Amino acid dipepetide frequency for Amycolatopsis rhizosphaerae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.269AlaAla: 20.269 ± 0.133	1.01AlaCys: 1.01 ± 0.023	7.581AlaAsp: 7.581 ± 0.056	9.286AlaGlu: 9.286 ± 0.093	3.653AlaPhe: 3.653 ± 0.041	13.603AlaGly: 13.603 ± 0.084	2.696AlaHis: 2.696 ± 0.041	4.281AlaIle: 4.281 ± 0.048	2.887AlaLys: 2.887 ± 0.044	14.461AlaLeu: 14.461 ± 0.095	2.556AlaMet: 2.556 ± 0.034	2.2AlaAsn: 2.2 ± 0.034	6.073AlaPro: 6.073 ± 0.059	3.688AlaGln: 3.688 ± 0.049	10.291AlaArg: 10.291 ± 0.085	5.727AlaSer: 5.727 ± 0.052	7.057AlaThr: 7.057 ± 0.065	11.776AlaVal: 11.776 ± 0.083	1.888AlaTrp: 1.888 ± 0.032	2.436AlaTyr: 2.436 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.988CysAla: 0.988 ± 0.021	0.095CysCys: 0.095 ± 0.007	0.415CysAsp: 0.415 ± 0.014	0.377CysGlu: 0.377 ± 0.013	0.223CysPhe: 0.223 ± 0.01	0.894CysGly: 0.894 ± 0.024	0.204CysHis: 0.204 ± 0.011	0.163CysIle: 0.163 ± 0.009	0.094CysLys: 0.094 ± 0.007	0.769CysLeu: 0.769 ± 0.018	0.091CysMet: 0.091 ± 0.007	0.121CysAsn: 0.121 ± 0.009	0.5CysPro: 0.5 ± 0.015	0.183CysGln: 0.183 ± 0.01	0.601CysArg: 0.601 ± 0.017	0.427CysSer: 0.427 ± 0.014	0.477CysThr: 0.477 ± 0.015	0.61CysVal: 0.61 ± 0.016	0.134CysTrp: 0.134 ± 0.007	0.173CysTyr: 0.173 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	6.823AspAla: 6.823 ± 0.058	0.362AspCys: 0.362 ± 0.012	3.077AspAsp: 3.077 ± 0.045	4.029AspGlu: 4.029 ± 0.049	1.637AspPhe: 1.637 ± 0.026	5.732AspGly: 5.732 ± 0.057	1.358AspHis: 1.358 ± 0.025	1.776AspIle: 1.776 ± 0.035	0.977AspLys: 0.977 ± 0.024	6.225AspLeu: 6.225 ± 0.054	0.687AspMet: 0.687 ± 0.017	0.958AspAsn: 0.958 ± 0.026	4.395AspPro: 4.395 ± 0.046	1.578AspGln: 1.578 ± 0.028	4.875AspArg: 4.875 ± 0.051	2.397AspSer: 2.397 ± 0.038	2.91AspThr: 2.91 ± 0.044	4.585AspVal: 4.585 ± 0.051	0.93AspTrp: 0.93 ± 0.021	1.205AspTyr: 1.205 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.216GluAla: 7.216 ± 0.07	0.333GluCys: 0.333 ± 0.013	2.781GluAsp: 2.781 ± 0.04	3.258GluGlu: 3.258 ± 0.048	1.729GluPhe: 1.729 ± 0.032	3.935GluGly: 3.935 ± 0.049	1.708GluHis: 1.708 ± 0.026	2.596GluIle: 2.596 ± 0.038	1.286GluLys: 1.286 ± 0.03	7.53GluLeu: 7.53 ± 0.075	0.873GluMet: 0.873 ± 0.019	1.105GluAsn: 1.105 ± 0.022	3.535GluPro: 3.535 ± 0.047	2.298GluGln: 2.298 ± 0.035	5.495GluArg: 5.495 ± 0.064	2.45GluSer: 2.45 ± 0.033	2.989GluThr: 2.989 ± 0.041	4.994GluVal: 4.994 ± 0.055	0.784GluTrp: 0.784 ± 0.02	1.057GluTyr: 1.057 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.107PheAla: 4.107 ± 0.044	0.279PheCys: 0.279 ± 0.012	2.136PheAsp: 2.136 ± 0.034	1.492PheGlu: 1.492 ± 0.028	0.948PhePhe: 0.948 ± 0.022	3.486PheGly: 3.486 ± 0.048	0.662PheHis: 0.662 ± 0.018	0.66PheIle: 0.66 ± 0.017	0.405PheLys: 0.405 ± 0.015	2.917PheLeu: 2.917 ± 0.038	0.331PheMet: 0.331 ± 0.012	0.544PheAsn: 0.544 ± 0.016	1.482PhePro: 1.482 ± 0.03	0.673PheGln: 0.673 ± 0.016	2.039PheArg: 2.039 ± 0.035	1.567PheSer: 1.567 ± 0.025	2.111PheThr: 2.111 ± 0.039	2.485PheVal: 2.485 ± 0.036	0.388PheTrp: 0.388 ± 0.013	0.586PheTyr: 0.586 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.357GlyAla: 10.357 ± 0.075	0.783GlyCys: 0.783 ± 0.019	4.785GlyAsp: 4.785 ± 0.047	5.571GlyGlu: 5.571 ± 0.053	3.115GlyPhe: 3.115 ± 0.037	8.294GlyGly: 8.294 ± 0.079	2.247GlyHis: 2.247 ± 0.036	3.77GlyIle: 3.77 ± 0.039	2.436GlyLys: 2.436 ± 0.039	9.922GlyLeu: 9.922 ± 0.073	2.031GlyMet: 2.031 ± 0.03	1.967GlyAsn: 1.967 ± 0.038	4.837GlyPro: 4.837 ± 0.048	2.913GlyGln: 2.913 ± 0.036	7.616GlyArg: 7.616 ± 0.062	5.044GlySer: 5.044 ± 0.052	5.956GlyThr: 5.956 ± 0.063	7.688GlyVal: 7.688 ± 0.062	1.751GlyTrp: 1.751 ± 0.029	2.453GlyTyr: 2.453 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.636HisAla: 2.636 ± 0.038	0.219HisCys: 0.219 ± 0.01	1.348HisAsp: 1.348 ± 0.027	1.286HisGlu: 1.286 ± 0.028	0.667HisPhe: 0.667 ± 0.017	2.466HisGly: 2.466 ± 0.037	0.707HisHis: 0.707 ± 0.02	0.641HisIle: 0.641 ± 0.016	0.289HisLys: 0.289 ± 0.012	2.479HisLeu: 2.479 ± 0.035	0.284HisMet: 0.284 ± 0.011	0.406HisAsn: 0.406 ± 0.013	1.784HisPro: 1.784 ± 0.031	0.663HisGln: 0.663 ± 0.02	2.122HisArg: 2.122 ± 0.033	0.977HisSer: 0.977 ± 0.019	1.188HisThr: 1.188 ± 0.021	1.685HisVal: 1.685 ± 0.026	0.395HisTrp: 0.395 ± 0.015	0.54HisTyr: 0.54 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.319IleAla: 5.319 ± 0.047	0.259IleCys: 0.259 ± 0.01	2.439IleAsp: 2.439 ± 0.034	2.172IleGlu: 2.172 ± 0.031	0.741IlePhe: 0.741 ± 0.021	3.845IleGly: 3.845 ± 0.046	0.6IleHis: 0.6 ± 0.017	0.983IleIle: 0.983 ± 0.022	0.649IleLys: 0.649 ± 0.019	2.627IleLeu: 2.627 ± 0.037	0.439IleMet: 0.439 ± 0.016	0.802IleAsn: 0.802 ± 0.019	1.944IlePro: 1.944 ± 0.031	0.767IleGln: 0.767 ± 0.021	2.471IleArg: 2.471 ± 0.034	1.806IleSer: 1.806 ± 0.032	2.483IleThr: 2.483 ± 0.031	3.057IleVal: 3.057 ± 0.035	0.382IleTrp: 0.382 ± 0.014	0.606IleTyr: 0.606 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.641LysAla: 2.641 ± 0.041	0.089LysCys: 0.089 ± 0.007	0.967LysAsp: 0.967 ± 0.027	0.974LysGlu: 0.974 ± 0.026	0.469LysPhe: 0.469 ± 0.015	1.454LysGly: 1.454 ± 0.03	0.427LysHis: 0.427 ± 0.014	0.937LysIle: 0.937 ± 0.02	0.573LysLys: 0.573 ± 0.018	2.121LysLeu: 2.121 ± 0.035	0.353LysMet: 0.353 ± 0.013	0.417LysAsn: 0.417 ± 0.013	1.393LysPro: 1.393 ± 0.027	0.688LysGln: 0.688 ± 0.019	1.468LysArg: 1.468 ± 0.028	0.954LysSer: 0.954 ± 0.022	1.207LysThr: 1.207 ± 0.024	1.869LysVal: 1.869 ± 0.035	0.249LysTrp: 0.249 ± 0.01	0.387LysTyr: 0.387 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.81LeuAla: 16.81 ± 0.115	0.864LeuCys: 0.864 ± 0.021	6.915LeuAsp: 6.915 ± 0.063	4.807LeuGlu: 4.807 ± 0.057	2.863LeuPhe: 2.863 ± 0.043	9.98LeuGly: 9.98 ± 0.077	2.354LeuHis: 2.354 ± 0.039	3.511LeuIle: 3.511 ± 0.043	1.682LeuLys: 1.682 ± 0.027	11.674LeuLeu: 11.674 ± 0.098	1.459LeuMet: 1.459 ± 0.029	1.777LeuAsn: 1.777 ± 0.029	6.803LeuPro: 6.803 ± 0.063	2.066LeuGln: 2.066 ± 0.032	9.389LeuArg: 9.389 ± 0.072	5.839LeuSer: 5.839 ± 0.05	6.761LeuThr: 6.761 ± 0.054	9.557LeuVal: 9.557 ± 0.082	1.282LeuTrp: 1.282 ± 0.027	1.773LeuTyr: 1.773 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.193MetAla: 2.193 ± 0.031	0.121MetCys: 0.121 ± 0.008	0.794MetAsp: 0.794 ± 0.019	0.627MetGlu: 0.627 ± 0.016	0.458MetPhe: 0.458 ± 0.014	1.147MetGly: 1.147 ± 0.022	0.332MetHis: 0.332 ± 0.012	0.741MetIle: 0.741 ± 0.017	0.382MetLys: 0.382 ± 0.014	1.749MetLeu: 1.749 ± 0.029	0.279MetMet: 0.279 ± 0.013	0.43MetAsn: 0.43 ± 0.012	1.107MetPro: 1.107 ± 0.024	0.38MetGln: 0.38 ± 0.014	1.41MetArg: 1.41 ± 0.027	1.219MetSer: 1.219 ± 0.023	1.511MetThr: 1.511 ± 0.027	1.29MetVal: 1.29 ± 0.024	0.181MetTrp: 0.181 ± 0.009	0.249MetTyr: 0.249 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.3AsnAla: 2.3 ± 0.033	0.148AsnCys: 0.148 ± 0.007	0.914AsnAsp: 0.914 ± 0.023	0.878AsnGlu: 0.878 ± 0.023	0.52AsnPhe: 0.52 ± 0.015	1.878AsnGly: 1.878 ± 0.032	0.419AsnHis: 0.419 ± 0.013	0.635AsnIle: 0.635 ± 0.017	0.355AsnLys: 0.355 ± 0.013	1.978AsnLeu: 1.978 ± 0.03	0.281AsnMet: 0.281 ± 0.012	0.443AsnAsn: 0.443 ± 0.017	1.537AsnPro: 1.537 ± 0.029	0.583AsnGln: 0.583 ± 0.017	1.4AsnArg: 1.4 ± 0.027	0.942AsnSer: 0.942 ± 0.025	1.142AsnThr: 1.142 ± 0.025	1.417AsnVal: 1.417 ± 0.023	0.282AsnTrp: 0.282 ± 0.013	0.454AsnTyr: 0.454 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	8.184ProAla: 8.184 ± 0.068	0.358ProCys: 0.358 ± 0.012	4.075ProAsp: 4.075 ± 0.046	4.422ProGlu: 4.422 ± 0.048	1.635ProPhe: 1.635 ± 0.026	6.891ProGly: 6.891 ± 0.069	1.287ProHis: 1.287 ± 0.022	1.619ProIle: 1.619 ± 0.03	1.214ProLys: 1.214 ± 0.025	5.339ProLeu: 5.339 ± 0.051	1.042ProMet: 1.042 ± 0.021	1.032ProAsn: 1.032 ± 0.02	3.442ProPro: 3.442 ± 0.047	1.573ProGln: 1.573 ± 0.034	3.943ProArg: 3.943 ± 0.04	3.19ProSer: 3.19 ± 0.04	2.775ProThr: 2.775 ± 0.038	5.633ProVal: 5.633 ± 0.057	0.894ProTrp: 0.894 ± 0.021	1.163ProTyr: 1.163 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.946GlnAla: 3.946 ± 0.047	0.184GlnCys: 0.184 ± 0.009	1.213GlnAsp: 1.213 ± 0.022	1.266GlnGlu: 1.266 ± 0.024	0.779GlnPhe: 0.779 ± 0.018	2.104GlnGly: 2.104 ± 0.032	0.661GlnHis: 0.661 ± 0.019	1.113GlnIle: 1.113 ± 0.026	0.519GlnLys: 0.519 ± 0.015	3.284GlnLeu: 3.284 ± 0.039	0.434GlnMet: 0.434 ± 0.014	0.526GlnAsn: 0.526 ± 0.016	1.749GlnPro: 1.749 ± 0.035	1.257GlnGln: 1.257 ± 0.032	2.679GlnArg: 2.679 ± 0.04	1.178GlnSer: 1.178 ± 0.024	1.324GlnThr: 1.324 ± 0.028	2.551GlnVal: 2.551 ± 0.038	0.476GlnTrp: 0.476 ± 0.015	0.572GlnTyr: 0.572 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.767ArgAla: 9.767 ± 0.074	0.607ArgCys: 0.607 ± 0.018	4.296ArgAsp: 4.296 ± 0.047	5.204ArgGlu: 5.204 ± 0.06	2.699ArgPhe: 2.699 ± 0.036	5.833ArgGly: 5.833 ± 0.054	2.132ArgHis: 2.132 ± 0.035	3.387ArgIle: 3.387 ± 0.04	1.751ArgLys: 1.751 ± 0.029	9.419ArgLeu: 9.419 ± 0.073	1.785ArgMet: 1.785 ± 0.027	1.48ArgAsn: 1.48 ± 0.028	4.882ArgPro: 4.882 ± 0.049	2.617ArgGln: 2.617 ± 0.037	8.318ArgArg: 8.318 ± 0.082	3.974ArgSer: 3.974 ± 0.048	4.77ArgThr: 4.77 ± 0.05	6.166ArgVal: 6.166 ± 0.058	1.46ArgTrp: 1.46 ± 0.029	2.015ArgTyr: 2.015 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.55SerAla: 6.55 ± 0.057	0.389SerCys: 0.389 ± 0.012	2.446SerAsp: 2.446 ± 0.035	2.478SerGlu: 2.478 ± 0.033	1.552SerPhe: 1.552 ± 0.027	5.877SerGly: 5.877 ± 0.061	0.928SerHis: 0.928 ± 0.021	1.566SerIle: 1.566 ± 0.03	0.924SerLys: 0.924 ± 0.021	4.966SerLeu: 4.966 ± 0.044	1.05SerMet: 1.05 ± 0.024	0.866SerAsn: 0.866 ± 0.021	3.17SerPro: 3.17 ± 0.036	1.215SerGln: 1.215 ± 0.023	3.749SerArg: 3.749 ± 0.042	2.779SerSer: 2.779 ± 0.044	3.081SerThr: 3.081 ± 0.039	4.255SerVal: 4.255 ± 0.042	0.953SerTrp: 0.953 ± 0.022	1.14SerTyr: 1.14 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	8.125ThrAla: 8.125 ± 0.07	0.395ThrCys: 0.395 ± 0.012	3.21ThrAsp: 3.21 ± 0.04	3.324ThrGlu: 3.324 ± 0.044	1.697ThrPhe: 1.697 ± 0.025	6.775ThrGly: 6.775 ± 0.053	1.119ThrHis: 1.119 ± 0.02	1.956ThrIle: 1.956 ± 0.032	1.128ThrLys: 1.128 ± 0.024	5.758ThrLeu: 5.758 ± 0.052	0.957ThrMet: 0.957 ± 0.02	1.02ThrAsn: 1.02 ± 0.024	3.669ThrPro: 3.669 ± 0.044	1.331ThrGln: 1.331 ± 0.026	3.985ThrArg: 3.985 ± 0.042	3.068ThrSer: 3.068 ± 0.043	3.845ThrThr: 3.845 ± 0.06	5.974ThrVal: 5.974 ± 0.06	0.874ThrTrp: 0.874 ± 0.019	1.234ThrTyr: 1.234 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	11.173ValAla: 11.173 ± 0.083	0.722ValCys: 0.722 ± 0.017	5.023ValAsp: 5.023 ± 0.052	4.781ValGlu: 4.781 ± 0.049	2.641ValPhe: 2.641 ± 0.037	6.335ValGly: 6.335 ± 0.055	2.017ValHis: 2.017 ± 0.032	3.089ValIle: 3.089 ± 0.039	1.523ValLys: 1.523 ± 0.028	10.514ValLeu: 10.514 ± 0.089	1.224ValMet: 1.224 ± 0.025	1.679ValAsn: 1.679 ± 0.033	5.386ValPro: 5.386 ± 0.06	2.044ValGln: 2.044 ± 0.033	7.211ValArg: 7.211 ± 0.067	4.522ValSer: 4.522 ± 0.049	5.681ValThr: 5.681 ± 0.054	8.454ValVal: 8.454 ± 0.069	1.118ValTrp: 1.118 ± 0.026	1.532ValTyr: 1.532 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.612TrpAla: 1.612 ± 0.028	0.148TrpCys: 0.148 ± 0.009	0.756TrpAsp: 0.756 ± 0.021	0.655TrpGlu: 0.655 ± 0.018	0.573TrpPhe: 0.573 ± 0.015	0.983TrpGly: 0.983 ± 0.024	0.419TrpHis: 0.419 ± 0.013	0.547TrpIle: 0.547 ± 0.015	0.283TrpLys: 0.283 ± 0.012	1.99TrpLeu: 1.99 ± 0.04	0.268TrpMet: 0.268 ± 0.012	0.348TrpAsn: 0.348 ± 0.013	0.843TrpPro: 0.843 ± 0.021	0.611TrpGln: 0.611 ± 0.016	1.49TrpArg: 1.49 ± 0.028	0.876TrpSer: 0.876 ± 0.021	0.984TrpThr: 0.984 ± 0.022	1.05TrpVal: 1.05 ± 0.024	0.367TrpTrp: 0.367 ± 0.014	0.322TrpTyr: 0.322 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.403TyrAla: 2.403 ± 0.032	0.174TyrCys: 0.174 ± 0.009	1.343TyrAsp: 1.343 ± 0.039	1.063TyrGlu: 1.063 ± 0.021	0.699TyrPhe: 0.699 ± 0.019	2.024TyrGly: 2.024 ± 0.031	0.508TyrHis: 0.508 ± 0.014	0.417TyrIle: 0.417 ± 0.014	0.278TyrLys: 0.278 ± 0.011	2.443TyrLeu: 2.443 ± 0.032	0.177TyrMet: 0.177 ± 0.008	0.384TyrAsn: 0.384 ± 0.017	1.178TyrPro: 1.178 ± 0.024	0.688TyrGln: 0.688 ± 0.019	2.008TyrArg: 2.008 ± 0.033	1.0TyrSer: 1.0 ± 0.021	1.194TyrThr: 1.194 ± 0.024	1.571TyrVal: 1.571 ± 0.028	0.339TyrTrp: 0.339 ± 0.013	0.499TyrTyr: 0.499 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7256 proteins (2237112 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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