Amino acid dipepetide frequency for Halalkaliarchaeum desulfuricum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.956AlaAla: 11.956 ± 0.159	0.736AlaCys: 0.736 ± 0.033	8.835AlaAsp: 8.835 ± 0.105	8.544AlaGlu: 8.544 ± 0.109	3.874AlaPhe: 3.874 ± 0.067	9.471AlaGly: 9.471 ± 0.12	1.719AlaHis: 1.719 ± 0.043	5.436AlaIle: 5.436 ± 0.082	1.893AlaLys: 1.893 ± 0.043	9.179AlaLeu: 9.179 ± 0.115	1.886AlaMet: 1.886 ± 0.047	2.15AlaAsn: 2.15 ± 0.048	3.648AlaPro: 3.648 ± 0.057	2.077AlaGln: 2.077 ± 0.049	5.97AlaArg: 5.97 ± 0.085	4.841AlaSer: 4.841 ± 0.075	6.198AlaThr: 6.198 ± 0.082	10.021AlaVal: 10.021 ± 0.137	1.023AlaTrp: 1.023 ± 0.038	2.605AlaTyr: 2.605 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.581CysAla: 0.581 ± 0.026	0.093CysCys: 0.093 ± 0.009	0.629CysAsp: 0.629 ± 0.028	0.654CysGlu: 0.654 ± 0.026	0.207CysPhe: 0.207 ± 0.017	0.93CysGly: 0.93 ± 0.035	0.201CysHis: 0.201 ± 0.012	0.277CysIle: 0.277 ± 0.019	0.156CysLys: 0.156 ± 0.01	0.586CysLeu: 0.586 ± 0.025	0.122CysMet: 0.122 ± 0.012	0.213CysAsn: 0.213 ± 0.018	0.608CysPro: 0.608 ± 0.03	0.138CysGln: 0.138 ± 0.013	0.546CysArg: 0.546 ± 0.025	0.432CysSer: 0.432 ± 0.02	0.424CysThr: 0.424 ± 0.022	0.564CysVal: 0.564 ± 0.03	0.082CysTrp: 0.082 ± 0.01	0.173CysTyr: 0.173 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	9.073AspAla: 9.073 ± 0.106	0.692AspCys: 0.692 ± 0.033	7.416AspAsp: 7.416 ± 0.104	7.928AspGlu: 7.928 ± 0.12	1.862AspPhe: 1.862 ± 0.047	8.197AspGly: 8.197 ± 0.112	1.867AspHis: 1.867 ± 0.053	2.863AspIle: 2.863 ± 0.059	0.949AspLys: 0.949 ± 0.032	6.597AspLeu: 6.597 ± 0.082	1.087AspMet: 1.087 ± 0.033	1.304AspAsn: 1.304 ± 0.041	5.075AspPro: 5.075 ± 0.081	1.602AspGln: 1.602 ± 0.039	7.364AspArg: 7.364 ± 0.097	3.444AspSer: 3.444 ± 0.066	3.941AspThr: 3.941 ± 0.075	8.077AspVal: 8.077 ± 0.108	1.081AspTrp: 1.081 ± 0.032	1.793AspTyr: 1.793 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	8.881GluAla: 8.881 ± 0.121	0.545GluCys: 0.545 ± 0.026	5.809GluAsp: 5.809 ± 0.084	8.829GluGlu: 8.829 ± 0.15	3.319GluPhe: 3.319 ± 0.061	6.112GluGly: 6.112 ± 0.077	1.988GluHis: 1.988 ± 0.045	4.778GluIle: 4.778 ± 0.084	2.033GluLys: 2.033 ± 0.054	8.898GluLeu: 8.898 ± 0.114	1.913GluMet: 1.913 ± 0.043	2.491GluAsn: 2.491 ± 0.061	4.765GluPro: 4.765 ± 0.092	2.581GluGln: 2.581 ± 0.056	7.449GluArg: 7.449 ± 0.104	5.348GluSer: 5.348 ± 0.077	7.04GluThr: 7.04 ± 0.097	6.165GluVal: 6.165 ± 0.099	1.191GluTrp: 1.191 ± 0.032	2.965GluTyr: 2.965 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	3.504PheAla: 3.504 ± 0.062	0.266PheCys: 0.266 ± 0.014	3.369PheAsp: 3.369 ± 0.061	3.604PheGlu: 3.604 ± 0.067	1.125PhePhe: 1.125 ± 0.044	3.345PheGly: 3.345 ± 0.063	0.638PheHis: 0.638 ± 0.031	1.085PheIle: 1.085 ± 0.035	0.491PheLys: 0.491 ± 0.023	3.036PheLeu: 3.036 ± 0.064	0.486PheMet: 0.486 ± 0.025	0.643PheAsn: 0.643 ± 0.025	1.411PhePro: 1.411 ± 0.04	0.735PheGln: 0.735 ± 0.029	1.942PheArg: 1.942 ± 0.051	1.712PheSer: 1.712 ± 0.044	1.829PheThr: 1.829 ± 0.046	3.22PheVal: 3.22 ± 0.058	0.384PheTrp: 0.384 ± 0.019	0.851PheTyr: 0.851 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.755GlyAla: 7.755 ± 0.112	0.8GlyCys: 0.8 ± 0.03	6.721GlyAsp: 6.721 ± 0.103	7.811GlyGlu: 7.811 ± 0.099	3.242GlyPhe: 3.242 ± 0.064	7.436GlyGly: 7.436 ± 0.098	1.636GlyHis: 1.636 ± 0.047	4.928GlyIle: 4.928 ± 0.076	1.983GlyLys: 1.983 ± 0.047	7.004GlyLeu: 7.004 ± 0.099	1.764GlyMet: 1.764 ± 0.045	2.088GlyAsn: 2.088 ± 0.049	3.31GlyPro: 3.31 ± 0.06	1.862GlyGln: 1.862 ± 0.049	5.142GlyArg: 5.142 ± 0.076	4.87GlySer: 4.87 ± 0.078	5.938GlyThr: 5.938 ± 0.087	7.707GlyVal: 7.707 ± 0.105	1.091GlyTrp: 1.091 ± 0.035	2.713GlyTyr: 2.713 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.97HisAla: 1.97 ± 0.045	0.204HisCys: 0.204 ± 0.015	1.837HisAsp: 1.837 ± 0.046	1.796HisGlu: 1.796 ± 0.045	0.487HisPhe: 0.487 ± 0.023	1.92HisGly: 1.92 ± 0.05	0.539HisHis: 0.539 ± 0.027	0.601HisIle: 0.601 ± 0.027	0.323HisLys: 0.323 ± 0.019	1.702HisLeu: 1.702 ± 0.042	0.261HisMet: 0.261 ± 0.015	0.489HisAsn: 0.489 ± 0.024	1.307HisPro: 1.307 ± 0.038	0.463HisGln: 0.463 ± 0.023	1.441HisArg: 1.441 ± 0.041	0.897HisSer: 0.897 ± 0.033	1.074HisThr: 1.074 ± 0.033	1.955HisVal: 1.955 ± 0.044	0.234HisTrp: 0.234 ± 0.015	0.529HisTyr: 0.529 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.287IleAla: 5.287 ± 0.07	0.305IleCys: 0.305 ± 0.02	4.555IleAsp: 4.555 ± 0.066	5.02IleGlu: 5.02 ± 0.078	0.977IlePhe: 0.977 ± 0.036	4.17IleGly: 4.17 ± 0.069	0.993IleHis: 0.993 ± 0.033	1.317IleIle: 1.317 ± 0.044	0.74IleLys: 0.74 ± 0.029	3.149IleLeu: 3.149 ± 0.069	0.524IleMet: 0.524 ± 0.023	0.887IleAsn: 0.887 ± 0.028	2.267IlePro: 2.267 ± 0.051	1.228IleGln: 1.228 ± 0.039	2.848IleArg: 2.848 ± 0.052	2.183IleSer: 2.183 ± 0.046	2.463IleThr: 2.463 ± 0.056	4.218IleVal: 4.218 ± 0.077	0.371IleTrp: 0.371 ± 0.019	0.957IleTyr: 0.957 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	1.744LysAla: 1.744 ± 0.046	0.124LysCys: 0.124 ± 0.011	1.099LysAsp: 1.099 ± 0.037	1.488LysGlu: 1.488 ± 0.049	0.522LysPhe: 0.522 ± 0.028	1.386LysGly: 1.386 ± 0.043	0.485LysHis: 0.485 ± 0.025	0.839LysIle: 0.839 ± 0.035	0.623LysLys: 0.623 ± 0.032	1.832LysLeu: 1.832 ± 0.046	0.372LysMet: 0.372 ± 0.019	0.571LysAsn: 0.571 ± 0.027	1.013LysPro: 1.013 ± 0.033	0.811LysGln: 0.811 ± 0.029	1.894LysArg: 1.894 ± 0.048	1.171LysSer: 1.171 ± 0.043	1.351LysThr: 1.351 ± 0.035	1.146LysVal: 1.146 ± 0.037	0.243LysTrp: 0.243 ± 0.015	0.609LysTyr: 0.609 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	10.244LeuAla: 10.244 ± 0.147	0.619LeuCys: 0.619 ± 0.028	6.933LeuAsp: 6.933 ± 0.088	8.365LeuGlu: 8.365 ± 0.105	3.25LeuPhe: 3.25 ± 0.07	7.226LeuGly: 7.226 ± 0.097	1.547LeuHis: 1.547 ± 0.042	3.082LeuIle: 3.082 ± 0.066	1.637LeuLys: 1.637 ± 0.046	8.553LeuLeu: 8.553 ± 0.139	1.203LeuMet: 1.203 ± 0.037	1.623LeuAsn: 1.623 ± 0.05	4.234LeuPro: 4.234 ± 0.062	2.262LeuGln: 2.262 ± 0.047	5.457LeuArg: 5.457 ± 0.089	6.081LeuSer: 6.081 ± 0.096	4.782LeuThr: 4.782 ± 0.075	8.057LeuVal: 8.057 ± 0.109	0.868LeuTrp: 0.868 ± 0.033	2.242LeuTyr: 2.242 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.716MetAla: 1.716 ± 0.04	0.112MetCys: 0.112 ± 0.011	1.231MetAsp: 1.231 ± 0.033	1.221MetGlu: 1.221 ± 0.037	0.486MetPhe: 0.486 ± 0.022	1.386MetGly: 1.386 ± 0.044	0.336MetHis: 0.336 ± 0.017	0.77MetIle: 0.77 ± 0.032	0.435MetLys: 0.435 ± 0.02	1.387MetLeu: 1.387 ± 0.044	0.321MetMet: 0.321 ± 0.02	0.597MetAsn: 0.597 ± 0.027	0.794MetPro: 0.794 ± 0.03	0.474MetGln: 0.474 ± 0.022	1.047MetArg: 1.047 ± 0.033	1.437MetSer: 1.437 ± 0.043	1.473MetThr: 1.473 ± 0.041	1.25MetVal: 1.25 ± 0.035	0.18MetTrp: 0.18 ± 0.014	0.452MetTyr: 0.452 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.382AsnAla: 2.382 ± 0.051	0.236AsnCys: 0.236 ± 0.018	1.656AsnAsp: 1.656 ± 0.044	1.901AsnGlu: 1.901 ± 0.047	0.627AsnPhe: 0.627 ± 0.029	1.868AsnGly: 1.868 ± 0.048	0.498AsnHis: 0.498 ± 0.023	0.797AsnIle: 0.797 ± 0.034	0.45AsnLys: 0.45 ± 0.027	1.929AsnLeu: 1.929 ± 0.046	0.377AsnMet: 0.377 ± 0.018	0.586AsnAsn: 0.586 ± 0.028	1.576AsnPro: 1.576 ± 0.045	0.577AsnGln: 0.577 ± 0.026	1.798AsnArg: 1.798 ± 0.044	0.957AsnSer: 0.957 ± 0.036	1.23AsnThr: 1.23 ± 0.033	2.298AsnVal: 2.298 ± 0.044	0.303AsnTrp: 0.303 ± 0.019	0.682AsnTyr: 0.682 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.452ProAla: 4.452 ± 0.072	0.275ProCys: 0.275 ± 0.019	5.129ProAsp: 5.129 ± 0.081	5.449ProGlu: 5.449 ± 0.082	1.675ProPhe: 1.675 ± 0.044	4.321ProGly: 4.321 ± 0.068	0.937ProHis: 0.937 ± 0.029	2.256ProIle: 2.256 ± 0.047	0.906ProLys: 0.906 ± 0.033	3.582ProLeu: 3.582 ± 0.064	0.844ProMet: 0.844 ± 0.031	1.139ProAsn: 1.139 ± 0.035	2.309ProPro: 2.309 ± 0.051	0.976ProGln: 0.976 ± 0.029	2.376ProArg: 2.376 ± 0.054	2.63ProSer: 2.63 ± 0.048	3.247ProThr: 3.247 ± 0.062	4.208ProVal: 4.208 ± 0.07	0.553ProTrp: 0.553 ± 0.021	1.194ProTyr: 1.194 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.211GlnAla: 2.211 ± 0.046	0.201GlnCys: 0.201 ± 0.015	1.205GlnAsp: 1.205 ± 0.04	1.832GlnGlu: 1.832 ± 0.051	1.089GlnPhe: 1.089 ± 0.031	1.657GlnGly: 1.657 ± 0.044	0.549GlnHis: 0.549 ± 0.026	1.146GlnIle: 1.146 ± 0.035	0.591GlnLys: 0.591 ± 0.028	2.668GlnLeu: 2.668 ± 0.049	0.486GlnMet: 0.486 ± 0.025	0.631GlnAsn: 0.631 ± 0.03	1.166GlnPro: 1.166 ± 0.034	0.861GlnGln: 0.861 ± 0.037	2.005GlnArg: 2.005 ± 0.049	1.43GlnSer: 1.43 ± 0.042	1.378GlnThr: 1.378 ± 0.039	1.697GlnVal: 1.697 ± 0.04	0.333GlnTrp: 0.333 ± 0.018	0.889GlnTyr: 0.889 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	5.971ArgAla: 5.971 ± 0.088	0.513ArgCys: 0.513 ± 0.024	4.976ArgAsp: 4.976 ± 0.067	7.645ArgGlu: 7.645 ± 0.098	2.431ArgPhe: 2.431 ± 0.051	4.767ArgGly: 4.767 ± 0.089	1.287ArgHis: 1.287 ± 0.036	3.602ArgIle: 3.602 ± 0.062	1.743ArgLys: 1.743 ± 0.046	6.318ArgLeu: 6.318 ± 0.092	1.361ArgMet: 1.361 ± 0.036	1.837ArgAsn: 1.837 ± 0.041	2.694ArgPro: 2.694 ± 0.057	1.893ArgGln: 1.893 ± 0.045	5.509ArgArg: 5.509 ± 0.1	3.74ArgSer: 3.74 ± 0.065	4.168ArgThr: 4.168 ± 0.064	5.098ArgVal: 5.098 ± 0.08	0.766ArgTrp: 0.766 ± 0.031	2.026ArgTyr: 2.026 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	4.932SerAla: 4.932 ± 0.083	0.379SerCys: 0.379 ± 0.021	4.344SerAsp: 4.344 ± 0.073	4.386SerGlu: 4.386 ± 0.079	1.874SerPhe: 1.874 ± 0.046	5.046SerGly: 5.046 ± 0.066	1.014SerHis: 1.014 ± 0.035	2.511SerIle: 2.511 ± 0.05	1.194SerLys: 1.194 ± 0.04	4.562SerLeu: 4.562 ± 0.073	1.056SerMet: 1.056 ± 0.031	1.272SerAsn: 1.272 ± 0.04	2.779SerPro: 2.779 ± 0.06	1.316SerGln: 1.316 ± 0.036	3.58SerArg: 3.58 ± 0.069	2.802SerSer: 2.802 ± 0.057	3.401SerThr: 3.401 ± 0.062	4.773SerVal: 4.773 ± 0.064	0.65SerTrp: 0.65 ± 0.031	1.439SerTyr: 1.439 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	6.527ThrAla: 6.527 ± 0.087	0.448ThrCys: 0.448 ± 0.024	5.4ThrAsp: 5.4 ± 0.075	4.914ThrGlu: 4.914 ± 0.064	2.195ThrPhe: 2.195 ± 0.056	5.589ThrGly: 5.589 ± 0.085	1.23ThrHis: 1.23 ± 0.037	3.061ThrIle: 3.061 ± 0.052	1.025ThrLys: 1.025 ± 0.032	5.547ThrLeu: 5.547 ± 0.079	1.042ThrMet: 1.042 ± 0.035	1.321ThrAsn: 1.321 ± 0.039	3.319ThrPro: 3.319 ± 0.07	1.316ThrGln: 1.316 ± 0.037	3.38ThrArg: 3.38 ± 0.064	2.631ThrSer: 2.631 ± 0.063	3.808ThrThr: 3.808 ± 0.077	6.646ThrVal: 6.646 ± 0.091	0.633ThrTrp: 0.633 ± 0.026	1.743ThrTyr: 1.743 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	9.265ValAla: 9.265 ± 0.119	0.713ValCys: 0.713 ± 0.03	7.677ValAsp: 7.677 ± 0.09	8.213ValGlu: 8.213 ± 0.108	3.119ValPhe: 3.119 ± 0.069	7.763ValGly: 7.763 ± 0.107	1.681ValHis: 1.681 ± 0.042	3.742ValIle: 3.742 ± 0.073	1.447ValLys: 1.447 ± 0.037	7.802ValLeu: 7.802 ± 0.122	1.389ValMet: 1.389 ± 0.037	1.9ValAsn: 1.9 ± 0.045	4.406ValPro: 4.406 ± 0.072	1.792ValGln: 1.792 ± 0.042	5.593ValArg: 5.593 ± 0.082	4.959ValSer: 4.959 ± 0.072	5.844ValThr: 5.844 ± 0.087	8.68ValVal: 8.68 ± 0.132	0.808ValTrp: 0.808 ± 0.031	2.237ValTyr: 2.237 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.89TrpAla: 0.89 ± 0.033	0.093TrpCys: 0.093 ± 0.01	0.735TrpAsp: 0.735 ± 0.029	0.989TrpGlu: 0.989 ± 0.034	0.461TrpPhe: 0.461 ± 0.021	0.852TrpGly: 0.852 ± 0.035	0.238TrpHis: 0.238 ± 0.017	0.647TrpIle: 0.647 ± 0.027	0.284TrpLys: 0.284 ± 0.017	1.267TrpLeu: 1.267 ± 0.035	0.228TrpMet: 0.228 ± 0.015	0.357TrpAsn: 0.357 ± 0.019	0.426TrpPro: 0.426 ± 0.02	0.379TrpGln: 0.379 ± 0.019	0.827TrpArg: 0.827 ± 0.033	0.548TrpSer: 0.548 ± 0.025	0.72TrpThr: 0.72 ± 0.028	0.77TrpVal: 0.77 ± 0.028	0.189TrpTrp: 0.189 ± 0.016	0.416TrpTyr: 0.416 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.723TyrAla: 2.723 ± 0.05	0.261TyrCys: 0.261 ± 0.016	2.658TyrAsp: 2.658 ± 0.067	2.51TyrGlu: 2.51 ± 0.056	0.851TyrPhe: 0.851 ± 0.035	2.359TyrGly: 2.359 ± 0.05	0.646TyrHis: 0.646 ± 0.026	0.72TyrIle: 0.72 ± 0.025	0.421TyrLys: 0.421 ± 0.022	2.666TyrLeu: 2.666 ± 0.059	0.385TyrMet: 0.385 ± 0.019	0.629TyrAsn: 0.629 ± 0.03	1.349TyrPro: 1.349 ± 0.041	0.685TyrGln: 0.685 ± 0.027	2.175TyrArg: 2.175 ± 0.052	1.2TyrSer: 1.2 ± 0.04	1.466TyrThr: 1.466 ± 0.043	2.479TyrVal: 2.479 ± 0.054	0.332TyrTrp: 0.332 ± 0.02	0.853TyrTyr: 0.853 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3224 proteins (966158 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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