Amino acid dipepetide frequency for Xanthomonadaceae bacterium NML91-0213

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.727AlaAla: 19.727 ± 0.253	1.327AlaCys: 1.327 ± 0.042	8.183AlaAsp: 8.183 ± 0.11	7.115AlaGlu: 7.115 ± 0.108	4.164AlaPhe: 4.164 ± 0.076	12.684AlaGly: 12.684 ± 0.132	2.8AlaHis: 2.8 ± 0.057	5.643AlaIle: 5.643 ± 0.084	2.355AlaLys: 2.355 ± 0.07	16.324AlaLeu: 16.324 ± 0.199	3.363AlaMet: 3.363 ± 0.058	2.584AlaAsn: 2.584 ± 0.068	6.781AlaPro: 6.781 ± 0.103	5.247AlaGln: 5.247 ± 0.086	11.79AlaArg: 11.79 ± 0.149	6.605AlaSer: 6.605 ± 0.098	6.697AlaThr: 6.697 ± 0.106	9.428AlaVal: 9.428 ± 0.105	2.222AlaTrp: 2.222 ± 0.052	2.42AlaTyr: 2.42 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.077CysAla: 1.077 ± 0.043	0.109CysCys: 0.109 ± 0.011	0.473CysAsp: 0.473 ± 0.022	0.454CysGlu: 0.454 ± 0.022	0.248CysPhe: 0.248 ± 0.017	0.884CysGly: 0.884 ± 0.033	0.23CysHis: 0.23 ± 0.015	0.318CysIle: 0.318 ± 0.02	0.112CysLys: 0.112 ± 0.01	0.691CysLeu: 0.691 ± 0.028	0.137CysMet: 0.137 ± 0.011	0.188CysAsn: 0.188 ± 0.014	0.419CysPro: 0.419 ± 0.023	0.206CysGln: 0.206 ± 0.015	0.62CysArg: 0.62 ± 0.028	0.404CysSer: 0.404 ± 0.02	0.446CysThr: 0.446 ± 0.023	0.643CysVal: 0.643 ± 0.027	0.124CysTrp: 0.124 ± 0.012	0.165CysTyr: 0.165 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	10.028AspAla: 10.028 ± 0.126	0.422AspCys: 0.422 ± 0.02	4.002AspAsp: 4.002 ± 0.08	3.491AspGlu: 3.491 ± 0.059	1.956AspPhe: 1.956 ± 0.046	6.498AspGly: 6.498 ± 0.092	1.305AspHis: 1.305 ± 0.042	2.428AspIle: 2.428 ± 0.056	0.982AspLys: 0.982 ± 0.039	5.659AspLeu: 5.659 ± 0.087	1.114AspMet: 1.114 ± 0.033	1.277AspAsn: 1.277 ± 0.043	3.951AspPro: 3.951 ± 0.067	1.53AspGln: 1.53 ± 0.042	4.638AspArg: 4.638 ± 0.073	2.485AspSer: 2.485 ± 0.058	2.878AspThr: 2.878 ± 0.055	4.548AspVal: 4.548 ± 0.072	1.122AspTrp: 1.122 ± 0.032	1.539AspTyr: 1.539 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.597GluAla: 7.597 ± 0.108	0.339GluCys: 0.339 ± 0.023	2.643GluAsp: 2.643 ± 0.053	2.51GluGlu: 2.51 ± 0.062	1.712GluPhe: 1.712 ± 0.048	4.241GluGly: 4.241 ± 0.088	1.392GluHis: 1.392 ± 0.04	2.465GluIle: 2.465 ± 0.063	1.251GluLys: 1.251 ± 0.048	6.113GluLeu: 6.113 ± 0.097	1.101GluMet: 1.101 ± 0.038	1.056GluAsn: 1.056 ± 0.036	2.751GluPro: 2.751 ± 0.057	2.423GluGln: 2.423 ± 0.065	5.821GluArg: 5.821 ± 0.087	2.393GluSer: 2.393 ± 0.056	2.513GluThr: 2.513 ± 0.055	4.279GluVal: 4.279 ± 0.07	0.74GluTrp: 0.74 ± 0.029	1.09GluTyr: 1.09 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.378PheAla: 4.378 ± 0.073	0.288PheCys: 0.288 ± 0.016	2.721PheAsp: 2.721 ± 0.064	1.995PheGlu: 1.995 ± 0.047	1.108PhePhe: 1.108 ± 0.034	3.271PheGly: 3.271 ± 0.062	0.776PheHis: 0.776 ± 0.032	1.157PheIle: 1.157 ± 0.039	0.581PheLys: 0.581 ± 0.024	2.828PheLeu: 2.828 ± 0.064	0.597PheMet: 0.597 ± 0.029	0.89PheAsn: 0.89 ± 0.032	1.337PhePro: 1.337 ± 0.042	0.885PheGln: 0.885 ± 0.033	2.337PheArg: 2.337 ± 0.044	1.723PheSer: 1.723 ± 0.045	1.471PheThr: 1.471 ± 0.045	2.585PheVal: 2.585 ± 0.053	0.457PheTrp: 0.457 ± 0.025	0.716PheTyr: 0.716 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.018GlyAla: 10.018 ± 0.121	0.774GlyCys: 0.774 ± 0.03	5.541GlyAsp: 5.541 ± 0.092	5.189GlyGlu: 5.189 ± 0.081	3.433GlyPhe: 3.433 ± 0.062	7.703GlyGly: 7.703 ± 0.107	2.222GlyHis: 2.222 ± 0.048	4.07GlyIle: 4.07 ± 0.065	2.137GlyLys: 2.137 ± 0.059	8.972GlyLeu: 8.972 ± 0.113	2.45GlyMet: 2.45 ± 0.051	2.204GlyAsn: 2.204 ± 0.056	3.336GlyPro: 3.336 ± 0.056	2.988GlyGln: 2.988 ± 0.057	7.329GlyArg: 7.329 ± 0.089	4.695GlySer: 4.695 ± 0.074	4.681GlyThr: 4.681 ± 0.08	6.687GlyVal: 6.687 ± 0.102	1.729GlyTrp: 1.729 ± 0.045	2.266GlyTyr: 2.266 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	3.497HisAla: 3.497 ± 0.065	0.263HisCys: 0.263 ± 0.017	1.431HisAsp: 1.431 ± 0.044	1.099HisGlu: 1.099 ± 0.032	0.778HisPhe: 0.778 ± 0.028	2.434HisGly: 2.434 ± 0.058	0.616HisHis: 0.616 ± 0.025	0.726HisIle: 0.726 ± 0.03	0.369HisLys: 0.369 ± 0.022	2.165HisLeu: 2.165 ± 0.056	0.42HisMet: 0.42 ± 0.024	0.469HisAsn: 0.469 ± 0.022	1.541HisPro: 1.541 ± 0.047	0.566HisGln: 0.566 ± 0.023	1.855HisArg: 1.855 ± 0.043	0.911HisSer: 0.911 ± 0.034	0.953HisThr: 0.953 ± 0.033	1.838HisVal: 1.838 ± 0.047	0.403HisTrp: 0.403 ± 0.023	0.575HisTyr: 0.575 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.295IleAla: 6.295 ± 0.093	0.32IleCys: 0.32 ± 0.02	3.475IleAsp: 3.475 ± 0.054	2.933IleGlu: 2.933 ± 0.061	0.949IlePhe: 0.949 ± 0.035	4.304IleGly: 4.304 ± 0.086	0.849IleHis: 0.849 ± 0.029	1.19IleIle: 1.19 ± 0.042	0.836IleLys: 0.836 ± 0.035	2.986IleLeu: 2.986 ± 0.063	0.496IleMet: 0.496 ± 0.025	1.126IleAsn: 1.126 ± 0.037	1.944IlePro: 1.944 ± 0.052	1.037IleGln: 1.037 ± 0.037	2.906IleArg: 2.906 ± 0.059	1.877IleSer: 1.877 ± 0.046	2.003IleThr: 2.003 ± 0.047	3.192IleVal: 3.192 ± 0.066	0.39IleTrp: 0.39 ± 0.018	0.686IleTyr: 0.686 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.491LysAla: 2.491 ± 0.072	0.099LysCys: 0.099 ± 0.01	1.021LysAsp: 1.021 ± 0.046	0.912LysGlu: 0.912 ± 0.038	0.571LysPhe: 0.571 ± 0.027	1.502LysGly: 1.502 ± 0.05	0.413LysHis: 0.413 ± 0.021	0.83LysIle: 0.83 ± 0.031	0.763LysLys: 0.763 ± 0.041	2.209LysLeu: 2.209 ± 0.055	0.426LysMet: 0.426 ± 0.026	0.474LysAsn: 0.474 ± 0.025	1.278LysPro: 1.278 ± 0.041	0.774LysGln: 0.774 ± 0.035	1.736LysArg: 1.736 ± 0.041	1.046LysSer: 1.046 ± 0.037	1.062LysThr: 1.062 ± 0.04	1.569LysVal: 1.569 ± 0.054	0.218LysTrp: 0.218 ± 0.015	0.473LysTyr: 0.473 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.805LeuAla: 15.805 ± 0.166	0.885LeuCys: 0.885 ± 0.028	7.034LeuAsp: 7.034 ± 0.09	5.814LeuGlu: 5.814 ± 0.09	3.245LeuPhe: 3.245 ± 0.063	8.635LeuGly: 8.635 ± 0.107	2.553LeuHis: 2.553 ± 0.054	3.336LeuIle: 3.336 ± 0.067	2.233LeuLys: 2.233 ± 0.061	12.058LeuLeu: 12.058 ± 0.19	2.079LeuMet: 2.079 ± 0.053	1.958LeuAsn: 1.958 ± 0.055	6.524LeuPro: 6.524 ± 0.089	4.13LeuGln: 4.13 ± 0.073	9.754LeuArg: 9.754 ± 0.131	5.116LeuSer: 5.116 ± 0.071	4.382LeuThr: 4.382 ± 0.063	8.573LeuVal: 8.573 ± 0.11	1.399LeuTrp: 1.399 ± 0.043	2.022LeuTyr: 2.022 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.78MetAla: 2.78 ± 0.056	0.139MetCys: 0.139 ± 0.012	1.146MetAsp: 1.146 ± 0.04	0.979MetGlu: 0.979 ± 0.032	0.625MetPhe: 0.625 ± 0.029	1.545MetGly: 1.545 ± 0.038	0.525MetHis: 0.525 ± 0.023	0.822MetIle: 0.822 ± 0.033	0.611MetLys: 0.611 ± 0.03	2.43MetLeu: 2.43 ± 0.056	0.445MetMet: 0.445 ± 0.021	0.536MetAsn: 0.536 ± 0.023	1.51MetPro: 1.51 ± 0.042	0.903MetGln: 0.903 ± 0.03	1.975MetArg: 1.975 ± 0.048	1.486MetSer: 1.486 ± 0.04	1.282MetThr: 1.282 ± 0.036	1.447MetVal: 1.447 ± 0.039	0.187MetTrp: 0.187 ± 0.012	0.347MetTyr: 0.347 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.019AsnAla: 3.019 ± 0.068	0.17AsnCys: 0.17 ± 0.012	1.218AsnAsp: 1.218 ± 0.043	1.013AsnGlu: 1.013 ± 0.032	0.772AsnPhe: 0.772 ± 0.032	1.995AsnGly: 1.995 ± 0.054	0.431AsnHis: 0.431 ± 0.02	0.912AsnIle: 0.912 ± 0.031	0.425AsnLys: 0.425 ± 0.023	2.179AsnLeu: 2.179 ± 0.05	0.42AsnMet: 0.42 ± 0.023	0.58AsnAsn: 0.58 ± 0.029	1.589AsnPro: 1.589 ± 0.044	0.626AsnGln: 0.626 ± 0.03	1.799AsnArg: 1.799 ± 0.043	0.921AsnSer: 0.921 ± 0.036	1.135AsnThr: 1.135 ± 0.044	1.681AsnVal: 1.681 ± 0.049	0.325AsnTrp: 0.325 ± 0.022	0.522AsnTyr: 0.522 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	8.197ProAla: 8.197 ± 0.113	0.33ProCys: 0.33 ± 0.02	3.848ProAsp: 3.848 ± 0.068	3.337ProGlu: 3.337 ± 0.064	1.522ProPhe: 1.522 ± 0.042	5.333ProGly: 5.333 ± 0.087	1.214ProHis: 1.214 ± 0.036	1.638ProIle: 1.638 ± 0.044	1.02ProLys: 1.02 ± 0.036	5.502ProLeu: 5.502 ± 0.084	1.321ProMet: 1.321 ± 0.036	0.94ProAsn: 0.94 ± 0.032	3.296ProPro: 3.296 ± 0.082	1.945ProGln: 1.945 ± 0.044	4.07ProArg: 4.07 ± 0.078	2.448ProSer: 2.448 ± 0.055	2.433ProThr: 2.433 ± 0.06	4.684ProVal: 4.684 ± 0.073	0.86ProTrp: 0.86 ± 0.032	1.086ProTyr: 1.086 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.404GlnAla: 5.404 ± 0.081	0.233GlnCys: 0.233 ± 0.016	1.53GlnAsp: 1.53 ± 0.041	1.417GlnGlu: 1.417 ± 0.041	0.996GlnPhe: 0.996 ± 0.036	2.597GlnGly: 2.597 ± 0.054	0.718GlnHis: 0.718 ± 0.025	1.239GlnIle: 1.239 ± 0.039	0.717GlnLys: 0.717 ± 0.035	4.009GlnLeu: 4.009 ± 0.066	0.718GlnMet: 0.718 ± 0.024	0.615GlnAsn: 0.615 ± 0.032	2.289GlnPro: 2.289 ± 0.055	1.649GlnGln: 1.649 ± 0.042	3.692GlnArg: 3.692 ± 0.066	1.494GlnSer: 1.494 ± 0.041	1.414GlnThr: 1.414 ± 0.04	2.867GlnVal: 2.867 ± 0.053	0.511GlnTrp: 0.511 ± 0.024	0.659GlnTyr: 0.659 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	10.28ArgAla: 10.28 ± 0.119	0.611ArgCys: 0.611 ± 0.028	5.334ArgAsp: 5.334 ± 0.084	5.376ArgGlu: 5.376 ± 0.081	3.091ArgPhe: 3.091 ± 0.062	6.22ArgGly: 6.22 ± 0.081	2.188ArgHis: 2.188 ± 0.057	4.283ArgIle: 4.283 ± 0.069	1.704ArgLys: 1.704 ± 0.046	9.592ArgLeu: 9.592 ± 0.128	2.291ArgMet: 2.291 ± 0.054	2.011ArgAsn: 2.011 ± 0.048	4.188ArgPro: 4.188 ± 0.075	3.143ArgGln: 3.143 ± 0.066	7.526ArgArg: 7.526 ± 0.112	3.841ArgSer: 3.841 ± 0.071	3.75ArgThr: 3.75 ± 0.063	6.385ArgVal: 6.385 ± 0.092	1.529ArgTrp: 1.529 ± 0.045	2.233ArgTyr: 2.233 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.985SerAla: 5.985 ± 0.089	0.357SerCys: 0.357 ± 0.019	2.617SerAsp: 2.617 ± 0.056	2.329SerGlu: 2.329 ± 0.054	1.652SerPhe: 1.652 ± 0.048	5.053SerGly: 5.053 ± 0.077	1.073SerHis: 1.073 ± 0.036	2.04SerIle: 2.04 ± 0.043	0.975SerLys: 0.975 ± 0.037	4.799SerLeu: 4.799 ± 0.069	1.054SerMet: 1.054 ± 0.033	1.167SerAsn: 1.167 ± 0.044	2.741SerPro: 2.741 ± 0.053	1.582SerGln: 1.582 ± 0.041	3.908SerArg: 3.908 ± 0.074	2.356SerSer: 2.356 ± 0.063	2.645SerThr: 2.645 ± 0.059	3.51SerVal: 3.51 ± 0.069	0.724SerTrp: 0.724 ± 0.029	1.092SerTyr: 1.092 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.196ThrAla: 6.196 ± 0.118	0.341ThrCys: 0.341 ± 0.023	2.457ThrAsp: 2.457 ± 0.059	1.965ThrGlu: 1.965 ± 0.047	1.435ThrPhe: 1.435 ± 0.042	4.864ThrGly: 4.864 ± 0.079	1.022ThrHis: 1.022 ± 0.036	2.008ThrIle: 2.008 ± 0.056	0.689ThrLys: 0.689 ± 0.033	5.851ThrLeu: 5.851 ± 0.076	0.913ThrMet: 0.913 ± 0.032	0.909ThrAsn: 0.909 ± 0.041	3.43ThrPro: 3.43 ± 0.06	1.298ThrGln: 1.298 ± 0.034	4.066ThrArg: 4.066 ± 0.077	2.211ThrSer: 2.211 ± 0.052	2.568ThrThr: 2.568 ± 0.064	3.928ThrVal: 3.928 ± 0.063	0.691ThrTrp: 0.691 ± 0.032	0.914ThrTyr: 0.914 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	10.441ValAla: 10.441 ± 0.135	0.617ValCys: 0.617 ± 0.029	5.195ValAsp: 5.195 ± 0.075	4.813ValGlu: 4.813 ± 0.07	2.512ValPhe: 2.512 ± 0.055	5.808ValGly: 5.808 ± 0.076	1.76ValHis: 1.76 ± 0.043	3.309ValIle: 3.309 ± 0.058	1.379ValLys: 1.379 ± 0.045	8.748ValLeu: 8.748 ± 0.11	1.562ValMet: 1.562 ± 0.04	1.77ValAsn: 1.77 ± 0.051	4.243ValPro: 4.243 ± 0.068	2.428ValGln: 2.428 ± 0.055	6.144ValArg: 6.144 ± 0.086	3.718ValSer: 3.718 ± 0.063	3.557ValThr: 3.557 ± 0.065	6.662ValVal: 6.662 ± 0.105	0.917ValTrp: 0.917 ± 0.029	1.468ValTyr: 1.468 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.455TrpAla: 1.455 ± 0.044	0.153TrpCys: 0.153 ± 0.013	0.692TrpAsp: 0.692 ± 0.028	0.601TrpGlu: 0.601 ± 0.024	0.552TrpPhe: 0.552 ± 0.024	0.888TrpGly: 0.888 ± 0.037	0.398TrpHis: 0.398 ± 0.021	0.671TrpIle: 0.671 ± 0.032	0.372TrpLys: 0.372 ± 0.022	2.263TrpLeu: 2.263 ± 0.054	0.437TrpMet: 0.437 ± 0.025	0.444TrpAsn: 0.444 ± 0.025	0.804TrpPro: 0.804 ± 0.032	0.712TrpGln: 0.712 ± 0.028	1.485TrpArg: 1.485 ± 0.045	0.865TrpSer: 0.865 ± 0.034	0.822TrpThr: 0.822 ± 0.032	0.954TrpVal: 0.954 ± 0.032	0.337TrpTrp: 0.337 ± 0.021	0.339TrpTyr: 0.339 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.788TyrAla: 2.788 ± 0.057	0.174TyrCys: 0.174 ± 0.013	1.294TyrAsp: 1.294 ± 0.042	1.088TyrGlu: 1.088 ± 0.035	0.779TyrPhe: 0.779 ± 0.029	1.963TyrGly: 1.963 ± 0.049	0.426TyrHis: 0.426 ± 0.021	0.706TyrIle: 0.706 ± 0.031	0.356TyrLys: 0.356 ± 0.018	2.157TyrLeu: 2.157 ± 0.047	0.374TyrMet: 0.374 ± 0.021	0.537TyrAsn: 0.537 ± 0.028	1.073TyrPro: 1.073 ± 0.036	0.696TyrGln: 0.696 ± 0.028	2.124TyrArg: 2.124 ± 0.052	1.066TyrSer: 1.066 ± 0.037	1.063TyrThr: 1.063 ± 0.036	1.591TyrVal: 1.591 ± 0.045	0.357TyrTrp: 0.357 ± 0.02	0.532TyrTyr: 0.532 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2879 proteins (949773 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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