Amino acid dipepetide frequency for Nocardiopsis gilva YIM 90087

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.128AlaAla: 19.128 ± 0.156	1.088AlaCys: 1.088 ± 0.03	8.868AlaAsp: 8.868 ± 0.076	9.309AlaGlu: 9.309 ± 0.088	3.469AlaPhe: 3.469 ± 0.049	10.94AlaGly: 10.94 ± 0.092	2.781AlaHis: 2.781 ± 0.042	4.498AlaIle: 4.498 ± 0.058	2.521AlaLys: 2.521 ± 0.047	13.28AlaLeu: 13.28 ± 0.104	2.788AlaMet: 2.788 ± 0.046	2.017AlaAsn: 2.017 ± 0.037	6.835AlaPro: 6.835 ± 0.087	3.508AlaGln: 3.508 ± 0.051	9.657AlaArg: 9.657 ± 0.107	6.065AlaSer: 6.065 ± 0.07	6.922AlaThr: 6.922 ± 0.071	11.1AlaVal: 11.1 ± 0.114	1.89AlaTrp: 1.89 ± 0.037	2.451AlaTyr: 2.451 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.057CysAla: 1.057 ± 0.025	0.123CysCys: 0.123 ± 0.009	0.539CysAsp: 0.539 ± 0.019	0.425CysGlu: 0.425 ± 0.017	0.227CysPhe: 0.227 ± 0.01	0.985CysGly: 0.985 ± 0.025	0.195CysHis: 0.195 ± 0.01	0.17CysIle: 0.17 ± 0.011	0.116CysLys: 0.116 ± 0.008	0.705CysLeu: 0.705 ± 0.022	0.144CysMet: 0.144 ± 0.01	0.129CysAsn: 0.129 ± 0.009	0.534CysPro: 0.534 ± 0.021	0.188CysGln: 0.188 ± 0.012	0.653CysArg: 0.653 ± 0.02	0.474CysSer: 0.474 ± 0.015	0.49CysThr: 0.49 ± 0.018	0.685CysVal: 0.685 ± 0.023	0.116CysTrp: 0.116 ± 0.009	0.177CysTyr: 0.177 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.188AspAla: 8.188 ± 0.083	0.42AspCys: 0.42 ± 0.017	4.615AspAsp: 4.615 ± 0.06	4.251AspGlu: 4.251 ± 0.062	1.726AspPhe: 1.726 ± 0.029	6.3AspGly: 6.3 ± 0.08	1.618AspHis: 1.618 ± 0.031	2.531AspIle: 2.531 ± 0.045	1.142AspLys: 1.142 ± 0.035	6.608AspLeu: 6.608 ± 0.075	1.052AspMet: 1.052 ± 0.027	1.05AspAsn: 1.05 ± 0.03	4.652AspPro: 4.652 ± 0.057	1.671AspGln: 1.671 ± 0.029	5.132AspArg: 5.132 ± 0.055	2.825AspSer: 2.825 ± 0.047	3.589AspThr: 3.589 ± 0.05	5.028AspVal: 5.028 ± 0.056	0.913AspTrp: 0.913 ± 0.028	1.385AspTyr: 1.385 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.418GluAla: 7.418 ± 0.075	0.436GluCys: 0.436 ± 0.016	3.198GluAsp: 3.198 ± 0.044	4.214GluGlu: 4.214 ± 0.058	1.778GluPhe: 1.778 ± 0.04	4.675GluGly: 4.675 ± 0.053	1.672GluHis: 1.672 ± 0.036	2.711GluIle: 2.711 ± 0.037	1.571GluLys: 1.571 ± 0.039	6.836GluLeu: 6.836 ± 0.085	1.205GluMet: 1.205 ± 0.032	1.156GluAsn: 1.156 ± 0.029	3.496GluPro: 3.496 ± 0.051	2.383GluGln: 2.383 ± 0.043	6.153GluArg: 6.153 ± 0.066	2.994GluSer: 2.994 ± 0.041	3.018GluThr: 3.018 ± 0.044	4.882GluVal: 4.882 ± 0.059	0.851GluTrp: 0.851 ± 0.024	1.166GluTyr: 1.166 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.622PheAla: 3.622 ± 0.051	0.296PheCys: 0.296 ± 0.013	2.161PheAsp: 2.161 ± 0.039	1.444PheGlu: 1.444 ± 0.031	0.916PhePhe: 0.916 ± 0.029	3.118PheGly: 3.118 ± 0.053	0.65PheHis: 0.65 ± 0.02	0.948PheIle: 0.948 ± 0.025	0.455PheLys: 0.455 ± 0.019	2.623PheLeu: 2.623 ± 0.045	0.442PheMet: 0.442 ± 0.017	0.578PheAsn: 0.578 ± 0.02	1.48PhePro: 1.48 ± 0.03	0.688PheGln: 0.688 ± 0.023	1.781PheArg: 1.781 ± 0.031	1.605PheSer: 1.605 ± 0.029	2.044PheThr: 2.044 ± 0.035	2.234PheVal: 2.234 ± 0.039	0.425PheTrp: 0.425 ± 0.018	0.602PheTyr: 0.602 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	10.818GlyAla: 10.818 ± 0.099	0.821GlyCys: 0.821 ± 0.023	5.528GlyAsp: 5.528 ± 0.064	5.451GlyGlu: 5.451 ± 0.062	2.785GlyPhe: 2.785 ± 0.043	8.485GlyGly: 8.485 ± 0.088	2.28GlyHis: 2.28 ± 0.036	3.74GlyIle: 3.74 ± 0.053	2.172GlyLys: 2.172 ± 0.045	8.913GlyLeu: 8.913 ± 0.086	2.187GlyMet: 2.187 ± 0.037	1.68GlyAsn: 1.68 ± 0.042	4.717GlyPro: 4.717 ± 0.064	2.547GlyGln: 2.547 ± 0.042	7.198GlyArg: 7.198 ± 0.085	5.009GlySer: 5.009 ± 0.063	5.857GlyThr: 5.857 ± 0.066	7.61GlyVal: 7.61 ± 0.079	1.573GlyTrp: 1.573 ± 0.035	2.368GlyTyr: 2.368 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.68HisAla: 2.68 ± 0.044	0.211HisCys: 0.211 ± 0.011	1.44HisAsp: 1.44 ± 0.033	1.193HisGlu: 1.193 ± 0.028	0.625HisPhe: 0.625 ± 0.022	2.363HisGly: 2.363 ± 0.043	0.699HisHis: 0.699 ± 0.022	0.799HisIle: 0.799 ± 0.022	0.355HisLys: 0.355 ± 0.016	2.31HisLeu: 2.31 ± 0.04	0.391HisMet: 0.391 ± 0.016	0.41HisAsn: 0.41 ± 0.016	1.747HisPro: 1.747 ± 0.034	0.607HisGln: 0.607 ± 0.021	2.035HisArg: 2.035 ± 0.037	1.087HisSer: 1.087 ± 0.028	1.307HisThr: 1.307 ± 0.026	1.724HisVal: 1.724 ± 0.037	0.345HisTrp: 0.345 ± 0.014	0.515HisTyr: 0.515 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.634IleAla: 5.634 ± 0.065	0.352IleCys: 0.352 ± 0.015	2.927IleAsp: 2.927 ± 0.044	2.341IleGlu: 2.341 ± 0.041	0.874IlePhe: 0.874 ± 0.028	4.108IleGly: 4.108 ± 0.054	0.708IleHis: 0.708 ± 0.02	1.341IleIle: 1.341 ± 0.034	0.733IleLys: 0.733 ± 0.021	2.807IleLeu: 2.807 ± 0.048	0.552IleMet: 0.552 ± 0.019	0.805IleAsn: 0.805 ± 0.025	2.137IlePro: 2.137 ± 0.036	0.809IleGln: 0.809 ± 0.026	2.618IleArg: 2.618 ± 0.042	2.139IleSer: 2.139 ± 0.04	2.653IleThr: 2.653 ± 0.04	3.288IleVal: 3.288 ± 0.048	0.395IleTrp: 0.395 ± 0.016	0.684IleTyr: 0.684 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.349LysAla: 2.349 ± 0.046	0.109LysCys: 0.109 ± 0.009	1.158LysAsp: 1.158 ± 0.034	1.3LysGlu: 1.3 ± 0.033	0.475LysPhe: 0.475 ± 0.017	1.739LysGly: 1.739 ± 0.04	0.412LysHis: 0.412 ± 0.016	0.86LysIle: 0.86 ± 0.026	0.761LysLys: 0.761 ± 0.034	1.884LysLeu: 1.884 ± 0.04	0.382LysMet: 0.382 ± 0.018	0.5LysAsn: 0.5 ± 0.02	1.113LysPro: 1.113 ± 0.033	0.618LysGln: 0.618 ± 0.02	1.653LysArg: 1.653 ± 0.037	1.078LysSer: 1.078 ± 0.026	1.071LysThr: 1.071 ± 0.027	1.752LysVal: 1.752 ± 0.035	0.235LysTrp: 0.235 ± 0.011	0.414LysTyr: 0.414 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.801LeuAla: 13.801 ± 0.117	0.789LeuCys: 0.789 ± 0.023	6.701LeuAsp: 6.701 ± 0.075	5.014LeuGlu: 5.014 ± 0.066	2.797LeuPhe: 2.797 ± 0.049	8.766LeuGly: 8.766 ± 0.081	2.186LeuHis: 2.186 ± 0.04	3.91LeuIle: 3.91 ± 0.058	1.782LeuLys: 1.782 ± 0.043	10.769LeuLeu: 10.769 ± 0.11	1.796LeuMet: 1.796 ± 0.035	1.756LeuAsn: 1.756 ± 0.037	5.922LeuPro: 5.922 ± 0.065	2.054LeuGln: 2.054 ± 0.037	8.753LeuArg: 8.753 ± 0.087	5.578LeuSer: 5.578 ± 0.062	6.224LeuThr: 6.224 ± 0.069	8.375LeuVal: 8.375 ± 0.081	1.269LeuTrp: 1.269 ± 0.029	1.735LeuTyr: 1.735 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.537MetAla: 2.537 ± 0.038	0.159MetCys: 0.159 ± 0.01	1.03MetAsp: 1.03 ± 0.027	0.935MetGlu: 0.935 ± 0.029	0.562MetPhe: 0.562 ± 0.018	1.597MetGly: 1.597 ± 0.035	0.385MetHis: 0.385 ± 0.015	0.741MetIle: 0.741 ± 0.021	0.395MetLys: 0.395 ± 0.016	2.001MetLeu: 2.001 ± 0.037	0.373MetMet: 0.373 ± 0.016	0.446MetAsn: 0.446 ± 0.017	1.202MetPro: 1.202 ± 0.027	0.427MetGln: 0.427 ± 0.016	1.744MetArg: 1.744 ± 0.034	1.486MetSer: 1.486 ± 0.026	1.507MetThr: 1.507 ± 0.031	1.616MetVal: 1.616 ± 0.032	0.257MetTrp: 0.257 ± 0.012	0.331MetTyr: 0.331 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.231AsnAla: 2.231 ± 0.037	0.171AsnCys: 0.171 ± 0.011	1.102AsnAsp: 1.102 ± 0.029	1.006AsnGlu: 1.006 ± 0.03	0.472AsnPhe: 0.472 ± 0.018	2.011AsnGly: 2.011 ± 0.04	0.396AsnHis: 0.396 ± 0.016	0.766AsnIle: 0.766 ± 0.023	0.351AsnLys: 0.351 ± 0.017	1.708AsnLeu: 1.708 ± 0.034	0.339AsnMet: 0.339 ± 0.013	0.424AsnAsn: 0.424 ± 0.018	1.418AsnPro: 1.418 ± 0.033	0.503AsnGln: 0.503 ± 0.019	1.357AsnArg: 1.357 ± 0.03	0.889AsnSer: 0.889 ± 0.024	1.052AsnThr: 1.052 ± 0.024	1.419AsnVal: 1.419 ± 0.029	0.271AsnTrp: 0.271 ± 0.013	0.428AsnTyr: 0.428 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.088ProAla: 7.088 ± 0.08	0.336ProCys: 0.336 ± 0.016	4.841ProAsp: 4.841 ± 0.055	4.818ProGlu: 4.818 ± 0.064	1.554ProPhe: 1.554 ± 0.029	6.009ProGly: 6.009 ± 0.073	1.412ProHis: 1.412 ± 0.032	1.837ProIle: 1.837 ± 0.031	1.154ProLys: 1.154 ± 0.032	4.966ProLeu: 4.966 ± 0.062	1.129ProMet: 1.129 ± 0.027	1.003ProAsn: 1.003 ± 0.024	3.573ProPro: 3.573 ± 0.071	1.677ProGln: 1.677 ± 0.036	4.078ProArg: 4.078 ± 0.059	3.273ProSer: 3.273 ± 0.051	3.416ProThr: 3.416 ± 0.048	4.871ProVal: 4.871 ± 0.06	0.892ProTrp: 0.892 ± 0.026	1.195ProTyr: 1.195 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.462GlnAla: 3.462 ± 0.04	0.19GlnCys: 0.19 ± 0.011	1.248GlnAsp: 1.248 ± 0.024	1.639GlnGlu: 1.639 ± 0.028	0.619GlnPhe: 0.619 ± 0.019	2.209GlnGly: 2.209 ± 0.036	0.608GlnHis: 0.608 ± 0.019	1.097GlnIle: 1.097 ± 0.026	0.546GlnLys: 0.546 ± 0.021	2.66GlnLeu: 2.66 ± 0.043	0.523GlnMet: 0.523 ± 0.019	0.474GlnAsn: 0.474 ± 0.018	1.55GlnPro: 1.55 ± 0.037	1.093GlnGln: 1.093 ± 0.038	2.773GlnArg: 2.773 ± 0.04	1.29GlnSer: 1.29 ± 0.029	1.284GlnThr: 1.284 ± 0.031	2.367GlnVal: 2.367 ± 0.043	0.442GlnTrp: 0.442 ± 0.018	0.464GlnTyr: 0.464 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.3ArgAla: 9.3 ± 0.101	0.671ArgCys: 0.671 ± 0.023	4.753ArgAsp: 4.753 ± 0.061	5.034ArgGlu: 5.034 ± 0.068	2.475ArgPhe: 2.475 ± 0.038	5.959ArgGly: 5.959 ± 0.068	2.011ArgHis: 2.011 ± 0.042	3.374ArgIle: 3.374 ± 0.044	1.614ArgLys: 1.614 ± 0.033	8.905ArgLeu: 8.905 ± 0.087	2.019ArgMet: 2.019 ± 0.036	1.459ArgAsn: 1.459 ± 0.032	4.823ArgPro: 4.823 ± 0.062	2.155ArgGln: 2.155 ± 0.039	8.006ArgArg: 8.006 ± 0.094	4.445ArgSer: 4.445 ± 0.063	4.757ArgThr: 4.757 ± 0.054	6.308ArgVal: 6.308 ± 0.071	1.296ArgTrp: 1.296 ± 0.027	1.825ArgTyr: 1.825 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	7.058SerAla: 7.058 ± 0.073	0.46SerCys: 0.46 ± 0.017	3.202SerAsp: 3.202 ± 0.052	2.966SerGlu: 2.966 ± 0.046	1.467SerPhe: 1.467 ± 0.036	6.294SerGly: 6.294 ± 0.066	1.041SerHis: 1.041 ± 0.024	1.808SerIle: 1.808 ± 0.035	0.956SerLys: 0.956 ± 0.029	4.63SerLeu: 4.63 ± 0.056	1.174SerMet: 1.174 ± 0.029	0.923SerAsn: 0.923 ± 0.025	3.22SerPro: 3.22 ± 0.052	1.272SerGln: 1.272 ± 0.027	3.683SerArg: 3.683 ± 0.051	3.138SerSer: 3.138 ± 0.052	3.315SerThr: 3.315 ± 0.046	4.171SerVal: 4.171 ± 0.051	0.911SerTrp: 0.911 ± 0.025	1.199SerTyr: 1.199 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	8.12ThrAla: 8.12 ± 0.079	0.447ThrCys: 0.447 ± 0.018	3.818ThrAsp: 3.818 ± 0.053	3.486ThrGlu: 3.486 ± 0.051	1.656ThrPhe: 1.656 ± 0.034	6.282ThrGly: 6.282 ± 0.078	1.194ThrHis: 1.194 ± 0.031	2.056ThrIle: 2.056 ± 0.037	1.049ThrLys: 1.049 ± 0.031	5.478ThrLeu: 5.478 ± 0.058	1.027ThrMet: 1.027 ± 0.027	1.023ThrAsn: 1.023 ± 0.029	4.041ThrPro: 4.041 ± 0.054	1.33ThrGln: 1.33 ± 0.031	4.036ThrArg: 4.036 ± 0.046	3.132ThrSer: 3.132 ± 0.041	3.685ThrThr: 3.685 ± 0.06	5.398ThrVal: 5.398 ± 0.06	0.924ThrTrp: 0.924 ± 0.025	1.224ThrTyr: 1.224 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	10.564ValAla: 10.564 ± 0.097	0.722ValCys: 0.722 ± 0.022	5.384ValAsp: 5.384 ± 0.062	5.015ValGlu: 5.015 ± 0.061	2.514ValPhe: 2.514 ± 0.044	6.781ValGly: 6.781 ± 0.072	1.839ValHis: 1.839 ± 0.032	3.435ValIle: 3.435 ± 0.045	1.483ValLys: 1.483 ± 0.032	8.999ValLeu: 8.999 ± 0.078	1.55ValMet: 1.55 ± 0.035	1.698ValAsn: 1.698 ± 0.038	4.745ValPro: 4.745 ± 0.065	1.879ValGln: 1.879 ± 0.039	6.665ValArg: 6.665 ± 0.063	4.392ValSer: 4.392 ± 0.056	5.084ValThr: 5.084 ± 0.063	7.774ValVal: 7.774 ± 0.081	1.141ValTrp: 1.141 ± 0.027	1.582ValTyr: 1.582 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.561TrpAla: 1.561 ± 0.03	0.152TrpCys: 0.152 ± 0.011	0.801TrpAsp: 0.801 ± 0.021	0.779TrpGlu: 0.779 ± 0.024	0.48TrpPhe: 0.48 ± 0.017	1.059TrpGly: 1.059 ± 0.028	0.356TrpHis: 0.356 ± 0.016	0.611TrpIle: 0.611 ± 0.021	0.339TrpLys: 0.339 ± 0.016	1.709TrpLeu: 1.709 ± 0.034	0.336TrpMet: 0.336 ± 0.015	0.387TrpAsn: 0.387 ± 0.017	0.806TrpPro: 0.806 ± 0.023	0.542TrpGln: 0.542 ± 0.019	1.411TrpArg: 1.411 ± 0.03	0.932TrpSer: 0.932 ± 0.026	0.887TrpThr: 0.887 ± 0.026	1.034TrpVal: 1.034 ± 0.03	0.358TrpTrp: 0.358 ± 0.016	0.3TrpTyr: 0.3 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.498TyrAla: 2.498 ± 0.046	0.18TyrCys: 0.18 ± 0.009	1.381TyrAsp: 1.381 ± 0.034	1.195TyrGlu: 1.195 ± 0.03	0.639TyrPhe: 0.639 ± 0.02	2.058TyrGly: 2.058 ± 0.042	0.401TyrHis: 0.401 ± 0.016	0.669TyrIle: 0.669 ± 0.024	0.368TyrLys: 0.368 ± 0.017	2.185TyrLeu: 2.185 ± 0.04	0.323TyrMet: 0.323 ± 0.015	0.394TyrAsn: 0.394 ± 0.016	1.113TyrPro: 1.113 ± 0.03	0.587TyrGln: 0.587 ± 0.018	1.802TyrArg: 1.802 ± 0.035	1.057TyrSer: 1.057 ± 0.031	1.244TyrThr: 1.244 ± 0.03	1.611TyrVal: 1.611 ± 0.035	0.339TyrTrp: 0.339 ± 0.016	0.489TyrTyr: 0.489 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5074 proteins (1623985 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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