Amino acid dipepetide frequency for Candidatus Frankia californiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.922AlaAla: 19.922 ± 0.232	1.186AlaCys: 1.186 ± 0.033	8.416AlaAsp: 8.416 ± 0.107	7.315AlaGlu: 7.315 ± 0.105	3.611AlaPhe: 3.611 ± 0.058	13.527AlaGly: 13.527 ± 0.144	2.755AlaHis: 2.755 ± 0.053	4.173AlaIle: 4.173 ± 0.058	2.063AlaLys: 2.063 ± 0.046	13.081AlaLeu: 13.081 ± 0.123	2.382AlaMet: 2.382 ± 0.042	2.069AlaAsn: 2.069 ± 0.045	5.931AlaPro: 5.931 ± 0.101	3.596AlaGln: 3.596 ± 0.062	10.58AlaArg: 10.58 ± 0.112	6.555AlaSer: 6.555 ± 0.08	7.396AlaThr: 7.396 ± 0.088	12.356AlaVal: 12.356 ± 0.146	1.763AlaTrp: 1.763 ± 0.037	2.302AlaTyr: 2.302 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.158CysAla: 1.158 ± 0.035	0.142CysCys: 0.142 ± 0.012	0.563CysAsp: 0.563 ± 0.025	0.419CysGlu: 0.419 ± 0.02	0.246CysPhe: 0.246 ± 0.014	1.001CysGly: 1.001 ± 0.03	0.238CysHis: 0.238 ± 0.016	0.215CysIle: 0.215 ± 0.014	0.117CysLys: 0.117 ± 0.01	0.829CysLeu: 0.829 ± 0.025	0.135CysMet: 0.135 ± 0.011	0.137CysAsn: 0.137 ± 0.012	0.598CysPro: 0.598 ± 0.026	0.225CysGln: 0.225 ± 0.014	0.799CysArg: 0.799 ± 0.031	0.517CysSer: 0.517 ± 0.024	0.491CysThr: 0.491 ± 0.021	0.677CysVal: 0.677 ± 0.025	0.165CysTrp: 0.165 ± 0.011	0.21CysTyr: 0.21 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.742AspAla: 7.742 ± 0.084	0.44AspCys: 0.44 ± 0.017	3.916AspAsp: 3.916 ± 0.066	3.543AspGlu: 3.543 ± 0.064	1.484AspPhe: 1.484 ± 0.039	6.025AspGly: 6.025 ± 0.078	1.567AspHis: 1.567 ± 0.04	2.209AspIle: 2.209 ± 0.057	0.932AspLys: 0.932 ± 0.031	6.731AspLeu: 6.731 ± 0.092	0.799AspMet: 0.799 ± 0.026	1.071AspAsn: 1.071 ± 0.031	4.515AspPro: 4.515 ± 0.06	1.802AspGln: 1.802 ± 0.04	5.335AspArg: 5.335 ± 0.077	2.647AspSer: 2.647 ± 0.045	3.116AspThr: 3.116 ± 0.05	5.491AspVal: 5.491 ± 0.079	0.844AspTrp: 0.844 ± 0.026	1.172AspTyr: 1.172 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.004GluAla: 6.004 ± 0.074	0.359GluCys: 0.359 ± 0.02	2.29GluAsp: 2.29 ± 0.044	2.58GluGlu: 2.58 ± 0.058	1.443GluPhe: 1.443 ± 0.036	3.183GluGly: 3.183 ± 0.053	1.513GluHis: 1.513 ± 0.043	2.607GluIle: 2.607 ± 0.053	1.18GluLys: 1.18 ± 0.035	6.072GluLeu: 6.072 ± 0.076	0.92GluMet: 0.92 ± 0.033	0.956GluAsn: 0.956 ± 0.026	3.056GluPro: 3.056 ± 0.056	2.179GluGln: 2.179 ± 0.045	4.982GluArg: 4.982 ± 0.074	2.315GluSer: 2.315 ± 0.042	2.732GluThr: 2.732 ± 0.052	4.213GluVal: 4.213 ± 0.063	0.675GluTrp: 0.675 ± 0.022	0.97GluTyr: 0.97 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.633PheAla: 3.633 ± 0.056	0.297PheCys: 0.297 ± 0.016	2.168PheAsp: 2.168 ± 0.042	1.227PheGlu: 1.227 ± 0.036	0.923PhePhe: 0.923 ± 0.031	3.053PheGly: 3.053 ± 0.058	0.655PheHis: 0.655 ± 0.025	0.829PheIle: 0.829 ± 0.028	0.377PheLys: 0.377 ± 0.018	2.596PheLeu: 2.596 ± 0.052	0.359PheMet: 0.359 ± 0.018	0.572PheAsn: 0.572 ± 0.023	1.414PhePro: 1.414 ± 0.033	0.701PheGln: 0.701 ± 0.023	1.912PheArg: 1.912 ± 0.046	1.554PheSer: 1.554 ± 0.04	2.022PheThr: 2.022 ± 0.04	2.421PheVal: 2.421 ± 0.046	0.35PheTrp: 0.35 ± 0.017	0.59PheTyr: 0.59 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.502GlyAla: 9.502 ± 0.116	0.932GlyCys: 0.932 ± 0.029	4.819GlyAsp: 4.819 ± 0.07	4.438GlyGlu: 4.438 ± 0.071	2.768GlyPhe: 2.768 ± 0.051	8.057GlyGly: 8.057 ± 0.122	2.29GlyHis: 2.29 ± 0.044	3.561GlyIle: 3.561 ± 0.063	1.898GlyLys: 1.898 ± 0.044	9.07GlyLeu: 9.07 ± 0.107	2.016GlyMet: 2.016 ± 0.042	1.754GlyAsn: 1.754 ± 0.045	5.076GlyPro: 5.076 ± 0.077	2.919GlyGln: 2.919 ± 0.057	8.264GlyArg: 8.264 ± 0.094	5.586GlySer: 5.586 ± 0.07	5.547GlyThr: 5.547 ± 0.069	7.567GlyVal: 7.567 ± 0.093	1.749GlyTrp: 1.749 ± 0.044	2.172GlyTyr: 2.172 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.797HisAla: 2.797 ± 0.053	0.203HisCys: 0.203 ± 0.012	1.543HisAsp: 1.543 ± 0.032	1.138HisGlu: 1.138 ± 0.032	0.582HisPhe: 0.582 ± 0.023	2.307HisGly: 2.307 ± 0.045	0.753HisHis: 0.753 ± 0.027	0.679HisIle: 0.679 ± 0.022	0.302HisLys: 0.302 ± 0.018	2.489HisLeu: 2.489 ± 0.043	0.338HisMet: 0.338 ± 0.015	0.424HisAsn: 0.424 ± 0.018	1.902HisPro: 1.902 ± 0.044	0.636HisGln: 0.636 ± 0.022	2.292HisArg: 2.292 ± 0.05	1.124HisSer: 1.124 ± 0.033	1.365HisThr: 1.365 ± 0.035	1.818HisVal: 1.818 ± 0.045	0.349HisTrp: 0.349 ± 0.015	0.512HisTyr: 0.512 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	4.972IleAla: 4.972 ± 0.079	0.379IleCys: 0.379 ± 0.019	2.762IleAsp: 2.762 ± 0.053	2.192IleGlu: 2.192 ± 0.043	0.925IlePhe: 0.925 ± 0.026	3.644IleGly: 3.644 ± 0.061	0.828IleHis: 0.828 ± 0.024	1.367IleIle: 1.367 ± 0.039	0.688IleLys: 0.688 ± 0.026	3.003IleLeu: 3.003 ± 0.055	0.609IleMet: 0.609 ± 0.022	0.85IleAsn: 0.85 ± 0.029	2.171IlePro: 2.171 ± 0.047	0.883IleGln: 0.883 ± 0.027	3.152IleArg: 3.152 ± 0.053	2.132IleSer: 2.132 ± 0.041	2.499IleThr: 2.499 ± 0.049	3.354IleVal: 3.354 ± 0.057	0.418IleTrp: 0.418 ± 0.018	0.713IleTyr: 0.713 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.088LysAla: 2.088 ± 0.04	0.101LysCys: 0.101 ± 0.01	0.897LysAsp: 0.897 ± 0.029	0.791LysGlu: 0.791 ± 0.033	0.361LysPhe: 0.361 ± 0.018	1.209LysGly: 1.209 ± 0.036	0.367LysHis: 0.367 ± 0.019	1.109LysIle: 1.109 ± 0.03	0.601LysLys: 0.601 ± 0.028	1.716LysLeu: 1.716 ± 0.041	0.35LysMet: 0.35 ± 0.016	0.454LysAsn: 0.454 ± 0.02	1.009LysPro: 1.009 ± 0.032	0.551LysGln: 0.551 ± 0.025	1.236LysArg: 1.236 ± 0.035	0.929LysSer: 0.929 ± 0.03	1.077LysThr: 1.077 ± 0.03	1.622LysVal: 1.622 ± 0.04	0.215LysTrp: 0.215 ± 0.015	0.354LysTyr: 0.354 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.481LeuAla: 15.481 ± 0.168	0.898LeuCys: 0.898 ± 0.033	6.828LeuAsp: 6.828 ± 0.09	4.429LeuGlu: 4.429 ± 0.063	2.623LeuPhe: 2.623 ± 0.058	8.512LeuGly: 8.512 ± 0.1	2.194LeuHis: 2.194 ± 0.05	3.477LeuIle: 3.477 ± 0.059	1.478LeuLys: 1.478 ± 0.037	11.045LeuLeu: 11.045 ± 0.114	1.392LeuMet: 1.392 ± 0.035	1.631LeuAsn: 1.631 ± 0.037	6.363LeuPro: 6.363 ± 0.086	2.127LeuGln: 2.127 ± 0.044	9.069LeuArg: 9.069 ± 0.096	5.541LeuSer: 5.541 ± 0.073	6.634LeuThr: 6.634 ± 0.088	9.293LeuVal: 9.293 ± 0.103	1.189LeuTrp: 1.189 ± 0.037	1.712LeuTyr: 1.712 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.199MetAla: 2.199 ± 0.039	0.177MetCys: 0.177 ± 0.014	0.838MetAsp: 0.838 ± 0.028	0.695MetGlu: 0.695 ± 0.022	0.558MetPhe: 0.558 ± 0.022	1.198MetGly: 1.198 ± 0.036	0.348MetHis: 0.348 ± 0.018	0.961MetIle: 0.961 ± 0.029	0.366MetLys: 0.366 ± 0.015	1.837MetLeu: 1.837 ± 0.04	0.329MetMet: 0.329 ± 0.017	0.424MetAsn: 0.424 ± 0.018	1.104MetPro: 1.104 ± 0.029	0.422MetGln: 0.422 ± 0.02	1.521MetArg: 1.521 ± 0.038	1.282MetSer: 1.282 ± 0.032	1.534MetThr: 1.534 ± 0.036	1.435MetVal: 1.435 ± 0.036	0.213MetTrp: 0.213 ± 0.013	0.288MetTyr: 0.288 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.214AsnAla: 2.214 ± 0.045	0.153AsnCys: 0.153 ± 0.013	0.983AsnAsp: 0.983 ± 0.031	0.821AsnGlu: 0.821 ± 0.029	0.456AsnPhe: 0.456 ± 0.021	1.792AsnGly: 1.792 ± 0.043	0.447AsnHis: 0.447 ± 0.017	0.779AsnIle: 0.779 ± 0.025	0.324AsnLys: 0.324 ± 0.018	1.825AsnLeu: 1.825 ± 0.04	0.315AsnMet: 0.315 ± 0.018	0.436AsnAsn: 0.436 ± 0.021	1.518AsnPro: 1.518 ± 0.041	0.532AsnGln: 0.532 ± 0.022	1.599AsnArg: 1.599 ± 0.037	0.967AsnSer: 0.967 ± 0.031	1.197AsnThr: 1.197 ± 0.035	1.446AsnVal: 1.446 ± 0.041	0.275AsnTrp: 0.275 ± 0.016	0.394AsnTyr: 0.394 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	8.845ProAla: 8.845 ± 0.118	0.421ProCys: 0.421 ± 0.02	4.778ProAsp: 4.778 ± 0.068	3.321ProGlu: 3.321 ± 0.052	1.62ProPhe: 1.62 ± 0.038	6.322ProGly: 6.322 ± 0.087	1.355ProHis: 1.355 ± 0.035	1.757ProIle: 1.757 ± 0.04	0.907ProLys: 0.907 ± 0.027	5.097ProLeu: 5.097 ± 0.063	1.008ProMet: 1.008 ± 0.026	1.031ProAsn: 1.031 ± 0.031	4.099ProPro: 4.099 ± 0.094	1.553ProGln: 1.553 ± 0.038	4.283ProArg: 4.283 ± 0.065	3.613ProSer: 3.613 ± 0.058	3.686ProThr: 3.686 ± 0.063	5.367ProVal: 5.367 ± 0.07	0.882ProTrp: 0.882 ± 0.03	1.146ProTyr: 1.146 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.997GlnAla: 3.997 ± 0.061	0.192GlnCys: 0.192 ± 0.013	1.27GlnAsp: 1.27 ± 0.036	1.247GlnGlu: 1.247 ± 0.034	0.72GlnPhe: 0.72 ± 0.025	1.837GlnGly: 1.837 ± 0.041	0.678GlnHis: 0.678 ± 0.025	1.359GlnIle: 1.359 ± 0.034	0.451GlnLys: 0.451 ± 0.021	3.029GlnLeu: 3.029 ± 0.053	0.576GlnMet: 0.576 ± 0.02	0.534GlnAsn: 0.534 ± 0.021	2.06GlnPro: 2.06 ± 0.046	1.133GlnGln: 1.133 ± 0.036	2.744GlnArg: 2.744 ± 0.055	1.295GlnSer: 1.295 ± 0.045	1.544GlnThr: 1.544 ± 0.035	2.623GlnVal: 2.623 ± 0.048	0.429GlnTrp: 0.429 ± 0.018	0.511GlnTyr: 0.511 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	10.082ArgAla: 10.082 ± 0.128	0.822ArgCys: 0.822 ± 0.031	4.712ArgAsp: 4.712 ± 0.063	4.39ArgGlu: 4.39 ± 0.069	2.588ArgPhe: 2.588 ± 0.047	6.095ArgGly: 6.095 ± 0.077	2.382ArgHis: 2.382 ± 0.047	3.722ArgIle: 3.722 ± 0.06	1.509ArgLys: 1.509 ± 0.033	9.287ArgLeu: 9.287 ± 0.104	2.041ArgMet: 2.041 ± 0.045	1.637ArgAsn: 1.637 ± 0.042	5.527ArgPro: 5.527 ± 0.082	2.772ArgGln: 2.772 ± 0.058	9.375ArgArg: 9.375 ± 0.1	4.902ArgSer: 4.902 ± 0.069	5.347ArgThr: 5.347 ± 0.065	6.285ArgVal: 6.285 ± 0.085	1.603ArgTrp: 1.603 ± 0.044	1.954ArgTyr: 1.954 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.726SerAla: 6.726 ± 0.075	0.496SerCys: 0.496 ± 0.022	3.077SerAsp: 3.077 ± 0.045	2.423SerGlu: 2.423 ± 0.043	1.552SerPhe: 1.552 ± 0.038	5.913SerGly: 5.913 ± 0.076	1.134SerHis: 1.134 ± 0.03	1.822SerIle: 1.822 ± 0.044	0.863SerLys: 0.863 ± 0.029	4.883SerLeu: 4.883 ± 0.068	1.211SerMet: 1.211 ± 0.033	0.961SerAsn: 0.961 ± 0.028	3.628SerPro: 3.628 ± 0.063	1.47SerGln: 1.47 ± 0.04	4.647SerArg: 4.647 ± 0.073	3.486SerSer: 3.486 ± 0.064	3.496SerThr: 3.496 ± 0.054	4.523SerVal: 4.523 ± 0.067	0.986SerTrp: 0.986 ± 0.03	1.24SerTyr: 1.24 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	8.406ThrAla: 8.406 ± 0.091	0.494ThrCys: 0.494 ± 0.022	3.737ThrAsp: 3.737 ± 0.06	2.811ThrGlu: 2.811 ± 0.051	1.689ThrPhe: 1.689 ± 0.043	6.398ThrGly: 6.398 ± 0.075	1.194ThrHis: 1.194 ± 0.03	2.353ThrIle: 2.353 ± 0.044	0.977ThrLys: 0.977 ± 0.028	5.858ThrLeu: 5.858 ± 0.077	1.064ThrMet: 1.064 ± 0.031	1.148ThrAsn: 1.148 ± 0.034	4.106ThrPro: 4.106 ± 0.06	1.416ThrGln: 1.416 ± 0.034	4.481ThrArg: 4.481 ± 0.078	3.464ThrSer: 3.464 ± 0.056	3.968ThrThr: 3.968 ± 0.067	6.0ThrVal: 6.0 ± 0.072	0.897ThrTrp: 0.897 ± 0.029	1.205ThrTyr: 1.205 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	11.378ValAla: 11.378 ± 0.106	0.837ValCys: 0.837 ± 0.028	5.783ValAsp: 5.783 ± 0.066	4.678ValGlu: 4.678 ± 0.06	2.423ValPhe: 2.423 ± 0.045	7.098ValGly: 7.098 ± 0.087	2.022ValHis: 2.022 ± 0.043	3.32ValIle: 3.32 ± 0.057	1.374ValLys: 1.374 ± 0.041	9.376ValLeu: 9.376 ± 0.105	1.356ValMet: 1.356 ± 0.033	1.633ValAsn: 1.633 ± 0.044	5.046ValPro: 5.046 ± 0.065	2.067ValGln: 2.067 ± 0.041	7.359ValArg: 7.359 ± 0.092	4.735ValSer: 4.735 ± 0.07	5.976ValThr: 5.976 ± 0.07	8.499ValVal: 8.499 ± 0.095	1.133ValTrp: 1.133 ± 0.032	1.505ValTyr: 1.505 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.544TrpAla: 1.544 ± 0.038	0.174TrpCys: 0.174 ± 0.012	0.794TrpAsp: 0.794 ± 0.027	0.691TrpGlu: 0.691 ± 0.027	0.472TrpPhe: 0.472 ± 0.022	0.955TrpGly: 0.955 ± 0.031	0.383TrpHis: 0.383 ± 0.018	0.652TrpIle: 0.652 ± 0.026	0.315TrpLys: 0.315 ± 0.016	1.781TrpLeu: 1.781 ± 0.042	0.293TrpMet: 0.293 ± 0.016	0.366TrpAsn: 0.366 ± 0.016	0.827TrpPro: 0.827 ± 0.024	0.568TrpGln: 0.568 ± 0.02	1.453TrpArg: 1.453 ± 0.037	0.903TrpSer: 0.903 ± 0.03	0.938TrpThr: 0.938 ± 0.028	1.046TrpVal: 1.046 ± 0.031	0.343TrpTrp: 0.343 ± 0.017	0.309TrpTyr: 0.309 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.288TyrAla: 2.288 ± 0.044	0.181TyrCys: 0.181 ± 0.014	1.207TyrAsp: 1.207 ± 0.033	1.08TyrGlu: 1.08 ± 0.033	0.609TyrPhe: 0.609 ± 0.022	1.858TyrGly: 1.858 ± 0.036	0.453TyrHis: 0.453 ± 0.02	0.589TyrIle: 0.589 ± 0.024	0.318TyrLys: 0.318 ± 0.018	2.311TyrLeu: 2.311 ± 0.048	0.234TyrMet: 0.234 ± 0.015	0.381TyrAsn: 0.381 ± 0.017	1.14TyrPro: 1.14 ± 0.034	0.672TyrGln: 0.672 ± 0.024	1.949TyrArg: 1.949 ± 0.046	0.994TyrSer: 0.994 ± 0.03	1.104TyrThr: 1.104 ± 0.034	1.561TyrVal: 1.561 ± 0.04	0.327TyrTrp: 0.327 ± 0.017	0.43TyrTyr: 0.43 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4681 proteins (1173277 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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