Amino acid dipepetide frequency for Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.298AlaAla: 10.298 ± 0.144	1.192AlaCys: 1.192 ± 0.03	5.05AlaAsp: 5.05 ± 0.068	5.569AlaGlu: 5.569 ± 0.072	3.635AlaPhe: 3.635 ± 0.056	7.528AlaGly: 7.528 ± 0.089	1.947AlaHis: 1.947 ± 0.035	5.965AlaIle: 5.965 ± 0.074	4.006AlaLys: 4.006 ± 0.062	11.705AlaLeu: 11.705 ± 0.107	3.039AlaMet: 3.039 ± 0.052	3.16AlaAsn: 3.16 ± 0.052	3.679AlaPro: 3.679 ± 0.06	4.609AlaGln: 4.609 ± 0.075	5.605AlaArg: 5.605 ± 0.074	5.525AlaSer: 5.525 ± 0.082	4.899AlaThr: 4.899 ± 0.071	6.698AlaVal: 6.698 ± 0.072	1.638AlaTrp: 1.638 ± 0.035	2.027AlaTyr: 2.027 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.068CysAla: 1.068 ± 0.031	0.199CysCys: 0.199 ± 0.011	0.643CysAsp: 0.643 ± 0.022	0.657CysGlu: 0.657 ± 0.023	0.458CysPhe: 0.458 ± 0.019	1.129CysGly: 1.129 ± 0.031	0.356CysHis: 0.356 ± 0.019	0.649CysIle: 0.649 ± 0.023	0.357CysLys: 0.357 ± 0.015	1.071CysLeu: 1.071 ± 0.033	0.255CysMet: 0.255 ± 0.012	0.343CysAsn: 0.343 ± 0.016	0.575CysPro: 0.575 ± 0.024	0.504CysGln: 0.504 ± 0.021	0.664CysArg: 0.664 ± 0.023	0.704CysSer: 0.704 ± 0.024	0.534CysThr: 0.534 ± 0.019	0.815CysVal: 0.815 ± 0.025	0.198CysTrp: 0.198 ± 0.012	0.371CysTyr: 0.371 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.379AspAla: 5.379 ± 0.071	0.511AspCys: 0.511 ± 0.019	3.019AspAsp: 3.019 ± 0.062	3.466AspGlu: 3.466 ± 0.048	2.057AspPhe: 2.057 ± 0.041	3.822AspGly: 3.822 ± 0.086	0.971AspHis: 0.971 ± 0.032	3.635AspIle: 3.635 ± 0.049	2.595AspLys: 2.595 ± 0.047	4.517AspLeu: 4.517 ± 0.052	1.382AspMet: 1.382 ± 0.032	2.342AspAsn: 2.342 ± 0.059	2.193AspPro: 2.193 ± 0.04	1.47AspGln: 1.47 ± 0.036	2.614AspArg: 2.614 ± 0.046	2.888AspSer: 2.888 ± 0.067	2.719AspThr: 2.719 ± 0.06	3.812AspVal: 3.812 ± 0.055	0.808AspTrp: 0.808 ± 0.025	1.942AspTyr: 1.942 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.285GluAla: 5.285 ± 0.08	0.518GluCys: 0.518 ± 0.02	2.375GluAsp: 2.375 ± 0.045	3.365GluGlu: 3.365 ± 0.068	1.78GluPhe: 1.78 ± 0.04	3.632GluGly: 3.632 ± 0.051	1.422GluHis: 1.422 ± 0.032	3.368GluIle: 3.368 ± 0.054	3.341GluLys: 3.341 ± 0.054	5.742GluLeu: 5.742 ± 0.078	1.814GluMet: 1.814 ± 0.036	2.489GluAsn: 2.489 ± 0.043	2.017GluPro: 2.017 ± 0.04	3.266GluGln: 3.266 ± 0.06	3.617GluArg: 3.617 ± 0.06	2.954GluSer: 2.954 ± 0.049	3.063GluThr: 3.063 ± 0.044	3.64GluVal: 3.64 ± 0.061	0.781GluTrp: 0.781 ± 0.026	1.566GluTyr: 1.566 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.666PheAla: 3.666 ± 0.055	0.577PheCys: 0.577 ± 0.022	2.293PheAsp: 2.293 ± 0.044	1.743PheGlu: 1.743 ± 0.035	1.712PhePhe: 1.712 ± 0.046	3.124PheGly: 3.124 ± 0.055	0.84PheHis: 0.84 ± 0.025	2.676PheIle: 2.676 ± 0.046	1.313PheLys: 1.313 ± 0.033	3.416PheLeu: 3.416 ± 0.059	1.044PheMet: 1.044 ± 0.028	1.74PheAsn: 1.74 ± 0.036	1.531PhePro: 1.531 ± 0.032	1.068PheGln: 1.068 ± 0.025	1.897PheArg: 1.897 ± 0.038	3.117PheSer: 3.117 ± 0.053	2.542PheThr: 2.542 ± 0.052	2.472PheVal: 2.472 ± 0.044	0.628PheTrp: 0.628 ± 0.023	1.231PheTyr: 1.231 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.304GlyAla: 6.304 ± 0.089	1.086GlyCys: 1.086 ± 0.03	3.839GlyAsp: 3.839 ± 0.081	4.536GlyGlu: 4.536 ± 0.068	3.2GlyPhe: 3.2 ± 0.053	5.453GlyGly: 5.453 ± 0.089	1.647GlyHis: 1.647 ± 0.037	5.088GlyIle: 5.088 ± 0.064	3.995GlyLys: 3.995 ± 0.057	7.201GlyLeu: 7.201 ± 0.088	2.366GlyMet: 2.366 ± 0.047	2.869GlyAsn: 2.869 ± 0.069	2.014GlyPro: 2.014 ± 0.041	2.853GlyGln: 2.853 ± 0.046	3.705GlyArg: 3.705 ± 0.061	4.049GlySer: 4.049 ± 0.074	3.702GlyThr: 3.702 ± 0.074	5.874GlyVal: 5.874 ± 0.073	1.312GlyTrp: 1.312 ± 0.035	2.624GlyTyr: 2.624 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.919HisAla: 1.919 ± 0.037	0.353HisCys: 0.353 ± 0.017	1.182HisAsp: 1.182 ± 0.033	1.127HisGlu: 1.127 ± 0.03	1.065HisPhe: 1.065 ± 0.029	1.718HisGly: 1.718 ± 0.037	0.807HisHis: 0.807 ± 0.026	1.41HisIle: 1.41 ± 0.035	0.808HisLys: 0.808 ± 0.028	2.286HisLeu: 2.286 ± 0.042	0.562HisMet: 0.562 ± 0.022	0.886HisAsn: 0.886 ± 0.026	1.325HisPro: 1.325 ± 0.032	1.126HisGln: 1.126 ± 0.029	1.272HisArg: 1.272 ± 0.03	1.273HisSer: 1.273 ± 0.031	1.145HisThr: 1.145 ± 0.029	1.33HisVal: 1.33 ± 0.032	0.395HisTrp: 0.395 ± 0.016	0.96HisTyr: 0.96 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.629IleAla: 6.629 ± 0.086	0.728IleCys: 0.728 ± 0.022	3.567IleAsp: 3.567 ± 0.079	3.306IleGlu: 3.306 ± 0.058	2.164IlePhe: 2.164 ± 0.046	4.593IleGly: 4.593 ± 0.069	1.266IleHis: 1.266 ± 0.027	3.592IleIle: 3.592 ± 0.064	2.458IleLys: 2.458 ± 0.046	5.131IleLeu: 5.131 ± 0.076	1.328IleMet: 1.328 ± 0.035	2.7IleAsn: 2.7 ± 0.046	2.864IlePro: 2.864 ± 0.045	1.863IleGln: 1.863 ± 0.042	3.086IleArg: 3.086 ± 0.043	3.837IleSer: 3.837 ± 0.059	3.763IleThr: 3.763 ± 0.055	4.066IleVal: 4.066 ± 0.06	0.745IleTrp: 0.745 ± 0.023	1.626IleTyr: 1.626 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.346LysAla: 4.346 ± 0.071	0.329LysCys: 0.329 ± 0.015	2.071LysAsp: 2.071 ± 0.042	2.593LysGlu: 2.593 ± 0.052	1.193LysPhe: 1.193 ± 0.028	3.059LysGly: 3.059 ± 0.051	0.893LysHis: 0.893 ± 0.027	2.513LysIle: 2.513 ± 0.048	2.424LysLys: 2.424 ± 0.048	4.224LysLeu: 4.224 ± 0.065	1.313LysMet: 1.313 ± 0.03	1.856LysAsn: 1.856 ± 0.04	2.123LysPro: 2.123 ± 0.04	1.905LysGln: 1.905 ± 0.04	2.622LysArg: 2.622 ± 0.049	2.305LysSer: 2.305 ± 0.043	2.677LysThr: 2.677 ± 0.047	2.907LysVal: 2.907 ± 0.048	0.481LysTrp: 0.481 ± 0.018	1.257LysTyr: 1.257 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.308LeuAla: 11.308 ± 0.102	1.332LeuCys: 1.332 ± 0.033	5.251LeuAsp: 5.251 ± 0.075	5.355LeuGlu: 5.355 ± 0.073	4.25LeuPhe: 4.25 ± 0.065	7.007LeuGly: 7.007 ± 0.08	2.311LeuHis: 2.311 ± 0.045	5.842LeuIle: 5.842 ± 0.087	4.582LeuLys: 4.582 ± 0.059	11.701LeuLeu: 11.701 ± 0.148	2.946LeuMet: 2.946 ± 0.048	4.227LeuAsn: 4.227 ± 0.064	5.673LeuPro: 5.673 ± 0.069	4.028LeuGln: 4.028 ± 0.066	6.137LeuArg: 6.137 ± 0.081	7.116LeuSer: 7.116 ± 0.079	6.517LeuThr: 6.517 ± 0.081	6.844LeuVal: 6.844 ± 0.086	1.428LeuTrp: 1.428 ± 0.037	2.64LeuTyr: 2.64 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.964MetAla: 2.964 ± 0.053	0.216MetCys: 0.216 ± 0.013	1.209MetAsp: 1.209 ± 0.03	1.285MetGlu: 1.285 ± 0.032	0.934MetPhe: 0.934 ± 0.025	1.967MetGly: 1.967 ± 0.046	0.534MetHis: 0.534 ± 0.021	1.497MetIle: 1.497 ± 0.038	1.425MetLys: 1.425 ± 0.035	3.116MetLeu: 3.116 ± 0.048	0.957MetMet: 0.957 ± 0.028	1.13MetAsn: 1.13 ± 0.028	1.424MetPro: 1.424 ± 0.03	1.227MetGln: 1.227 ± 0.029	1.516MetArg: 1.516 ± 0.03	1.838MetSer: 1.838 ± 0.037	1.799MetThr: 1.799 ± 0.034	1.983MetVal: 1.983 ± 0.044	0.285MetTrp: 0.285 ± 0.013	0.537MetTyr: 0.537 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.722AsnAla: 3.722 ± 0.053	0.378AsnCys: 0.378 ± 0.014	2.12AsnAsp: 2.12 ± 0.045	2.019AsnGlu: 2.019 ± 0.037	1.312AsnPhe: 1.312 ± 0.033	3.105AsnGly: 3.105 ± 0.061	0.883AsnHis: 0.883 ± 0.024	2.46AsnIle: 2.46 ± 0.047	1.648AsnLys: 1.648 ± 0.037	3.515AsnLeu: 3.515 ± 0.055	0.971AsnMet: 0.971 ± 0.025	1.604AsnAsn: 1.604 ± 0.038	2.114AsnPro: 2.114 ± 0.047	1.524AsnGln: 1.524 ± 0.035	1.975AsnArg: 1.975 ± 0.041	2.064AsnSer: 2.064 ± 0.047	2.163AsnThr: 2.163 ± 0.045	2.728AsnVal: 2.728 ± 0.052	0.551AsnTrp: 0.551 ± 0.019	1.25AsnTyr: 1.25 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.536ProAla: 4.536 ± 0.058	0.409ProCys: 0.409 ± 0.017	2.874ProAsp: 2.874 ± 0.042	3.332ProGlu: 3.332 ± 0.057	1.845ProPhe: 1.845 ± 0.036	3.523ProGly: 3.523 ± 0.051	1.033ProHis: 1.033 ± 0.027	1.852ProIle: 1.852 ± 0.039	1.492ProLys: 1.492 ± 0.032	5.175ProLeu: 5.175 ± 0.066	1.078ProMet: 1.078 ± 0.026	1.273ProAsn: 1.273 ± 0.031	1.737ProPro: 1.737 ± 0.036	2.241ProGln: 2.241 ± 0.044	1.993ProArg: 1.993 ± 0.042	2.118ProSer: 2.118 ± 0.036	2.12ProThr: 2.12 ± 0.046	4.052ProVal: 4.052 ± 0.065	0.762ProTrp: 0.762 ± 0.024	1.212ProTyr: 1.212 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.583GlnAla: 4.583 ± 0.07	0.405GlnCys: 0.405 ± 0.019	1.782GlnAsp: 1.782 ± 0.036	2.325GlnGlu: 2.325 ± 0.045	1.455GlnPhe: 1.455 ± 0.036	2.986GlnGly: 2.986 ± 0.047	1.21GlnHis: 1.21 ± 0.031	2.311GlnIle: 2.311 ± 0.037	1.86GlnLys: 1.86 ± 0.041	4.779GlnLeu: 4.779 ± 0.074	1.21GlnMet: 1.21 ± 0.029	1.54GlnAsn: 1.54 ± 0.034	2.115GlnPro: 2.115 ± 0.051	3.108GlnGln: 3.108 ± 0.066	2.968GlnArg: 2.968 ± 0.051	2.236GlnSer: 2.236 ± 0.048	2.276GlnThr: 2.276 ± 0.042	2.793GlnVal: 2.793 ± 0.049	0.719GlnTrp: 0.719 ± 0.024	1.21GlnTyr: 1.21 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.549ArgAla: 4.549 ± 0.058	0.639ArgCys: 0.639 ± 0.023	3.018ArgAsp: 3.018 ± 0.053	3.79ArgGlu: 3.79 ± 0.066	2.584ArgPhe: 2.584 ± 0.04	3.343ArgGly: 3.343 ± 0.057	1.695ArgHis: 1.695 ± 0.039	3.438ArgIle: 3.438 ± 0.053	2.437ArgLys: 2.437 ± 0.046	6.363ArgLeu: 6.363 ± 0.086	1.647ArgMet: 1.647 ± 0.037	2.024ArgAsn: 2.024 ± 0.041	2.201ArgPro: 2.201 ± 0.04	3.144ArgGln: 3.144 ± 0.057	3.588ArgArg: 3.588 ± 0.065	2.655ArgSer: 2.655 ± 0.051	2.522ArgThr: 2.522 ± 0.042	3.717ArgVal: 3.717 ± 0.06	0.948ArgTrp: 0.948 ± 0.029	2.216ArgTyr: 2.216 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.715SerAla: 5.715 ± 0.07	0.646SerCys: 0.646 ± 0.023	3.038SerAsp: 3.038 ± 0.046	3.086SerGlu: 3.086 ± 0.054	2.277SerPhe: 2.277 ± 0.045	5.194SerGly: 5.194 ± 0.076	1.41SerHis: 1.41 ± 0.031	3.084SerIle: 3.084 ± 0.057	1.985SerLys: 1.985 ± 0.043	6.602SerLeu: 6.602 ± 0.07	1.452SerMet: 1.452 ± 0.031	1.816SerAsn: 1.816 ± 0.038	2.61SerPro: 2.61 ± 0.044	2.557SerGln: 2.557 ± 0.044	3.44SerArg: 3.44 ± 0.049	3.464SerSer: 3.464 ± 0.056	2.935SerThr: 2.935 ± 0.051	4.243SerVal: 4.243 ± 0.063	0.997SerTrp: 0.997 ± 0.025	1.625SerTyr: 1.625 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.076ThrAla: 5.076 ± 0.065	0.569ThrCys: 0.569 ± 0.019	2.777ThrAsp: 2.777 ± 0.057	2.653ThrGlu: 2.653 ± 0.05	2.18ThrPhe: 2.18 ± 0.046	4.573ThrGly: 4.573 ± 0.064	1.307ThrHis: 1.307 ± 0.032	3.051ThrIle: 3.051 ± 0.055	1.57ThrLys: 1.57 ± 0.035	7.522ThrLeu: 7.522 ± 0.087	1.154ThrMet: 1.154 ± 0.025	1.637ThrAsn: 1.637 ± 0.052	3.4ThrPro: 3.4 ± 0.05	2.321ThrGln: 2.321 ± 0.052	3.021ThrArg: 3.021 ± 0.046	2.955ThrSer: 2.955 ± 0.062	3.029ThrThr: 3.029 ± 0.058	4.048ThrVal: 4.048 ± 0.081	0.853ThrTrp: 0.853 ± 0.03	1.229ThrTyr: 1.229 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.875ValAla: 6.875 ± 0.078	0.859ValCys: 0.859 ± 0.026	3.764ValAsp: 3.764 ± 0.059	3.945ValGlu: 3.945 ± 0.065	2.579ValPhe: 2.579 ± 0.04	4.783ValGly: 4.783 ± 0.072	1.217ValHis: 1.217 ± 0.028	4.597ValIle: 4.597 ± 0.061	3.238ValLys: 3.238 ± 0.051	7.102ValLeu: 7.102 ± 0.086	2.21ValMet: 2.21 ± 0.043	2.885ValAsn: 2.885 ± 0.042	2.992ValPro: 2.992 ± 0.043	2.324ValGln: 2.324 ± 0.042	3.698ValArg: 3.698 ± 0.056	4.476ValSer: 4.476 ± 0.062	4.313ValThr: 4.313 ± 0.075	5.581ValVal: 5.581 ± 0.08	0.99ValTrp: 0.99 ± 0.027	1.793ValTyr: 1.793 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.021TrpAla: 1.021 ± 0.031	0.198TrpCys: 0.198 ± 0.012	0.631TrpAsp: 0.631 ± 0.024	0.607TrpGlu: 0.607 ± 0.022	0.714TrpPhe: 0.714 ± 0.024	0.93TrpGly: 0.93 ± 0.028	0.457TrpHis: 0.457 ± 0.019	0.794TrpIle: 0.794 ± 0.022	0.534TrpLys: 0.534 ± 0.022	2.325TrpLeu: 2.325 ± 0.046	0.451TrpMet: 0.451 ± 0.019	0.496TrpAsn: 0.496 ± 0.022	0.679TrpPro: 0.679 ± 0.022	1.163TrpGln: 1.163 ± 0.028	1.165TrpArg: 1.165 ± 0.038	0.811TrpSer: 0.811 ± 0.025	0.624TrpThr: 0.624 ± 0.024	0.942TrpVal: 0.942 ± 0.022	0.24TrpTrp: 0.24 ± 0.014	0.449TrpTyr: 0.449 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.529TyrAla: 2.529 ± 0.045	0.407TyrCys: 0.407 ± 0.018	1.637TyrAsp: 1.637 ± 0.036	1.275TyrGlu: 1.275 ± 0.033	1.236TyrPhe: 1.236 ± 0.031	2.248TyrGly: 2.248 ± 0.05	0.745TyrHis: 0.745 ± 0.023	1.488TyrIle: 1.488 ± 0.031	1.023TyrLys: 1.023 ± 0.029	3.006TyrLeu: 3.006 ± 0.057	0.665TyrMet: 0.665 ± 0.021	1.089TyrAsn: 1.089 ± 0.028	1.388TyrPro: 1.388 ± 0.034	1.569TyrGln: 1.569 ± 0.033	1.935TyrArg: 1.935 ± 0.039	1.793TyrSer: 1.793 ± 0.034	1.583TyrThr: 1.583 ± 0.042	1.677TyrVal: 1.677 ± 0.04	0.472TyrTrp: 0.472 ± 0.02	0.995TyrTyr: 0.995 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4538 proteins (1423640 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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