Amino acid dipepetide frequency for Largemouth bass reovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.598AlaAla: 6.598 ± 1.155
0.66AlaCys: 0.66 ± 0.415
5.674AlaAsp: 5.674 ± 1.046
3.563AlaGlu: 3.563 ± 0.935
3.035AlaPhe: 3.035 ± 0.782
4.487AlaGly: 4.487 ± 0.683
1.32AlaHis: 1.32 ± 0.386
4.883AlaIle: 4.883 ± 0.842
4.355AlaLys: 4.355 ± 0.672
7.654AlaLeu: 7.654 ± 1.28
2.243AlaMet: 2.243 ± 0.75
4.091AlaAsn: 4.091 ± 0.851
3.431AlaPro: 3.431 ± 0.769
3.431AlaGln: 3.431 ± 0.872
5.015AlaArg: 5.015 ± 0.524
5.806AlaSer: 5.806 ± 0.765
6.07AlaThr: 6.07 ± 0.746
6.202AlaVal: 6.202 ± 0.889
1.188AlaTrp: 1.188 ± 0.687
1.452AlaTyr: 1.452 ± 0.476
0.0AlaXaa: 0.0 ± 0.0
Cys
0.924CysAla: 0.924 ± 0.23
0.132CysCys: 0.132 ± 0.154
1.584CysAsp: 1.584 ± 0.446
0.528CysGlu: 0.528 ± 0.253
1.056CysPhe: 1.056 ± 0.53
1.056CysGly: 1.056 ± 0.291
0.264CysHis: 0.264 ± 0.183
0.66CysIle: 0.66 ± 0.376
0.132CysLys: 0.132 ± 0.154
0.66CysLeu: 0.66 ± 0.273
0.264CysMet: 0.264 ± 0.181
0.0CysAsn: 0.0 ± 0.0
0.528CysPro: 0.528 ± 0.29
0.396CysGln: 0.396 ± 0.261
0.396CysArg: 0.396 ± 0.233
1.056CysSer: 1.056 ± 0.268
0.528CysThr: 0.528 ± 0.219
0.528CysVal: 0.528 ± 0.182
0.264CysTrp: 0.264 ± 0.17
0.792CysTyr: 0.792 ± 0.353
0.0CysXaa: 0.0 ± 0.0
Asp
5.41AspAla: 5.41 ± 0.982
0.924AspCys: 0.924 ± 0.391
4.883AspAsp: 4.883 ± 0.704
3.563AspGlu: 3.563 ± 0.664
1.979AspPhe: 1.979 ± 0.568
3.827AspGly: 3.827 ± 0.653
0.924AspHis: 0.924 ± 0.372
3.563AspIle: 3.563 ± 0.728
3.563AspLys: 3.563 ± 0.58
5.015AspLeu: 5.015 ± 0.821
1.452AspMet: 1.452 ± 0.547
2.771AspAsn: 2.771 ± 0.724
3.695AspPro: 3.695 ± 0.515
1.847AspGln: 1.847 ± 0.317
4.883AspArg: 4.883 ± 0.54
4.223AspSer: 4.223 ± 0.772
4.883AspThr: 4.883 ± 0.873
5.41AspVal: 5.41 ± 0.852
1.32AspTrp: 1.32 ± 0.367
1.715AspTyr: 1.715 ± 0.463
0.0AspXaa: 0.0 ± 0.0
Glu
4.619GluAla: 4.619 ± 0.523
0.264GluCys: 0.264 ± 0.155
2.771GluAsp: 2.771 ± 0.414
1.979GluGlu: 1.979 ± 0.468
2.111GluPhe: 2.111 ± 0.487
2.771GluGly: 2.771 ± 0.376
1.056GluHis: 1.056 ± 0.412
2.507GluIle: 2.507 ± 0.531
1.979GluLys: 1.979 ± 0.519
4.091GluLeu: 4.091 ± 0.645
1.452GluMet: 1.452 ± 0.431
1.584GluAsn: 1.584 ± 0.559
2.903GluPro: 2.903 ± 0.814
2.375GluGln: 2.375 ± 0.412
3.299GluArg: 3.299 ± 0.878
2.903GluSer: 2.903 ± 0.639
3.563GluThr: 3.563 ± 0.696
4.091GluVal: 4.091 ± 0.73
0.66GluTrp: 0.66 ± 0.302
1.056GluTyr: 1.056 ± 0.43
0.0GluXaa: 0.0 ± 0.0
Phe
1.979PheAla: 1.979 ± 0.485
0.528PheCys: 0.528 ± 0.254
3.167PheAsp: 3.167 ± 0.624
2.375PheGlu: 2.375 ± 0.629
1.32PhePhe: 1.32 ± 0.497
2.375PheGly: 2.375 ± 0.492
0.792PheHis: 0.792 ± 0.3
2.507PheIle: 2.507 ± 0.494
0.792PheLys: 0.792 ± 0.321
2.771PheLeu: 2.771 ± 1.112
1.188PheMet: 1.188 ± 0.362
2.111PheAsn: 2.111 ± 0.692
1.979PhePro: 1.979 ± 0.471
1.32PheGln: 1.32 ± 0.3
1.979PheArg: 1.979 ± 0.485
2.903PheSer: 2.903 ± 0.877
2.111PheThr: 2.111 ± 0.547
2.507PheVal: 2.507 ± 0.508
0.792PheTrp: 0.792 ± 0.209
1.056PheTyr: 1.056 ± 0.314
0.0PheXaa: 0.0 ± 0.0
Gly
5.015GlyAla: 5.015 ± 0.67
0.528GlyCys: 0.528 ± 0.227
4.223GlyAsp: 4.223 ± 0.953
2.243GlyGlu: 2.243 ± 0.519
2.243GlyPhe: 2.243 ± 0.656
2.771GlyGly: 2.771 ± 0.66
0.924GlyHis: 0.924 ± 0.466
2.639GlyIle: 2.639 ± 0.576
2.903GlyLys: 2.903 ± 0.404
4.751GlyLeu: 4.751 ± 0.681
1.979GlyMet: 1.979 ± 0.413
2.507GlyAsn: 2.507 ± 0.602
2.243GlyPro: 2.243 ± 0.393
1.847GlyGln: 1.847 ± 0.558
3.563GlyArg: 3.563 ± 0.903
3.827GlySer: 3.827 ± 0.862
3.563GlyThr: 3.563 ± 0.664
5.41GlyVal: 5.41 ± 0.554
1.188GlyTrp: 1.188 ± 0.39
2.507GlyTyr: 2.507 ± 0.489
0.0GlyXaa: 0.0 ± 0.0
His
1.188HisAla: 1.188 ± 0.417
0.264HisCys: 0.264 ± 0.155
1.452HisAsp: 1.452 ± 0.488
0.528HisGlu: 0.528 ± 0.34
0.924HisPhe: 0.924 ± 0.241
1.584HisGly: 1.584 ± 0.694
0.396HisHis: 0.396 ± 0.34
0.528HisIle: 0.528 ± 0.26
0.924HisLys: 0.924 ± 0.355
1.847HisLeu: 1.847 ± 0.417
0.396HisMet: 0.396 ± 0.214
0.66HisAsn: 0.66 ± 0.326
1.188HisPro: 1.188 ± 0.263
1.056HisGln: 1.056 ± 0.531
0.792HisArg: 0.792 ± 0.351
1.32HisSer: 1.32 ± 0.301
1.188HisThr: 1.188 ± 0.53
1.188HisVal: 1.188 ± 0.343
0.264HisTrp: 0.264 ± 0.158
0.528HisTyr: 0.528 ± 0.321
0.0HisXaa: 0.0 ± 0.0
Ile
5.015IleAla: 5.015 ± 0.707
0.792IleCys: 0.792 ± 0.19
3.035IleAsp: 3.035 ± 1.003
3.167IleGlu: 3.167 ± 0.59
1.452IlePhe: 1.452 ± 0.305
1.584IleGly: 1.584 ± 0.532
0.924IleHis: 0.924 ± 0.37
1.979IleIle: 1.979 ± 0.565
2.507IleLys: 2.507 ± 0.523
2.903IleLeu: 2.903 ± 0.75
1.979IleMet: 1.979 ± 0.329
2.771IleAsn: 2.771 ± 0.657
4.091IlePro: 4.091 ± 0.48
2.507IleGln: 2.507 ± 0.51
3.035IleArg: 3.035 ± 1.052
4.355IleSer: 4.355 ± 0.844
3.167IleThr: 3.167 ± 0.624
3.563IleVal: 3.563 ± 0.572
0.528IleTrp: 0.528 ± 0.35
1.584IleTyr: 1.584 ± 0.397
0.0IleXaa: 0.0 ± 0.0
Lys
4.619LysAla: 4.619 ± 1.034
0.924LysCys: 0.924 ± 0.501
2.639LysAsp: 2.639 ± 0.743
1.715LysGlu: 1.715 ± 0.404
1.715LysPhe: 1.715 ± 0.716
2.375LysGly: 2.375 ± 0.543
0.792LysHis: 0.792 ± 0.566
1.979LysIle: 1.979 ± 0.516
3.167LysLys: 3.167 ± 0.626
5.015LysLeu: 5.015 ± 0.865
1.584LysMet: 1.584 ± 0.582
1.979LysAsn: 1.979 ± 0.57
1.847LysPro: 1.847 ± 0.292
2.375LysGln: 2.375 ± 0.509
1.452LysArg: 1.452 ± 0.58
3.035LysSer: 3.035 ± 0.526
2.111LysThr: 2.111 ± 0.671
3.563LysVal: 3.563 ± 0.872
1.188LysTrp: 1.188 ± 0.37
1.452LysTyr: 1.452 ± 0.388
0.0LysXaa: 0.0 ± 0.0
Leu
6.598LeuAla: 6.598 ± 1.099
1.056LeuCys: 1.056 ± 0.317
5.674LeuAsp: 5.674 ± 1.357
4.883LeuGlu: 4.883 ± 0.638
3.563LeuPhe: 3.563 ± 0.482
5.278LeuGly: 5.278 ± 0.707
1.452LeuHis: 1.452 ± 0.452
4.487LeuIle: 4.487 ± 1.112
5.278LeuLys: 5.278 ± 1.019
7.918LeuLeu: 7.918 ± 0.972
2.639LeuMet: 2.639 ± 0.659
3.959LeuAsn: 3.959 ± 0.557
4.355LeuPro: 4.355 ± 1.008
2.507LeuGln: 2.507 ± 0.418
6.73LeuArg: 6.73 ± 0.934
6.73LeuSer: 6.73 ± 0.708
8.05LeuThr: 8.05 ± 1.145
5.278LeuVal: 5.278 ± 1.116
0.792LeuTrp: 0.792 ± 0.34
2.507LeuTyr: 2.507 ± 0.663
0.0LeuXaa: 0.0 ± 0.0
Met
3.299MetAla: 3.299 ± 0.592
0.264MetCys: 0.264 ± 0.296
3.167MetAsp: 3.167 ± 0.56
1.979MetGlu: 1.979 ± 0.528
0.924MetPhe: 0.924 ± 0.245
0.924MetGly: 0.924 ± 0.318
0.396MetHis: 0.396 ± 0.176
2.375MetIle: 2.375 ± 0.728
1.188MetLys: 1.188 ± 0.439
2.903MetLeu: 2.903 ± 0.714
1.188MetMet: 1.188 ± 0.367
0.924MetAsn: 0.924 ± 0.455
2.111MetPro: 2.111 ± 0.543
0.66MetGln: 0.66 ± 0.217
1.847MetArg: 1.847 ± 0.701
1.056MetSer: 1.056 ± 0.446
2.111MetThr: 2.111 ± 0.369
1.715MetVal: 1.715 ± 0.39
0.528MetTrp: 0.528 ± 0.229
1.056MetTyr: 1.056 ± 0.403
0.0MetXaa: 0.0 ± 0.0
Asn
3.299AsnAla: 3.299 ± 0.647
0.528AsnCys: 0.528 ± 0.37
3.167AsnAsp: 3.167 ± 0.401
1.715AsnGlu: 1.715 ± 0.538
1.452AsnPhe: 1.452 ± 0.325
3.299AsnGly: 3.299 ± 0.638
1.32AsnHis: 1.32 ± 0.511
2.111AsnIle: 2.111 ± 0.443
1.584AsnLys: 1.584 ± 0.338
3.695AsnLeu: 3.695 ± 0.637
0.792AsnMet: 0.792 ± 0.457
1.452AsnAsn: 1.452 ± 0.457
2.507AsnPro: 2.507 ± 0.587
1.979AsnGln: 1.979 ± 0.523
2.111AsnArg: 2.111 ± 0.41
2.507AsnSer: 2.507 ± 0.489
2.639AsnThr: 2.639 ± 0.601
4.091AsnVal: 4.091 ± 0.634
1.188AsnTrp: 1.188 ± 0.311
1.715AsnTyr: 1.715 ± 0.57
0.0AsnXaa: 0.0 ± 0.0
Pro
5.41ProAla: 5.41 ± 0.639
0.132ProCys: 0.132 ± 0.154
2.111ProAsp: 2.111 ± 0.599
2.243ProGlu: 2.243 ± 0.419
1.584ProPhe: 1.584 ± 0.495
3.695ProGly: 3.695 ± 0.372
0.924ProHis: 0.924 ± 0.261
2.639ProIle: 2.639 ± 0.335
1.979ProLys: 1.979 ± 0.354
5.41ProLeu: 5.41 ± 0.681
1.452ProMet: 1.452 ± 0.277
2.507ProAsn: 2.507 ± 0.586
3.431ProPro: 3.431 ± 0.671
1.979ProGln: 1.979 ± 0.317
3.431ProArg: 3.431 ± 0.691
4.355ProSer: 4.355 ± 0.851
3.431ProThr: 3.431 ± 0.796
4.487ProVal: 4.487 ± 0.517
1.056ProTrp: 1.056 ± 0.403
1.584ProTyr: 1.584 ± 0.608
0.0ProXaa: 0.0 ± 0.0
Gln
3.827GlnAla: 3.827 ± 0.74
0.528GlnCys: 0.528 ± 0.332
2.111GlnAsp: 2.111 ± 0.543
1.715GlnGlu: 1.715 ± 0.645
1.715GlnPhe: 1.715 ± 0.394
1.32GlnGly: 1.32 ± 0.393
0.792GlnHis: 0.792 ± 0.3
2.507GlnIle: 2.507 ± 0.726
0.924GlnLys: 0.924 ± 0.295
4.355GlnLeu: 4.355 ± 0.537
1.584GlnMet: 1.584 ± 0.405
1.584GlnAsn: 1.584 ± 0.589
1.715GlnPro: 1.715 ± 0.425
1.584GlnGln: 1.584 ± 0.311
2.111GlnArg: 2.111 ± 0.469
3.035GlnSer: 3.035 ± 0.745
3.035GlnThr: 3.035 ± 0.504
3.827GlnVal: 3.827 ± 0.949
0.528GlnTrp: 0.528 ± 0.237
1.188GlnTyr: 1.188 ± 0.35
0.0GlnXaa: 0.0 ± 0.0
Arg
4.223ArgAla: 4.223 ± 0.573
0.66ArgCys: 0.66 ± 0.285
2.903ArgAsp: 2.903 ± 0.402
2.375ArgGlu: 2.375 ± 0.472
1.979ArgPhe: 1.979 ± 0.343
3.431ArgGly: 3.431 ± 0.961
0.924ArgHis: 0.924 ± 0.279
3.035ArgIle: 3.035 ± 0.578
1.979ArgLys: 1.979 ± 0.514
5.542ArgLeu: 5.542 ± 0.728
2.375ArgMet: 2.375 ± 0.361
2.375ArgAsn: 2.375 ± 0.563
3.035ArgPro: 3.035 ± 0.602
3.035ArgGln: 3.035 ± 0.578
4.355ArgArg: 4.355 ± 0.675
5.542ArgSer: 5.542 ± 1.135
3.563ArgThr: 3.563 ± 0.629
4.487ArgVal: 4.487 ± 0.85
1.188ArgTrp: 1.188 ± 0.304
2.111ArgTyr: 2.111 ± 0.596
0.0ArgXaa: 0.0 ± 0.0
Ser
5.542SerAla: 5.542 ± 0.819
0.792SerCys: 0.792 ± 0.414
4.223SerAsp: 4.223 ± 0.368
3.167SerGlu: 3.167 ± 0.819
3.299SerPhe: 3.299 ± 0.707
6.334SerGly: 6.334 ± 1.412
1.32SerHis: 1.32 ± 0.459
2.903SerIle: 2.903 ± 0.529
4.091SerLys: 4.091 ± 0.568
8.182SerLeu: 8.182 ± 1.209
2.243SerMet: 2.243 ± 0.451
3.035SerAsn: 3.035 ± 0.744
3.959SerPro: 3.959 ± 0.436
3.035SerGln: 3.035 ± 0.486
3.563SerArg: 3.563 ± 0.606
6.466SerSer: 6.466 ± 1.7
7.126SerThr: 7.126 ± 0.843
5.278SerVal: 5.278 ± 0.927
0.924SerTrp: 0.924 ± 0.312
1.452SerTyr: 1.452 ± 0.481
0.0SerXaa: 0.0 ± 0.0
Thr
5.938ThrAla: 5.938 ± 1.213
0.792ThrCys: 0.792 ± 0.34
4.223ThrAsp: 4.223 ± 0.663
4.223ThrGlu: 4.223 ± 0.811
2.243ThrPhe: 2.243 ± 0.405
3.299ThrGly: 3.299 ± 0.746
1.584ThrHis: 1.584 ± 0.486
3.827ThrIle: 3.827 ± 0.939
3.563ThrLys: 3.563 ± 0.596
6.73ThrLeu: 6.73 ± 0.529
1.715ThrMet: 1.715 ± 0.713
2.375ThrAsn: 2.375 ± 0.327
4.619ThrPro: 4.619 ± 0.76
3.035ThrGln: 3.035 ± 0.785
4.355ThrArg: 4.355 ± 0.538
7.522ThrSer: 7.522 ± 0.972
5.015ThrThr: 5.015 ± 0.927
4.487ThrVal: 4.487 ± 0.629
1.056ThrTrp: 1.056 ± 0.478
1.452ThrTyr: 1.452 ± 0.456
0.0ThrXaa: 0.0 ± 0.0
Val
3.959ValAla: 3.959 ± 0.672
1.452ValCys: 1.452 ± 0.567
5.542ValAsp: 5.542 ± 1.627
3.563ValGlu: 3.563 ± 0.668
2.243ValPhe: 2.243 ± 0.474
4.091ValGly: 4.091 ± 0.583
1.452ValHis: 1.452 ± 0.361
3.959ValIle: 3.959 ± 0.888
2.771ValLys: 2.771 ± 0.518
5.674ValLeu: 5.674 ± 0.941
2.243ValMet: 2.243 ± 0.363
4.619ValAsn: 4.619 ± 0.741
4.223ValPro: 4.223 ± 0.987
2.507ValGln: 2.507 ± 0.642
4.223ValArg: 4.223 ± 0.847
6.73ValSer: 6.73 ± 1.16
6.466ValThr: 6.466 ± 1.127
4.883ValVal: 4.883 ± 0.806
1.056ValTrp: 1.056 ± 0.32
2.507ValTyr: 2.507 ± 0.676
0.0ValXaa: 0.0 ± 0.0
Trp
1.847TrpAla: 1.847 ± 0.585
0.396TrpCys: 0.396 ± 0.211
0.792TrpAsp: 0.792 ± 0.213
0.924TrpGlu: 0.924 ± 0.292
0.264TrpPhe: 0.264 ± 0.187
0.264TrpGly: 0.264 ± 0.172
0.132TrpHis: 0.132 ± 0.101
0.66TrpIle: 0.66 ± 0.28
0.924TrpLys: 0.924 ± 0.507
1.188TrpLeu: 1.188 ± 0.557
0.396TrpMet: 0.396 ± 0.25
0.528TrpAsn: 0.528 ± 0.262
0.924TrpPro: 0.924 ± 0.319
0.792TrpGln: 0.792 ± 0.257
0.924TrpArg: 0.924 ± 0.265
1.715TrpSer: 1.715 ± 0.453
1.32TrpThr: 1.32 ± 0.279
1.056TrpVal: 1.056 ± 0.345
0.132TrpTrp: 0.132 ± 0.154
0.66TrpTyr: 0.66 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.847TyrAla: 1.847 ± 0.631
0.132TyrCys: 0.132 ± 0.111
2.507TyrAsp: 2.507 ± 0.75
1.584TyrGlu: 1.584 ± 0.272
1.452TyrPhe: 1.452 ± 0.526
2.111TyrGly: 2.111 ± 0.371
0.528TyrHis: 0.528 ± 0.227
1.188TyrIle: 1.188 ± 0.384
0.924TyrLys: 0.924 ± 0.226
3.431TyrLeu: 3.431 ± 0.606
1.32TyrMet: 1.32 ± 0.389
1.32TyrAsn: 1.32 ± 0.385
1.056TyrPro: 1.056 ± 0.342
1.847TyrGln: 1.847 ± 0.586
1.056TyrArg: 1.056 ± 0.339
1.847TyrSer: 1.847 ± 0.265
2.111TyrThr: 2.111 ± 0.45
2.111TyrVal: 2.111 ± 0.498
0.0TyrTrp: 0.0 ± 0.0
1.32TyrTyr: 1.32 ± 0.419
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (7579 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski