Amino acid dipepetide frequency for Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.703AlaAla: 2.703 ± 0.083
0.363AlaCys: 0.363 ± 0.024
2.331AlaAsp: 2.331 ± 0.064
3.805AlaGlu: 3.805 ± 0.077
2.757AlaPhe: 2.757 ± 0.068
3.627AlaGly: 3.627 ± 0.077
0.753AlaHis: 0.753 ± 0.03
5.878AlaIle: 5.878 ± 0.094
4.428AlaLys: 4.428 ± 0.084
6.636AlaLeu: 6.636 ± 0.099
1.253AlaMet: 1.253 ± 0.047
2.16AlaAsn: 2.16 ± 0.056
1.615AlaPro: 1.615 ± 0.05
1.14AlaGln: 1.14 ± 0.047
2.296AlaArg: 2.296 ± 0.062
3.755AlaSer: 3.755 ± 0.081
2.724AlaThr: 2.724 ± 0.066
4.061AlaVal: 4.061 ± 0.084
0.528AlaTrp: 0.528 ± 0.032
2.862AlaTyr: 2.862 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.261CysAla: 0.261 ± 0.023
0.088CysCys: 0.088 ± 0.013
0.355CysAsp: 0.355 ± 0.02
0.474CysGlu: 0.474 ± 0.027
0.214CysPhe: 0.214 ± 0.02
0.657CysGly: 0.657 ± 0.034
0.117CysHis: 0.117 ± 0.012
0.474CysIle: 0.474 ± 0.028
0.57CysLys: 0.57 ± 0.03
0.384CysLeu: 0.384 ± 0.024
0.131CysMet: 0.131 ± 0.014
0.339CysAsn: 0.339 ± 0.022
0.537CysPro: 0.537 ± 0.031
0.116CysGln: 0.116 ± 0.012
0.228CysArg: 0.228 ± 0.017
0.384CysSer: 0.384 ± 0.025
0.237CysThr: 0.237 ± 0.019
0.365CysVal: 0.365 ± 0.025
0.066CysTrp: 0.066 ± 0.01
0.321CysTyr: 0.321 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
2.301AspAla: 2.301 ± 0.06
0.331AspCys: 0.331 ± 0.022
2.032AspAsp: 2.032 ± 0.06
4.25AspGlu: 4.25 ± 0.087
2.414AspPhe: 2.414 ± 0.056
2.557AspGly: 2.557 ± 0.067
0.519AspHis: 0.519 ± 0.026
4.821AspIle: 4.821 ± 0.089
4.198AspLys: 4.198 ± 0.092
4.925AspLeu: 4.925 ± 0.082
0.971AspMet: 0.971 ± 0.037
1.958AspAsn: 1.958 ± 0.052
2.222AspPro: 2.222 ± 0.049
0.719AspGln: 0.719 ± 0.033
1.728AspArg: 1.728 ± 0.054
2.478AspSer: 2.478 ± 0.063
1.773AspThr: 1.773 ± 0.048
3.594AspVal: 3.594 ± 0.067
0.567AspTrp: 0.567 ± 0.029
2.561AspTyr: 2.561 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
4.087GluAla: 4.087 ± 0.081
0.455GluCys: 0.455 ± 0.026
3.599GluAsp: 3.599 ± 0.079
6.998GluGlu: 6.998 ± 0.126
2.847GluPhe: 2.847 ± 0.071
4.312GluGly: 4.312 ± 0.088
0.745GluHis: 0.745 ± 0.036
7.986GluIle: 7.986 ± 0.124
7.097GluLys: 7.097 ± 0.11
7.539GluLeu: 7.539 ± 0.126
1.478GluMet: 1.478 ± 0.046
3.632GluAsn: 3.632 ± 0.071
1.699GluPro: 1.699 ± 0.046
1.133GluGln: 1.133 ± 0.038
3.036GluArg: 3.036 ± 0.076
3.062GluSer: 3.062 ± 0.065
2.546GluThr: 2.546 ± 0.063
5.496GluVal: 5.496 ± 0.091
0.681GluTrp: 0.681 ± 0.028
3.147GluTyr: 3.147 ± 0.073
0.0GluXaa: 0.0 ± 0.0
Phe
2.441PheAla: 2.441 ± 0.07
0.255PheCys: 0.255 ± 0.019
2.135PheAsp: 2.135 ± 0.053
2.401PheGlu: 2.401 ± 0.054
2.07PhePhe: 2.07 ± 0.057
2.689PheGly: 2.689 ± 0.062
0.728PheHis: 0.728 ± 0.034
4.188PheIle: 4.188 ± 0.104
3.024PheLys: 3.024 ± 0.067
5.011PheLeu: 5.011 ± 0.108
0.979PheMet: 0.979 ± 0.033
2.399PheAsn: 2.399 ± 0.063
1.854PhePro: 1.854 ± 0.054
0.838PheGln: 0.838 ± 0.032
1.714PheArg: 1.714 ± 0.052
3.732PheSer: 3.732 ± 0.077
2.465PheThr: 2.465 ± 0.065
2.827PheVal: 2.827 ± 0.053
0.508PheTrp: 0.508 ± 0.028
2.391PheTyr: 2.391 ± 0.067
0.0PheXaa: 0.0 ± 0.0
Gly
3.326GlyAla: 3.326 ± 0.071
0.406GlyCys: 0.406 ± 0.027
2.784GlyAsp: 2.784 ± 0.064
4.397GlyGlu: 4.397 ± 0.077
3.159GlyPhe: 3.159 ± 0.068
4.174GlyGly: 4.174 ± 0.082
0.851GlyHis: 0.851 ± 0.034
7.196GlyIle: 7.196 ± 0.091
5.764GlyLys: 5.764 ± 0.103
6.139GlyLeu: 6.139 ± 0.102
1.392GlyMet: 1.392 ± 0.047
2.932GlyAsn: 2.932 ± 0.073
1.569GlyPro: 1.569 ± 0.044
1.088GlyGln: 1.088 ± 0.049
2.554GlyArg: 2.554 ± 0.058
3.626GlySer: 3.626 ± 0.061
2.767GlyThr: 2.767 ± 0.071
4.851GlyVal: 4.851 ± 0.075
0.782GlyTrp: 0.782 ± 0.031
3.503GlyTyr: 3.503 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
0.722HisAla: 0.722 ± 0.034
0.106HisCys: 0.106 ± 0.012
0.562HisAsp: 0.562 ± 0.028
0.893HisGlu: 0.893 ± 0.033
0.603HisPhe: 0.603 ± 0.027
1.019HisGly: 1.019 ± 0.038
0.315HisHis: 0.315 ± 0.024
1.177HisIle: 1.177 ± 0.043
0.883HisLys: 0.883 ± 0.033
1.15HisLeu: 1.15 ± 0.042
0.27HisMet: 0.27 ± 0.019
0.52HisAsn: 0.52 ± 0.029
0.685HisPro: 0.685 ± 0.029
0.257HisGln: 0.257 ± 0.018
0.507HisArg: 0.507 ± 0.027
0.79HisSer: 0.79 ± 0.033
0.636HisThr: 0.636 ± 0.03
1.022HisVal: 1.022 ± 0.04
0.15HisTrp: 0.15 ± 0.015
0.677HisTyr: 0.677 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.275IleAla: 6.275 ± 0.101
0.52IleCys: 0.52 ± 0.028
5.01IleAsp: 5.01 ± 0.094
6.758IleGlu: 6.758 ± 0.115
4.102IlePhe: 4.102 ± 0.099
6.117IleGly: 6.117 ± 0.097
1.186IleHis: 1.186 ± 0.05
9.853IleIle: 9.853 ± 0.151
7.588IleLys: 7.588 ± 0.12
9.708IleLeu: 9.708 ± 0.141
1.954IleMet: 1.954 ± 0.055
5.014IleAsn: 5.014 ± 0.099
4.455IlePro: 4.455 ± 0.075
1.97IleGln: 1.97 ± 0.059
4.213IleArg: 4.213 ± 0.086
7.371IleSer: 7.371 ± 0.121
5.044IleThr: 5.044 ± 0.095
7.15IleVal: 7.15 ± 0.103
0.724IleTrp: 0.724 ± 0.035
4.514IleTyr: 4.514 ± 0.09
0.0IleXaa: 0.0 ± 0.0
Lys
4.247LysAla: 4.247 ± 0.089
0.575LysCys: 0.575 ± 0.037
4.565LysAsp: 4.565 ± 0.09
7.767LysGlu: 7.767 ± 0.122
2.833LysPhe: 2.833 ± 0.059
5.238LysGly: 5.238 ± 0.098
0.752LysHis: 0.752 ± 0.03
8.725LysIle: 8.725 ± 0.13
6.586LysLys: 6.586 ± 0.111
7.696LysLeu: 7.696 ± 0.129
1.851LysMet: 1.851 ± 0.048
3.709LysAsn: 3.709 ± 0.078
2.813LysPro: 2.813 ± 0.055
1.548LysGln: 1.548 ± 0.053
3.742LysArg: 3.742 ± 0.071
3.998LysSer: 3.998 ± 0.075
3.139LysThr: 3.139 ± 0.064
6.304LysVal: 6.304 ± 0.108
0.827LysTrp: 0.827 ± 0.034
3.967LysTyr: 3.967 ± 0.077
0.0LysXaa: 0.0 ± 0.0
Leu
6.676LeuAla: 6.676 ± 0.115
0.516LeuCys: 0.516 ± 0.027
4.808LeuAsp: 4.808 ± 0.077
6.208LeuGlu: 6.208 ± 0.092
4.338LeuPhe: 4.338 ± 0.092
6.949LeuGly: 6.949 ± 0.101
1.428LeuHis: 1.428 ± 0.045
9.258LeuIle: 9.258 ± 0.131
8.266LeuLys: 8.266 ± 0.127
10.274LeuLeu: 10.274 ± 0.151
2.178LeuMet: 2.178 ± 0.057
5.167LeuAsn: 5.167 ± 0.086
4.263LeuPro: 4.263 ± 0.076
2.359LeuGln: 2.359 ± 0.06
4.544LeuArg: 4.544 ± 0.097
7.946LeuSer: 7.946 ± 0.116
5.233LeuThr: 5.233 ± 0.086
6.855LeuVal: 6.855 ± 0.102
0.854LeuTrp: 0.854 ± 0.035
4.425LeuTyr: 4.425 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
1.31MetAla: 1.31 ± 0.046
0.12MetCys: 0.12 ± 0.013
0.902MetAsp: 0.902 ± 0.035
1.424MetGlu: 1.424 ± 0.041
0.827MetPhe: 0.827 ± 0.035
1.4MetGly: 1.4 ± 0.044
0.245MetHis: 0.245 ± 0.017
2.024MetIle: 2.024 ± 0.051
2.115MetLys: 2.115 ± 0.048
2.079MetLeu: 2.079 ± 0.052
0.524MetMet: 0.524 ± 0.03
1.067MetAsn: 1.067 ± 0.039
0.773MetPro: 0.773 ± 0.037
0.463MetGln: 0.463 ± 0.026
1.165MetArg: 1.165 ± 0.038
1.532MetSer: 1.532 ± 0.044
0.924MetThr: 0.924 ± 0.029
1.278MetVal: 1.278 ± 0.042
0.218MetTrp: 0.218 ± 0.016
0.802MetTyr: 0.802 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.594AsnAla: 2.594 ± 0.058
0.376AsnCys: 0.376 ± 0.022
2.06AsnAsp: 2.06 ± 0.058
3.546AsnGlu: 3.546 ± 0.08
2.273AsnPhe: 2.273 ± 0.059
3.222AsnGly: 3.222 ± 0.096
0.496AsnHis: 0.496 ± 0.027
4.725AsnIle: 4.725 ± 0.09
3.759AsnLys: 3.759 ± 0.071
4.858AsnLeu: 4.858 ± 0.087
0.931AsnMet: 0.931 ± 0.039
2.49AsnAsn: 2.49 ± 0.075
2.363AsnPro: 2.363 ± 0.065
0.947AsnGln: 0.947 ± 0.036
1.699AsnArg: 1.699 ± 0.048
3.206AsnSer: 3.206 ± 0.078
2.193AsnThr: 2.193 ± 0.06
3.8AsnVal: 3.8 ± 0.085
0.545AsnTrp: 0.545 ± 0.028
2.639AsnTyr: 2.639 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
1.885ProAla: 1.885 ± 0.05
0.228ProCys: 0.228 ± 0.017
1.727ProAsp: 1.727 ± 0.047
2.674ProGlu: 2.674 ± 0.054
1.998ProPhe: 1.998 ± 0.057
2.087ProGly: 2.087 ± 0.063
0.646ProHis: 0.646 ± 0.026
3.455ProIle: 3.455 ± 0.072
2.664ProLys: 2.664 ± 0.064
4.037ProLeu: 4.037 ± 0.069
0.707ProMet: 0.707 ± 0.031
1.946ProAsn: 1.946 ± 0.056
1.85ProPro: 1.85 ± 0.067
1.17ProGln: 1.17 ± 0.048
1.335ProArg: 1.335 ± 0.044
2.871ProSer: 2.871 ± 0.07
2.082ProThr: 2.082 ± 0.054
2.723ProVal: 2.723 ± 0.062
0.476ProTrp: 0.476 ± 0.029
2.139ProTyr: 2.139 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
1.209GlnAla: 1.209 ± 0.047
0.113GlnCys: 0.113 ± 0.012
0.863GlnAsp: 0.863 ± 0.031
1.319GlnGlu: 1.319 ± 0.043
0.872GlnPhe: 0.872 ± 0.034
1.508GlnGly: 1.508 ± 0.05
0.289GlnHis: 0.289 ± 0.019
2.141GlnIle: 2.141 ± 0.057
1.581GlnLys: 1.581 ± 0.049
2.319GlnLeu: 2.319 ± 0.061
0.483GlnMet: 0.483 ± 0.024
1.004GlnAsn: 1.004 ± 0.042
0.757GlnPro: 0.757 ± 0.038
0.821GlnGln: 0.821 ± 0.05
0.91GlnArg: 0.91 ± 0.034
1.053GlnSer: 1.053 ± 0.04
0.975GlnThr: 0.975 ± 0.041
1.478GlnVal: 1.478 ± 0.051
0.26GlnTrp: 0.26 ± 0.019
0.968GlnTyr: 0.968 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.238ArgAla: 2.238 ± 0.06
0.263ArgCys: 0.263 ± 0.021
2.227ArgAsp: 2.227 ± 0.066
3.626ArgGlu: 3.626 ± 0.083
1.768ArgPhe: 1.768 ± 0.054
2.88ArgGly: 2.88 ± 0.068
0.524ArgHis: 0.524 ± 0.03
3.959ArgIle: 3.959 ± 0.08
3.986ArgLys: 3.986 ± 0.072
4.02ArgLeu: 4.02 ± 0.086
0.924ArgMet: 0.924 ± 0.029
1.921ArgAsn: 1.921 ± 0.055
1.207ArgPro: 1.207 ± 0.044
0.827ArgGln: 0.827 ± 0.034
2.362ArgArg: 2.362 ± 0.061
2.045ArgSer: 2.045 ± 0.054
1.546ArgThr: 1.546 ± 0.047
3.181ArgVal: 3.181 ± 0.073
0.476ArgTrp: 0.476 ± 0.025
1.74ArgTyr: 1.74 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.409SerAla: 3.409 ± 0.076
0.429SerCys: 0.429 ± 0.026
2.731SerAsp: 2.731 ± 0.053
3.876SerGlu: 3.876 ± 0.076
3.257SerPhe: 3.257 ± 0.07
4.015SerGly: 4.015 ± 0.063
0.912SerHis: 0.912 ± 0.034
6.095SerIle: 6.095 ± 0.104
4.841SerLys: 4.841 ± 0.093
7.7SerLeu: 7.7 ± 0.117
1.592SerMet: 1.592 ± 0.046
3.005SerAsn: 3.005 ± 0.072
2.838SerPro: 2.838 ± 0.063
1.724SerGln: 1.724 ± 0.056
2.466SerArg: 2.466 ± 0.064
5.074SerSer: 5.074 ± 0.106
3.325SerThr: 3.325 ± 0.09
4.19SerVal: 4.19 ± 0.074
0.759SerTrp: 0.759 ± 0.037
3.074SerTyr: 3.074 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
2.858ThrAla: 2.858 ± 0.066
0.282ThrCys: 0.282 ± 0.021
1.806ThrAsp: 1.806 ± 0.052
2.503ThrGlu: 2.503 ± 0.062
2.223ThrPhe: 2.223 ± 0.062
3.032ThrGly: 3.032 ± 0.069
0.774ThrHis: 0.774 ± 0.031
4.56ThrIle: 4.56 ± 0.09
2.841ThrLys: 2.841 ± 0.061
5.23ThrLeu: 5.23 ± 0.085
0.945ThrMet: 0.945 ± 0.037
2.148ThrAsn: 2.148 ± 0.06
2.317ThrPro: 2.317 ± 0.06
1.238ThrGln: 1.238 ± 0.046
1.834ThrArg: 1.834 ± 0.047
3.362ThrSer: 3.362 ± 0.078
2.971ThrThr: 2.971 ± 0.109
3.556ThrVal: 3.556 ± 0.071
0.488ThrTrp: 0.488 ± 0.027
2.395ThrTyr: 2.395 ± 0.077
0.0ThrXaa: 0.0 ± 0.0
Val
3.86ValAla: 3.86 ± 0.087
0.421ValCys: 0.421 ± 0.023
3.527ValAsp: 3.527 ± 0.078
4.843ValGlu: 4.843 ± 0.103
3.029ValPhe: 3.029 ± 0.071
4.152ValGly: 4.152 ± 0.083
0.846ValHis: 0.846 ± 0.035
7.775ValIle: 7.775 ± 0.097
6.642ValLys: 6.642 ± 0.096
6.557ValLeu: 6.557 ± 0.089
1.453ValMet: 1.453 ± 0.043
3.998ValAsn: 3.998 ± 0.09
2.593ValPro: 2.593 ± 0.056
1.323ValGln: 1.323 ± 0.04
3.137ValArg: 3.137 ± 0.081
4.89ValSer: 4.89 ± 0.1
3.822ValThr: 3.822 ± 0.081
5.287ValVal: 5.287 ± 0.1
0.617ValTrp: 0.617 ± 0.029
3.599ValTyr: 3.599 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.536TrpAla: 0.536 ± 0.025
0.057TrpCys: 0.057 ± 0.007
0.509TrpAsp: 0.509 ± 0.027
0.657TrpGlu: 0.657 ± 0.029
0.544TrpPhe: 0.544 ± 0.029
0.678TrpGly: 0.678 ± 0.034
0.169TrpHis: 0.169 ± 0.015
0.99TrpIle: 0.99 ± 0.037
0.825TrpLys: 0.825 ± 0.031
1.054TrpLeu: 1.054 ± 0.043
0.228TrpMet: 0.228 ± 0.018
0.623TrpAsn: 0.623 ± 0.031
0.228TrpPro: 0.228 ± 0.017
0.203TrpGln: 0.203 ± 0.017
0.534TrpArg: 0.534 ± 0.028
0.541TrpSer: 0.541 ± 0.026
0.435TrpThr: 0.435 ± 0.022
0.722TrpVal: 0.722 ± 0.031
0.164TrpTrp: 0.164 ± 0.015
0.525TrpTyr: 0.525 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.738TyrAla: 2.738 ± 0.058
0.414TyrCys: 0.414 ± 0.029
2.387TyrAsp: 2.387 ± 0.059
3.157TyrGlu: 3.157 ± 0.071
2.519TyrPhe: 2.519 ± 0.058
2.949TyrGly: 2.949 ± 0.074
0.648TyrHis: 0.648 ± 0.028
4.244TyrIle: 4.244 ± 0.08
3.226TyrLys: 3.226 ± 0.066
5.226TyrLeu: 5.226 ± 0.093
0.949TyrMet: 0.949 ± 0.034
2.691TyrAsn: 2.691 ± 0.084
2.065TyrPro: 2.065 ± 0.059
1.038TyrGln: 1.038 ± 0.05
1.715TyrArg: 1.715 ± 0.05
3.598TyrSer: 3.598 ± 0.081
2.524TyrThr: 2.524 ± 0.061
3.63TyrVal: 3.63 ± 0.079
0.53TyrTrp: 0.53 ± 0.026
2.942TyrTyr: 2.942 ± 0.083
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2805 proteins (757948 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski