Amino acid dipepetide frequency for Nadsonia fulvescens var. elongata DSM 6958

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.232AlaAla: 5.232 ± 0.08	0.761AlaCys: 0.761 ± 0.018	3.373AlaAsp: 3.373 ± 0.037	3.806AlaGlu: 3.806 ± 0.049	2.588AlaPhe: 2.588 ± 0.037	3.734AlaGly: 3.734 ± 0.049	1.324AlaHis: 1.324 ± 0.023	4.259AlaIle: 4.259 ± 0.048	4.223AlaLys: 4.223 ± 0.054	6.312AlaLeu: 6.312 ± 0.054	1.383AlaMet: 1.383 ± 0.027	3.399AlaAsn: 3.399 ± 0.042	2.97AlaPro: 2.97 ± 0.043	2.551AlaGln: 2.551 ± 0.04	3.201AlaArg: 3.201 ± 0.039	6.286AlaSer: 6.286 ± 0.065	4.133AlaThr: 4.133 ± 0.048	4.102AlaVal: 4.102 ± 0.047	0.649AlaTrp: 0.649 ± 0.018	1.89AlaTyr: 1.89 ± 0.031	0.001AlaXaa: 0.001 ± 0.001
Cys	0.654CysAla: 0.654 ± 0.016	0.202CysCys: 0.202 ± 0.009	0.692CysAsp: 0.692 ± 0.015	0.611CysGlu: 0.611 ± 0.015	0.545CysPhe: 0.545 ± 0.014	0.837CysGly: 0.837 ± 0.02	0.315CysHis: 0.315 ± 0.012	0.764CysIle: 0.764 ± 0.016	0.59CysLys: 0.59 ± 0.015	1.17CysLeu: 1.17 ± 0.022	0.233CysMet: 0.233 ± 0.01	0.504CysAsn: 0.504 ± 0.016	0.526CysPro: 0.526 ± 0.015	0.453CysGln: 0.453 ± 0.015	0.55CysArg: 0.55 ± 0.014	0.903CysSer: 0.903 ± 0.021	0.598CysThr: 0.598 ± 0.016	0.731CysVal: 0.731 ± 0.018	0.124CysTrp: 0.124 ± 0.007	0.372CysTyr: 0.372 ± 0.014	0.001CysXaa: 0.001 ± 0.001
Asp	3.362AspAla: 3.362 ± 0.037	0.616AspCys: 0.616 ± 0.016	4.43AspAsp: 4.43 ± 0.06	4.425AspGlu: 4.425 ± 0.057	2.571AspPhe: 2.571 ± 0.026	3.049AspGly: 3.049 ± 0.044	1.23AspHis: 1.23 ± 0.02	4.245AspIle: 4.245 ± 0.042	3.133AspLys: 3.133 ± 0.031	5.397AspLeu: 5.397 ± 0.044	1.175AspMet: 1.175 ± 0.022	3.34AspAsn: 3.34 ± 0.034	2.563AspPro: 2.563 ± 0.034	1.976AspGln: 1.976 ± 0.03	2.398AspArg: 2.398 ± 0.035	5.243AspSer: 5.243 ± 0.059	3.144AspThr: 3.144 ± 0.035	3.131AspVal: 3.131 ± 0.034	0.608AspTrp: 0.608 ± 0.015	2.002AspTyr: 2.002 ± 0.027	0.001AspXaa: 0.001 ± 0.001
Glu	4.084GluAla: 4.084 ± 0.049	0.642GluCys: 0.642 ± 0.017	4.078GluAsp: 4.078 ± 0.051	5.27GluGlu: 5.27 ± 0.081	2.553GluPhe: 2.553 ± 0.031	2.919GluGly: 2.919 ± 0.036	1.117GluHis: 1.117 ± 0.021	4.205GluIle: 4.205 ± 0.039	4.451GluLys: 4.451 ± 0.055	5.765GluLeu: 5.765 ± 0.06	1.296GluMet: 1.296 ± 0.021	3.651GluAsn: 3.651 ± 0.047	2.124GluPro: 2.124 ± 0.033	2.213GluGln: 2.213 ± 0.037	2.95GluArg: 2.95 ± 0.045	5.166GluSer: 5.166 ± 0.056	3.585GluThr: 3.585 ± 0.039	3.423GluVal: 3.423 ± 0.042	0.703GluTrp: 0.703 ± 0.018	1.963GluTyr: 1.963 ± 0.029	0.001GluXaa: 0.001 ± 0.001
Phe	2.536PheAla: 2.536 ± 0.036	0.54PheCys: 0.54 ± 0.015	2.701PheAsp: 2.701 ± 0.034	2.54PheGlu: 2.54 ± 0.03	1.837PhePhe: 1.837 ± 0.035	2.737PheGly: 2.737 ± 0.045	0.855PheHis: 0.855 ± 0.018	2.535PheIle: 2.535 ± 0.031	2.361PheLys: 2.361 ± 0.032	3.704PheLeu: 3.704 ± 0.042	0.881PheMet: 0.881 ± 0.02	2.277PheAsn: 2.277 ± 0.035	1.707PhePro: 1.707 ± 0.025	1.433PheGln: 1.433 ± 0.024	1.696PheArg: 1.696 ± 0.026	3.84PheSer: 3.84 ± 0.046	2.353PheThr: 2.353 ± 0.037	2.493PheVal: 2.493 ± 0.036	0.496PheTrp: 0.496 ± 0.014	1.348PheTyr: 1.348 ± 0.025	0.001PheXaa: 0.001 ± 0.001
Gly	3.506GlyAla: 3.506 ± 0.051	0.707GlyCys: 0.707 ± 0.017	3.053GlyAsp: 3.053 ± 0.039	2.933GlyGlu: 2.933 ± 0.036	2.632GlyPhe: 2.632 ± 0.037	3.91GlyGly: 3.91 ± 0.065	1.351GlyHis: 1.351 ± 0.025	3.758GlyIle: 3.758 ± 0.044	3.423GlyLys: 3.423 ± 0.038	5.305GlyLeu: 5.305 ± 0.054	1.146GlyMet: 1.146 ± 0.026	2.917GlyAsn: 2.917 ± 0.036	2.085GlyPro: 2.085 ± 0.034	2.004GlyGln: 2.004 ± 0.031	2.513GlyArg: 2.513 ± 0.036	5.316GlySer: 5.316 ± 0.051	3.146GlyThr: 3.146 ± 0.04	3.6GlyVal: 3.6 ± 0.048	0.715GlyTrp: 0.715 ± 0.016	1.982GlyTyr: 1.982 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	1.242HisAla: 1.242 ± 0.024	0.268HisCys: 0.268 ± 0.01	1.216HisAsp: 1.216 ± 0.028	1.252HisGlu: 1.252 ± 0.022	0.907HisPhe: 0.907 ± 0.018	1.283HisGly: 1.283 ± 0.023	0.824HisHis: 0.824 ± 0.031	1.416HisIle: 1.416 ± 0.022	1.148HisLys: 1.148 ± 0.021	2.004HisLeu: 2.004 ± 0.027	0.406HisMet: 0.406 ± 0.013	1.275HisAsn: 1.275 ± 0.027	1.213HisPro: 1.213 ± 0.023	1.057HisGln: 1.057 ± 0.029	1.117HisArg: 1.117 ± 0.023	1.949HisSer: 1.949 ± 0.028	1.21HisThr: 1.21 ± 0.023	1.128HisVal: 1.128 ± 0.021	0.223HisTrp: 0.223 ± 0.01	0.743HisTyr: 0.743 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.107IleAla: 4.107 ± 0.045	0.814IleCys: 0.814 ± 0.02	3.914IleAsp: 3.914 ± 0.036	3.988IleGlu: 3.988 ± 0.04	2.579IlePhe: 2.579 ± 0.04	3.361IleGly: 3.361 ± 0.04	1.384IleHis: 1.384 ± 0.023	4.078IleIle: 4.078 ± 0.042	4.103IleLys: 4.103 ± 0.038	5.763IleLeu: 5.763 ± 0.06	1.327IleMet: 1.327 ± 0.022	3.661IleAsn: 3.661 ± 0.035	3.302IlePro: 3.302 ± 0.04	2.319IleGln: 2.319 ± 0.032	2.889IleArg: 2.889 ± 0.035	5.978IleSer: 5.978 ± 0.05	3.709IleThr: 3.709 ± 0.036	3.692IleVal: 3.692 ± 0.04	0.709IleTrp: 0.709 ± 0.017	1.999IleTyr: 1.999 ± 0.024	0.001IleXaa: 0.001 ± 0.001
Lys	4.127LysAla: 4.127 ± 0.049	0.635LysCys: 0.635 ± 0.017	3.343LysAsp: 3.343 ± 0.034	4.05LysGlu: 4.05 ± 0.048	2.373LysPhe: 2.373 ± 0.029	2.823LysGly: 2.823 ± 0.033	1.227LysHis: 1.227 ± 0.024	3.904LysIle: 3.904 ± 0.033	4.766LysLys: 4.766 ± 0.068	5.814LysLeu: 5.814 ± 0.057	1.21LysMet: 1.21 ± 0.021	3.45LysAsn: 3.45 ± 0.039	2.924LysPro: 2.924 ± 0.04	2.294LysGln: 2.294 ± 0.031	3.505LysArg: 3.505 ± 0.042	5.458LysSer: 5.458 ± 0.055	3.626LysThr: 3.626 ± 0.04	3.603LysVal: 3.603 ± 0.04	0.675LysTrp: 0.675 ± 0.016	2.092LysTyr: 2.092 ± 0.029	0.001LysXaa: 0.001 ± 0.001
Leu	6.839LeuAla: 6.839 ± 0.068	1.131LeuCys: 1.131 ± 0.024	5.372LeuAsp: 5.372 ± 0.051	5.783LeuGlu: 5.783 ± 0.056	3.686LeuPhe: 3.686 ± 0.045	5.011LeuGly: 5.011 ± 0.054	1.917LeuHis: 1.917 ± 0.03	5.446LeuIle: 5.446 ± 0.055	5.926LeuLys: 5.926 ± 0.055	8.381LeuLeu: 8.381 ± 0.087	1.837LeuMet: 1.837 ± 0.025	4.937LeuAsn: 4.937 ± 0.044	4.681LeuPro: 4.681 ± 0.045	3.625LeuGln: 3.625 ± 0.046	4.488LeuArg: 4.488 ± 0.044	8.657LeuSer: 8.657 ± 0.072	5.244LeuThr: 5.244 ± 0.051	5.615LeuVal: 5.615 ± 0.052	0.937LeuTrp: 0.937 ± 0.024	2.681LeuTyr: 2.681 ± 0.039	0.001LeuXaa: 0.001 ± 0.001
Met	1.72MetAla: 1.72 ± 0.024	0.233MetCys: 0.233 ± 0.009	1.218MetAsp: 1.218 ± 0.024	1.169MetGlu: 1.169 ± 0.024	0.741MetPhe: 0.741 ± 0.018	1.287MetGly: 1.287 ± 0.023	0.316MetHis: 0.316 ± 0.011	1.262MetIle: 1.262 ± 0.022	1.233MetLys: 1.233 ± 0.021	1.642MetLeu: 1.642 ± 0.025	0.49MetMet: 0.49 ± 0.016	1.127MetAsn: 1.127 ± 0.025	0.97MetPro: 0.97 ± 0.02	0.573MetGln: 0.573 ± 0.016	0.899MetArg: 0.899 ± 0.021	2.077MetSer: 2.077 ± 0.03	1.222MetThr: 1.222 ± 0.021	1.338MetVal: 1.338 ± 0.022	0.181MetTrp: 0.181 ± 0.009	0.538MetTyr: 0.538 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.078AsnAla: 3.078 ± 0.036	0.595AsnCys: 0.595 ± 0.017	3.458AsnAsp: 3.458 ± 0.043	3.431AsnGlu: 3.431 ± 0.038	2.085AsnPhe: 2.085 ± 0.027	3.363AsnGly: 3.363 ± 0.046	1.335AsnHis: 1.335 ± 0.024	3.735AsnIle: 3.735 ± 0.039	3.108AsnLys: 3.108 ± 0.039	4.689AsnLeu: 4.689 ± 0.044	1.18AsnMet: 1.18 ± 0.024	4.272AsnAsn: 4.272 ± 0.088	2.667AsnPro: 2.667 ± 0.039	2.226AsnGln: 2.226 ± 0.039	2.362AsnArg: 2.362 ± 0.033	5.559AsnSer: 5.559 ± 0.074	3.278AsnThr: 3.278 ± 0.039	2.849AsnVal: 2.849 ± 0.03	0.56AsnTrp: 0.56 ± 0.015	1.867AsnTyr: 1.867 ± 0.026	0.001AsnXaa: 0.001 ± 0.0
Pro	3.236ProAla: 3.236 ± 0.045	0.386ProCys: 0.386 ± 0.014	2.266ProAsp: 2.266 ± 0.032	3.141ProGlu: 3.141 ± 0.032	1.886ProPhe: 1.886 ± 0.025	2.476ProGly: 2.476 ± 0.033	1.034ProHis: 1.034 ± 0.02	2.978ProIle: 2.978 ± 0.035	2.644ProLys: 2.644 ± 0.034	4.265ProLeu: 4.265 ± 0.044	0.873ProMet: 0.873 ± 0.021	2.371ProAsn: 2.371 ± 0.037	2.659ProPro: 2.659 ± 0.057	1.845ProGln: 1.845 ± 0.034	2.057ProArg: 2.057 ± 0.03	4.988ProSer: 4.988 ± 0.066	3.227ProThr: 3.227 ± 0.039	3.248ProVal: 3.248 ± 0.037	0.422ProTrp: 0.422 ± 0.014	1.371ProTyr: 1.371 ± 0.024	0.001ProXaa: 0.001 ± 0.001
Gln	2.653GlnAla: 2.653 ± 0.042	0.374GlnCys: 0.374 ± 0.012	1.876GlnAsp: 1.876 ± 0.029	2.293GlnGlu: 2.293 ± 0.032	1.545GlnPhe: 1.545 ± 0.025	1.908GlnGly: 1.908 ± 0.033	0.982GlnHis: 0.982 ± 0.028	2.334GlnIle: 2.334 ± 0.033	2.361GlnLys: 2.361 ± 0.031	3.75GlnLeu: 3.75 ± 0.047	0.789GlnMet: 0.789 ± 0.018	2.084GlnAsn: 2.084 ± 0.035	1.794GlnPro: 1.794 ± 0.038	3.182GlnGln: 3.182 ± 0.184	1.997GlnArg: 1.997 ± 0.03	3.253GlnSer: 3.253 ± 0.037	2.134GlnThr: 2.134 ± 0.034	2.239GlnVal: 2.239 ± 0.033	0.39GlnTrp: 0.39 ± 0.014	1.298GlnTyr: 1.298 ± 0.024	0.002GlnXaa: 0.002 ± 0.001
Arg	3.164ArgAla: 3.164 ± 0.039	0.524ArgCys: 0.524 ± 0.015	2.679ArgAsp: 2.679 ± 0.037	2.903ArgGlu: 2.903 ± 0.04	1.977ArgPhe: 1.977 ± 0.027	2.594ArgGly: 2.594 ± 0.04	1.106ArgHis: 1.106 ± 0.02	2.842ArgIle: 2.842 ± 0.034	3.203ArgLys: 3.203 ± 0.039	4.603ArgLeu: 4.603 ± 0.045	0.986ArgMet: 0.986 ± 0.021	2.406ArgAsn: 2.406 ± 0.036	2.085ArgPro: 2.085 ± 0.031	2.071ArgGln: 2.071 ± 0.028	3.046ArgArg: 3.046 ± 0.043	4.024ArgSer: 4.024 ± 0.053	2.411ArgThr: 2.411 ± 0.035	2.84ArgVal: 2.84 ± 0.033	0.504ArgTrp: 0.504 ± 0.013	1.524ArgTyr: 1.524 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	5.926SerAla: 5.926 ± 0.056	0.91SerCys: 0.91 ± 0.024	5.088SerAsp: 5.088 ± 0.055	5.076SerGlu: 5.076 ± 0.054	3.755SerPhe: 3.755 ± 0.042	5.29SerGly: 5.29 ± 0.065	2.108SerHis: 2.108 ± 0.037	5.669SerIle: 5.669 ± 0.061	5.509SerLys: 5.509 ± 0.059	8.857SerLeu: 8.857 ± 0.067	1.792SerMet: 1.792 ± 0.028	5.339SerAsn: 5.339 ± 0.071	4.86SerPro: 4.86 ± 0.079	3.68SerGln: 3.68 ± 0.05	4.347SerArg: 4.347 ± 0.055	11.558SerSer: 11.558 ± 0.136	6.433SerThr: 6.433 ± 0.073	5.375SerVal: 5.375 ± 0.046	0.862SerTrp: 0.862 ± 0.019	2.645SerTyr: 2.645 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.039ThrAla: 4.039 ± 0.043	0.642ThrCys: 0.642 ± 0.017	2.975ThrAsp: 2.975 ± 0.034	3.371ThrGlu: 3.371 ± 0.036	2.201ThrPhe: 2.201 ± 0.029	3.588ThrGly: 3.588 ± 0.048	1.213ThrHis: 1.213 ± 0.022	3.845ThrIle: 3.845 ± 0.041	3.622ThrLys: 3.622 ± 0.036	5.365ThrLeu: 5.365 ± 0.05	1.109ThrMet: 1.109 ± 0.02	3.133ThrAsn: 3.133 ± 0.043	3.676ThrPro: 3.676 ± 0.045	2.027ThrGln: 2.027 ± 0.029	2.67ThrArg: 2.67 ± 0.036	5.816ThrSer: 5.816 ± 0.059	4.245ThrThr: 4.245 ± 0.058	3.634ThrVal: 3.634 ± 0.039	0.581ThrTrp: 0.581 ± 0.016	1.63ThrTyr: 1.63 ± 0.025	0.001ThrXaa: 0.001 ± 0.001
Val	4.109ValAla: 4.109 ± 0.047	0.793ValCys: 0.793 ± 0.017	3.62ValAsp: 3.62 ± 0.036	3.687ValGlu: 3.687 ± 0.044	2.548ValPhe: 2.548 ± 0.039	3.305ValGly: 3.305 ± 0.042	1.215ValHis: 1.215 ± 0.022	3.806ValIle: 3.806 ± 0.046	3.665ValLys: 3.665 ± 0.037	5.381ValLeu: 5.381 ± 0.05	1.221ValMet: 1.221 ± 0.02	3.12ValAsn: 3.12 ± 0.036	2.888ValPro: 2.888 ± 0.032	2.01ValGln: 2.01 ± 0.03	2.69ValArg: 2.69 ± 0.032	5.451ValSer: 5.451 ± 0.05	3.402ValThr: 3.402 ± 0.039	3.834ValVal: 3.834 ± 0.044	0.658ValTrp: 0.658 ± 0.019	1.863ValTyr: 1.863 ± 0.031	0.002ValXaa: 0.002 ± 0.001
Trp	0.685TrpAla: 0.685 ± 0.017	0.169TrpCys: 0.169 ± 0.008	0.687TrpAsp: 0.687 ± 0.019	0.582TrpGlu: 0.582 ± 0.014	0.436TrpPhe: 0.436 ± 0.013	0.605TrpGly: 0.605 ± 0.02	0.221TrpHis: 0.221 ± 0.01	0.689TrpIle: 0.689 ± 0.02	0.722TrpLys: 0.722 ± 0.019	0.961TrpLeu: 0.961 ± 0.019	0.237TrpMet: 0.237 ± 0.009	0.615TrpAsn: 0.615 ± 0.016	0.339TrpPro: 0.339 ± 0.012	0.351TrpGln: 0.351 ± 0.01	0.584TrpArg: 0.584 ± 0.016	0.877TrpSer: 0.877 ± 0.021	0.577TrpThr: 0.577 ± 0.017	0.681TrpVal: 0.681 ± 0.018	0.187TrpTrp: 0.187 ± 0.009	0.338TrpTyr: 0.338 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.877TyrAla: 1.877 ± 0.031	0.433TyrCys: 0.433 ± 0.014	1.998TyrAsp: 1.998 ± 0.029	1.845TyrGlu: 1.845 ± 0.026	1.424TyrPhe: 1.424 ± 0.025	1.925TyrGly: 1.925 ± 0.028	0.808TyrHis: 0.808 ± 0.018	1.91TyrIle: 1.91 ± 0.029	1.708TyrLys: 1.708 ± 0.026	3.068TyrLeu: 3.068 ± 0.034	0.662TyrMet: 0.662 ± 0.018	1.821TyrAsn: 1.821 ± 0.025	1.341TyrPro: 1.341 ± 0.023	1.344TyrGln: 1.344 ± 0.027	1.532TyrArg: 1.532 ± 0.026	2.675TyrSer: 2.675 ± 0.037	1.704TyrThr: 1.704 ± 0.026	1.711TyrVal: 1.711 ± 0.027	0.362TyrTrp: 0.362 ± 0.012	1.191TyrTyr: 1.191 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.003XaaGlu: 0.003 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.003XaaLys: 0.003 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.058XaaXaa: 0.058 ± 0.028

Statistics based on 5636 proteins (2669257 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---