Amino acid dipepetide frequency for Changjiang picorna-like virus 14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.543AlaAla: 7.543 ± 4.74
0.359AlaCys: 0.359 ± 0.223
3.951AlaAsp: 3.951 ± 0.096
2.874AlaGlu: 2.874 ± 0.016
3.592AlaPhe: 3.592 ± 0.462
5.747AlaGly: 5.747 ± 1.145
0.718AlaHis: 0.718 ± 0.143
4.31AlaIle: 4.31 ± 0.27
3.233AlaLys: 3.233 ± 0.239
5.747AlaLeu: 5.747 ± 0.032
1.796AlaMet: 1.796 ± 0.525
4.31AlaAsn: 4.31 ± 2.625
3.233AlaPro: 3.233 ± 1.527
3.951AlaGln: 3.951 ± 0.684
3.951AlaArg: 3.951 ± 0.684
7.543AlaSer: 7.543 ± 0.031
8.98AlaThr: 8.98 ± 3.261
6.106AlaVal: 6.106 ± 0.922
1.796AlaTrp: 1.796 ± 0.652
2.155AlaTyr: 2.155 ± 1.607
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.718CysAsp: 0.718 ± 0.445
1.078CysGlu: 1.078 ± 0.668
1.437CysPhe: 1.437 ± 0.286
1.078CysGly: 1.078 ± 0.08
0.359CysHis: 0.359 ± 0.223
0.0CysIle: 0.0 ± 0.0
1.078CysLys: 1.078 ± 0.509
0.359CysLeu: 0.359 ± 0.223
0.0CysMet: 0.0 ± 0.0
0.718CysAsn: 0.718 ± 0.143
0.359CysPro: 0.359 ± 0.366
0.359CysGln: 0.359 ± 0.223
0.718CysArg: 0.718 ± 0.445
0.359CysSer: 0.359 ± 0.366
0.359CysThr: 0.359 ± 0.223
0.718CysVal: 0.718 ± 0.445
0.0CysTrp: 0.0 ± 0.0
0.718CysTyr: 0.718 ± 0.143
0.0CysXaa: 0.0 ± 0.0
Asp
2.514AspAla: 2.514 ± 0.382
1.796AspCys: 1.796 ± 0.525
4.31AspAsp: 4.31 ± 0.859
2.514AspGlu: 2.514 ± 0.207
3.233AspPhe: 3.233 ± 1.416
2.514AspGly: 2.514 ± 0.795
1.437AspHis: 1.437 ± 0.302
4.67AspIle: 4.67 ± 0.047
2.155AspLys: 2.155 ± 0.748
3.233AspLeu: 3.233 ± 0.827
1.437AspMet: 1.437 ± 0.875
3.951AspAsn: 3.951 ± 0.096
4.31AspPro: 4.31 ± 0.859
1.078AspGln: 1.078 ± 0.509
1.437AspArg: 1.437 ± 0.286
2.874AspSer: 2.874 ± 1.161
3.592AspThr: 3.592 ± 0.127
2.874AspVal: 2.874 ± 0.016
1.796AspTrp: 1.796 ± 1.114
2.155AspTyr: 2.155 ± 0.429
0.0AspXaa: 0.0 ± 0.0
Glu
5.388GluAla: 5.388 ± 0.398
0.359GluCys: 0.359 ± 0.223
3.233GluAsp: 3.233 ± 0.239
3.592GluGlu: 3.592 ± 1.05
3.233GluPhe: 3.233 ± 1.416
2.514GluGly: 2.514 ± 1.559
0.718GluHis: 0.718 ± 0.445
0.718GluIle: 0.718 ± 0.143
2.514GluLys: 2.514 ± 0.971
8.98GluLeu: 8.98 ± 2.037
1.078GluMet: 1.078 ± 0.08
2.155GluAsn: 2.155 ± 0.748
4.31GluPro: 4.31 ± 0.859
3.233GluGln: 3.233 ± 0.239
2.874GluArg: 2.874 ± 0.016
2.155GluSer: 2.155 ± 0.748
1.796GluThr: 1.796 ± 0.525
3.233GluVal: 3.233 ± 0.827
0.359GluTrp: 0.359 ± 0.223
0.718GluTyr: 0.718 ± 0.445
0.0GluXaa: 0.0 ± 0.0
Phe
2.874PheAla: 2.874 ± 1.75
0.718PheCys: 0.718 ± 0.445
2.155PheAsp: 2.155 ± 0.429
4.67PheGlu: 4.67 ± 0.636
1.796PhePhe: 1.796 ± 1.114
3.951PheGly: 3.951 ± 1.082
1.078PheHis: 1.078 ± 0.08
1.437PheIle: 1.437 ± 0.302
3.951PheLys: 3.951 ± 1.273
3.233PheLeu: 3.233 ± 0.827
1.437PheMet: 1.437 ± 1.006
0.359PheAsn: 0.359 ± 0.223
1.796PhePro: 1.796 ± 0.652
1.796PheGln: 1.796 ± 0.652
2.155PheArg: 2.155 ± 0.159
4.31PheSer: 4.31 ± 0.907
3.233PheThr: 3.233 ± 1.416
4.31PheVal: 4.31 ± 0.318
0.0PheTrp: 0.0 ± 0.0
0.718PheTyr: 0.718 ± 0.445
0.0PheXaa: 0.0 ± 0.0
Gly
5.388GlyAla: 5.388 ± 0.779
0.359GlyCys: 0.359 ± 0.366
3.951GlyAsp: 3.951 ± 0.684
5.029GlyGlu: 5.029 ± 0.764
2.514GlyPhe: 2.514 ± 0.382
3.951GlyGly: 3.951 ± 0.684
0.359GlyHis: 0.359 ± 0.223
4.31GlyIle: 4.31 ± 1.496
2.155GlyLys: 2.155 ± 0.748
7.902GlyLeu: 7.902 ± 0.986
2.514GlyMet: 2.514 ± 0.971
2.514GlyAsn: 2.514 ± 0.207
1.437GlyPro: 1.437 ± 0.286
5.029GlyGln: 5.029 ± 2.179
3.951GlyArg: 3.951 ± 0.493
4.31GlySer: 4.31 ± 0.859
4.67GlyThr: 4.67 ± 0.636
3.233GlyVal: 3.233 ± 0.827
0.359GlyTrp: 0.359 ± 0.366
1.796GlyTyr: 1.796 ± 0.525
0.0GlyXaa: 0.0 ± 0.0
His
1.078HisAla: 1.078 ± 0.509
0.0HisCys: 0.0 ± 0.0
0.718HisAsp: 0.718 ± 0.143
0.718HisGlu: 0.718 ± 0.445
1.437HisPhe: 1.437 ± 0.302
1.796HisGly: 1.796 ± 0.064
0.0HisHis: 0.0 ± 0.0
1.437HisIle: 1.437 ± 0.302
1.078HisLys: 1.078 ± 0.08
1.796HisLeu: 1.796 ± 0.525
0.359HisMet: 0.359 ± 0.223
0.718HisAsn: 0.718 ± 0.143
1.437HisPro: 1.437 ± 0.302
0.718HisGln: 0.718 ± 0.143
1.437HisArg: 1.437 ± 0.891
2.155HisSer: 2.155 ± 0.748
1.437HisThr: 1.437 ± 0.302
1.078HisVal: 1.078 ± 0.08
0.359HisTrp: 0.359 ± 0.223
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
6.825IleAla: 6.825 ± 0.7
1.796IleCys: 1.796 ± 0.652
1.796IleAsp: 1.796 ± 0.064
3.233IleGlu: 3.233 ± 0.239
2.874IlePhe: 2.874 ± 1.193
3.951IleGly: 3.951 ± 0.684
1.078IleHis: 1.078 ± 0.668
2.874IleIle: 2.874 ± 0.573
2.874IleLys: 2.874 ± 0.016
3.951IleLeu: 3.951 ± 0.684
0.718IleMet: 0.718 ± 0.143
2.514IleAsn: 2.514 ± 0.795
3.592IlePro: 3.592 ± 0.462
2.874IleGln: 2.874 ± 0.016
2.514IleArg: 2.514 ± 0.971
3.592IleSer: 3.592 ± 0.127
5.029IleThr: 5.029 ± 1.002
3.951IleVal: 3.951 ± 0.684
0.718IleTrp: 0.718 ± 0.143
1.437IleTyr: 1.437 ± 0.302
0.0IleXaa: 0.0 ± 0.0
Lys
4.67LysAla: 4.67 ± 1.13
0.0LysCys: 0.0 ± 0.0
2.874LysAsp: 2.874 ± 1.782
2.514LysGlu: 2.514 ± 1.559
1.437LysPhe: 1.437 ± 0.286
3.951LysGly: 3.951 ± 1.273
1.796LysHis: 1.796 ± 1.114
3.592LysIle: 3.592 ± 0.462
3.233LysLys: 3.233 ± 2.005
3.951LysLeu: 3.951 ± 0.684
1.437LysMet: 1.437 ± 0.302
2.155LysAsn: 2.155 ± 1.336
1.437LysPro: 1.437 ± 0.875
1.078LysGln: 1.078 ± 0.08
1.437LysArg: 1.437 ± 0.891
4.31LysSer: 4.31 ± 2.084
2.874LysThr: 2.874 ± 0.573
2.514LysVal: 2.514 ± 0.971
1.437LysTrp: 1.437 ± 0.302
3.233LysTyr: 3.233 ± 0.938
0.0LysXaa: 0.0 ± 0.0
Leu
6.466LeuAla: 6.466 ± 1.066
1.437LeuCys: 1.437 ± 0.286
5.388LeuAsp: 5.388 ± 0.398
4.67LeuGlu: 4.67 ± 2.307
3.233LeuPhe: 3.233 ± 1.416
6.106LeuGly: 6.106 ± 0.334
2.874LeuHis: 2.874 ± 1.193
4.67LeuIle: 4.67 ± 1.718
5.747LeuLys: 5.747 ± 1.209
7.902LeuLeu: 7.902 ± 2.546
2.514LeuMet: 2.514 ± 0.58
2.514LeuAsn: 2.514 ± 1.384
4.31LeuPro: 4.31 ± 0.318
3.592LeuGln: 3.592 ± 1.639
4.67LeuArg: 4.67 ± 0.636
5.388LeuSer: 5.388 ± 1.368
4.31LeuThr: 4.31 ± 0.27
6.466LeuVal: 6.466 ± 0.111
1.078LeuTrp: 1.078 ± 0.509
2.514LeuTyr: 2.514 ± 0.382
0.0LeuXaa: 0.0 ± 0.0
Met
2.874MetAla: 2.874 ± 0.573
0.0MetCys: 0.0 ± 0.0
1.437MetAsp: 1.437 ± 0.302
1.078MetGlu: 1.078 ± 0.509
0.718MetPhe: 0.718 ± 0.143
1.796MetGly: 1.796 ± 0.064
0.0MetHis: 0.0 ± 0.0
1.796MetIle: 1.796 ± 0.064
2.514MetLys: 2.514 ± 0.971
1.796MetLeu: 1.796 ± 1.114
1.078MetMet: 1.078 ± 0.668
1.796MetAsn: 1.796 ± 0.525
1.437MetPro: 1.437 ± 0.302
0.0MetGln: 0.0 ± 0.0
1.078MetArg: 1.078 ± 0.509
2.155MetSer: 2.155 ± 0.429
1.796MetThr: 1.796 ± 0.064
1.437MetVal: 1.437 ± 0.891
0.0MetTrp: 0.0 ± 0.0
0.718MetTyr: 0.718 ± 0.445
0.0MetXaa: 0.0 ± 0.0
Asn
3.233AsnAla: 3.233 ± 0.938
0.359AsnCys: 0.359 ± 0.223
2.155AsnAsp: 2.155 ± 0.159
1.078AsnGlu: 1.078 ± 0.08
1.796AsnPhe: 1.796 ± 0.652
2.155AsnGly: 2.155 ± 0.159
1.078AsnHis: 1.078 ± 0.509
2.155AsnIle: 2.155 ± 0.748
1.796AsnLys: 1.796 ± 0.064
5.029AsnLeu: 5.029 ± 0.764
1.796AsnMet: 1.796 ± 0.064
1.078AsnAsn: 1.078 ± 0.509
3.233AsnPro: 3.233 ± 0.239
1.437AsnGln: 1.437 ± 0.875
1.437AsnArg: 1.437 ± 0.286
4.67AsnSer: 4.67 ± 0.636
3.592AsnThr: 3.592 ± 0.462
1.796AsnVal: 1.796 ± 1.241
1.078AsnTrp: 1.078 ± 0.509
2.155AsnTyr: 2.155 ± 1.607
0.0AsnXaa: 0.0 ± 0.0
Pro
3.951ProAla: 3.951 ± 1.67
0.359ProCys: 0.359 ± 0.366
3.592ProAsp: 3.592 ± 0.716
1.796ProGlu: 1.796 ± 1.114
3.233ProPhe: 3.233 ± 1.527
2.874ProGly: 2.874 ± 0.016
0.359ProHis: 0.359 ± 0.223
3.951ProIle: 3.951 ± 0.096
1.078ProLys: 1.078 ± 0.08
4.67ProLeu: 4.67 ± 0.636
2.874ProMet: 2.874 ± 1.161
2.155ProAsn: 2.155 ± 2.195
3.592ProPro: 3.592 ± 2.481
1.796ProGln: 1.796 ± 0.064
1.796ProArg: 1.796 ± 1.241
3.592ProSer: 3.592 ± 0.462
6.466ProThr: 6.466 ± 0.111
3.592ProVal: 3.592 ± 1.893
1.078ProTrp: 1.078 ± 0.08
2.874ProTyr: 2.874 ± 0.573
0.0ProXaa: 0.0 ± 0.0
Gln
2.874GlnAla: 2.874 ± 1.193
0.359GlnCys: 0.359 ± 0.223
2.514GlnAsp: 2.514 ± 0.795
3.233GlnGlu: 3.233 ± 2.005
2.155GlnPhe: 2.155 ± 0.748
2.514GlnGly: 2.514 ± 0.207
1.796GlnHis: 1.796 ± 0.652
2.874GlnIle: 2.874 ± 0.016
2.514GlnLys: 2.514 ± 1.559
2.874GlnLeu: 2.874 ± 0.605
0.359GlnMet: 0.359 ± 0.223
1.796GlnAsn: 1.796 ± 1.241
1.078GlnPro: 1.078 ± 0.509
2.155GlnGln: 2.155 ± 0.159
2.514GlnArg: 2.514 ± 0.382
3.233GlnSer: 3.233 ± 0.35
2.155GlnThr: 2.155 ± 1.018
1.437GlnVal: 1.437 ± 0.286
0.718GlnTrp: 0.718 ± 0.143
2.514GlnTyr: 2.514 ± 0.795
0.0GlnXaa: 0.0 ± 0.0
Arg
3.592ArgAla: 3.592 ± 0.716
0.0ArgCys: 0.0 ± 0.0
3.233ArgAsp: 3.233 ± 0.827
1.796ArgGlu: 1.796 ± 1.114
1.437ArgPhe: 1.437 ± 0.286
5.029ArgGly: 5.029 ± 0.413
1.078ArgHis: 1.078 ± 0.668
4.31ArgIle: 4.31 ± 1.447
2.155ArgLys: 2.155 ± 0.159
5.029ArgLeu: 5.029 ± 0.175
1.078ArgMet: 1.078 ± 0.08
2.155ArgAsn: 2.155 ± 0.748
3.233ArgPro: 3.233 ± 0.938
2.514ArgGln: 2.514 ± 0.971
3.592ArgArg: 3.592 ± 0.462
2.874ArgSer: 2.874 ± 0.605
1.437ArgThr: 1.437 ± 0.891
2.874ArgVal: 2.874 ± 0.605
0.0ArgTrp: 0.0 ± 0.0
1.796ArgTyr: 1.796 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
8.98SerAla: 8.98 ± 0.906
0.718SerCys: 0.718 ± 0.445
2.874SerAsp: 2.874 ± 0.016
1.796SerGlu: 1.796 ± 0.064
3.592SerPhe: 3.592 ± 0.127
5.029SerGly: 5.029 ± 0.175
2.155SerHis: 2.155 ± 0.429
6.106SerIle: 6.106 ± 0.843
4.31SerLys: 4.31 ± 0.907
3.592SerLeu: 3.592 ± 1.05
1.796SerMet: 1.796 ± 0.525
2.874SerAsn: 2.874 ± 0.016
2.874SerPro: 2.874 ± 0.605
1.796SerGln: 1.796 ± 0.064
4.67SerArg: 4.67 ± 1.225
6.825SerSer: 6.825 ± 0.477
5.388SerThr: 5.388 ± 2.545
5.388SerVal: 5.388 ± 0.779
1.078SerTrp: 1.078 ± 0.08
3.951SerTyr: 3.951 ± 1.082
0.0SerXaa: 0.0 ± 0.0
Thr
5.388ThrAla: 5.388 ± 3.134
0.359ThrCys: 0.359 ± 0.366
2.155ThrAsp: 2.155 ± 1.018
5.029ThrGlu: 5.029 ± 0.175
3.592ThrPhe: 3.592 ± 1.304
3.233ThrGly: 3.233 ± 0.35
0.718ThrHis: 0.718 ± 0.732
3.951ThrIle: 3.951 ± 0.493
3.592ThrLys: 3.592 ± 1.05
6.466ThrLeu: 6.466 ± 1.066
0.359ThrMet: 0.359 ± 0.223
5.388ThrAsn: 5.388 ± 0.398
7.184ThrPro: 7.184 ± 2.02
2.514ThrGln: 2.514 ± 0.382
3.951ThrArg: 3.951 ± 1.273
6.106ThrSer: 6.106 ± 0.922
8.261ThrThr: 8.261 ± 3.706
2.874ThrVal: 2.874 ± 1.161
0.718ThrTrp: 0.718 ± 0.143
1.437ThrTyr: 1.437 ± 0.302
0.0ThrXaa: 0.0 ± 0.0
Val
4.31ValAla: 4.31 ± 0.859
0.718ValCys: 0.718 ± 0.445
3.592ValAsp: 3.592 ± 0.716
4.67ValGlu: 4.67 ± 0.047
1.437ValPhe: 1.437 ± 0.302
4.67ValGly: 4.67 ± 0.541
1.796ValHis: 1.796 ± 0.525
2.514ValIle: 2.514 ± 0.382
2.155ValLys: 2.155 ± 0.748
5.029ValLeu: 5.029 ± 0.413
1.078ValMet: 1.078 ± 0.08
1.437ValAsn: 1.437 ± 0.891
4.31ValPro: 4.31 ± 3.213
3.233ValGln: 3.233 ± 0.239
2.514ValArg: 2.514 ± 0.971
6.106ValSer: 6.106 ± 0.334
3.233ValThr: 3.233 ± 0.35
4.31ValVal: 4.31 ± 0.859
0.359ValTrp: 0.359 ± 0.366
3.592ValTyr: 3.592 ± 0.127
0.0ValXaa: 0.0 ± 0.0
Trp
1.078TrpAla: 1.078 ± 0.509
0.359TrpCys: 0.359 ± 0.223
1.437TrpAsp: 1.437 ± 0.286
0.359TrpGlu: 0.359 ± 0.223
1.437TrpPhe: 1.437 ± 0.286
0.718TrpGly: 0.718 ± 0.143
0.0TrpHis: 0.0 ± 0.0
1.078TrpIle: 1.078 ± 0.08
0.0TrpLys: 0.0 ± 0.0
1.796TrpLeu: 1.796 ± 0.525
0.0TrpMet: 0.0 ± 0.0
0.359TrpAsn: 0.359 ± 0.223
0.718TrpPro: 0.718 ± 0.143
0.718TrpGln: 0.718 ± 0.445
0.0TrpArg: 0.0 ± 0.0
1.437TrpSer: 1.437 ± 0.875
1.437TrpThr: 1.437 ± 0.302
0.718TrpVal: 0.718 ± 0.143
0.0TrpTrp: 0.0 ± 0.0
0.718TrpTyr: 0.718 ± 0.143
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.874TyrAla: 2.874 ± 1.75
0.359TyrCys: 0.359 ± 0.223
1.796TyrAsp: 1.796 ± 0.652
1.437TyrGlu: 1.437 ± 0.891
2.155TyrPhe: 2.155 ± 0.429
2.155TyrGly: 2.155 ± 0.429
0.359TyrHis: 0.359 ± 0.223
1.437TyrIle: 1.437 ± 0.286
1.796TyrLys: 1.796 ± 1.114
2.514TyrLeu: 2.514 ± 1.972
1.437TyrMet: 1.437 ± 0.286
2.155TyrAsn: 2.155 ± 1.018
1.796TyrPro: 1.796 ± 0.064
1.796TyrGln: 1.796 ± 0.525
2.514TyrArg: 2.514 ± 0.971
1.796TyrSer: 1.796 ± 0.652
3.233TyrThr: 3.233 ± 0.938
2.155TyrVal: 2.155 ± 0.429
1.437TyrTrp: 1.437 ± 0.302
0.359TyrTyr: 0.359 ± 0.223
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2785 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski