Amino acid dipepetide frequency for Bacteroides sp. CAG:1060

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.474AlaAla: 7.474 ± 0.144	1.152AlaCys: 1.152 ± 0.053	4.668AlaAsp: 4.668 ± 0.092	5.123AlaGlu: 5.123 ± 0.114	3.327AlaPhe: 3.327 ± 0.09	6.007AlaGly: 6.007 ± 0.114	1.357AlaHis: 1.357 ± 0.05	4.724AlaIle: 4.724 ± 0.104	4.409AlaLys: 4.409 ± 0.102	7.575AlaLeu: 7.575 ± 0.15	2.168AlaMet: 2.168 ± 0.069	2.663AlaAsn: 2.663 ± 0.073	2.657AlaPro: 2.657 ± 0.082	2.415AlaGln: 2.415 ± 0.071	3.484AlaArg: 3.484 ± 0.092	5.46AlaSer: 5.46 ± 0.102	3.511AlaThr: 3.511 ± 0.085	5.829AlaVal: 5.829 ± 0.113	0.784AlaTrp: 0.784 ± 0.048	2.7AlaTyr: 2.7 ± 0.075	0.004AlaXaa: 0.004 ± 0.003
Cys	1.152CysAla: 1.152 ± 0.041	0.246CysCys: 0.246 ± 0.025	0.91CysAsp: 0.91 ± 0.039	0.842CysGlu: 0.842 ± 0.044	0.697CysPhe: 0.697 ± 0.032	1.407CysGly: 1.407 ± 0.052	0.339CysHis: 0.339 ± 0.025	0.948CysIle: 0.948 ± 0.04	0.78CysLys: 0.78 ± 0.044	1.262CysLeu: 1.262 ± 0.056	0.275CysMet: 0.275 ± 0.025	0.579CysAsn: 0.579 ± 0.031	0.641CysPro: 0.641 ± 0.036	0.319CysGln: 0.319 ± 0.023	0.852CysArg: 0.852 ± 0.038	1.055CysSer: 1.055 ± 0.05	0.79CysThr: 0.79 ± 0.041	0.939CysVal: 0.939 ± 0.039	0.149CysTrp: 0.149 ± 0.014	0.54CysTyr: 0.54 ± 0.035	0.0CysXaa: 0.0 ± 0.0
Asp	4.833AspAla: 4.833 ± 0.1	0.846AspCys: 0.846 ± 0.039	2.938AspAsp: 2.938 ± 0.081	3.803AspGlu: 3.803 ± 0.098	2.988AspPhe: 2.988 ± 0.086	4.92AspGly: 4.92 ± 0.114	0.91AspHis: 0.91 ± 0.049	4.6AspIle: 4.6 ± 0.098	4.192AspLys: 4.192 ± 0.089	4.482AspLeu: 4.482 ± 0.103	1.744AspMet: 1.744 ± 0.063	2.791AspAsn: 2.791 ± 0.076	2.22AspPro: 2.22 ± 0.062	1.059AspGln: 1.059 ± 0.048	2.899AspArg: 2.899 ± 0.083	4.051AspSer: 4.051 ± 0.112	2.855AspThr: 2.855 ± 0.073	4.128AspVal: 4.128 ± 0.099	0.778AspTrp: 0.778 ± 0.042	2.857AspTyr: 2.857 ± 0.079	0.0AspXaa: 0.0 ± 0.0
Glu	4.606GluAla: 4.606 ± 0.101	0.815GluCys: 0.815 ± 0.038	3.813GluAsp: 3.813 ± 0.101	4.382GluGlu: 4.382 ± 0.117	2.812GluPhe: 2.812 ± 0.085	4.314GluGly: 4.314 ± 0.102	1.246GluHis: 1.246 ± 0.045	4.389GluIle: 4.389 ± 0.093	4.505GluLys: 4.505 ± 0.11	5.81GluLeu: 5.81 ± 0.12	1.964GluMet: 1.964 ± 0.06	2.967GluAsn: 2.967 ± 0.076	2.063GluPro: 2.063 ± 0.069	2.084GluGln: 2.084 ± 0.066	3.186GluArg: 3.186 ± 0.089	3.822GluSer: 3.822 ± 0.088	2.787GluThr: 2.787 ± 0.074	4.175GluVal: 4.175 ± 0.094	0.799GluTrp: 0.799 ± 0.048	2.723GluTyr: 2.723 ± 0.077	0.0GluXaa: 0.0 ± 0.0
Phe	3.453PheAla: 3.453 ± 0.086	0.751PheCys: 0.751 ± 0.038	2.988PheAsp: 2.988 ± 0.082	2.562PheGlu: 2.562 ± 0.072	2.135PhePhe: 2.135 ± 0.074	3.642PheGly: 3.642 ± 0.092	0.832PheHis: 0.832 ± 0.04	2.708PheIle: 2.708 ± 0.087	2.464PheLys: 2.464 ± 0.078	3.666PheLeu: 3.666 ± 0.091	1.198PheMet: 1.198 ± 0.054	2.119PheAsn: 2.119 ± 0.066	1.736PhePro: 1.736 ± 0.056	1.032PheGln: 1.032 ± 0.045	2.44PheArg: 2.44 ± 0.069	3.602PheSer: 3.602 ± 0.085	2.421PheThr: 2.421 ± 0.067	3.184PheVal: 3.184 ± 0.07	0.528PheTrp: 0.528 ± 0.032	1.633PheTyr: 1.633 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	5.62GlyAla: 5.62 ± 0.122	1.103GlyCys: 1.103 ± 0.048	3.942GlyAsp: 3.942 ± 0.09	4.434GlyGlu: 4.434 ± 0.091	3.296GlyPhe: 3.296 ± 0.08	5.45GlyGly: 5.45 ± 0.144	1.469GlyHis: 1.469 ± 0.057	5.429GlyIle: 5.429 ± 0.104	5.446GlyLys: 5.446 ± 0.109	6.327GlyLeu: 6.327 ± 0.107	2.071GlyMet: 2.071 ± 0.067	3.168GlyAsn: 3.168 ± 0.07	1.786GlyPro: 1.786 ± 0.059	2.09GlyGln: 2.09 ± 0.063	3.78GlyArg: 3.78 ± 0.091	4.668GlySer: 4.668 ± 0.099	4.281GlyThr: 4.281 ± 0.106	5.345GlyVal: 5.345 ± 0.123	0.927GlyTrp: 0.927 ± 0.047	3.271GlyTyr: 3.271 ± 0.089	0.006GlyXaa: 0.006 ± 0.003
His	1.111HisAla: 1.111 ± 0.047	0.364HisCys: 0.364 ± 0.03	0.943HisAsp: 0.943 ± 0.044	0.852HisGlu: 0.852 ± 0.045	0.995HisPhe: 0.995 ± 0.039	1.357HisGly: 1.357 ± 0.049	0.492HisHis: 0.492 ± 0.035	1.604HisIle: 1.604 ± 0.049	1.022HisLys: 1.022 ± 0.041	1.672HisLeu: 1.672 ± 0.063	0.284HisMet: 0.284 ± 0.025	0.834HisAsn: 0.834 ± 0.046	1.01HisPro: 1.01 ± 0.046	0.486HisGln: 0.486 ± 0.03	0.958HisArg: 0.958 ± 0.051	1.268HisSer: 1.268 ± 0.046	0.9HisThr: 0.9 ± 0.041	1.037HisVal: 1.037 ± 0.047	0.209HisTrp: 0.209 ± 0.018	0.83HisTyr: 0.83 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	5.282IleAla: 5.282 ± 0.131	1.161IleCys: 1.161 ± 0.05	4.262IleAsp: 4.262 ± 0.086	4.027IleGlu: 4.027 ± 0.093	2.692IlePhe: 2.692 ± 0.083	4.593IleGly: 4.593 ± 0.101	1.161IleHis: 1.161 ± 0.051	4.206IleIle: 4.206 ± 0.104	3.658IleLys: 3.658 ± 0.092	5.827IleLeu: 5.827 ± 0.119	1.417IleMet: 1.417 ± 0.055	2.733IleAsn: 2.733 ± 0.068	3.224IlePro: 3.224 ± 0.083	1.734IleGln: 1.734 ± 0.052	3.404IleArg: 3.404 ± 0.086	5.293IleSer: 5.293 ± 0.122	3.484IleThr: 3.484 ± 0.089	4.821IleVal: 4.821 ± 0.102	0.699IleTrp: 0.699 ± 0.035	2.41IleTyr: 2.41 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	4.98LysAla: 4.98 ± 0.11	0.627LysCys: 0.627 ± 0.036	4.07LysAsp: 4.07 ± 0.085	4.416LysGlu: 4.416 ± 0.111	2.462LysPhe: 2.462 ± 0.068	4.362LysGly: 4.362 ± 0.106	0.995LysHis: 0.995 ± 0.044	3.791LysIle: 3.791 ± 0.074	4.049LysLys: 4.049 ± 0.093	4.713LysLeu: 4.713 ± 0.087	2.231LysMet: 2.231 ± 0.069	2.785LysAsn: 2.785 ± 0.07	2.175LysPro: 2.175 ± 0.069	1.655LysGln: 1.655 ± 0.056	2.891LysArg: 2.891 ± 0.076	4.024LysSer: 4.024 ± 0.091	3.313LysThr: 3.313 ± 0.08	4.554LysVal: 4.554 ± 0.103	0.813LysTrp: 0.813 ± 0.038	2.948LysTyr: 2.948 ± 0.079	0.0LysXaa: 0.0 ± 0.0
Leu	6.673LeuAla: 6.673 ± 0.116	1.581LeuCys: 1.581 ± 0.059	5.262LeuAsp: 5.262 ± 0.102	5.303LeuGlu: 5.303 ± 0.127	3.784LeuPhe: 3.784 ± 0.102	6.329LeuGly: 6.329 ± 0.123	1.618LeuHis: 1.618 ± 0.059	4.947LeuIle: 4.947 ± 0.118	5.882LeuLys: 5.882 ± 0.108	7.879LeuLeu: 7.879 ± 0.164	2.475LeuMet: 2.475 ± 0.065	3.517LeuAsn: 3.517 ± 0.085	3.925LeuPro: 3.925 ± 0.082	2.475LeuGln: 2.475 ± 0.078	4.405LeuArg: 4.405 ± 0.087	7.631LeuSer: 7.631 ± 0.119	4.455LeuThr: 4.455 ± 0.099	6.075LeuVal: 6.075 ± 0.132	0.921LeuTrp: 0.921 ± 0.048	3.249LeuTyr: 3.249 ± 0.086	0.004LeuXaa: 0.004 ± 0.003
Met	2.187MetAla: 2.187 ± 0.057	0.286MetCys: 0.286 ± 0.025	1.728MetAsp: 1.728 ± 0.051	1.804MetGlu: 1.804 ± 0.06	1.121MetPhe: 1.121 ± 0.051	1.701MetGly: 1.701 ± 0.059	0.457MetHis: 0.457 ± 0.032	1.659MetIle: 1.659 ± 0.061	2.009MetLys: 2.009 ± 0.065	2.502MetLeu: 2.502 ± 0.071	0.898MetMet: 0.898 ± 0.039	1.217MetAsn: 1.217 ± 0.048	1.212MetPro: 1.212 ± 0.05	0.782MetGln: 0.782 ± 0.039	1.438MetArg: 1.438 ± 0.053	1.982MetSer: 1.982 ± 0.068	1.548MetThr: 1.548 ± 0.062	1.782MetVal: 1.782 ± 0.055	0.273MetTrp: 0.273 ± 0.026	0.883MetTyr: 0.883 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	3.426AsnAla: 3.426 ± 0.085	0.559AsnCys: 0.559 ± 0.04	2.222AsnAsp: 2.222 ± 0.071	2.173AsnGlu: 2.173 ± 0.061	1.862AsnPhe: 1.862 ± 0.058	3.458AsnGly: 3.458 ± 0.094	0.745AsnHis: 0.745 ± 0.039	3.199AsnIle: 3.199 ± 0.08	2.259AsnLys: 2.259 ± 0.062	3.755AsnLeu: 3.755 ± 0.087	1.188AsnMet: 1.188 ± 0.043	1.759AsnAsn: 1.759 ± 0.072	2.189AsnPro: 2.189 ± 0.067	0.985AsnGln: 0.985 ± 0.051	1.792AsnArg: 1.792 ± 0.062	2.824AsnSer: 2.824 ± 0.089	2.14AsnThr: 2.14 ± 0.063	2.975AsnVal: 2.975 ± 0.084	0.561AsnTrp: 0.561 ± 0.035	1.835AsnTyr: 1.835 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	2.944ProAla: 2.944 ± 0.094	0.468ProCys: 0.468 ± 0.034	2.853ProAsp: 2.853 ± 0.077	3.755ProGlu: 3.755 ± 0.094	1.877ProPhe: 1.877 ± 0.064	2.874ProGly: 2.874 ± 0.079	0.697ProHis: 0.697 ± 0.038	2.121ProIle: 2.121 ± 0.079	1.844ProLys: 1.844 ± 0.058	3.157ProLeu: 3.157 ± 0.076	1.008ProMet: 1.008 ± 0.05	1.27ProAsn: 1.27 ± 0.056	0.764ProPro: 0.764 ± 0.04	1.411ProGln: 1.411 ± 0.053	1.432ProArg: 1.432 ± 0.061	2.833ProSer: 2.833 ± 0.075	1.715ProThr: 1.715 ± 0.06	3.387ProVal: 3.387 ± 0.08	0.47ProTrp: 0.47 ± 0.039	1.606ProTyr: 1.606 ± 0.057	0.0ProXaa: 0.0 ± 0.0
Gln	2.108GlnAla: 2.108 ± 0.066	0.31GlnCys: 0.31 ± 0.024	1.475GlnAsp: 1.475 ± 0.047	1.703GlnGlu: 1.703 ± 0.064	1.213GlnPhe: 1.213 ± 0.059	1.887GlnGly: 1.887 ± 0.059	0.439GlnHis: 0.439 ± 0.031	1.959GlnIle: 1.959 ± 0.069	1.906GlnLys: 1.906 ± 0.066	2.353GlnLeu: 2.353 ± 0.069	0.859GlnMet: 0.859 ± 0.039	1.277GlnAsn: 1.277 ± 0.049	0.917GlnPro: 0.917 ± 0.041	0.964GlnGln: 0.964 ± 0.054	1.471GlnArg: 1.471 ± 0.052	1.693GlnSer: 1.693 ± 0.059	1.635GlnThr: 1.635 ± 0.058	1.738GlnVal: 1.738 ± 0.072	0.35GlnTrp: 0.35 ± 0.025	1.215GlnTyr: 1.215 ± 0.053	0.0GlnXaa: 0.0 ± 0.0
Arg	3.083ArgAla: 3.083 ± 0.078	0.683ArgCys: 0.683 ± 0.035	2.541ArgAsp: 2.541 ± 0.073	3.218ArgGlu: 3.218 ± 0.084	2.346ArgPhe: 2.346 ± 0.059	2.845ArgGly: 2.845 ± 0.087	1.113ArgHis: 1.113 ± 0.055	3.849ArgIle: 3.849 ± 0.107	3.428ArgLys: 3.428 ± 0.083	4.6ArgLeu: 4.6 ± 0.099	1.589ArgMet: 1.589 ± 0.054	2.268ArgAsn: 2.268 ± 0.064	1.819ArgPro: 1.819 ± 0.066	1.572ArgGln: 1.572 ± 0.064	2.818ArgArg: 2.818 ± 0.076	3.269ArgSer: 3.269 ± 0.089	2.551ArgThr: 2.551 ± 0.07	3.013ArgVal: 3.013 ± 0.084	0.615ArgTrp: 0.615 ± 0.036	2.262ArgTyr: 2.262 ± 0.067	0.0ArgXaa: 0.0 ± 0.0
Ser	5.62SerAla: 5.62 ± 0.114	1.09SerCys: 1.09 ± 0.047	4.49SerAsp: 4.49 ± 0.095	4.513SerGlu: 4.513 ± 0.101	3.449SerPhe: 3.449 ± 0.088	6.002SerGly: 6.002 ± 0.115	1.27SerHis: 1.27 ± 0.049	4.536SerIle: 4.536 ± 0.096	3.836SerLys: 3.836 ± 0.089	6.704SerLeu: 6.704 ± 0.128	1.717SerMet: 1.717 ± 0.061	2.599SerAsn: 2.599 ± 0.089	2.58SerPro: 2.58 ± 0.072	1.79SerGln: 1.79 ± 0.061	3.64SerArg: 3.64 ± 0.086	5.351SerSer: 5.351 ± 0.13	3.458SerThr: 3.458 ± 0.089	5.295SerVal: 5.295 ± 0.099	0.809SerTrp: 0.809 ± 0.045	2.886SerTyr: 2.886 ± 0.082	0.0SerXaa: 0.0 ± 0.0
Thr	3.987ThrAla: 3.987 ± 0.092	0.648ThrCys: 0.648 ± 0.039	3.102ThrAsp: 3.102 ± 0.068	2.891ThrGlu: 2.891 ± 0.071	2.307ThrPhe: 2.307 ± 0.059	4.24ThrGly: 4.24 ± 0.101	0.877ThrHis: 0.877 ± 0.043	3.658ThrIle: 3.658 ± 0.086	2.661ThrLys: 2.661 ± 0.074	5.03ThrLeu: 5.03 ± 0.114	1.181ThrMet: 1.181 ± 0.046	1.835ThrAsn: 1.835 ± 0.063	2.5ThrPro: 2.5 ± 0.071	1.289ThrGln: 1.289 ± 0.05	2.214ThrArg: 2.214 ± 0.068	3.309ThrSer: 3.309 ± 0.088	2.539ThrThr: 2.539 ± 0.081	4.221ThrVal: 4.221 ± 0.093	0.557ThrTrp: 0.557 ± 0.034	2.009ThrTyr: 2.009 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	5.193ValAla: 5.193 ± 0.114	1.219ValCys: 1.219 ± 0.058	4.19ValAsp: 4.19 ± 0.085	4.405ValGlu: 4.405 ± 0.105	3.195ValPhe: 3.195 ± 0.087	4.538ValGly: 4.538 ± 0.107	1.237ValHis: 1.237 ± 0.054	4.552ValIle: 4.552 ± 0.105	4.38ValLys: 4.38 ± 0.11	6.644ValLeu: 6.644 ± 0.115	1.788ValMet: 1.788 ± 0.064	2.988ValAsn: 2.988 ± 0.088	3.017ValPro: 3.017 ± 0.075	1.821ValGln: 1.821 ± 0.058	3.689ValArg: 3.689 ± 0.087	5.688ValSer: 5.688 ± 0.12	3.817ValThr: 3.817 ± 0.093	5.262ValVal: 5.262 ± 0.126	0.821ValTrp: 0.821 ± 0.039	2.489ValTyr: 2.489 ± 0.074	0.004ValXaa: 0.004 ± 0.003
Trp	0.801TrpAla: 0.801 ± 0.04	0.168TrpCys: 0.168 ± 0.017	0.718TrpAsp: 0.718 ± 0.037	0.662TrpGlu: 0.662 ± 0.035	0.505TrpPhe: 0.505 ± 0.034	0.898TrpGly: 0.898 ± 0.045	0.257TrpHis: 0.257 ± 0.023	0.724TrpIle: 0.724 ± 0.041	0.836TrpLys: 0.836 ± 0.042	1.014TrpLeu: 1.014 ± 0.048	0.404TrpMet: 0.404 ± 0.024	0.627TrpAsn: 0.627 ± 0.038	0.292TrpPro: 0.292 ± 0.026	0.403TrpGln: 0.403 ± 0.029	0.598TrpArg: 0.598 ± 0.039	0.73TrpSer: 0.73 ± 0.039	0.701TrpThr: 0.701 ± 0.038	0.672TrpVal: 0.672 ± 0.038	0.259TrpTrp: 0.259 ± 0.024	0.513TrpTyr: 0.513 ± 0.034	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.959TyrAla: 2.959 ± 0.081	0.641TyrCys: 0.641 ± 0.035	2.775TyrAsp: 2.775 ± 0.081	2.394TyrGlu: 2.394 ± 0.07	2.03TyrPhe: 2.03 ± 0.061	3.081TyrGly: 3.081 ± 0.081	0.718TyrHis: 0.718 ± 0.036	2.481TyrIle: 2.481 ± 0.067	2.29TyrLys: 2.29 ± 0.076	3.42TyrLeu: 3.42 ± 0.075	1.006TyrMet: 1.006 ± 0.047	1.91TyrAsn: 1.91 ± 0.063	1.757TyrPro: 1.757 ± 0.055	1.109TyrGln: 1.109 ± 0.045	2.088TyrArg: 2.088 ± 0.073	3.081TyrSer: 3.081 ± 0.081	2.156TyrThr: 2.156 ± 0.067	2.504TyrVal: 2.504 ± 0.073	0.457TyrTrp: 0.457 ± 0.027	1.949TyrTyr: 1.949 ± 0.067	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.002	0.004XaaGly: 0.004 ± 0.003	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.002	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.004XaaArg: 0.004 ± 0.003	0.002XaaSer: 0.002 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.002XaaTrp: 0.002 ± 0.002	0.0XaaTyr: 0.0 ± 0.0	0.025XaaXaa: 0.025 ± 0.009

Statistics based on 1576 proteins (516703 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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