Amino acid dipepetide frequency for Apilactobacillus ozensis DSM 23829 = JCM 17196

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.914AlaAla: 4.914 ± 0.522
0.399AlaCys: 0.399 ± 0.032
3.716AlaAsp: 3.716 ± 0.131
3.25AlaGlu: 3.25 ± 0.101
2.886AlaPhe: 2.886 ± 0.106
4.244AlaGly: 4.244 ± 0.142
1.129AlaHis: 1.129 ± 0.048
5.537AlaIle: 5.537 ± 0.127
5.751AlaLys: 5.751 ± 0.177
5.783AlaLeu: 5.783 ± 0.119
1.639AlaMet: 1.639 ± 0.066
4.147AlaAsn: 4.147 ± 0.31
1.632AlaPro: 1.632 ± 0.065
2.436AlaGln: 2.436 ± 0.185
2.13AlaArg: 2.13 ± 0.092
4.617AlaSer: 4.617 ± 0.724
3.326AlaThr: 3.326 ± 0.119
4.133AlaVal: 4.133 ± 0.111
0.505AlaTrp: 0.505 ± 0.035
2.372AlaTyr: 2.372 ± 0.109
0.002AlaXaa: 0.002 ± 0.002
Cys
0.307CysAla: 0.307 ± 0.029
0.058CysCys: 0.058 ± 0.012
0.332CysAsp: 0.332 ± 0.029
0.242CysGlu: 0.242 ± 0.027
0.26CysPhe: 0.26 ± 0.025
0.489CysGly: 0.489 ± 0.035
0.143CysHis: 0.143 ± 0.019
0.463CysIle: 0.463 ± 0.033
0.346CysLys: 0.346 ± 0.029
0.539CysLeu: 0.539 ± 0.039
0.097CysMet: 0.097 ± 0.014
0.309CysAsn: 0.309 ± 0.028
0.214CysPro: 0.214 ± 0.026
0.166CysGln: 0.166 ± 0.02
0.161CysArg: 0.161 ± 0.022
0.357CysSer: 0.357 ± 0.028
0.284CysThr: 0.284 ± 0.027
0.309CysVal: 0.309 ± 0.03
0.069CysTrp: 0.069 ± 0.012
0.194CysTyr: 0.194 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.974AspAla: 3.974 ± 0.18
0.323AspCys: 0.323 ± 0.032
4.165AspAsp: 4.165 ± 0.132
4.124AspGlu: 4.124 ± 0.121
2.835AspPhe: 2.835 ± 0.09
3.536AspGly: 3.536 ± 0.087
0.924AspHis: 0.924 ± 0.049
4.626AspIle: 4.626 ± 0.108
5.463AspLys: 5.463 ± 0.128
5.306AspLeu: 5.306 ± 0.118
1.494AspMet: 1.494 ± 0.061
4.518AspAsn: 4.518 ± 0.121
1.473AspPro: 1.473 ± 0.068
1.641AspGln: 1.641 ± 0.059
1.729AspArg: 1.729 ± 0.072
4.092AspSer: 4.092 ± 0.143
2.771AspThr: 2.771 ± 0.075
4.221AspVal: 4.221 ± 0.118
0.53AspTrp: 0.53 ± 0.034
2.692AspTyr: 2.692 ± 0.092
0.0AspXaa: 0.0 ± 0.0
Glu
3.08GluAla: 3.08 ± 0.094
0.224GluCys: 0.224 ± 0.024
2.937GluAsp: 2.937 ± 0.102
2.798GluGlu: 2.798 ± 0.113
2.22GluPhe: 2.22 ± 0.075
2.31GluGly: 2.31 ± 0.086
1.233GluHis: 1.233 ± 0.053
4.52GluIle: 4.52 ± 0.119
4.744GluLys: 4.744 ± 0.138
5.053GluLeu: 5.053 ± 0.128
1.614GluMet: 1.614 ± 0.061
4.05GluAsn: 4.05 ± 0.121
1.496GluPro: 1.496 ± 0.073
2.171GluGln: 2.171 ± 0.082
1.846GluArg: 1.846 ± 0.076
2.893GluSer: 2.893 ± 0.083
2.487GluThr: 2.487 ± 0.081
3.257GluVal: 3.257 ± 0.097
0.443GluTrp: 0.443 ± 0.035
2.213GluTyr: 2.213 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
2.612PheAla: 2.612 ± 0.098
0.272PheCys: 0.272 ± 0.026
2.785PheAsp: 2.785 ± 0.078
2.227PheGlu: 2.227 ± 0.072
1.999PhePhe: 1.999 ± 0.086
2.955PheGly: 2.955 ± 0.075
0.802PheHis: 0.802 ± 0.045
3.912PheIle: 3.912 ± 0.137
3.513PheLys: 3.513 ± 0.095
3.893PheLeu: 3.893 ± 0.116
1.201PheMet: 1.201 ± 0.059
3.471PheAsn: 3.471 ± 0.117
1.261PhePro: 1.261 ± 0.058
1.116PheGln: 1.116 ± 0.052
1.249PheArg: 1.249 ± 0.052
3.206PheSer: 3.206 ± 0.1
2.204PheThr: 2.204 ± 0.072
2.937PheVal: 2.937 ± 0.106
0.436PheTrp: 0.436 ± 0.031
1.957PheTyr: 1.957 ± 0.068
0.0PheXaa: 0.0 ± 0.0
Gly
3.743GlyAla: 3.743 ± 0.125
0.38GlyCys: 0.38 ± 0.034
3.153GlyAsp: 3.153 ± 0.1
2.842GlyGlu: 2.842 ± 0.088
3.017GlyPhe: 3.017 ± 0.094
3.801GlyGly: 3.801 ± 0.129
1.325GlyHis: 1.325 ± 0.052
5.677GlyIle: 5.677 ± 0.156
5.055GlyLys: 5.055 ± 0.124
5.657GlyLeu: 5.657 ± 0.138
1.803GlyMet: 1.803 ± 0.083
3.762GlyAsn: 3.762 ± 0.103
1.36GlyPro: 1.36 ± 0.064
2.038GlyGln: 2.038 ± 0.073
2.075GlyArg: 2.075 ± 0.086
4.087GlySer: 4.087 ± 0.112
3.518GlyThr: 3.518 ± 0.114
4.202GlyVal: 4.202 ± 0.141
0.602GlyTrp: 0.602 ± 0.038
2.815GlyTyr: 2.815 ± 0.088
0.0GlyXaa: 0.0 ± 0.0
His
1.141HisAla: 1.141 ± 0.058
0.108HisCys: 0.108 ± 0.018
1.256HisAsp: 1.256 ± 0.058
1.1HisGlu: 1.1 ± 0.052
0.987HisPhe: 0.987 ± 0.047
1.369HisGly: 1.369 ± 0.065
0.537HisHis: 0.537 ± 0.042
1.408HisIle: 1.408 ± 0.051
1.484HisLys: 1.484 ± 0.065
1.835HisLeu: 1.835 ± 0.065
0.452HisMet: 0.452 ± 0.031
1.263HisAsn: 1.263 ± 0.053
0.892HisPro: 0.892 ± 0.044
0.775HisGln: 0.775 ± 0.043
0.74HisArg: 0.74 ± 0.043
1.224HisSer: 1.224 ± 0.053
0.892HisThr: 0.892 ± 0.05
1.093HisVal: 1.093 ± 0.06
0.164HisTrp: 0.164 ± 0.019
0.846HisTyr: 0.846 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
5.634IleAla: 5.634 ± 0.133
0.606IleCys: 0.606 ± 0.043
5.17IleAsp: 5.17 ± 0.131
4.188IleGlu: 4.188 ± 0.112
3.757IlePhe: 3.757 ± 0.128
5.108IleGly: 5.108 ± 0.148
1.378IleHis: 1.378 ± 0.062
7.263IleIle: 7.263 ± 0.212
7.086IleLys: 7.086 ± 0.167
7.505IleLeu: 7.505 ± 0.199
2.012IleMet: 2.012 ± 0.078
6.475IleAsn: 6.475 ± 0.153
2.967IlePro: 2.967 ± 0.092
2.547IleGln: 2.547 ± 0.074
2.501IleArg: 2.501 ± 0.079
6.413IleSer: 6.413 ± 0.146
4.393IleThr: 4.393 ± 0.113
5.583IleVal: 5.583 ± 0.126
0.484IleTrp: 0.484 ± 0.038
2.932IleTyr: 2.932 ± 0.09
0.002IleXaa: 0.002 ± 0.003
Lys
5.103LysAla: 5.103 ± 0.129
0.311LysCys: 0.311 ± 0.029
4.829LysAsp: 4.829 ± 0.125
4.467LysGlu: 4.467 ± 0.129
3.05LysPhe: 3.05 ± 0.086
3.575LysGly: 3.575 ± 0.107
1.853LysHis: 1.853 ± 0.085
6.816LysIle: 6.816 ± 0.171
7.146LysLys: 7.146 ± 0.161
7.745LysLeu: 7.745 ± 0.168
2.98LysMet: 2.98 ± 0.09
6.83LysAsn: 6.83 ± 0.155
2.439LysPro: 2.439 ± 0.078
3.704LysGln: 3.704 ± 0.104
2.934LysArg: 2.934 ± 0.096
5.431LysSer: 5.431 ± 0.152
4.124LysThr: 4.124 ± 0.105
5.366LysVal: 5.366 ± 0.133
0.731LysTrp: 0.731 ± 0.044
3.879LysTyr: 3.879 ± 0.098
0.0LysXaa: 0.0 ± 0.0
Leu
5.996LeuAla: 5.996 ± 0.139
0.507LeuCys: 0.507 ± 0.033
5.553LeuAsp: 5.553 ± 0.133
4.147LeuGlu: 4.147 ± 0.122
3.903LeuPhe: 3.903 ± 0.13
5.975LeuGly: 5.975 ± 0.138
1.457LeuHis: 1.457 ± 0.054
7.796LeuIle: 7.796 ± 0.185
7.57LeuLys: 7.57 ± 0.16
7.953LeuLeu: 7.953 ± 0.213
2.289LeuMet: 2.289 ± 0.091
6.669LeuAsn: 6.669 ± 0.153
3.361LeuPro: 3.361 ± 0.085
2.886LeuGln: 2.886 ± 0.091
3.027LeuArg: 3.027 ± 0.097
7.747LeuSer: 7.747 ± 0.164
4.997LeuThr: 4.997 ± 0.114
5.802LeuVal: 5.802 ± 0.13
0.595LeuTrp: 0.595 ± 0.04
2.805LeuTyr: 2.805 ± 0.094
0.002LeuXaa: 0.002 ± 0.002
Met
1.743MetAla: 1.743 ± 0.066
0.136MetCys: 0.136 ± 0.018
1.514MetAsp: 1.514 ± 0.056
1.226MetGlu: 1.226 ± 0.059
1.083MetPhe: 1.083 ± 0.061
1.697MetGly: 1.697 ± 0.083
0.588MetHis: 0.588 ± 0.04
2.13MetIle: 2.13 ± 0.078
2.135MetLys: 2.135 ± 0.071
2.515MetLeu: 2.515 ± 0.086
0.802MetMet: 0.802 ± 0.046
1.911MetAsn: 1.911 ± 0.062
1.109MetPro: 1.109 ± 0.057
1.219MetGln: 1.219 ± 0.049
0.871MetArg: 0.871 ± 0.041
1.925MetSer: 1.925 ± 0.068
1.397MetThr: 1.397 ± 0.057
1.66MetVal: 1.66 ± 0.063
0.18MetTrp: 0.18 ± 0.022
0.839MetTyr: 0.839 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
4.601AsnAla: 4.601 ± 0.28
0.339AsnCys: 0.339 ± 0.03
4.571AsnAsp: 4.571 ± 0.126
3.794AsnGlu: 3.794 ± 0.088
2.757AsnPhe: 2.757 ± 0.091
4.509AsnGly: 4.509 ± 0.133
1.717AsnHis: 1.717 ± 0.066
5.677AsnIle: 5.677 ± 0.14
6.12AsnLys: 6.12 ± 0.153
6.152AsnLeu: 6.152 ± 0.169
1.793AsnMet: 1.793 ± 0.064
6.27AsnAsn: 6.27 ± 0.221
2.63AsnPro: 2.63 ± 0.09
3.163AsnGln: 3.163 ± 0.088
2.307AsnArg: 2.307 ± 0.077
4.947AsnSer: 4.947 ± 0.285
3.153AsnThr: 3.153 ± 0.096
4.795AsnVal: 4.795 ± 0.115
0.648AsnTrp: 0.648 ± 0.042
3.004AsnTyr: 3.004 ± 0.104
0.002AsnXaa: 0.002 ± 0.002
Pro
1.816ProAla: 1.816 ± 0.073
0.106ProCys: 0.106 ± 0.014
2.022ProAsp: 2.022 ± 0.081
2.204ProGlu: 2.204 ± 0.071
1.57ProPhe: 1.57 ± 0.059
1.881ProGly: 1.881 ± 0.083
0.519ProHis: 0.519 ± 0.034
2.75ProIle: 2.75 ± 0.082
2.637ProLys: 2.637 ± 0.078
2.628ProLeu: 2.628 ± 0.097
0.724ProMet: 0.724 ± 0.045
2.035ProAsn: 2.035 ± 0.07
0.447ProPro: 0.447 ± 0.033
1.04ProGln: 1.04 ± 0.053
0.94ProArg: 0.94 ± 0.05
2.238ProSer: 2.238 ± 0.074
1.789ProThr: 1.789 ± 0.065
2.213ProVal: 2.213 ± 0.077
0.256ProTrp: 0.256 ± 0.024
1.309ProTyr: 1.309 ± 0.057
0.005ProXaa: 0.005 ± 0.003
Gln
2.667GlnAla: 2.667 ± 0.193
0.124GlnCys: 0.124 ± 0.018
1.722GlnAsp: 1.722 ± 0.076
1.641GlnGlu: 1.641 ± 0.062
1.505GlnPhe: 1.505 ± 0.058
1.835GlnGly: 1.835 ± 0.067
0.671GlnHis: 0.671 ± 0.041
2.957GlnIle: 2.957 ± 0.084
3.128GlnLys: 3.128 ± 0.101
3.497GlnLeu: 3.497 ± 0.095
1.028GlnMet: 1.028 ± 0.053
2.563GlnAsn: 2.563 ± 0.095
1.06GlnPro: 1.06 ± 0.054
1.574GlnGln: 1.574 ± 0.076
1.406GlnArg: 1.406 ± 0.067
2.563GlnSer: 2.563 ± 0.193
1.828GlnThr: 1.828 ± 0.064
2.356GlnVal: 2.356 ± 0.077
0.341GlnTrp: 0.341 ± 0.03
1.459GlnTyr: 1.459 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
1.962ArgAla: 1.962 ± 0.072
0.171ArgCys: 0.171 ± 0.019
1.964ArgAsp: 1.964 ± 0.079
1.89ArgGlu: 1.89 ± 0.072
1.521ArgPhe: 1.521 ± 0.068
2.015ArgGly: 2.015 ± 0.079
0.712ArgHis: 0.712 ± 0.04
2.768ArgIle: 2.768 ± 0.094
2.877ArgLys: 2.877 ± 0.082
3.036ArgLeu: 3.036 ± 0.085
0.987ArgMet: 0.987 ± 0.053
2.155ArgAsn: 2.155 ± 0.067
1.143ArgPro: 1.143 ± 0.053
1.282ArgGln: 1.282 ± 0.061
1.567ArgArg: 1.567 ± 0.074
1.86ArgSer: 1.86 ± 0.073
1.648ArgThr: 1.648 ± 0.066
2.169ArgVal: 2.169 ± 0.072
0.217ArgTrp: 0.217 ± 0.025
1.445ArgTyr: 1.445 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
4.559SerAla: 4.559 ± 0.548
0.293SerCys: 0.293 ± 0.029
4.583SerAsp: 4.583 ± 0.14
3.605SerGlu: 3.605 ± 0.087
3.241SerPhe: 3.241 ± 0.105
4.49SerGly: 4.49 ± 0.121
1.321SerHis: 1.321 ± 0.049
6.079SerIle: 6.079 ± 0.11
5.88SerLys: 5.88 ± 0.137
6.327SerLeu: 6.327 ± 0.154
1.789SerMet: 1.789 ± 0.085
5.405SerAsn: 5.405 ± 0.281
1.786SerPro: 1.786 ± 0.068
2.543SerGln: 2.543 ± 0.167
2.351SerArg: 2.351 ± 0.074
5.173SerSer: 5.173 ± 0.362
3.448SerThr: 3.448 ± 0.105
4.391SerVal: 4.391 ± 0.098
0.535SerTrp: 0.535 ± 0.034
2.803SerTyr: 2.803 ± 0.121
0.002SerXaa: 0.002 ± 0.002
Thr
3.508ThrAla: 3.508 ± 0.154
0.277ThrCys: 0.277 ± 0.027
2.93ThrAsp: 2.93 ± 0.106
2.28ThrGlu: 2.28 ± 0.093
2.319ThrPhe: 2.319 ± 0.074
3.672ThrGly: 3.672 ± 0.093
0.996ThrHis: 0.996 ± 0.055
4.467ThrIle: 4.467 ± 0.116
3.806ThrLys: 3.806 ± 0.096
4.801ThrLeu: 4.801 ± 0.124
1.24ThrMet: 1.24 ± 0.062
3.425ThrAsn: 3.425 ± 0.115
2.118ThrPro: 2.118 ± 0.073
1.526ThrGln: 1.526 ± 0.063
1.501ThrArg: 1.501 ± 0.052
3.541ThrSer: 3.541 ± 0.091
2.787ThrThr: 2.787 ± 0.089
3.485ThrVal: 3.485 ± 0.113
0.431ThrTrp: 0.431 ± 0.035
1.777ThrTyr: 1.777 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
4.511ValAla: 4.511 ± 0.122
0.424ValCys: 0.424 ± 0.032
4.239ValAsp: 4.239 ± 0.113
3.319ValGlu: 3.319 ± 0.105
2.708ValPhe: 2.708 ± 0.087
4.442ValGly: 4.442 ± 0.13
1.155ValHis: 1.155 ± 0.052
5.5ValIle: 5.5 ± 0.152
5.182ValLys: 5.182 ± 0.138
5.783ValLeu: 5.783 ± 0.15
1.542ValMet: 1.542 ± 0.064
4.387ValAsn: 4.387 ± 0.104
2.231ValPro: 2.231 ± 0.08
2.031ValGln: 2.031 ± 0.066
2.04ValArg: 2.04 ± 0.08
5.067ValSer: 5.067 ± 0.103
3.603ValThr: 3.603 ± 0.099
4.682ValVal: 4.682 ± 0.123
0.514ValTrp: 0.514 ± 0.033
2.296ValTyr: 2.296 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.401TrpAla: 0.401 ± 0.03
0.041TrpCys: 0.041 ± 0.01
0.477TrpAsp: 0.477 ± 0.038
0.307TrpGlu: 0.307 ± 0.024
0.429TrpPhe: 0.429 ± 0.038
0.505TrpGly: 0.505 ± 0.036
0.214TrpHis: 0.214 ± 0.022
0.844TrpIle: 0.844 ± 0.045
0.535TrpLys: 0.535 ± 0.038
0.943TrpLeu: 0.943 ± 0.056
0.251TrpMet: 0.251 ± 0.024
0.496TrpAsn: 0.496 ± 0.041
0.212TrpPro: 0.212 ± 0.024
0.392TrpGln: 0.392 ± 0.031
0.341TrpArg: 0.341 ± 0.032
0.514TrpSer: 0.514 ± 0.037
0.353TrpThr: 0.353 ± 0.029
0.491TrpVal: 0.491 ± 0.035
0.101TrpTrp: 0.101 ± 0.016
0.309TrpTyr: 0.309 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.273TyrAla: 2.273 ± 0.098
0.24TyrCys: 0.24 ± 0.024
2.519TyrAsp: 2.519 ± 0.084
1.934TyrGlu: 1.934 ± 0.073
1.959TyrPhe: 1.959 ± 0.07
2.506TyrGly: 2.506 ± 0.076
0.89TyrHis: 0.89 ± 0.047
2.815TyrIle: 2.815 ± 0.09
2.856TyrLys: 2.856 ± 0.108
4.082TyrLeu: 4.082 ± 0.105
0.94TyrMet: 0.94 ± 0.046
2.808TyrAsn: 2.808 ± 0.111
1.295TyrPro: 1.295 ± 0.052
1.678TyrGln: 1.678 ± 0.072
1.671TyrArg: 1.671 ± 0.055
2.708TyrSer: 2.708 ± 0.073
1.886TyrThr: 1.886 ± 0.079
2.513TyrVal: 2.513 ± 0.087
0.376TyrTrp: 0.376 ± 0.031
1.701TyrTyr: 1.701 ± 0.078
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.005XaaAla: 0.005 ± 0.003
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.002XaaGlu: 0.002 ± 0.002
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.002XaaLys: 0.002 ± 0.002
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.002XaaGln: 0.002 ± 0.002
0.0XaaArg: 0.0 ± 0.0
0.002XaaSer: 0.002 ± 0.002
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.002XaaTyr: 0.002 ± 0.002
0.207XaaXaa: 0.207 ± 0.097
Statistics based on 1405 proteins (433825 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski