Amino acid dipepetide frequency for Mycoplasma mycoides subsp. mycoides SC (strain PG1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.122AlaAla: 2.122 ± 0.121
0.419AlaCys: 0.419 ± 0.036
2.335AlaAsp: 2.335 ± 0.072
1.859AlaGlu: 1.859 ± 0.089
2.47AlaPhe: 2.47 ± 0.087
2.473AlaGly: 2.473 ± 0.091
0.617AlaHis: 0.617 ± 0.046
5.309AlaIle: 5.309 ± 0.153
4.742AlaLys: 4.742 ± 0.129
4.188AlaLeu: 4.188 ± 0.122
0.754AlaMet: 0.754 ± 0.061
3.09AlaAsn: 3.09 ± 0.103
0.967AlaPro: 0.967 ± 0.067
1.158AlaGln: 1.158 ± 0.05
1.553AlaArg: 1.553 ± 0.072
2.961AlaSer: 2.961 ± 0.103
2.748AlaThr: 2.748 ± 0.104
2.373AlaVal: 2.373 ± 0.102
0.373AlaTrp: 0.373 ± 0.04
1.662AlaTyr: 1.662 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.357CysAla: 0.357 ± 0.034
0.116CysCys: 0.116 ± 0.023
0.46CysAsp: 0.46 ± 0.038
0.347CysGlu: 0.347 ± 0.041
0.479CysPhe: 0.479 ± 0.037
0.347CysGly: 0.347 ± 0.034
0.091CysHis: 0.091 ± 0.018
0.526CysIle: 0.526 ± 0.043
0.491CysLys: 0.491 ± 0.039
0.895CysLeu: 0.895 ± 0.058
0.094CysMet: 0.094 ± 0.018
0.41CysAsn: 0.41 ± 0.035
0.097CysPro: 0.097 ± 0.017
0.188CysGln: 0.188 ± 0.022
0.113CysArg: 0.113 ± 0.016
0.61CysSer: 0.61 ± 0.048
0.341CysThr: 0.341 ± 0.034
0.241CysVal: 0.241 ± 0.026
0.091CysTrp: 0.091 ± 0.015
0.272CysTyr: 0.272 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
2.301AspAla: 2.301 ± 0.088
0.416AspCys: 0.416 ± 0.035
3.127AspAsp: 3.127 ± 0.113
3.994AspGlu: 3.994 ± 0.123
3.425AspPhe: 3.425 ± 0.115
2.191AspGly: 2.191 ± 0.087
0.873AspHis: 0.873 ± 0.056
5.431AspIle: 5.431 ± 0.137
6.035AspLys: 6.035 ± 0.171
6.138AspLeu: 6.138 ± 0.168
0.851AspMet: 0.851 ± 0.053
3.991AspAsn: 3.991 ± 0.122
1.499AspPro: 1.499 ± 0.063
3.205AspGln: 3.205 ± 0.112
1.089AspArg: 1.089 ± 0.063
2.874AspSer: 2.874 ± 0.114
2.197AspThr: 2.197 ± 0.09
3.149AspVal: 3.149 ± 0.1
0.642AspTrp: 0.642 ± 0.053
3.04AspTyr: 3.04 ± 0.103
0.0AspXaa: 0.0 ± 0.0
Glu
2.135GluAla: 2.135 ± 0.099
0.285GluCys: 0.285 ± 0.031
2.539GluAsp: 2.539 ± 0.086
3.306GluGlu: 3.306 ± 0.134
3.183GluPhe: 3.183 ± 0.108
1.662GluGly: 1.662 ± 0.08
0.88GluHis: 0.88 ± 0.05
6.962GluIle: 6.962 ± 0.174
6.53GluLys: 6.53 ± 0.184
6.433GluLeu: 6.433 ± 0.165
1.227GluMet: 1.227 ± 0.069
4.63GluAsn: 4.63 ± 0.129
1.183GluPro: 1.183 ± 0.07
2.989GluGln: 2.989 ± 0.109
1.315GluArg: 1.315 ± 0.063
3.049GluSer: 3.049 ± 0.098
2.836GluThr: 2.836 ± 0.089
3.631GluVal: 3.631 ± 0.127
0.548GluTrp: 0.548 ± 0.039
2.564GluTyr: 2.564 ± 0.099
0.0GluXaa: 0.0 ± 0.0
Phe
2.163PheAla: 2.163 ± 0.097
0.426PheCys: 0.426 ± 0.041
3.565PheAsp: 3.565 ± 0.101
2.908PheGlu: 2.908 ± 0.092
2.401PhePhe: 2.401 ± 0.101
2.357PheGly: 2.357 ± 0.111
0.598PheHis: 0.598 ± 0.043
5.199PheIle: 5.199 ± 0.169
5.926PheLys: 5.926 ± 0.138
5.14PheLeu: 5.14 ± 0.168
1.03PheMet: 1.03 ± 0.057
4.902PheAsn: 4.902 ± 0.145
1.077PhePro: 1.077 ± 0.059
1.008PheGln: 1.008 ± 0.061
1.327PheArg: 1.327 ± 0.062
4.188PheSer: 4.188 ± 0.121
2.479PheThr: 2.479 ± 0.095
2.805PheVal: 2.805 ± 0.119
0.545PheTrp: 0.545 ± 0.046
2.432PheTyr: 2.432 ± 0.095
0.0PheXaa: 0.0 ± 0.0
Gly
2.46GlyAla: 2.46 ± 0.116
0.285GlyCys: 0.285 ± 0.034
1.759GlyAsp: 1.759 ± 0.084
2.06GlyGlu: 2.06 ± 0.088
2.68GlyPhe: 2.68 ± 0.105
2.482GlyGly: 2.482 ± 0.111
0.736GlyHis: 0.736 ± 0.052
4.373GlyIle: 4.373 ± 0.138
3.406GlyLys: 3.406 ± 0.1
4.786GlyLeu: 4.786 ± 0.15
1.152GlyMet: 1.152 ± 0.061
2.147GlyAsn: 2.147 ± 0.092
0.776GlyPro: 0.776 ± 0.05
1.249GlyGln: 1.249 ± 0.063
1.271GlyArg: 1.271 ± 0.068
3.155GlySer: 3.155 ± 0.102
2.185GlyThr: 2.185 ± 0.093
2.961GlyVal: 2.961 ± 0.114
0.635GlyTrp: 0.635 ± 0.049
2.814GlyTyr: 2.814 ± 0.125
0.0GlyXaa: 0.0 ± 0.0
His
0.588HisAla: 0.588 ± 0.043
0.106HisCys: 0.106 ± 0.019
0.692HisAsp: 0.692 ± 0.05
0.651HisGlu: 0.651 ± 0.038
0.783HisPhe: 0.783 ± 0.045
0.617HisGly: 0.617 ± 0.048
0.269HisHis: 0.269 ± 0.029
1.556HisIle: 1.556 ± 0.073
1.346HisLys: 1.346 ± 0.067
1.337HisLeu: 1.337 ± 0.066
0.178HisMet: 0.178 ± 0.026
1.074HisAsn: 1.074 ± 0.066
0.488HisPro: 0.488 ± 0.044
0.573HisGln: 0.573 ± 0.048
0.363HisArg: 0.363 ± 0.039
0.995HisSer: 0.995 ± 0.054
0.67HisThr: 0.67 ± 0.05
0.52HisVal: 0.52 ± 0.044
0.125HisTrp: 0.125 ± 0.019
0.717HisTyr: 0.717 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
5.096IleAla: 5.096 ± 0.142
0.961IleCys: 0.961 ± 0.062
6.129IleAsp: 6.129 ± 0.147
5.484IleGlu: 5.484 ± 0.159
5.002IlePhe: 5.002 ± 0.144
4.993IleGly: 4.993 ± 0.163
1.105IleHis: 1.105 ± 0.06
9.945IleIle: 9.945 ± 0.227
11.156IleLys: 11.156 ± 0.188
9.062IleLeu: 9.062 ± 0.204
1.321IleMet: 1.321 ± 0.056
8.862IleAsn: 8.862 ± 0.215
2.786IlePro: 2.786 ± 0.106
3.115IleGln: 3.115 ± 0.09
2.711IleArg: 2.711 ± 0.087
8.139IleSer: 8.139 ± 0.169
5.259IleThr: 5.259 ± 0.123
5.124IleVal: 5.124 ± 0.13
0.808IleTrp: 0.808 ± 0.063
4.223IleTyr: 4.223 ± 0.13
0.0IleXaa: 0.0 ± 0.0
Lys
4.304LysAla: 4.304 ± 0.113
0.341LysCys: 0.341 ± 0.039
6.721LysAsp: 6.721 ± 0.163
8.446LysGlu: 8.446 ± 0.206
4.129LysPhe: 4.129 ± 0.108
3.985LysGly: 3.985 ± 0.125
1.474LysHis: 1.474 ± 0.075
10.399LysIle: 10.399 ± 0.203
12.058LysLys: 12.058 ± 0.246
9.344LysLeu: 9.344 ± 0.177
2.197LysMet: 2.197 ± 0.088
10.054LysAsn: 10.054 ± 0.205
3.168LysPro: 3.168 ± 0.114
5.453LysGln: 5.453 ± 0.137
2.961LysArg: 2.961 ± 0.101
5.641LysSer: 5.641 ± 0.141
6.883LysThr: 6.883 ± 0.129
5.268LysVal: 5.268 ± 0.143
1.033LysTrp: 1.033 ± 0.061
4.774LysTyr: 4.774 ± 0.126
0.0LysXaa: 0.0 ± 0.0
Leu
4.811LeuAla: 4.811 ± 0.131
0.607LeuCys: 0.607 ± 0.04
6.589LeuAsp: 6.589 ± 0.163
6.874LeuGlu: 6.874 ± 0.168
4.943LeuPhe: 4.943 ± 0.172
4.163LeuGly: 4.163 ± 0.129
1.155LeuHis: 1.155 ± 0.058
9.76LeuIle: 9.76 ± 0.243
11.178LeuLys: 11.178 ± 0.224
9.269LeuLeu: 9.269 ± 0.228
1.484LeuMet: 1.484 ± 0.068
8.073LeuAsn: 8.073 ± 0.194
2.401LeuPro: 2.401 ± 0.095
2.645LeuGln: 2.645 ± 0.085
2.382LeuArg: 2.382 ± 0.091
6.668LeuSer: 6.668 ± 0.178
6.016LeuThr: 6.016 ± 0.138
5.738LeuVal: 5.738 ± 0.146
0.87LeuTrp: 0.87 ± 0.056
3.165LeuTyr: 3.165 ± 0.104
0.0LeuXaa: 0.0 ± 0.0
Met
0.945MetAla: 0.945 ± 0.058
0.122MetCys: 0.122 ± 0.018
0.604MetAsp: 0.604 ± 0.045
0.504MetGlu: 0.504 ± 0.04
1.452MetPhe: 1.452 ± 0.102
0.814MetGly: 0.814 ± 0.058
0.219MetHis: 0.219 ± 0.031
1.744MetIle: 1.744 ± 0.083
1.869MetLys: 1.869 ± 0.075
1.881MetLeu: 1.881 ± 0.08
0.329MetMet: 0.329 ± 0.038
1.302MetAsn: 1.302 ± 0.065
0.479MetPro: 0.479 ± 0.036
0.632MetGln: 0.632 ± 0.044
0.495MetArg: 0.495 ± 0.042
1.44MetSer: 1.44 ± 0.072
0.814MetThr: 0.814 ± 0.054
0.967MetVal: 0.967 ± 0.061
0.157MetTrp: 0.157 ± 0.021
0.704MetTyr: 0.704 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
2.839AsnAla: 2.839 ± 0.088
0.41AsnCys: 0.41 ± 0.039
4.674AsnAsp: 4.674 ± 0.142
4.069AsnGlu: 4.069 ± 0.135
3.963AsnPhe: 3.963 ± 0.116
3.158AsnGly: 3.158 ± 0.122
1.462AsnHis: 1.462 ± 0.077
7.394AsnIle: 7.394 ± 0.169
10.875AsnLys: 10.875 ± 0.221
7.97AsnLeu: 7.97 ± 0.178
1.427AsnMet: 1.427 ± 0.074
8.233AsnAsn: 8.233 ± 0.291
2.132AsnPro: 2.132 ± 0.083
4.063AsnGln: 4.063 ± 0.15
2.244AsnArg: 2.244 ± 0.093
5.534AsnSer: 5.534 ± 0.146
3.919AsnThr: 3.919 ± 0.116
3.863AsnVal: 3.863 ± 0.111
1.033AsnTrp: 1.033 ± 0.053
3.353AsnTyr: 3.353 ± 0.117
0.0AsnXaa: 0.0 ± 0.0
Pro
1.017ProAla: 1.017 ± 0.071
0.128ProCys: 0.128 ± 0.021
1.218ProAsp: 1.218 ± 0.061
1.412ProGlu: 1.412 ± 0.072
1.293ProPhe: 1.293 ± 0.068
1.296ProGly: 1.296 ± 0.069
0.335ProHis: 0.335 ± 0.034
2.886ProIle: 2.886 ± 0.084
2.219ProLys: 2.219 ± 0.09
2.579ProLeu: 2.579 ± 0.089
0.47ProMet: 0.47 ± 0.039
2.116ProAsn: 2.116 ± 0.088
0.376ProPro: 0.376 ± 0.035
0.573ProGln: 0.573 ± 0.04
0.673ProArg: 0.673 ± 0.047
1.662ProSer: 1.662 ± 0.071
1.681ProThr: 1.681 ± 0.079
1.402ProVal: 1.402 ± 0.071
0.232ProTrp: 0.232 ± 0.027
1.067ProTyr: 1.067 ± 0.062
0.0ProXaa: 0.0 ± 0.0
Gln
2.226GlnAla: 2.226 ± 0.084
0.094GlnCys: 0.094 ± 0.016
1.503GlnAsp: 1.503 ± 0.069
2.254GlnGlu: 2.254 ± 0.092
1.744GlnPhe: 1.744 ± 0.079
1.236GlnGly: 1.236 ± 0.065
0.448GlnHis: 0.448 ± 0.039
4.702GlnIle: 4.702 ± 0.133
3.86GlnLys: 3.86 ± 0.109
3.6GlnLeu: 3.6 ± 0.124
0.573GlnMet: 0.573 ± 0.043
2.996GlnAsn: 2.996 ± 0.094
0.798GlnPro: 0.798 ± 0.055
1.499GlnGln: 1.499 ± 0.076
1.067GlnArg: 1.067 ± 0.063
1.791GlnSer: 1.791 ± 0.084
2.423GlnThr: 2.423 ± 0.096
2.147GlnVal: 2.147 ± 0.077
0.504GlnTrp: 0.504 ± 0.048
1.321GlnTyr: 1.321 ± 0.071
0.0GlnXaa: 0.0 ± 0.0
Arg
1.152ArgAla: 1.152 ± 0.065
0.125ArgCys: 0.125 ± 0.023
1.462ArgAsp: 1.462 ± 0.083
1.412ArgGlu: 1.412 ± 0.077
1.703ArgPhe: 1.703 ± 0.068
1.005ArgGly: 1.005 ± 0.067
0.385ArgHis: 0.385 ± 0.038
2.786ArgIle: 2.786 ± 0.09
2.37ArgLys: 2.37 ± 0.087
2.532ArgLeu: 2.532 ± 0.094
0.695ArgMet: 0.695 ± 0.043
2.01ArgAsn: 2.01 ± 0.08
0.911ArgPro: 0.911 ± 0.055
0.98ArgGln: 0.98 ± 0.06
0.917ArgArg: 0.917 ± 0.047
1.618ArgSer: 1.618 ± 0.079
1.847ArgThr: 1.847 ± 0.086
1.549ArgVal: 1.549 ± 0.081
0.301ArgTrp: 0.301 ± 0.034
1.136ArgTyr: 1.136 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
2.633SerAla: 2.633 ± 0.087
0.588SerCys: 0.588 ± 0.041
3.421SerAsp: 3.421 ± 0.112
3.431SerGlu: 3.431 ± 0.11
4.101SerPhe: 4.101 ± 0.136
3.058SerGly: 3.058 ± 0.11
0.798SerHis: 0.798 ± 0.049
5.847SerIle: 5.847 ± 0.169
7.146SerLys: 7.146 ± 0.149
7.106SerLeu: 7.106 ± 0.2
1.196SerMet: 1.196 ± 0.061
5.328SerAsn: 5.328 ± 0.156
1.509SerPro: 1.509 ± 0.069
2.088SerGln: 2.088 ± 0.082
1.988SerArg: 1.988 ± 0.082
5.121SerSer: 5.121 ± 0.177
3.59SerThr: 3.59 ± 0.102
3.565SerVal: 3.565 ± 0.095
0.952SerTrp: 0.952 ± 0.06
3.027SerTyr: 3.027 ± 0.097
0.0SerXaa: 0.0 ± 0.0
Thr
2.172ThrAla: 2.172 ± 0.081
0.269ThrCys: 0.269 ± 0.028
2.908ThrAsp: 2.908 ± 0.086
2.316ThrGlu: 2.316 ± 0.095
2.51ThrPhe: 2.51 ± 0.095
2.633ThrGly: 2.633 ± 0.107
0.811ThrHis: 0.811 ± 0.052
5.428ThrIle: 5.428 ± 0.132
6.323ThrLys: 6.323 ± 0.128
4.843ThrLeu: 4.843 ± 0.124
0.823ThrMet: 0.823 ± 0.051
5.447ThrAsn: 5.447 ± 0.134
1.703ThrPro: 1.703 ± 0.078
1.509ThrGln: 1.509 ± 0.057
1.587ThrArg: 1.587 ± 0.056
4.101ThrSer: 4.101 ± 0.139
3.396ThrThr: 3.396 ± 0.115
2.279ThrVal: 2.279 ± 0.087
0.504ThrTrp: 0.504 ± 0.039
2.366ThrTyr: 2.366 ± 0.078
0.0ThrXaa: 0.0 ± 0.0
Val
2.661ValAla: 2.661 ± 0.108
0.495ValCys: 0.495 ± 0.043
3.274ValAsp: 3.274 ± 0.12
3.484ValGlu: 3.484 ± 0.123
3.19ValPhe: 3.19 ± 0.103
2.833ValGly: 2.833 ± 0.113
0.617ValHis: 0.617 ± 0.047
5.907ValIle: 5.907 ± 0.122
5.199ValLys: 5.199 ± 0.14
5.91ValLeu: 5.91 ± 0.14
0.867ValMet: 0.867 ± 0.056
3.716ValAsn: 3.716 ± 0.112
1.271ValPro: 1.271 ± 0.062
1.321ValGln: 1.321 ± 0.061
1.049ValArg: 1.049 ± 0.066
3.497ValSer: 3.497 ± 0.11
2.266ValThr: 2.266 ± 0.088
3.734ValVal: 3.734 ± 0.135
0.419ValTrp: 0.419 ± 0.041
2.298ValTyr: 2.298 ± 0.102
0.0ValXaa: 0.0 ± 0.0
Trp
0.419TrpAla: 0.419 ± 0.032
0.1TrpCys: 0.1 ± 0.016
0.686TrpAsp: 0.686 ± 0.056
0.491TrpGlu: 0.491 ± 0.041
0.664TrpPhe: 0.664 ± 0.046
0.351TrpGly: 0.351 ± 0.038
0.131TrpHis: 0.131 ± 0.019
0.974TrpIle: 0.974 ± 0.063
1.086TrpLys: 1.086 ± 0.056
0.92TrpLeu: 0.92 ± 0.06
0.235TrpMet: 0.235 ± 0.032
0.942TrpAsn: 0.942 ± 0.054
0.15TrpPro: 0.15 ± 0.022
0.51TrpGln: 0.51 ± 0.043
0.294TrpArg: 0.294 ± 0.031
0.645TrpSer: 0.645 ± 0.051
0.676TrpThr: 0.676 ± 0.045
0.57TrpVal: 0.57 ± 0.041
0.172TrpTrp: 0.172 ± 0.026
0.432TrpTyr: 0.432 ± 0.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.772TyrAla: 1.772 ± 0.072
0.272TyrCys: 0.272 ± 0.032
2.805TyrAsp: 2.805 ± 0.114
2.582TyrGlu: 2.582 ± 0.096
2.363TyrPhe: 2.363 ± 0.087
1.719TyrGly: 1.719 ± 0.083
0.645TyrHis: 0.645 ± 0.042
4.154TyrIle: 4.154 ± 0.138
4.818TyrLys: 4.818 ± 0.11
4.858TyrLeu: 4.858 ± 0.13
0.567TyrMet: 0.567 ± 0.043
3.293TyrAsn: 3.293 ± 0.106
0.864TyrPro: 0.864 ± 0.052
2.025TyrGln: 2.025 ± 0.088
1.496TyrArg: 1.496 ± 0.078
2.805TyrSer: 2.805 ± 0.102
1.7TyrThr: 1.7 ± 0.078
2.122TyrVal: 2.122 ± 0.1
0.507TyrTrp: 0.507 ± 0.041
2.053TyrTyr: 2.053 ± 0.102
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 978 proteins (319461 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski