Amino acid dipepetide frequency for Streptomyces kanasensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.921AlaAla: 23.921 ± 0.217	1.069AlaCys: 1.069 ± 0.03	8.728AlaAsp: 8.728 ± 0.081	8.801AlaGlu: 8.801 ± 0.11	3.49AlaPhe: 3.49 ± 0.048	14.344AlaGly: 14.344 ± 0.108	3.192AlaHis: 3.192 ± 0.04	2.939AlaIle: 2.939 ± 0.049	2.539AlaLys: 2.539 ± 0.047	14.908AlaLeu: 14.908 ± 0.127	2.479AlaMet: 2.479 ± 0.04	1.76AlaAsn: 1.76 ± 0.037	8.382AlaPro: 8.382 ± 0.101	3.53AlaGln: 3.53 ± 0.055	11.615AlaArg: 11.615 ± 0.102	5.641AlaSer: 5.641 ± 0.059	7.399AlaThr: 7.399 ± 0.071	13.238AlaVal: 13.238 ± 0.131	2.026AlaTrp: 2.026 ± 0.033	2.975AlaTyr: 2.975 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.165CysAla: 1.165 ± 0.026	0.097CysCys: 0.097 ± 0.007	0.489CysAsp: 0.489 ± 0.017	0.403CysGlu: 0.403 ± 0.016	0.213CysPhe: 0.213 ± 0.012	1.025CysGly: 1.025 ± 0.027	0.197CysHis: 0.197 ± 0.01	0.127CysIle: 0.127 ± 0.008	0.097CysLys: 0.097 ± 0.008	0.743CysLeu: 0.743 ± 0.022	0.101CysMet: 0.101 ± 0.008	0.128CysAsn: 0.128 ± 0.008	0.52CysPro: 0.52 ± 0.019	0.14CysGln: 0.14 ± 0.009	0.679CysArg: 0.679 ± 0.02	0.419CysSer: 0.419 ± 0.017	0.465CysThr: 0.465 ± 0.018	0.702CysVal: 0.702 ± 0.022	0.131CysTrp: 0.131 ± 0.009	0.134CysTyr: 0.134 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.469AspAla: 8.469 ± 0.079	0.428AspCys: 0.428 ± 0.018	3.715AspAsp: 3.715 ± 0.055	3.904AspGlu: 3.904 ± 0.048	1.54AspPhe: 1.54 ± 0.035	7.087AspGly: 7.087 ± 0.076	1.478AspHis: 1.478 ± 0.03	1.587AspIle: 1.587 ± 0.028	1.035AspLys: 1.035 ± 0.027	6.07AspLeu: 6.07 ± 0.067	0.781AspMet: 0.781 ± 0.021	0.835AspAsn: 0.835 ± 0.026	4.799AspPro: 4.799 ± 0.063	1.381AspGln: 1.381 ± 0.031	5.432AspArg: 5.432 ± 0.061	2.084AspSer: 2.084 ± 0.037	3.211AspThr: 3.211 ± 0.047	5.124AspVal: 5.124 ± 0.062	1.011AspTrp: 1.011 ± 0.022	0.981AspTyr: 0.981 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.687GluAla: 7.687 ± 0.09	0.364GluCys: 0.364 ± 0.013	2.807GluAsp: 2.807 ± 0.043	3.639GluGlu: 3.639 ± 0.053	1.303GluPhe: 1.303 ± 0.03	4.437GluGly: 4.437 ± 0.056	1.448GluHis: 1.448 ± 0.032	1.862GluIle: 1.862 ± 0.041	1.307GluLys: 1.307 ± 0.034	6.579GluLeu: 6.579 ± 0.073	0.816GluMet: 0.816 ± 0.024	0.939GluAsn: 0.939 ± 0.024	3.48GluPro: 3.48 ± 0.057	1.972GluGln: 1.972 ± 0.036	5.819GluArg: 5.819 ± 0.064	2.132GluSer: 2.132 ± 0.033	2.773GluThr: 2.773 ± 0.039	4.718GluVal: 4.718 ± 0.063	0.761GluTrp: 0.761 ± 0.022	1.116GluTyr: 1.116 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.597PheAla: 3.597 ± 0.05	0.262PheCys: 0.262 ± 0.011	1.882PheAsp: 1.882 ± 0.037	1.283PheGlu: 1.283 ± 0.028	0.797PhePhe: 0.797 ± 0.024	2.837PheGly: 2.837 ± 0.046	0.611PheHis: 0.611 ± 0.019	0.541PheIle: 0.541 ± 0.019	0.426PheLys: 0.426 ± 0.019	2.521PheLeu: 2.521 ± 0.051	0.363PheMet: 0.363 ± 0.013	0.488PheAsn: 0.488 ± 0.017	1.321PhePro: 1.321 ± 0.027	0.611PheGln: 0.611 ± 0.02	1.83PheArg: 1.83 ± 0.035	1.287PheSer: 1.287 ± 0.026	1.946PheThr: 1.946 ± 0.035	2.158PheVal: 2.158 ± 0.039	0.407PheTrp: 0.407 ± 0.017	0.521PheTyr: 0.521 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	12.543GlyAla: 12.543 ± 0.124	0.909GlyCys: 0.909 ± 0.025	5.632GlyAsp: 5.632 ± 0.068	5.162GlyGlu: 5.162 ± 0.054	2.729GlyPhe: 2.729 ± 0.043	10.016GlyGly: 10.016 ± 0.106	2.436GlyHis: 2.436 ± 0.038	2.964GlyIle: 2.964 ± 0.041	2.177GlyLys: 2.177 ± 0.043	9.33GlyLeu: 9.33 ± 0.085	1.9GlyMet: 1.9 ± 0.035	1.61GlyAsn: 1.61 ± 0.039	5.95GlyPro: 5.95 ± 0.071	2.378GlyGln: 2.378 ± 0.036	8.864GlyArg: 8.864 ± 0.079	5.015GlySer: 5.015 ± 0.063	6.857GlyThr: 6.857 ± 0.075	7.955GlyVal: 7.955 ± 0.077	1.7GlyTrp: 1.7 ± 0.031	2.208GlyTyr: 2.208 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.963HisAla: 2.963 ± 0.04	0.221HisCys: 0.221 ± 0.012	1.396HisAsp: 1.396 ± 0.033	1.203HisGlu: 1.203 ± 0.028	0.629HisPhe: 0.629 ± 0.021	2.534HisGly: 2.534 ± 0.04	0.74HisHis: 0.74 ± 0.02	0.544HisIle: 0.544 ± 0.021	0.32HisLys: 0.32 ± 0.013	2.523HisLeu: 2.523 ± 0.045	0.324HisMet: 0.324 ± 0.012	0.352HisAsn: 0.352 ± 0.017	1.9HisPro: 1.9 ± 0.036	0.644HisGln: 0.644 ± 0.02	2.305HisArg: 2.305 ± 0.038	0.921HisSer: 0.921 ± 0.024	1.396HisThr: 1.396 ± 0.03	1.872HisVal: 1.872 ± 0.03	0.357HisTrp: 0.357 ± 0.014	0.468HisTyr: 0.468 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.026IleAla: 4.026 ± 0.058	0.239IleCys: 0.239 ± 0.013	1.913IleAsp: 1.913 ± 0.033	1.725IleGlu: 1.725 ± 0.035	0.559IlePhe: 0.559 ± 0.018	3.059IleGly: 3.059 ± 0.044	0.556IleHis: 0.556 ± 0.017	0.703IleIle: 0.703 ± 0.021	0.602IleLys: 0.602 ± 0.021	1.97IleLeu: 1.97 ± 0.04	0.397IleMet: 0.397 ± 0.016	0.568IleAsn: 0.568 ± 0.019	1.483IlePro: 1.483 ± 0.032	0.587IleGln: 0.587 ± 0.019	1.98IleArg: 1.98 ± 0.034	1.286IleSer: 1.286 ± 0.028	1.859IleThr: 1.859 ± 0.035	2.355IleVal: 2.355 ± 0.042	0.293IleTrp: 0.293 ± 0.014	0.426IleTyr: 0.426 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.659LysAla: 2.659 ± 0.048	0.095LysCys: 0.095 ± 0.007	1.137LysAsp: 1.137 ± 0.029	1.056LysGlu: 1.056 ± 0.029	0.397LysPhe: 0.397 ± 0.016	1.686LysGly: 1.686 ± 0.032	0.367LysHis: 0.367 ± 0.014	0.718LysIle: 0.718 ± 0.023	0.686LysLys: 0.686 ± 0.026	1.759LysLeu: 1.759 ± 0.034	0.347LysMet: 0.347 ± 0.014	0.451LysAsn: 0.451 ± 0.017	1.222LysPro: 1.222 ± 0.028	0.576LysGln: 0.576 ± 0.02	1.344LysArg: 1.344 ± 0.027	0.898LysSer: 0.898 ± 0.022	1.148LysThr: 1.148 ± 0.031	1.764LysVal: 1.764 ± 0.039	0.216LysTrp: 0.216 ± 0.01	0.392LysTyr: 0.392 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.41LeuAla: 15.41 ± 0.131	0.818LeuCys: 0.818 ± 0.02	6.785LeuAsp: 6.785 ± 0.07	4.714LeuGlu: 4.714 ± 0.057	2.469LeuPhe: 2.469 ± 0.046	9.123LeuGly: 9.123 ± 0.083	2.378LeuHis: 2.378 ± 0.038	2.589LeuIle: 2.589 ± 0.048	1.78LeuLys: 1.78 ± 0.039	11.379LeuLeu: 11.379 ± 0.118	1.559LeuMet: 1.559 ± 0.028	1.444LeuAsn: 1.444 ± 0.029	6.503LeuPro: 6.503 ± 0.077	1.97LeuGln: 1.97 ± 0.035	8.976LeuArg: 8.976 ± 0.086	4.742LeuSer: 4.742 ± 0.056	6.664LeuThr: 6.664 ± 0.072	9.222LeuVal: 9.222 ± 0.085	1.266LeuTrp: 1.266 ± 0.029	1.836LeuTyr: 1.836 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.2MetAla: 2.2 ± 0.039	0.133MetCys: 0.133 ± 0.009	0.876MetAsp: 0.876 ± 0.023	0.756MetGlu: 0.756 ± 0.023	0.424MetPhe: 0.424 ± 0.016	1.291MetGly: 1.291 ± 0.03	0.327MetHis: 0.327 ± 0.013	0.558MetIle: 0.558 ± 0.018	0.373MetLys: 0.373 ± 0.015	1.546MetLeu: 1.546 ± 0.032	0.261MetMet: 0.261 ± 0.014	0.379MetAsn: 0.379 ± 0.015	1.074MetPro: 1.074 ± 0.027	0.381MetGln: 0.381 ± 0.016	1.412MetArg: 1.412 ± 0.027	1.198MetSer: 1.198 ± 0.028	1.466MetThr: 1.466 ± 0.026	1.231MetVal: 1.231 ± 0.027	0.21MetTrp: 0.21 ± 0.011	0.304MetTyr: 0.304 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.004AsnAla: 2.004 ± 0.036	0.138AsnCys: 0.138 ± 0.009	0.871AsnAsp: 0.871 ± 0.024	0.698AsnGlu: 0.698 ± 0.021	0.418AsnPhe: 0.418 ± 0.015	1.687AsnGly: 1.687 ± 0.04	0.378AsnHis: 0.378 ± 0.015	0.511AsnIle: 0.511 ± 0.02	0.363AsnLys: 0.363 ± 0.016	1.446AsnLeu: 1.446 ± 0.029	0.277AsnMet: 0.277 ± 0.013	0.345AsnAsn: 0.345 ± 0.014	1.196AsnPro: 1.196 ± 0.029	0.458AsnGln: 0.458 ± 0.019	1.186AsnArg: 1.186 ± 0.028	0.729AsnSer: 0.729 ± 0.022	1.005AsnThr: 1.005 ± 0.028	1.305AsnVal: 1.305 ± 0.032	0.239AsnTrp: 0.239 ± 0.013	0.341AsnTyr: 0.341 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.889ProAla: 9.889 ± 0.105	0.37ProCys: 0.37 ± 0.017	4.836ProAsp: 4.836 ± 0.061	4.275ProGlu: 4.275 ± 0.054	1.492ProPhe: 1.492 ± 0.033	7.375ProGly: 7.375 ± 0.086	1.469ProHis: 1.469 ± 0.027	1.113ProIle: 1.113 ± 0.028	1.008ProLys: 1.008 ± 0.025	5.465ProLeu: 5.465 ± 0.055	0.982ProMet: 0.982 ± 0.024	0.804ProAsn: 0.804 ± 0.022	4.199ProPro: 4.199 ± 0.066	1.719ProGln: 1.719 ± 0.045	4.503ProArg: 4.503 ± 0.06	3.192ProSer: 3.192 ± 0.053	3.344ProThr: 3.344 ± 0.049	5.843ProVal: 5.843 ± 0.055	0.944ProTrp: 0.944 ± 0.022	1.504ProTyr: 1.504 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.469GlnAla: 3.469 ± 0.054	0.16GlnCys: 0.16 ± 0.01	1.304GlnAsp: 1.304 ± 0.03	1.366GlnGlu: 1.366 ± 0.033	0.582GlnPhe: 0.582 ± 0.019	2.187GlnGly: 2.187 ± 0.046	0.595GlnHis: 0.595 ± 0.022	0.882GlnIle: 0.882 ± 0.023	0.528GlnLys: 0.528 ± 0.019	2.68GlnLeu: 2.68 ± 0.04	0.427GlnMet: 0.427 ± 0.015	0.401GlnAsn: 0.401 ± 0.016	1.622GlnPro: 1.622 ± 0.046	1.095GlnGln: 1.095 ± 0.037	2.227GlnArg: 2.227 ± 0.032	0.993GlnSer: 0.993 ± 0.027	1.173GlnThr: 1.173 ± 0.026	2.209GlnVal: 2.209 ± 0.039	0.437GlnTrp: 0.437 ± 0.015	0.582GlnTyr: 0.582 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	11.107ArgAla: 11.107 ± 0.107	0.688ArgCys: 0.688 ± 0.02	4.836ArgAsp: 4.836 ± 0.058	4.837ArgGlu: 4.837 ± 0.06	2.339ArgPhe: 2.339 ± 0.039	6.6ArgGly: 6.6 ± 0.077	2.331ArgHis: 2.331 ± 0.04	2.995ArgIle: 2.995 ± 0.039	1.521ArgLys: 1.521 ± 0.032	9.284ArgLeu: 9.284 ± 0.082	1.81ArgMet: 1.81 ± 0.029	1.255ArgAsn: 1.255 ± 0.027	5.661ArgPro: 5.661 ± 0.074	2.226ArgGln: 2.226 ± 0.039	8.645ArgArg: 8.645 ± 0.095	3.939ArgSer: 3.939 ± 0.05	5.725ArgThr: 5.725 ± 0.064	6.665ArgVal: 6.665 ± 0.06	1.485ArgTrp: 1.485 ± 0.032	1.906ArgTyr: 1.906 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.164SerAla: 6.164 ± 0.064	0.403SerCys: 0.403 ± 0.016	2.359SerAsp: 2.359 ± 0.035	2.058SerGlu: 2.058 ± 0.037	1.348SerPhe: 1.348 ± 0.032	5.613SerGly: 5.613 ± 0.057	0.961SerHis: 0.961 ± 0.022	1.16SerIle: 1.16 ± 0.027	0.839SerLys: 0.839 ± 0.022	4.406SerLeu: 4.406 ± 0.056	0.873SerMet: 0.873 ± 0.023	0.701SerAsn: 0.701 ± 0.023	3.054SerPro: 3.054 ± 0.046	1.032SerGln: 1.032 ± 0.025	3.542SerArg: 3.542 ± 0.045	2.359SerSer: 2.359 ± 0.04	2.83SerThr: 2.83 ± 0.043	3.944SerVal: 3.944 ± 0.056	0.836SerTrp: 0.836 ± 0.024	1.044SerTyr: 1.044 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	9.491ThrAla: 9.491 ± 0.082	0.427ThrCys: 0.427 ± 0.016	3.633ThrAsp: 3.633 ± 0.061	3.011ThrGlu: 3.011 ± 0.043	1.523ThrPhe: 1.523 ± 0.032	7.201ThrGly: 7.201 ± 0.071	1.232ThrHis: 1.232 ± 0.028	1.457ThrIle: 1.457 ± 0.029	1.022ThrLys: 1.022 ± 0.03	5.538ThrLeu: 5.538 ± 0.056	0.854ThrMet: 0.854 ± 0.023	0.902ThrAsn: 0.902 ± 0.024	4.373ThrPro: 4.373 ± 0.058	1.206ThrGln: 1.206 ± 0.028	4.162ThrArg: 4.162 ± 0.056	2.871ThrSer: 2.871 ± 0.046	3.985ThrThr: 3.985 ± 0.067	6.197ThrVal: 6.197 ± 0.061	0.919ThrTrp: 0.919 ± 0.024	1.35ThrTyr: 1.35 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	11.598ValAla: 11.598 ± 0.096	0.809ValCys: 0.809 ± 0.02	5.367ValAsp: 5.367 ± 0.066	5.014ValGlu: 5.014 ± 0.056	2.368ValPhe: 2.368 ± 0.039	6.813ValGly: 6.813 ± 0.064	2.126ValHis: 2.126 ± 0.037	2.451ValIle: 2.451 ± 0.043	1.635ValLys: 1.635 ± 0.034	9.741ValLeu: 9.741 ± 0.088	1.325ValMet: 1.325 ± 0.026	1.513ValAsn: 1.513 ± 0.034	5.786ValPro: 5.786 ± 0.057	1.913ValGln: 1.913 ± 0.033	7.987ValArg: 7.987 ± 0.071	4.076ValSer: 4.076 ± 0.051	5.845ValThr: 5.845 ± 0.069	8.55ValVal: 8.55 ± 0.092	1.203ValTrp: 1.203 ± 0.028	1.641ValTyr: 1.641 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.717TrpAla: 1.717 ± 0.035	0.165TrpCys: 0.165 ± 0.009	0.834TrpAsp: 0.834 ± 0.026	0.788TrpGlu: 0.788 ± 0.024	0.48TrpPhe: 0.48 ± 0.017	1.084TrpGly: 1.084 ± 0.029	0.383TrpHis: 0.383 ± 0.015	0.498TrpIle: 0.498 ± 0.018	0.32TrpLys: 0.32 ± 0.013	1.763TrpLeu: 1.763 ± 0.032	0.278TrpMet: 0.278 ± 0.012	0.372TrpAsn: 0.372 ± 0.015	0.756TrpPro: 0.756 ± 0.022	0.55TrpGln: 0.55 ± 0.017	1.429TrpArg: 1.429 ± 0.029	0.895TrpSer: 0.895 ± 0.022	1.083TrpThr: 1.083 ± 0.028	1.007TrpVal: 1.007 ± 0.023	0.356TrpTrp: 0.356 ± 0.017	0.366TrpTyr: 0.366 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.9TyrAla: 2.9 ± 0.045	0.176TyrCys: 0.176 ± 0.01	1.553TyrAsp: 1.553 ± 0.041	1.265TyrGlu: 1.265 ± 0.026	0.589TyrPhe: 0.589 ± 0.019	2.335TyrGly: 2.335 ± 0.041	0.408TyrHis: 0.408 ± 0.016	0.387TyrIle: 0.387 ± 0.015	0.338TyrLys: 0.338 ± 0.014	1.976TyrLeu: 1.976 ± 0.037	0.244TyrMet: 0.244 ± 0.011	0.348TyrAsn: 0.348 ± 0.015	1.045TyrPro: 1.045 ± 0.024	0.551TyrGln: 0.551 ± 0.019	1.919TyrArg: 1.919 ± 0.032	0.849TyrSer: 0.849 ± 0.024	1.18TyrThr: 1.18 ± 0.029	1.703TyrVal: 1.703 ± 0.032	0.327TyrTrp: 0.327 ± 0.016	0.419TyrTyr: 0.419 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5622 proteins (1780286 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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