Amino acid dipepetide frequency for Marchantia polymorpha (Liverwort) (Marchantia aquatica)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.825AlaAla: 8.825 ± 0.053	1.327AlaCys: 1.327 ± 0.015	3.957AlaAsp: 3.957 ± 0.028	5.259AlaGlu: 5.259 ± 0.034	2.756AlaPhe: 2.756 ± 0.018	5.767AlaGly: 5.767 ± 0.031	1.617AlaHis: 1.617 ± 0.012	3.359AlaIle: 3.359 ± 0.022	3.934AlaLys: 3.934 ± 0.025	7.714AlaLeu: 7.714 ± 0.035	1.948AlaMet: 1.948 ± 0.016	2.521AlaAsn: 2.521 ± 0.017	3.946AlaPro: 3.946 ± 0.033	2.928AlaGln: 2.928 ± 0.023	4.769AlaArg: 4.769 ± 0.027	6.987AlaSer: 6.987 ± 0.033	4.27AlaThr: 4.27 ± 0.025	5.794AlaVal: 5.794 ± 0.03	0.9AlaTrp: 0.9 ± 0.01	1.774AlaTyr: 1.774 ± 0.014	0.0AlaXaa: 0.0 ± 0.0
Cys	1.242CysAla: 1.242 ± 0.013	0.503CysCys: 0.503 ± 0.008	0.802CysAsp: 0.802 ± 0.01	0.883CysGlu: 0.883 ± 0.011	0.701CysPhe: 0.701 ± 0.009	1.308CysGly: 1.308 ± 0.014	0.44CysHis: 0.44 ± 0.009	0.772CysIle: 0.772 ± 0.01	0.865CysLys: 0.865 ± 0.01	1.661CysLeu: 1.661 ± 0.016	0.39CysMet: 0.39 ± 0.007	0.634CysAsn: 0.634 ± 0.009	0.987CysPro: 0.987 ± 0.012	0.616CysGln: 0.616 ± 0.007	1.125CysArg: 1.125 ± 0.013	1.661CysSer: 1.661 ± 0.017	1.0CysThr: 1.0 ± 0.011	1.073CysVal: 1.073 ± 0.012	0.243CysTrp: 0.243 ± 0.005	0.424CysTyr: 0.424 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.997AspAla: 3.997 ± 0.022	0.907AspCys: 0.907 ± 0.01	3.569AspAsp: 3.569 ± 0.029	4.202AspGlu: 4.202 ± 0.031	2.144AspPhe: 2.144 ± 0.015	4.075AspGly: 4.075 ± 0.024	1.171AspHis: 1.171 ± 0.01	2.506AspIle: 2.506 ± 0.018	2.428AspLys: 2.428 ± 0.024	4.944AspLeu: 4.944 ± 0.022	1.278AspMet: 1.278 ± 0.012	1.728AspAsn: 1.728 ± 0.015	2.699AspPro: 2.699 ± 0.02	1.689AspGln: 1.689 ± 0.014	3.018AspArg: 3.018 ± 0.029	4.342AspSer: 4.342 ± 0.027	2.447AspThr: 2.447 ± 0.023	3.891AspVal: 3.891 ± 0.022	0.748AspTrp: 0.748 ± 0.01	1.381AspTyr: 1.381 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	5.558GluAla: 5.558 ± 0.032	0.871GluCys: 0.871 ± 0.01	4.193GluAsp: 4.193 ± 0.028	6.245GluGlu: 6.245 ± 0.058	2.146GluPhe: 2.146 ± 0.016	4.264GluGly: 4.264 ± 0.025	1.38GluHis: 1.38 ± 0.014	3.115GluIle: 3.115 ± 0.021	4.344GluLys: 4.344 ± 0.039	6.017GluLeu: 6.017 ± 0.039	1.546GluMet: 1.546 ± 0.016	2.515GluAsn: 2.515 ± 0.019	2.437GluPro: 2.437 ± 0.028	2.573GluGln: 2.573 ± 0.018	4.398GluArg: 4.398 ± 0.035	4.844GluSer: 4.844 ± 0.027	3.161GluThr: 3.161 ± 0.025	4.462GluVal: 4.462 ± 0.028	0.756GluTrp: 0.756 ± 0.01	1.514GluTyr: 1.514 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	2.59PheAla: 2.59 ± 0.02	0.767PheCys: 0.767 ± 0.009	2.011PheAsp: 2.011 ± 0.015	2.181PheGlu: 2.181 ± 0.015	1.615PhePhe: 1.615 ± 0.016	2.781PheGly: 2.781 ± 0.021	0.912PheHis: 0.912 ± 0.01	1.505PheIle: 1.505 ± 0.014	1.645PheLys: 1.645 ± 0.014	3.615PheLeu: 3.615 ± 0.027	0.843PheMet: 0.843 ± 0.01	1.328PheAsn: 1.328 ± 0.012	1.784PhePro: 1.784 ± 0.015	1.459PheGln: 1.459 ± 0.012	2.052PheArg: 2.052 ± 0.018	3.326PheSer: 3.326 ± 0.022	1.904PheThr: 1.904 ± 0.015	2.587PheVal: 2.587 ± 0.018	0.532PheTrp: 0.532 ± 0.008	1.061PheTyr: 1.061 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	5.367GlyAla: 5.367 ± 0.032	1.164GlyCys: 1.164 ± 0.014	3.644GlyAsp: 3.644 ± 0.023	4.012GlyGlu: 4.012 ± 0.024	2.629GlyPhe: 2.629 ± 0.02	6.473GlyGly: 6.473 ± 0.06	1.681GlyHis: 1.681 ± 0.018	3.034GlyIle: 3.034 ± 0.022	3.666GlyLys: 3.666 ± 0.025	6.223GlyLeu: 6.223 ± 0.028	1.587GlyMet: 1.587 ± 0.015	2.661GlyAsn: 2.661 ± 0.021	3.337GlyPro: 3.337 ± 0.028	2.535GlyGln: 2.535 ± 0.017	4.852GlyArg: 4.852 ± 0.03	6.429GlySer: 6.429 ± 0.037	3.734GlyThr: 3.734 ± 0.022	4.744GlyVal: 4.744 ± 0.023	1.007GlyTrp: 1.007 ± 0.011	1.757GlyTyr: 1.757 ± 0.017	0.0GlyXaa: 0.0 ± 0.0
His	1.593HisAla: 1.593 ± 0.012	0.492HisCys: 0.492 ± 0.007	1.158HisAsp: 1.158 ± 0.012	1.407HisGlu: 1.407 ± 0.013	0.944HisPhe: 0.944 ± 0.011	1.704HisGly: 1.704 ± 0.014	0.841HisHis: 0.841 ± 0.014	1.046HisIle: 1.046 ± 0.011	1.006HisLys: 1.006 ± 0.011	2.313HisLeu: 2.313 ± 0.018	0.556HisMet: 0.556 ± 0.008	0.766HisAsn: 0.766 ± 0.009	1.36HisPro: 1.36 ± 0.013	1.03HisGln: 1.03 ± 0.014	1.553HisArg: 1.553 ± 0.016	1.969HisSer: 1.969 ± 0.016	1.087HisThr: 1.087 ± 0.012	1.582HisVal: 1.582 ± 0.012	0.316HisTrp: 0.316 ± 0.006	0.624HisTyr: 0.624 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	3.444IleAla: 3.444 ± 0.02	0.901IleCys: 0.901 ± 0.01	2.366IleAsp: 2.366 ± 0.017	2.63IleGlu: 2.63 ± 0.019	1.765IlePhe: 1.765 ± 0.016	2.768IleGly: 2.768 ± 0.021	1.063IleHis: 1.063 ± 0.01	2.023IleIle: 2.023 ± 0.016	2.044IleLys: 2.044 ± 0.016	4.293IleLeu: 4.293 ± 0.023	0.983IleMet: 0.983 ± 0.01	1.503IleAsn: 1.503 ± 0.014	2.573IlePro: 2.573 ± 0.022	1.715IleGln: 1.715 ± 0.017	2.525IleArg: 2.525 ± 0.019	3.713IleSer: 3.713 ± 0.02	2.255IleThr: 2.255 ± 0.017	3.095IleVal: 3.095 ± 0.02	0.588IleTrp: 0.588 ± 0.009	1.121IleTyr: 1.121 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	4.22LysAla: 4.22 ± 0.029	0.757LysCys: 0.757 ± 0.01	3.005LysAsp: 3.005 ± 0.023	4.058LysGlu: 4.058 ± 0.04	1.753LysPhe: 1.753 ± 0.014	3.188LysGly: 3.188 ± 0.022	1.152LysHis: 1.152 ± 0.012	2.323LysIle: 2.323 ± 0.017	3.739LysLys: 3.739 ± 0.034	5.03LysLeu: 5.03 ± 0.029	1.208LysMet: 1.208 ± 0.013	1.879LysAsn: 1.879 ± 0.014	2.401LysPro: 2.401 ± 0.018	2.089LysGln: 2.089 ± 0.017	3.455LysArg: 3.455 ± 0.024	4.084LysSer: 4.084 ± 0.029	2.586LysThr: 2.586 ± 0.019	3.595LysVal: 3.595 ± 0.019	0.652LysTrp: 0.652 ± 0.009	1.337LysTyr: 1.337 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	7.419LeuAla: 7.419 ± 0.035	1.685LeuCys: 1.685 ± 0.016	5.006LeuAsp: 5.006 ± 0.025	6.526LeuGlu: 6.526 ± 0.038	3.238LeuPhe: 3.238 ± 0.024	5.908LeuGly: 5.908 ± 0.029	2.464LeuHis: 2.464 ± 0.02	3.65LeuIle: 3.65 ± 0.023	5.095LeuLys: 5.095 ± 0.03	9.605LeuLeu: 9.605 ± 0.048	2.026LeuMet: 2.026 ± 0.015	3.27LeuAsn: 3.27 ± 0.023	5.411LeuPro: 5.411 ± 0.033	4.787LeuGln: 4.787 ± 0.035	6.095LeuArg: 6.095 ± 0.032	7.847LeuSer: 7.847 ± 0.041	4.703LeuThr: 4.703 ± 0.029	6.319LeuVal: 6.319 ± 0.03	1.168LeuTrp: 1.168 ± 0.013	2.271LeuTyr: 2.271 ± 0.017	0.0LeuXaa: 0.0 ± 0.0
Met	2.234MetAla: 2.234 ± 0.018	0.352MetCys: 0.352 ± 0.006	1.341MetAsp: 1.341 ± 0.014	1.755MetGlu: 1.755 ± 0.016	0.72MetPhe: 0.72 ± 0.008	1.56MetGly: 1.56 ± 0.014	0.513MetHis: 0.513 ± 0.007	0.964MetIle: 0.964 ± 0.01	1.34MetLys: 1.34 ± 0.013	2.042MetLeu: 2.042 ± 0.015	0.648MetMet: 0.648 ± 0.009	0.838MetAsn: 0.838 ± 0.01	1.058MetPro: 1.058 ± 0.011	1.014MetGln: 1.014 ± 0.013	1.377MetArg: 1.377 ± 0.012	1.831MetSer: 1.831 ± 0.013	1.168MetThr: 1.168 ± 0.012	1.487MetVal: 1.487 ± 0.013	0.292MetTrp: 0.292 ± 0.006	0.556MetTyr: 0.556 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.608AsnAla: 2.608 ± 0.016	0.699AsnCys: 0.699 ± 0.011	1.672AsnAsp: 1.672 ± 0.015	2.033AsnGlu: 2.033 ± 0.014	1.59AsnPhe: 1.59 ± 0.014	2.675AsnGly: 2.675 ± 0.022	0.826AsnHis: 0.826 ± 0.01	1.728AsnIle: 1.728 ± 0.016	1.686AsnLys: 1.686 ± 0.016	3.861AsnLeu: 3.861 ± 0.027	0.89AsnMet: 0.89 ± 0.01	1.493AsnAsn: 1.493 ± 0.017	1.925AsnPro: 1.925 ± 0.017	1.406AsnGln: 1.406 ± 0.018	1.934AsnArg: 1.934 ± 0.016	3.167AsnSer: 3.167 ± 0.024	1.67AsnThr: 1.67 ± 0.014	2.57AsnVal: 2.57 ± 0.018	0.526AsnTrp: 0.526 ± 0.008	0.99AsnTyr: 0.99 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	4.429ProAla: 4.429 ± 0.048	0.791ProCys: 0.791 ± 0.01	2.606ProAsp: 2.606 ± 0.021	3.35ProGlu: 3.35 ± 0.028	1.791ProPhe: 1.791 ± 0.016	3.673ProGly: 3.673 ± 0.026	1.172ProHis: 1.172 ± 0.012	1.994ProIle: 1.994 ± 0.012	2.439ProLys: 2.439 ± 0.019	4.48ProLeu: 4.48 ± 0.027	1.051ProMet: 1.051 ± 0.012	1.759ProAsn: 1.759 ± 0.016	4.521ProPro: 4.521 ± 0.057	2.113ProGln: 2.113 ± 0.024	3.168ProArg: 3.168 ± 0.024	5.559ProSer: 5.559 ± 0.041	2.976ProThr: 2.976 ± 0.026	3.617ProVal: 3.617 ± 0.025	0.652ProTrp: 0.652 ± 0.008	1.188ProTyr: 1.188 ± 0.012	0.0ProXaa: 0.0 ± 0.0
Gln	3.232GlnAla: 3.232 ± 0.022	0.589GlnCys: 0.589 ± 0.008	1.861GlnAsp: 1.861 ± 0.014	2.703GlnGlu: 2.703 ± 0.024	1.343GlnPhe: 1.343 ± 0.012	2.518GlnGly: 2.518 ± 0.018	1.063GlnHis: 1.063 ± 0.015	1.835GlnIle: 1.835 ± 0.015	2.113GlnLys: 2.113 ± 0.018	3.932GlnLeu: 3.932 ± 0.026	1.003GlnMet: 1.003 ± 0.01	1.506GlnAsn: 1.506 ± 0.018	2.001GlnPro: 2.001 ± 0.022	2.884GlnGln: 2.884 ± 0.059	2.707GlnArg: 2.707 ± 0.018	3.216GlnSer: 3.216 ± 0.022	1.935GlnThr: 1.935 ± 0.016	2.64GlnVal: 2.64 ± 0.018	0.513GlnTrp: 0.513 ± 0.007	0.925GlnTyr: 0.925 ± 0.011	0.0GlnXaa: 0.0 ± 0.0
Arg	4.705ArgAla: 4.705 ± 0.028	1.076ArgCys: 1.076 ± 0.013	3.233ArgAsp: 3.233 ± 0.026	4.176ArgGlu: 4.176 ± 0.036	2.136ArgPhe: 2.136 ± 0.017	4.305ArgGly: 4.305 ± 0.03	1.515ArgHis: 1.515 ± 0.015	2.785ArgIle: 2.785 ± 0.02	3.698ArgLys: 3.698 ± 0.025	5.768ArgLeu: 5.768 ± 0.031	1.5ArgMet: 1.5 ± 0.013	2.4ArgAsn: 2.4 ± 0.019	3.189ArgPro: 3.189 ± 0.024	2.397ArgGln: 2.397 ± 0.021	5.39ArgArg: 5.39 ± 0.043	5.603ArgSer: 5.603 ± 0.032	3.136ArgThr: 3.136 ± 0.021	3.827ArgVal: 3.827 ± 0.021	0.887ArgTrp: 0.887 ± 0.011	1.419ArgTyr: 1.419 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	6.606SerAla: 6.606 ± 0.03	1.59SerCys: 1.59 ± 0.016	4.221SerAsp: 4.221 ± 0.029	4.985SerGlu: 4.985 ± 0.031	3.311SerPhe: 3.311 ± 0.023	6.471SerGly: 6.471 ± 0.039	1.906SerHis: 1.906 ± 0.015	3.632SerIle: 3.632 ± 0.023	4.37SerLys: 4.37 ± 0.029	7.987SerLeu: 7.987 ± 0.034	1.971SerMet: 1.971 ± 0.015	3.229SerAsn: 3.229 ± 0.023	5.195SerPro: 5.195 ± 0.042	3.29SerGln: 3.29 ± 0.024	5.554SerArg: 5.554 ± 0.033	10.686SerSer: 10.686 ± 0.071	5.128SerThr: 5.128 ± 0.029	5.533SerVal: 5.533 ± 0.027	1.147SerTrp: 1.147 ± 0.012	1.9SerTyr: 1.9 ± 0.013	0.0SerXaa: 0.0 ± 0.0
Thr	4.12ThrAla: 4.12 ± 0.025	0.936ThrCys: 0.936 ± 0.011	2.497ThrAsp: 2.497 ± 0.018	2.978ThrGlu: 2.978 ± 0.022	2.012ThrPhe: 2.012 ± 0.015	3.873ThrGly: 3.873 ± 0.023	1.091ThrHis: 1.091 ± 0.013	2.367ThrIle: 2.367 ± 0.019	2.492ThrLys: 2.492 ± 0.019	4.861ThrLeu: 4.861 ± 0.024	1.194ThrMet: 1.194 ± 0.012	1.806ThrAsn: 1.806 ± 0.017	3.094ThrPro: 3.094 ± 0.028	1.78ThrGln: 1.78 ± 0.016	2.937ThrArg: 2.937 ± 0.023	5.132ThrSer: 5.132 ± 0.032	3.102ThrThr: 3.102 ± 0.022	3.608ThrVal: 3.608 ± 0.021	0.684ThrTrp: 0.684 ± 0.009	1.279ThrTyr: 1.279 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	5.605ValAla: 5.605 ± 0.026	1.205ValCys: 1.205 ± 0.014	3.932ValAsp: 3.932 ± 0.019	4.731ValGlu: 4.731 ± 0.027	2.406ValPhe: 2.406 ± 0.018	4.552ValGly: 4.552 ± 0.026	1.62ValHis: 1.62 ± 0.012	2.939ValIle: 2.939 ± 0.02	3.577ValLys: 3.577 ± 0.022	6.566ValLeu: 6.566 ± 0.03	1.525ValMet: 1.525 ± 0.013	2.362ValAsn: 2.362 ± 0.019	3.649ValPro: 3.649 ± 0.03	2.766ValGln: 2.766 ± 0.018	3.844ValArg: 3.844 ± 0.024	5.367ValSer: 5.367 ± 0.028	3.535ValThr: 3.535 ± 0.023	5.286ValVal: 5.286 ± 0.028	0.818ValTrp: 0.818 ± 0.011	1.759ValTyr: 1.759 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.879TrpAla: 0.879 ± 0.011	0.239TrpCys: 0.239 ± 0.005	0.693TrpAsp: 0.693 ± 0.01	0.764TrpGlu: 0.764 ± 0.009	0.449TrpPhe: 0.449 ± 0.007	0.8TrpGly: 0.8 ± 0.009	0.308TrpHis: 0.308 ± 0.006	0.656TrpIle: 0.656 ± 0.009	0.805TrpLys: 0.805 ± 0.01	1.208TrpLeu: 1.208 ± 0.012	0.338TrpMet: 0.338 ± 0.006	0.624TrpAsn: 0.624 ± 0.01	0.593TrpPro: 0.593 ± 0.009	0.553TrpGln: 0.553 ± 0.008	0.984TrpArg: 0.984 ± 0.012	1.051TrpSer: 1.051 ± 0.011	0.78TrpThr: 0.78 ± 0.011	0.73TrpVal: 0.73 ± 0.01	0.247TrpTrp: 0.247 ± 0.006	0.331TrpTyr: 0.331 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.679TyrAla: 1.679 ± 0.014	0.479TyrCys: 0.479 ± 0.007	1.396TyrAsp: 1.396 ± 0.015	1.462TyrGlu: 1.462 ± 0.014	1.049TyrPhe: 1.049 ± 0.012	1.872TyrGly: 1.872 ± 0.019	0.612TyrHis: 0.612 ± 0.008	1.136TyrIle: 1.136 ± 0.013	1.229TyrLys: 1.229 ± 0.013	2.374TyrLeu: 2.374 ± 0.019	0.606TyrMet: 0.606 ± 0.009	1.123TyrAsn: 1.123 ± 0.012	1.167TyrPro: 1.167 ± 0.012	0.897TyrGln: 0.897 ± 0.009	1.406TyrArg: 1.406 ± 0.014	1.898TyrSer: 1.898 ± 0.017	1.266TyrThr: 1.266 ± 0.012	1.604TyrVal: 1.604 ± 0.013	0.357TyrTrp: 0.357 ± 0.007	0.776TyrTyr: 0.776 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.005XaaXaa: 0.005 ± 0.002

Statistics based on 21856 proteins (9495625 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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