Amino acid dipepetide frequency for Melioribacter roseus (strain JCM 17771 / P3M-2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.549AlaAla: 5.549 ± 0.095
0.551AlaCys: 0.551 ± 0.029
3.593AlaAsp: 3.593 ± 0.063
4.633AlaGlu: 4.633 ± 0.079
3.082AlaPhe: 3.082 ± 0.061
5.342AlaGly: 5.342 ± 0.087
0.979AlaHis: 0.979 ± 0.032
4.719AlaIle: 4.719 ± 0.083
4.105AlaLys: 4.105 ± 0.065
6.618AlaLeu: 6.618 ± 0.096
1.308AlaMet: 1.308 ± 0.044
2.712AlaAsn: 2.712 ± 0.056
2.071AlaPro: 2.071 ± 0.045
1.934AlaGln: 1.934 ± 0.05
2.829AlaArg: 2.829 ± 0.056
3.753AlaSer: 3.753 ± 0.065
2.716AlaThr: 2.716 ± 0.062
4.974AlaVal: 4.974 ± 0.084
0.601AlaTrp: 0.601 ± 0.027
2.491AlaTyr: 2.491 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.445CysAla: 0.445 ± 0.021
0.087CysCys: 0.087 ± 0.01
0.495CysAsp: 0.495 ± 0.022
0.447CysGlu: 0.447 ± 0.021
0.286CysPhe: 0.286 ± 0.017
0.742CysGly: 0.742 ± 0.032
0.241CysHis: 0.241 ± 0.034
0.485CysIle: 0.485 ± 0.027
0.462CysLys: 0.462 ± 0.022
0.484CysLeu: 0.484 ± 0.02
0.138CysMet: 0.138 ± 0.012
0.43CysAsn: 0.43 ± 0.022
0.388CysPro: 0.388 ± 0.022
0.143CysGln: 0.143 ± 0.014
0.353CysArg: 0.353 ± 0.02
0.523CysSer: 0.523 ± 0.029
0.331CysThr: 0.331 ± 0.02
0.453CysVal: 0.453 ± 0.023
0.086CysTrp: 0.086 ± 0.009
0.278CysTyr: 0.278 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.241AspAla: 3.241 ± 0.07
0.399AspCys: 0.399 ± 0.021
2.909AspAsp: 2.909 ± 0.063
4.27AspGlu: 4.27 ± 0.065
3.297AspPhe: 3.297 ± 0.059
3.758AspGly: 3.758 ± 0.081
0.638AspHis: 0.638 ± 0.027
4.944AspIle: 4.944 ± 0.076
4.589AspLys: 4.589 ± 0.071
4.988AspLeu: 4.988 ± 0.085
1.009AspMet: 1.009 ± 0.031
3.17AspAsn: 3.17 ± 0.06
2.193AspPro: 2.193 ± 0.042
1.033AspGln: 1.033 ± 0.034
2.275AspArg: 2.275 ± 0.053
3.533AspSer: 3.533 ± 0.071
2.62AspThr: 2.62 ± 0.05
3.25AspVal: 3.25 ± 0.068
0.723AspTrp: 0.723 ± 0.029
3.077AspTyr: 3.077 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
4.393GluAla: 4.393 ± 0.072
0.407GluCys: 0.407 ± 0.021
3.453GluAsp: 3.453 ± 0.072
5.867GluGlu: 5.867 ± 0.121
3.477GluPhe: 3.477 ± 0.059
4.055GluGly: 4.055 ± 0.071
1.008GluHis: 1.008 ± 0.03
6.973GluIle: 6.973 ± 0.092
6.81GluLys: 6.81 ± 0.114
7.27GluLeu: 7.27 ± 0.092
1.575GluMet: 1.575 ± 0.045
4.721GluAsn: 4.721 ± 0.066
2.035GluPro: 2.035 ± 0.048
1.839GluGln: 1.839 ± 0.051
3.142GluArg: 3.142 ± 0.061
3.829GluSer: 3.829 ± 0.06
3.235GluThr: 3.235 ± 0.065
3.81GluVal: 3.81 ± 0.08
0.689GluTrp: 0.689 ± 0.029
3.064GluTyr: 3.064 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
2.952PheAla: 2.952 ± 0.063
0.389PheCys: 0.389 ± 0.021
3.238PheAsp: 3.238 ± 0.051
3.433PheGlu: 3.433 ± 0.059
2.548PhePhe: 2.548 ± 0.068
3.649PheGly: 3.649 ± 0.068
0.742PheHis: 0.742 ± 0.023
4.233PheIle: 4.233 ± 0.085
3.061PheLys: 3.061 ± 0.056
4.552PheLeu: 4.552 ± 0.085
0.991PheMet: 0.991 ± 0.036
2.984PheAsn: 2.984 ± 0.068
1.742PhePro: 1.742 ± 0.041
1.121PheGln: 1.121 ± 0.034
2.068PheArg: 2.068 ± 0.046
3.514PheSer: 3.514 ± 0.068
2.73PheThr: 2.73 ± 0.054
3.307PheVal: 3.307 ± 0.062
0.567PheTrp: 0.567 ± 0.028
2.453PheTyr: 2.453 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
4.654GlyAla: 4.654 ± 0.084
0.577GlyCys: 0.577 ± 0.031
3.386GlyAsp: 3.386 ± 0.063
4.015GlyGlu: 4.015 ± 0.071
3.502GlyPhe: 3.502 ± 0.069
4.917GlyGly: 4.917 ± 0.1
1.031GlyHis: 1.031 ± 0.034
6.191GlyIle: 6.191 ± 0.091
5.619GlyLys: 5.619 ± 0.082
5.93GlyLeu: 5.93 ± 0.088
1.651GlyMet: 1.651 ± 0.042
3.688GlyAsn: 3.688 ± 0.072
1.414GlyPro: 1.414 ± 0.039
1.519GlyGln: 1.519 ± 0.045
2.676GlyArg: 2.676 ± 0.055
3.839GlySer: 3.839 ± 0.077
3.336GlyThr: 3.336 ± 0.083
4.327GlyVal: 4.327 ± 0.073
0.877GlyTrp: 0.877 ± 0.036
3.211GlyTyr: 3.211 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
0.901HisAla: 0.901 ± 0.034
0.162HisCys: 0.162 ± 0.013
0.793HisAsp: 0.793 ± 0.031
0.893HisGlu: 0.893 ± 0.028
0.887HisPhe: 0.887 ± 0.031
0.984HisGly: 0.984 ± 0.031
0.359HisHis: 0.359 ± 0.024
1.205HisIle: 1.205 ± 0.036
1.074HisLys: 1.074 ± 0.034
1.355HisLeu: 1.355 ± 0.033
0.292HisMet: 0.292 ± 0.016
0.842HisAsn: 0.842 ± 0.03
0.898HisPro: 0.898 ± 0.035
0.393HisGln: 0.393 ± 0.02
0.676HisArg: 0.676 ± 0.026
1.008HisSer: 1.008 ± 0.032
0.852HisThr: 0.852 ± 0.031
0.748HisVal: 0.748 ± 0.028
0.195HisTrp: 0.195 ± 0.014
0.723HisTyr: 0.723 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.797IleAla: 5.797 ± 0.08
0.604IleCys: 0.604 ± 0.023
5.534IleAsp: 5.534 ± 0.074
6.616IleGlu: 6.616 ± 0.104
3.933IlePhe: 3.933 ± 0.077
5.21IleGly: 5.21 ± 0.086
1.261IleHis: 1.261 ± 0.035
7.343IleIle: 7.343 ± 0.11
6.825IleLys: 6.825 ± 0.088
7.78IleLeu: 7.78 ± 0.107
1.514IleMet: 1.514 ± 0.041
5.027IleAsn: 5.027 ± 0.08
3.495IlePro: 3.495 ± 0.061
1.893IleGln: 1.893 ± 0.044
3.456IleArg: 3.456 ± 0.056
5.689IleSer: 5.689 ± 0.088
4.559IleThr: 4.559 ± 0.071
5.359IleVal: 5.359 ± 0.072
0.758IleTrp: 0.758 ± 0.03
3.528IleTyr: 3.528 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
4.429LysAla: 4.429 ± 0.087
0.457LysCys: 0.457 ± 0.029
3.976LysAsp: 3.976 ± 0.076
6.568LysGlu: 6.568 ± 0.092
3.47LysPhe: 3.47 ± 0.055
4.191LysGly: 4.191 ± 0.069
1.085LysHis: 1.085 ± 0.033
7.768LysIle: 7.768 ± 0.095
7.148LysLys: 7.148 ± 0.119
7.289LysLeu: 7.289 ± 0.094
1.881LysMet: 1.881 ± 0.041
5.204LysAsn: 5.204 ± 0.075
2.66LysPro: 2.66 ± 0.05
1.823LysGln: 1.823 ± 0.046
3.299LysArg: 3.299 ± 0.059
4.757LysSer: 4.757 ± 0.079
3.681LysThr: 3.681 ± 0.069
4.346LysVal: 4.346 ± 0.078
0.742LysTrp: 0.742 ± 0.027
3.714LysTyr: 3.714 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
5.823LeuAla: 5.823 ± 0.081
0.627LeuCys: 0.627 ± 0.029
4.676LeuAsp: 4.676 ± 0.075
5.921LeuGlu: 5.921 ± 0.086
5.058LeuPhe: 5.058 ± 0.103
5.594LeuGly: 5.594 ± 0.08
1.37LeuHis: 1.37 ± 0.04
8.547LeuIle: 8.547 ± 0.121
8.026LeuLys: 8.026 ± 0.093
8.968LeuLeu: 8.968 ± 0.139
2.116LeuMet: 2.116 ± 0.051
5.8LeuAsn: 5.8 ± 0.08
3.801LeuPro: 3.801 ± 0.065
2.353LeuGln: 2.353 ± 0.047
4.06LeuArg: 4.06 ± 0.067
6.641LeuSer: 6.641 ± 0.086
4.915LeuThr: 4.915 ± 0.082
4.935LeuVal: 4.935 ± 0.078
0.864LeuTrp: 0.864 ± 0.029
3.518LeuTyr: 3.518 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
1.438MetAla: 1.438 ± 0.039
0.132MetCys: 0.132 ± 0.011
0.928MetAsp: 0.928 ± 0.029
1.246MetGlu: 1.246 ± 0.034
0.829MetPhe: 0.829 ± 0.031
1.332MetGly: 1.332 ± 0.039
0.353MetHis: 0.353 ± 0.021
1.694MetIle: 1.694 ± 0.043
2.304MetLys: 2.304 ± 0.049
1.839MetLeu: 1.839 ± 0.04
0.534MetMet: 0.534 ± 0.027
1.352MetAsn: 1.352 ± 0.037
0.989MetPro: 0.989 ± 0.031
0.549MetGln: 0.549 ± 0.023
0.847MetArg: 0.847 ± 0.028
1.311MetSer: 1.311 ± 0.038
1.128MetThr: 1.128 ± 0.037
1.134MetVal: 1.134 ± 0.033
0.185MetTrp: 0.185 ± 0.012
0.554MetTyr: 0.554 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.424AsnAla: 3.424 ± 0.065
0.475AsnCys: 0.475 ± 0.024
2.99AsnAsp: 2.99 ± 0.064
3.764AsnGlu: 3.764 ± 0.069
3.007AsnPhe: 3.007 ± 0.063
3.769AsnGly: 3.769 ± 0.079
0.812AsnHis: 0.812 ± 0.029
4.922AsnIle: 4.922 ± 0.078
4.382AsnLys: 4.382 ± 0.071
5.774AsnLeu: 5.774 ± 0.08
1.128AsnMet: 1.128 ± 0.031
3.394AsnAsn: 3.394 ± 0.076
2.983AsnPro: 2.983 ± 0.062
1.494AsnGln: 1.494 ± 0.046
2.419AsnArg: 2.419 ± 0.054
3.607AsnSer: 3.607 ± 0.067
2.501AsnThr: 2.501 ± 0.058
3.282AsnVal: 3.282 ± 0.064
0.622AsnTrp: 0.622 ± 0.03
3.103AsnTyr: 3.103 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
2.552ProAla: 2.552 ± 0.05
0.228ProCys: 0.228 ± 0.013
2.826ProAsp: 2.826 ± 0.059
3.666ProGlu: 3.666 ± 0.072
1.933ProPhe: 1.933 ± 0.039
2.664ProGly: 2.664 ± 0.053
0.639ProHis: 0.639 ± 0.025
2.293ProIle: 2.293 ± 0.05
2.053ProLys: 2.053 ± 0.045
3.13ProLeu: 3.13 ± 0.062
0.626ProMet: 0.626 ± 0.026
1.767ProAsn: 1.767 ± 0.046
1.282ProPro: 1.282 ± 0.038
1.066ProGln: 1.066 ± 0.033
1.213ProArg: 1.213 ± 0.035
2.234ProSer: 2.234 ± 0.048
1.653ProThr: 1.653 ± 0.044
3.083ProVal: 3.083 ± 0.053
0.403ProTrp: 0.403 ± 0.022
1.607ProTyr: 1.607 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
1.479GlnAla: 1.479 ± 0.037
0.164GlnCys: 0.164 ± 0.012
1.015GlnAsp: 1.015 ± 0.03
1.502GlnGlu: 1.502 ± 0.042
1.232GlnPhe: 1.232 ± 0.033
1.291GlnGly: 1.291 ± 0.041
0.349GlnHis: 0.349 ± 0.019
2.301GlnIle: 2.301 ± 0.046
2.25GlnLys: 2.25 ± 0.049
2.544GlnLeu: 2.544 ± 0.056
0.644GlnMet: 0.644 ± 0.027
1.686GlnAsn: 1.686 ± 0.041
0.896GlnPro: 0.896 ± 0.033
0.748GlnGln: 0.748 ± 0.03
1.102GlnArg: 1.102 ± 0.036
1.545GlnSer: 1.545 ± 0.037
1.386GlnThr: 1.386 ± 0.038
1.353GlnVal: 1.353 ± 0.04
0.274GlnTrp: 0.274 ± 0.017
1.079GlnTyr: 1.079 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.345ArgAla: 2.345 ± 0.056
0.263ArgCys: 0.263 ± 0.019
2.158ArgAsp: 2.158 ± 0.048
3.076ArgGlu: 3.076 ± 0.056
2.242ArgPhe: 2.242 ± 0.054
2.354ArgGly: 2.354 ± 0.054
0.673ArgHis: 0.673 ± 0.025
4.009ArgIle: 4.009 ± 0.062
3.711ArgLys: 3.711 ± 0.062
4.11ArgLeu: 4.11 ± 0.069
0.997ArgMet: 0.997 ± 0.029
2.551ArgAsn: 2.551 ± 0.057
1.302ArgPro: 1.302 ± 0.042
1.188ArgGln: 1.188 ± 0.038
1.92ArgArg: 1.92 ± 0.052
2.14ArgSer: 2.14 ± 0.052
1.968ArgThr: 1.968 ± 0.048
2.285ArgVal: 2.285 ± 0.05
0.49ArgTrp: 0.49 ± 0.022
1.924ArgTyr: 1.924 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.296SerAla: 4.296 ± 0.074
0.445SerCys: 0.445 ± 0.025
3.713SerAsp: 3.713 ± 0.075
4.355SerGlu: 4.355 ± 0.081
3.18SerPhe: 3.18 ± 0.072
4.835SerGly: 4.835 ± 0.083
1.023SerHis: 1.023 ± 0.038
5.052SerIle: 5.052 ± 0.078
4.251SerLys: 4.251 ± 0.066
6.004SerLeu: 6.004 ± 0.087
1.225SerMet: 1.225 ± 0.035
3.163SerAsn: 3.163 ± 0.065
2.336SerPro: 2.336 ± 0.052
1.646SerGln: 1.646 ± 0.04
2.525SerArg: 2.525 ± 0.056
3.956SerSer: 3.956 ± 0.071
2.794SerThr: 2.794 ± 0.064
4.481SerVal: 4.481 ± 0.061
0.639SerTrp: 0.639 ± 0.028
2.718SerTyr: 2.718 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
3.745ThrAla: 3.745 ± 0.066
0.305ThrCys: 0.305 ± 0.019
2.943ThrAsp: 2.943 ± 0.054
3.207ThrGlu: 3.207 ± 0.067
2.279ThrPhe: 2.279 ± 0.056
4.135ThrGly: 4.135 ± 0.07
0.765ThrHis: 0.765 ± 0.024
4.082ThrIle: 4.082 ± 0.069
3.013ThrLys: 3.013 ± 0.056
4.663ThrLeu: 4.663 ± 0.081
0.837ThrMet: 0.837 ± 0.031
2.474ThrAsn: 2.474 ± 0.06
2.166ThrPro: 2.166 ± 0.042
1.187ThrGln: 1.187 ± 0.029
1.744ThrArg: 1.744 ± 0.049
2.865ThrSer: 2.865 ± 0.06
2.602ThrThr: 2.602 ± 0.057
3.613ThrVal: 3.613 ± 0.088
0.454ThrTrp: 0.454 ± 0.023
1.833ThrTyr: 1.833 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
3.896ValAla: 3.896 ± 0.081
0.574ValCys: 0.574 ± 0.026
3.718ValAsp: 3.718 ± 0.062
4.4ValGlu: 4.4 ± 0.076
3.019ValPhe: 3.019 ± 0.061
3.85ValGly: 3.85 ± 0.075
0.929ValHis: 0.929 ± 0.033
5.491ValIle: 5.491 ± 0.074
4.812ValLys: 4.812 ± 0.081
5.142ValLeu: 5.142 ± 0.086
1.262ValMet: 1.262 ± 0.044
3.488ValAsn: 3.488 ± 0.063
2.26ValPro: 2.26 ± 0.051
1.363ValGln: 1.363 ± 0.037
2.553ValArg: 2.553 ± 0.057
4.153ValSer: 4.153 ± 0.065
3.215ValThr: 3.215 ± 0.078
4.137ValVal: 4.137 ± 0.069
0.683ValTrp: 0.683 ± 0.027
2.851ValTyr: 2.851 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.626TrpAla: 0.626 ± 0.03
0.082TrpCys: 0.082 ± 0.009
0.62TrpAsp: 0.62 ± 0.025
0.706TrpGlu: 0.706 ± 0.029
0.475TrpPhe: 0.475 ± 0.024
0.757TrpGly: 0.757 ± 0.029
0.247TrpHis: 0.247 ± 0.017
0.887TrpIle: 0.887 ± 0.032
0.794TrpLys: 0.794 ± 0.03
0.928TrpLeu: 0.928 ± 0.03
0.224TrpMet: 0.224 ± 0.016
0.744TrpAsn: 0.744 ± 0.03
0.267TrpPro: 0.267 ± 0.016
0.382TrpGln: 0.382 ± 0.021
0.486TrpArg: 0.486 ± 0.025
0.622TrpSer: 0.622 ± 0.028
0.52TrpThr: 0.52 ± 0.025
0.536TrpVal: 0.536 ± 0.026
0.184TrpTrp: 0.184 ± 0.013
0.472TrpTyr: 0.472 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.573TyrAla: 2.573 ± 0.054
0.37TyrCys: 0.37 ± 0.019
2.948TyrAsp: 2.948 ± 0.061
3.067TyrGlu: 3.067 ± 0.065
2.537TyrPhe: 2.537 ± 0.059
2.928TyrGly: 2.928 ± 0.054
0.734TyrHis: 0.734 ± 0.028
3.041TyrIle: 3.041 ± 0.061
3.201TyrLys: 3.201 ± 0.062
4.242TyrLeu: 4.242 ± 0.077
0.726TyrMet: 0.726 ± 0.025
2.656TyrAsn: 2.656 ± 0.058
1.741TyrPro: 1.741 ± 0.05
1.166TyrGln: 1.166 ± 0.036
2.063TyrArg: 2.063 ± 0.046
3.118TyrSer: 3.118 ± 0.068
2.173TyrThr: 2.173 ± 0.056
2.384TyrVal: 2.384 ± 0.05
0.528TyrTrp: 0.528 ± 0.03
2.322TyrTyr: 2.322 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2833 proteins (1007411 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski