Amino acid dipepetide frequency for Porcine rotavirus A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.898AlaAla: 2.898 ± 0.964
1.317AlaCys: 1.317 ± 0.494
4.478AlaAsp: 4.478 ± 0.957
2.371AlaGlu: 2.371 ± 0.607
1.844AlaPhe: 1.844 ± 0.673
2.371AlaGly: 2.371 ± 0.75
0.527AlaHis: 0.527 ± 0.348
2.634AlaIle: 2.634 ± 0.586
3.161AlaLys: 3.161 ± 1.133
5.005AlaLeu: 5.005 ± 0.66
1.054AlaMet: 1.054 ± 0.483
4.215AlaAsn: 4.215 ± 1.165
2.107AlaPro: 2.107 ± 0.849
1.581AlaGln: 1.581 ± 0.708
2.898AlaArg: 2.898 ± 1.202
4.215AlaSer: 4.215 ± 1.097
3.161AlaThr: 3.161 ± 0.748
3.688AlaVal: 3.688 ± 0.789
0.0AlaTrp: 0.0 ± 0.0
1.317AlaTyr: 1.317 ± 0.573
0.0AlaXaa: 0.0 ± 0.0
Cys
0.263CysAla: 0.263 ± 0.257
0.263CysCys: 0.263 ± 0.242
1.317CysAsp: 1.317 ± 0.555
0.79CysGlu: 0.79 ± 0.369
1.054CysPhe: 1.054 ± 0.369
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.527CysIle: 0.527 ± 0.343
1.581CysLys: 1.581 ± 0.694
1.054CysLeu: 1.054 ± 0.714
0.79CysMet: 0.79 ± 0.43
1.317CysAsn: 1.317 ± 0.663
0.263CysPro: 0.263 ± 0.289
0.79CysGln: 0.79 ± 0.538
1.054CysArg: 1.054 ± 0.968
1.581CysSer: 1.581 ± 0.913
0.79CysThr: 0.79 ± 0.634
0.263CysVal: 0.263 ± 0.243
0.0CysTrp: 0.0 ± 0.0
0.527CysTyr: 0.527 ± 0.308
0.0CysXaa: 0.0 ± 0.0
Asp
3.688AspAla: 3.688 ± 1.295
0.79AspCys: 0.79 ± 0.312
3.688AspAsp: 3.688 ± 1.092
4.215AspGlu: 4.215 ± 0.623
2.371AspPhe: 2.371 ± 0.843
1.581AspGly: 1.581 ± 0.449
1.581AspHis: 1.581 ± 0.561
4.742AspIle: 4.742 ± 1.175
4.478AspLys: 4.478 ± 0.922
3.688AspLeu: 3.688 ± 0.705
2.107AspMet: 2.107 ± 0.9
3.425AspAsn: 3.425 ± 1.035
1.844AspPro: 1.844 ± 0.96
2.898AspGln: 2.898 ± 0.926
2.107AspArg: 2.107 ± 0.687
5.005AspSer: 5.005 ± 1.913
3.161AspThr: 3.161 ± 0.793
6.849AspVal: 6.849 ± 1.238
0.527AspTrp: 0.527 ± 0.337
4.478AspTyr: 4.478 ± 0.86
0.0AspXaa: 0.0 ± 0.0
Glu
3.161GluAla: 3.161 ± 0.743
0.0GluCys: 0.0 ± 0.0
3.161GluAsp: 3.161 ± 0.854
2.371GluGlu: 2.371 ± 0.841
2.371GluPhe: 2.371 ± 0.674
1.317GluGly: 1.317 ± 0.459
0.263GluHis: 0.263 ± 0.257
4.742GluIle: 4.742 ± 1.199
3.952GluLys: 3.952 ± 0.906
6.849GluLeu: 6.849 ± 1.489
2.634GluMet: 2.634 ± 0.937
4.215GluAsn: 4.215 ± 0.725
2.107GluPro: 2.107 ± 0.886
1.844GluGln: 1.844 ± 0.986
2.898GluArg: 2.898 ± 0.838
3.425GluSer: 3.425 ± 1.036
3.425GluThr: 3.425 ± 0.976
3.952GluVal: 3.952 ± 0.892
1.054GluTrp: 1.054 ± 0.531
5.796GluTyr: 5.796 ± 1.527
0.0GluXaa: 0.0 ± 0.0
Phe
1.317PheAla: 1.317 ± 0.628
0.263PheCys: 0.263 ± 0.234
2.107PheAsp: 2.107 ± 0.997
2.898PheGlu: 2.898 ± 0.772
0.527PhePhe: 0.527 ± 0.327
1.844PheGly: 1.844 ± 0.532
1.581PheHis: 1.581 ± 0.709
4.215PheIle: 4.215 ± 0.998
3.688PheLys: 3.688 ± 0.795
4.215PheLeu: 4.215 ± 0.907
0.0PheMet: 0.0 ± 0.0
3.425PheAsn: 3.425 ± 1.092
1.844PhePro: 1.844 ± 0.864
1.844PheGln: 1.844 ± 0.688
1.317PheArg: 1.317 ± 0.367
3.425PheSer: 3.425 ± 0.936
3.425PheThr: 3.425 ± 0.994
1.844PheVal: 1.844 ± 0.452
0.263PheTrp: 0.263 ± 0.243
1.317PheTyr: 1.317 ± 0.421
0.0PheXaa: 0.0 ± 0.0
Gly
0.527GlyAla: 0.527 ± 0.295
0.79GlyCys: 0.79 ± 0.45
0.79GlyAsp: 0.79 ± 0.312
1.844GlyGlu: 1.844 ± 0.898
1.054GlyPhe: 1.054 ± 0.594
1.054GlyGly: 1.054 ± 0.468
0.79GlyHis: 0.79 ± 0.379
3.161GlyIle: 3.161 ± 0.853
3.688GlyLys: 3.688 ± 0.925
2.107GlyLeu: 2.107 ± 0.821
1.844GlyMet: 1.844 ± 0.602
1.054GlyAsn: 1.054 ± 0.651
1.581GlyPro: 1.581 ± 0.615
0.79GlyGln: 0.79 ± 0.362
1.844GlyArg: 1.844 ± 0.922
2.107GlySer: 2.107 ± 0.938
2.107GlyThr: 2.107 ± 1.246
2.107GlyVal: 2.107 ± 0.629
0.79GlyTrp: 0.79 ± 0.423
0.79GlyTyr: 0.79 ± 0.429
0.0GlyXaa: 0.0 ± 0.0
His
1.581HisAla: 1.581 ± 0.492
0.263HisCys: 0.263 ± 0.242
1.844HisAsp: 1.844 ± 0.555
0.527HisGlu: 0.527 ± 0.291
0.263HisPhe: 0.263 ± 0.242
1.317HisGly: 1.317 ± 0.889
0.263HisHis: 0.263 ± 0.227
0.527HisIle: 0.527 ± 0.308
2.634HisLys: 2.634 ± 0.729
1.317HisLeu: 1.317 ± 0.57
0.0HisMet: 0.0 ± 0.0
0.79HisAsn: 0.79 ± 0.339
0.263HisPro: 0.263 ± 0.233
0.79HisGln: 0.79 ± 0.524
0.263HisArg: 0.263 ± 0.242
1.844HisSer: 1.844 ± 0.632
1.317HisThr: 1.317 ± 0.51
1.317HisVal: 1.317 ± 0.636
0.263HisTrp: 0.263 ± 0.227
1.054HisTyr: 1.054 ± 0.444
0.0HisXaa: 0.0 ± 0.0
Ile
4.742IleAla: 4.742 ± 1.035
0.527IleCys: 0.527 ± 0.286
5.796IleAsp: 5.796 ± 1.575
5.269IleGlu: 5.269 ± 0.935
2.371IlePhe: 2.371 ± 0.656
2.634IleGly: 2.634 ± 0.855
1.581IleHis: 1.581 ± 0.627
5.796IleIle: 5.796 ± 1.543
4.478IleLys: 4.478 ± 1.2
7.64IleLeu: 7.64 ± 1.318
0.79IleMet: 0.79 ± 0.426
5.532IleAsn: 5.532 ± 0.841
3.425IlePro: 3.425 ± 0.964
3.161IleGln: 3.161 ± 0.759
4.742IleArg: 4.742 ± 0.753
3.425IleSer: 3.425 ± 1.248
4.742IleThr: 4.742 ± 1.071
4.215IleVal: 4.215 ± 1.153
0.263IleTrp: 0.263 ± 0.234
3.425IleTyr: 3.425 ± 0.882
0.0IleXaa: 0.0 ± 0.0
Lys
1.844LysAla: 1.844 ± 0.702
1.844LysCys: 1.844 ± 0.448
3.952LysAsp: 3.952 ± 0.798
6.059LysGlu: 6.059 ± 2.075
2.634LysPhe: 2.634 ± 0.702
2.107LysGly: 2.107 ± 0.614
1.581LysHis: 1.581 ± 0.509
3.425LysIle: 3.425 ± 0.614
4.215LysLys: 4.215 ± 1.309
7.376LysLeu: 7.376 ± 1.518
2.634LysMet: 2.634 ± 0.956
3.952LysAsn: 3.952 ± 0.844
2.371LysPro: 2.371 ± 0.458
3.688LysGln: 3.688 ± 0.848
3.952LysArg: 3.952 ± 0.544
4.215LysSer: 4.215 ± 1.367
3.952LysThr: 3.952 ± 0.591
2.634LysVal: 2.634 ± 0.786
1.581LysTrp: 1.581 ± 0.925
3.425LysTyr: 3.425 ± 1.207
0.0LysXaa: 0.0 ± 0.0
Leu
4.742LeuAla: 4.742 ± 1.032
0.527LeuCys: 0.527 ± 0.578
5.796LeuAsp: 5.796 ± 1.134
5.532LeuGlu: 5.532 ± 1.765
3.952LeuPhe: 3.952 ± 0.766
2.107LeuGly: 2.107 ± 0.679
1.844LeuHis: 1.844 ± 0.81
6.849LeuIle: 6.849 ± 0.731
5.796LeuLys: 5.796 ± 1.144
8.957LeuLeu: 8.957 ± 1.468
3.425LeuMet: 3.425 ± 0.998
6.586LeuAsn: 6.586 ± 1.069
3.688LeuPro: 3.688 ± 0.665
3.425LeuGln: 3.425 ± 1.245
5.269LeuArg: 5.269 ± 1.054
8.43LeuSer: 8.43 ± 2.088
5.796LeuThr: 5.796 ± 1.068
4.742LeuVal: 4.742 ± 1.226
0.527LeuTrp: 0.527 ± 0.367
2.371LeuTyr: 2.371 ± 0.894
0.0LeuXaa: 0.0 ± 0.0
Met
1.844MetAla: 1.844 ± 0.617
0.0MetCys: 0.0 ± 0.0
3.161MetAsp: 3.161 ± 1.018
1.317MetGlu: 1.317 ± 0.808
2.107MetPhe: 2.107 ± 0.453
1.054MetGly: 1.054 ± 0.413
0.527MetHis: 0.527 ± 0.321
1.317MetIle: 1.317 ± 0.77
2.634MetLys: 2.634 ± 0.586
3.688MetLeu: 3.688 ± 0.803
0.79MetMet: 0.79 ± 0.522
2.107MetAsn: 2.107 ± 0.56
0.79MetPro: 0.79 ± 0.346
1.054MetGln: 1.054 ± 0.636
2.107MetArg: 2.107 ± 0.744
3.688MetSer: 3.688 ± 0.919
1.054MetThr: 1.054 ± 0.429
0.79MetVal: 0.79 ± 0.369
0.79MetTrp: 0.79 ± 0.369
1.317MetTyr: 1.317 ± 0.527
0.0MetXaa: 0.0 ± 0.0
Asn
4.478AsnAla: 4.478 ± 0.919
1.317AsnCys: 1.317 ± 0.795
3.161AsnAsp: 3.161 ± 0.79
5.005AsnGlu: 5.005 ± 0.935
2.371AsnPhe: 2.371 ± 0.85
2.634AsnGly: 2.634 ± 0.806
1.844AsnHis: 1.844 ± 0.971
4.742AsnIle: 4.742 ± 0.812
4.742AsnLys: 4.742 ± 1.014
6.586AsnLeu: 6.586 ± 1.22
2.107AsnMet: 2.107 ± 0.554
2.634AsnAsn: 2.634 ± 0.696
2.107AsnPro: 2.107 ± 0.628
2.634AsnGln: 2.634 ± 0.727
2.371AsnArg: 2.371 ± 0.678
4.478AsnSer: 4.478 ± 0.942
3.688AsnThr: 3.688 ± 1.17
5.269AsnVal: 5.269 ± 1.582
1.844AsnTrp: 1.844 ± 0.738
4.215AsnTyr: 4.215 ± 1.064
0.0AsnXaa: 0.0 ± 0.0
Pro
1.581ProAla: 1.581 ± 0.784
0.0ProCys: 0.0 ± 0.0
2.107ProAsp: 2.107 ± 0.709
1.054ProGlu: 1.054 ± 0.541
1.844ProPhe: 1.844 ± 0.617
1.844ProGly: 1.844 ± 0.577
0.527ProHis: 0.527 ± 0.308
3.425ProIle: 3.425 ± 0.513
0.263ProLys: 0.263 ± 0.233
2.107ProLeu: 2.107 ± 0.447
1.317ProMet: 1.317 ± 0.498
2.371ProAsn: 2.371 ± 0.902
2.371ProPro: 2.371 ± 0.974
1.581ProGln: 1.581 ± 0.728
2.371ProArg: 2.371 ± 0.397
2.898ProSer: 2.898 ± 1.027
2.107ProThr: 2.107 ± 0.997
2.371ProVal: 2.371 ± 1.115
0.0ProTrp: 0.0 ± 0.0
2.107ProTyr: 2.107 ± 0.745
0.0ProXaa: 0.0 ± 0.0
Gln
1.844GlnAla: 1.844 ± 0.721
0.263GlnCys: 0.263 ± 0.272
1.844GlnAsp: 1.844 ± 1.078
2.371GlnGlu: 2.371 ± 0.516
1.581GlnPhe: 1.581 ± 0.606
0.263GlnGly: 0.263 ± 0.234
1.581GlnHis: 1.581 ± 0.707
3.688GlnIle: 3.688 ± 0.949
2.634GlnLys: 2.634 ± 0.999
4.478GlnLeu: 4.478 ± 1.258
0.79GlnMet: 0.79 ± 0.435
3.688GlnAsn: 3.688 ± 1.06
0.263GlnPro: 0.263 ± 0.257
3.688GlnGln: 3.688 ± 1.094
2.107GlnArg: 2.107 ± 0.796
2.371GlnSer: 2.371 ± 0.468
2.898GlnThr: 2.898 ± 0.757
2.634GlnVal: 2.634 ± 0.806
0.527GlnTrp: 0.527 ± 0.484
2.634GlnTyr: 2.634 ± 0.74
0.0GlnXaa: 0.0 ± 0.0
Arg
1.317ArgAla: 1.317 ± 0.547
1.054ArgCys: 1.054 ± 0.509
2.371ArgAsp: 2.371 ± 0.714
2.371ArgGlu: 2.371 ± 0.903
1.844ArgPhe: 1.844 ± 0.532
1.581ArgGly: 1.581 ± 0.364
1.054ArgHis: 1.054 ± 0.494
2.898ArgIle: 2.898 ± 0.759
2.634ArgLys: 2.634 ± 0.668
2.634ArgLeu: 2.634 ± 0.552
2.898ArgMet: 2.898 ± 0.863
4.478ArgAsn: 4.478 ± 1.09
1.844ArgPro: 1.844 ± 0.602
2.898ArgGln: 2.898 ± 0.606
2.634ArgArg: 2.634 ± 0.797
3.161ArgSer: 3.161 ± 1.003
3.688ArgThr: 3.688 ± 0.771
3.161ArgVal: 3.161 ± 1.035
1.054ArgTrp: 1.054 ± 0.386
2.107ArgTyr: 2.107 ± 0.651
0.0ArgXaa: 0.0 ± 0.0
Ser
2.898SerAla: 2.898 ± 1.028
0.79SerCys: 0.79 ± 0.448
3.952SerAsp: 3.952 ± 1.278
5.269SerGlu: 5.269 ± 1.008
3.952SerPhe: 3.952 ± 1.033
1.844SerGly: 1.844 ± 0.435
0.79SerHis: 0.79 ± 0.357
5.796SerIle: 5.796 ± 1.649
5.005SerLys: 5.005 ± 0.643
6.059SerLeu: 6.059 ± 1.219
3.161SerMet: 3.161 ± 0.833
5.532SerAsn: 5.532 ± 1.512
2.107SerPro: 2.107 ± 0.736
4.478SerGln: 4.478 ± 0.67
3.425SerArg: 3.425 ± 0.708
6.849SerSer: 6.849 ± 1.978
5.269SerThr: 5.269 ± 1.069
5.532SerVal: 5.532 ± 1.12
0.263SerTrp: 0.263 ± 0.243
2.898SerTyr: 2.898 ± 1.085
0.0SerXaa: 0.0 ± 0.0
Thr
3.161ThrAla: 3.161 ± 1.014
0.527ThrCys: 0.527 ± 0.365
4.215ThrAsp: 4.215 ± 1.136
2.371ThrGlu: 2.371 ± 0.516
4.215ThrPhe: 4.215 ± 0.847
1.581ThrGly: 1.581 ± 0.697
0.79ThrHis: 0.79 ± 0.379
6.586ThrIle: 6.586 ± 1.258
2.898ThrLys: 2.898 ± 0.598
7.64ThrLeu: 7.64 ± 2.03
2.371ThrMet: 2.371 ± 0.602
3.161ThrAsn: 3.161 ± 1.298
2.107ThrPro: 2.107 ± 0.552
2.107ThrGln: 2.107 ± 0.676
2.634ThrArg: 2.634 ± 0.794
5.796ThrSer: 5.796 ± 1.033
6.586ThrThr: 6.586 ± 2.047
3.688ThrVal: 3.688 ± 1.093
1.317ThrTrp: 1.317 ± 0.413
2.371ThrTyr: 2.371 ± 0.971
0.0ThrXaa: 0.0 ± 0.0
Val
5.269ValAla: 5.269 ± 0.765
1.844ValCys: 1.844 ± 0.78
5.005ValAsp: 5.005 ± 1.717
4.742ValGlu: 4.742 ± 1.123
2.107ValPhe: 2.107 ± 0.806
2.107ValGly: 2.107 ± 0.65
1.054ValHis: 1.054 ± 0.55
4.742ValIle: 4.742 ± 0.96
4.478ValLys: 4.478 ± 1.073
5.005ValLeu: 5.005 ± 1.174
1.581ValMet: 1.581 ± 0.753
4.742ValAsn: 4.742 ± 1.22
1.581ValPro: 1.581 ± 0.783
1.317ValGln: 1.317 ± 0.448
1.317ValArg: 1.317 ± 0.559
3.425ValSer: 3.425 ± 0.735
5.269ValThr: 5.269 ± 1.169
2.898ValVal: 2.898 ± 0.594
1.054ValTrp: 1.054 ± 0.674
1.581ValTyr: 1.581 ± 0.478
0.0ValXaa: 0.0 ± 0.0
Trp
0.263TrpAla: 0.263 ± 0.243
0.79TrpCys: 0.79 ± 0.726
0.79TrpAsp: 0.79 ± 0.341
0.263TrpGlu: 0.263 ± 0.319
0.263TrpPhe: 0.263 ± 0.242
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.054TrpIle: 1.054 ± 0.403
2.107TrpLys: 2.107 ± 0.779
1.317TrpLeu: 1.317 ± 0.498
0.263TrpMet: 0.263 ± 0.272
0.79TrpAsn: 0.79 ± 0.556
0.263TrpPro: 0.263 ± 0.289
0.79TrpGln: 0.79 ± 0.563
0.263TrpArg: 0.263 ± 0.242
0.79TrpSer: 0.79 ± 0.357
0.79TrpThr: 0.79 ± 0.56
0.79TrpVal: 0.79 ± 0.402
0.263TrpTrp: 0.263 ± 0.289
1.317TrpTyr: 1.317 ± 0.361
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.425TyrAla: 3.425 ± 0.715
1.054TyrCys: 1.054 ± 0.529
3.688TyrAsp: 3.688 ± 1.279
2.898TyrGlu: 2.898 ± 1.042
2.634TyrPhe: 2.634 ± 0.602
1.581TyrGly: 1.581 ± 0.647
0.263TyrHis: 0.263 ± 0.242
3.688TyrIle: 3.688 ± 0.889
2.634TyrLys: 2.634 ± 0.756
2.634TyrLeu: 2.634 ± 1.014
1.317TyrMet: 1.317 ± 0.461
4.215TyrAsn: 4.215 ± 1.001
1.317TyrPro: 1.317 ± 0.593
0.79TyrGln: 0.79 ± 0.394
2.107TyrArg: 2.107 ± 0.894
4.742TyrSer: 4.742 ± 1.651
2.898TyrThr: 2.898 ± 1.053
2.371TyrVal: 2.371 ± 0.706
0.79TyrTrp: 0.79 ± 0.382
3.425TyrTyr: 3.425 ± 1.399
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (3797 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski