SerAsn: 5.083 ± 0.428
2.919SerPro: 2.919 ± 0.26
2.785SerGln: 2.785 ± 0.175
1.879SerArg: 1.879 ± 0.164
6.492SerSer: 6.492 ± 0.52
5.754SerThr: 5.754 ± 0.392
5.016SerVal: 5.016 ± 0.38
0.721SerTrp: 0.721 ± 0.129
3.053SerTyr: 3.053 ± 0.214
0.0SerXaa: 0.0 ± 0.0
Thr
6.09ThrAla: 6.09 ± 0.475
0.621ThrCys: 0.621 ± 0.117
4.915ThrAsp: 4.915 ± 0.287
4.06ThrGlu: 4.06 ± 0.253
3.808ThrPhe: 3.808 ± 0.339
7.381ThrGly: 7.381 ± 0.71
0.822ThrHis: 0.822 ± 0.129
5.469ThrIle: 5.469 ± 0.487
3.238ThrLys: 3.238 ± 0.267
5.888ThrLeu: 5.888 ± 0.414
1.04ThrMet: 1.04 ± 0.164
4.982ThrAsn: 4.982 ± 0.442
3.741ThrPro: 3.741 ± 0.283
2.382ThrGln: 2.382 ± 0.244
2.265ThrArg: 2.265 ± 0.203
6.392ThrSer: 6.392 ± 0.513
6.677ThrThr: 6.677 ± 0.669
5.637ThrVal: 5.637 ± 0.426
0.721ThrTrp: 0.721 ± 0.097
3.372ThrTyr: 3.372 ± 0.267
0.0ThrXaa: 0.0 ± 0.0
Val
4.58ValAla: 4.58 ± 0.27
0.503ValCys: 0.503 ± 0.094
5.15ValAsp: 5.15 ± 0.302
4.16ValGlu: 4.16 ± 0.303
2.936ValPhe: 2.936 ± 0.209
4.899ValGly: 4.899 ± 0.304
0.688ValHis: 0.688 ± 0.111
4.546ValIle: 4.546 ± 0.249
3.54ValLys: 3.54 ± 0.316
4.496ValLeu: 4.496 ± 0.322
1.292ValMet: 1.292 ± 0.17
4.177ValAsn: 4.177 ± 0.317
2.818ValPro: 2.818 ± 0.214
2.013ValGln: 2.013 ± 0.161
2.718ValArg: 2.718 ± 0.218
6.224ValSer: 6.224 ± 0.489
4.261ValThr: 4.261 ± 0.354
4.999ValVal: 4.999 ± 0.408
0.637ValTrp: 0.637 ± 0.098
2.55ValTyr: 2.55 ± 0.308
0.0ValXaa: 0.0 ± 0.0
Trp
0.805TrpAla: 0.805 ± 0.103
0.134TrpCys: 0.134 ± 0.046
1.057TrpAsp: 1.057 ± 0.14
0.654TrpGlu: 0.654 ± 0.147
0.386TrpPhe: 0.386 ± 0.087
0.621TrpGly: 0.621 ± 0.137
0.218TrpHis: 0.218 ± 0.061
0.654TrpIle: 0.654 ± 0.129
0.671TrpLys: 0.671 ± 0.128
0.47TrpLeu: 0.47 ± 0.126
0.319TrpMet: 0.319 ± 0.074
0.956TrpAsn: 0.956 ± 0.146
0.201TrpPro: 0.201 ± 0.073
0.453TrpGln: 0.453 ± 0.091
0.503TrpArg: 0.503 ± 0.106
0.872TrpSer: 0.872 ± 0.127
0.973TrpThr: 0.973 ± 0.189
0.889TrpVal: 0.889 ± 0.127
0.067TrpTrp: 0.067 ± 0.035
0.554TrpTyr: 0.554 ± 0.106
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.818TyrAla: 2.818 ± 0.196
0.487TyrCys: 0.487 ± 0.094
2.986TyrAsp: 2.986 ± 0.168
2.198TyrGlu: 2.198 ± 0.229
2.013TyrPhe: 2.013 ± 0.184
2.634TyrGly: 2.634 ± 0.215
0.688TyrHis: 0.688 ± 0.122
2.869TyrIle: 2.869 ± 0.197
2.449TyrLys: 2.449 ± 0.217
3.221TyrLeu: 3.221 ± 0.222
0.772TyrMet: 0.772 ± 0.161
2.869TyrAsn: 2.869 ± 0.22
1.61TyrPro: 1.61 ± 0.163
1.577TyrGln: 1.577 ± 0.169
1.728TyrArg: 1.728 ± 0.17
2.701TyrSer: 2.701 ± 0.193
3.154TyrThr: 3.154 ± 0.273
3.137TyrVal: 3.137 ± 0.259
0.52TyrTrp: 0.52 ± 0.093
1.862TyrTyr: 1.862 ± 0.164
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 213 proteins (59610 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski