Amino acid dipepetide frequency for Alicyclobacillus montanus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.898AlaAla: 7.898 ± 0.111	0.886AlaCys: 0.886 ± 0.038	3.809AlaAsp: 3.809 ± 0.071	5.451AlaGlu: 5.451 ± 0.096	3.337AlaPhe: 3.337 ± 0.076	6.143AlaGly: 6.143 ± 0.097	2.037AlaHis: 2.037 ± 0.056	5.582AlaIle: 5.582 ± 0.093	3.987AlaLys: 3.987 ± 0.079	9.099AlaLeu: 9.099 ± 0.117	2.517AlaMet: 2.517 ± 0.057	2.892AlaAsn: 2.892 ± 0.068	2.673AlaPro: 2.673 ± 0.063	3.191AlaGln: 3.191 ± 0.074	4.209AlaArg: 4.209 ± 0.082	5.12AlaSer: 5.12 ± 0.088	4.054AlaThr: 4.054 ± 0.074	6.693AlaVal: 6.693 ± 0.095	1.171AlaTrp: 1.171 ± 0.036	2.676AlaTyr: 2.676 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.596CysAla: 0.596 ± 0.028	0.122CysCys: 0.122 ± 0.013	0.44CysAsp: 0.44 ± 0.022	0.462CysGlu: 0.462 ± 0.021	0.336CysPhe: 0.336 ± 0.02	0.901CysGly: 0.901 ± 0.038	0.275CysHis: 0.275 ± 0.019	0.581CysIle: 0.581 ± 0.027	0.385CysLys: 0.385 ± 0.021	1.001CysLeu: 1.001 ± 0.035	0.241CysMet: 0.241 ± 0.017	0.308CysAsn: 0.308 ± 0.018	0.481CysPro: 0.481 ± 0.024	0.424CysGln: 0.424 ± 0.023	0.542CysArg: 0.542 ± 0.023	0.647CysSer: 0.647 ± 0.027	0.486CysThr: 0.486 ± 0.022	0.628CysVal: 0.628 ± 0.029	0.094CysTrp: 0.094 ± 0.009	0.268CysTyr: 0.268 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.995AspAla: 3.995 ± 0.073	0.462AspCys: 0.462 ± 0.025	2.075AspAsp: 2.075 ± 0.053	3.643AspGlu: 3.643 ± 0.08	2.023AspPhe: 2.023 ± 0.048	3.358AspGly: 3.358 ± 0.071	0.979AspHis: 0.979 ± 0.034	3.228AspIle: 3.228 ± 0.065	2.095AspLys: 2.095 ± 0.054	4.337AspLeu: 4.337 ± 0.077	1.174AspMet: 1.174 ± 0.038	1.306AspAsn: 1.306 ± 0.038	1.83AspPro: 1.83 ± 0.05	1.309AspGln: 1.309 ± 0.041	2.283AspArg: 2.283 ± 0.058	2.496AspSer: 2.496 ± 0.051	2.269AspThr: 2.269 ± 0.054	3.885AspVal: 3.885 ± 0.081	0.947AspTrp: 0.947 ± 0.038	1.434AspTyr: 1.434 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.512GluAla: 5.512 ± 0.099	0.465GluCys: 0.465 ± 0.025	2.779GluAsp: 2.779 ± 0.058	5.086GluGlu: 5.086 ± 0.091	2.112GluPhe: 2.112 ± 0.052	3.537GluGly: 3.537 ± 0.071	1.623GluHis: 1.623 ± 0.043	4.305GluIle: 4.305 ± 0.078	3.95GluLys: 3.95 ± 0.079	6.002GluLeu: 6.002 ± 0.104	1.952GluMet: 1.952 ± 0.046	2.806GluAsn: 2.806 ± 0.067	1.855GluPro: 1.855 ± 0.049	3.325GluGln: 3.325 ± 0.064	4.532GluArg: 4.532 ± 0.097	3.79GluSer: 3.79 ± 0.077	3.299GluThr: 3.299 ± 0.055	4.218GluVal: 4.218 ± 0.077	1.18GluTrp: 1.18 ± 0.041	1.758GluTyr: 1.758 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.75PheAla: 3.75 ± 0.084	0.482PheCys: 0.482 ± 0.02	1.784PheAsp: 1.784 ± 0.05	2.167PheGlu: 2.167 ± 0.055	1.908PhePhe: 1.908 ± 0.049	3.069PheGly: 3.069 ± 0.064	1.207PheHis: 1.207 ± 0.038	2.382PheIle: 2.382 ± 0.061	1.056PheLys: 1.056 ± 0.036	4.66PheLeu: 4.66 ± 0.091	0.925PheMet: 0.925 ± 0.034	1.141PheAsn: 1.141 ± 0.035	1.872PhePro: 1.872 ± 0.047	1.822PheGln: 1.822 ± 0.044	2.04PheArg: 2.04 ± 0.047	3.118PheSer: 3.118 ± 0.06	2.078PheThr: 2.078 ± 0.053	3.088PheVal: 3.088 ± 0.063	0.693PheTrp: 0.693 ± 0.03	1.439PheTyr: 1.439 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	5.267GlyAla: 5.267 ± 0.098	0.827GlyCys: 0.827 ± 0.032	2.939GlyAsp: 2.939 ± 0.063	3.9GlyGlu: 3.9 ± 0.067	3.066GlyPhe: 3.066 ± 0.067	5.113GlyGly: 5.113 ± 0.098	1.78GlyHis: 1.78 ± 0.047	5.214GlyIle: 5.214 ± 0.088	3.683GlyLys: 3.683 ± 0.071	7.171GlyLeu: 7.171 ± 0.109	2.272GlyMet: 2.272 ± 0.049	2.422GlyAsn: 2.422 ± 0.066	2.055GlyPro: 2.055 ± 0.057	3.277GlyGln: 3.277 ± 0.075	3.626GlyArg: 3.626 ± 0.07	4.235GlySer: 4.235 ± 0.082	3.815GlyThr: 3.815 ± 0.078	5.546GlyVal: 5.546 ± 0.08	1.248GlyTrp: 1.248 ± 0.04	2.732GlyTyr: 2.732 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.023HisAla: 2.023 ± 0.047	0.276HisCys: 0.276 ± 0.019	0.991HisAsp: 0.991 ± 0.035	1.468HisGlu: 1.468 ± 0.041	1.111HisPhe: 1.111 ± 0.037	1.729HisGly: 1.729 ± 0.047	1.067HisHis: 1.067 ± 0.042	1.512HisIle: 1.512 ± 0.043	0.816HisLys: 0.816 ± 0.033	2.98HisLeu: 2.98 ± 0.064	0.654HisMet: 0.654 ± 0.029	0.73HisAsn: 0.73 ± 0.026	1.744HisPro: 1.744 ± 0.048	1.467HisGln: 1.467 ± 0.042	1.583HisArg: 1.583 ± 0.047	1.657HisSer: 1.657 ± 0.047	1.337HisThr: 1.337 ± 0.04	2.011HisVal: 2.011 ± 0.05	0.49HisTrp: 0.49 ± 0.023	0.84HisTyr: 0.84 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.797IleAla: 5.797 ± 0.091	0.682IleCys: 0.682 ± 0.032	3.09IleAsp: 3.09 ± 0.063	4.181IleGlu: 4.181 ± 0.08	2.429IlePhe: 2.429 ± 0.066	4.94IleGly: 4.94 ± 0.09	1.852IleHis: 1.852 ± 0.052	3.144IleIle: 3.144 ± 0.082	1.793IleLys: 1.793 ± 0.044	6.981IleLeu: 6.981 ± 0.103	1.223IleMet: 1.223 ± 0.04	1.704IleAsn: 1.704 ± 0.056	3.324IlePro: 3.324 ± 0.06	3.232IleGln: 3.232 ± 0.069	3.945IleArg: 3.945 ± 0.074	4.035IleSer: 4.035 ± 0.07	2.911IleThr: 2.911 ± 0.062	4.872IleVal: 4.872 ± 0.084	0.876IleTrp: 0.876 ± 0.033	1.956IleTyr: 1.956 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	3.251LysAla: 3.251 ± 0.067	0.249LysCys: 0.249 ± 0.016	1.989LysAsp: 1.989 ± 0.055	3.209LysGlu: 3.209 ± 0.063	1.347LysPhe: 1.347 ± 0.039	2.547LysGly: 2.547 ± 0.059	1.017LysHis: 1.017 ± 0.031	2.987LysIle: 2.987 ± 0.065	2.621LysLys: 2.621 ± 0.062	4.283LysLeu: 4.283 ± 0.072	1.334LysMet: 1.334 ± 0.043	1.952LysAsn: 1.952 ± 0.048	1.946LysPro: 1.946 ± 0.046	1.996LysGln: 1.996 ± 0.049	2.985LysArg: 2.985 ± 0.058	2.883LysSer: 2.883 ± 0.054	2.428LysThr: 2.428 ± 0.055	2.99LysVal: 2.99 ± 0.065	0.627LysTrp: 0.627 ± 0.026	1.225LysTyr: 1.225 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	9.779LeuAla: 9.779 ± 0.137	1.036LeuCys: 1.036 ± 0.036	4.748LeuAsp: 4.748 ± 0.093	6.472LeuGlu: 6.472 ± 0.106	4.409LeuPhe: 4.409 ± 0.095	7.402LeuGly: 7.402 ± 0.116	2.916LeuHis: 2.916 ± 0.064	5.61LeuIle: 5.61 ± 0.101	4.154LeuLys: 4.154 ± 0.073	11.844LeuLeu: 11.844 ± 0.19	2.597LeuMet: 2.597 ± 0.045	3.467LeuAsn: 3.467 ± 0.075	5.188LeuPro: 5.188 ± 0.084	5.74LeuGln: 5.74 ± 0.092	5.991LeuArg: 5.991 ± 0.108	7.78LeuSer: 7.78 ± 0.096	5.581LeuThr: 5.581 ± 0.081	6.952LeuVal: 6.952 ± 0.099	1.362LeuTrp: 1.362 ± 0.043	3.21LeuTyr: 3.21 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.427MetAla: 2.427 ± 0.059	0.148MetCys: 0.148 ± 0.013	1.375MetAsp: 1.375 ± 0.037	1.795MetGlu: 1.795 ± 0.051	0.92MetPhe: 0.92 ± 0.035	1.934MetGly: 1.934 ± 0.049	0.569MetHis: 0.569 ± 0.023	1.639MetIle: 1.639 ± 0.042	1.455MetLys: 1.455 ± 0.044	2.67MetLeu: 2.67 ± 0.052	0.9MetMet: 0.9 ± 0.031	1.257MetAsn: 1.257 ± 0.037	1.24MetPro: 1.24 ± 0.041	1.256MetGln: 1.256 ± 0.036	1.595MetArg: 1.595 ± 0.045	1.826MetSer: 1.826 ± 0.047	1.545MetThr: 1.545 ± 0.044	1.892MetVal: 1.892 ± 0.047	0.282MetTrp: 0.282 ± 0.018	0.677MetTyr: 0.677 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.858AsnAla: 2.858 ± 0.066	0.297AsnCys: 0.297 ± 0.019	1.442AsnAsp: 1.442 ± 0.048	2.04AsnGlu: 2.04 ± 0.047	1.236AsnPhe: 1.236 ± 0.034	2.866AsnGly: 2.866 ± 0.088	1.058AsnHis: 1.058 ± 0.039	2.181AsnIle: 2.181 ± 0.053	1.307AsnLys: 1.307 ± 0.04	3.54AsnLeu: 3.54 ± 0.064	0.907AsnMet: 0.907 ± 0.031	1.186AsnAsn: 1.186 ± 0.043	2.244AsnPro: 2.244 ± 0.061	1.875AsnGln: 1.875 ± 0.054	2.21AsnArg: 2.21 ± 0.055	2.113AsnSer: 2.113 ± 0.062	1.728AsnThr: 1.728 ± 0.054	2.484AsnVal: 2.484 ± 0.057	0.61AsnTrp: 0.61 ± 0.029	1.083AsnTyr: 1.083 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.056ProAla: 3.056 ± 0.071	0.302ProCys: 0.302 ± 0.018	2.338ProAsp: 2.338 ± 0.056	3.073ProGlu: 3.073 ± 0.068	2.004ProPhe: 2.004 ± 0.051	3.073ProGly: 3.073 ± 0.07	1.173ProHis: 1.173 ± 0.038	2.846ProIle: 2.846 ± 0.06	1.886ProLys: 1.886 ± 0.043	4.389ProLeu: 4.389 ± 0.066	1.056ProMet: 1.056 ± 0.036	1.792ProAsn: 1.792 ± 0.05	1.434ProPro: 1.434 ± 0.043	1.78ProGln: 1.78 ± 0.045	1.771ProArg: 1.771 ± 0.044	2.987ProSer: 2.987 ± 0.067	2.256ProThr: 2.256 ± 0.058	3.586ProVal: 3.586 ± 0.073	0.645ProTrp: 0.645 ± 0.027	1.612ProTyr: 1.612 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	3.987GlnAla: 3.987 ± 0.083	0.289GlnCys: 0.289 ± 0.019	1.686GlnAsp: 1.686 ± 0.047	3.055GlnGlu: 3.055 ± 0.06	1.738GlnPhe: 1.738 ± 0.044	2.689GlnGly: 2.689 ± 0.055	1.165GlnHis: 1.165 ± 0.038	3.032GlnIle: 3.032 ± 0.064	2.505GlnLys: 2.505 ± 0.063	4.851GlnLeu: 4.851 ± 0.075	1.427GlnMet: 1.427 ± 0.041	1.922GlnAsn: 1.922 ± 0.047	2.103GlnPro: 2.103 ± 0.045	2.669GlnGln: 2.669 ± 0.072	2.587GlnArg: 2.587 ± 0.059	3.205GlnSer: 3.205 ± 0.069	2.759GlnThr: 2.759 ± 0.066	3.241GlnVal: 3.241 ± 0.065	0.745GlnTrp: 0.745 ± 0.031	1.369GlnTyr: 1.369 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	3.82ArgAla: 3.82 ± 0.082	0.49ArgCys: 0.49 ± 0.026	2.547ArgAsp: 2.547 ± 0.056	3.876ArgGlu: 3.876 ± 0.077	2.458ArgPhe: 2.458 ± 0.056	3.266ArgGly: 3.266 ± 0.061	1.489ArgHis: 1.489 ± 0.042	3.807ArgIle: 3.807 ± 0.069	3.049ArgLys: 3.049 ± 0.066	6.32ArgLeu: 6.32 ± 0.107	1.839ArgMet: 1.839 ± 0.045	1.88ArgAsn: 1.88 ± 0.044	2.193ArgPro: 2.193 ± 0.049	2.897ArgGln: 2.897 ± 0.068	3.639ArgArg: 3.639 ± 0.078	3.155ArgSer: 3.155 ± 0.049	2.613ArgThr: 2.613 ± 0.058	4.078ArgVal: 4.078 ± 0.078	0.921ArgTrp: 0.921 ± 0.032	1.932ArgTyr: 1.932 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.078SerAla: 5.078 ± 0.086	0.503SerCys: 0.503 ± 0.026	2.904SerAsp: 2.904 ± 0.058	3.806SerGlu: 3.806 ± 0.068	2.854SerPhe: 2.854 ± 0.063	4.988SerGly: 4.988 ± 0.089	1.616SerHis: 1.616 ± 0.041	4.231SerIle: 4.231 ± 0.082	2.602SerLys: 2.602 ± 0.057	7.126SerLeu: 7.126 ± 0.088	1.978SerMet: 1.978 ± 0.044	2.423SerAsn: 2.423 ± 0.073	2.805SerPro: 2.805 ± 0.061	2.871SerGln: 2.871 ± 0.067	3.215SerArg: 3.215 ± 0.063	4.691SerSer: 4.691 ± 0.106	3.495SerThr: 3.495 ± 0.076	4.951SerVal: 4.951 ± 0.084	0.929SerTrp: 0.929 ± 0.037	1.964SerTyr: 1.964 ± 0.049	0.001SerXaa: 0.001 ± 0.001
Thr	4.443ThrAla: 4.443 ± 0.07	0.448ThrCys: 0.448 ± 0.023	2.308ThrAsp: 2.308 ± 0.047	3.074ThrGlu: 3.074 ± 0.064	2.236ThrPhe: 2.236 ± 0.05	4.218ThrGly: 4.218 ± 0.08	1.382ThrHis: 1.382 ± 0.047	3.12ThrIle: 3.12 ± 0.066	1.794ThrLys: 1.794 ± 0.044	5.823ThrLeu: 5.823 ± 0.082	1.194ThrMet: 1.194 ± 0.038	1.77ThrAsn: 1.77 ± 0.048	2.633ThrPro: 2.633 ± 0.054	1.879ThrGln: 1.879 ± 0.049	2.496ThrArg: 2.496 ± 0.053	3.459ThrSer: 3.459 ± 0.09	2.82ThrThr: 2.82 ± 0.066	4.489ThrVal: 4.489 ± 0.091	0.707ThrTrp: 0.707 ± 0.032	1.714ThrTyr: 1.714 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	6.352ValAla: 6.352 ± 0.088	0.771ValCys: 0.771 ± 0.032	3.813ValAsp: 3.813 ± 0.071	4.767ValGlu: 4.767 ± 0.087	3.045ValPhe: 3.045 ± 0.061	5.025ValGly: 5.025 ± 0.091	1.986ValHis: 1.986 ± 0.052	4.588ValIle: 4.588 ± 0.088	3.012ValLys: 3.012 ± 0.059	7.734ValLeu: 7.734 ± 0.109	1.953ValMet: 1.953 ± 0.042	2.611ValAsn: 2.611 ± 0.057	3.255ValPro: 3.255 ± 0.061	3.349ValGln: 3.349 ± 0.059	4.029ValArg: 4.029 ± 0.08	5.04ValSer: 5.04 ± 0.078	4.021ValThr: 4.021 ± 0.081	5.752ValVal: 5.752 ± 0.089	1.115ValTrp: 1.115 ± 0.035	2.359ValTyr: 2.359 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.893TrpAla: 0.893 ± 0.035	0.117TrpCys: 0.117 ± 0.01	0.646TrpAsp: 0.646 ± 0.028	0.763TrpGlu: 0.763 ± 0.026	0.696TrpPhe: 0.696 ± 0.03	0.874TrpGly: 0.874 ± 0.031	0.323TrpHis: 0.323 ± 0.018	1.237TrpIle: 1.237 ± 0.041	0.749TrpLys: 0.749 ± 0.034	2.012TrpLeu: 2.012 ± 0.049	0.594TrpMet: 0.594 ± 0.027	0.639TrpAsn: 0.639 ± 0.028	0.565TrpPro: 0.565 ± 0.027	0.856TrpGln: 0.856 ± 0.033	0.931TrpArg: 0.931 ± 0.034	0.953TrpSer: 0.953 ± 0.038	0.83TrpThr: 0.83 ± 0.029	1.028TrpVal: 1.028 ± 0.033	0.286TrpTrp: 0.286 ± 0.019	0.415TrpTyr: 0.415 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.644TyrAla: 2.644 ± 0.054	0.367TyrCys: 0.367 ± 0.022	1.426TyrAsp: 1.426 ± 0.04	1.8TyrGlu: 1.8 ± 0.046	1.412TyrPhe: 1.412 ± 0.04	2.517TyrGly: 2.517 ± 0.055	0.973TyrHis: 0.973 ± 0.035	1.741TyrIle: 1.741 ± 0.046	0.964TyrLys: 0.964 ± 0.036	3.415TyrLeu: 3.415 ± 0.067	0.663TyrMet: 0.663 ± 0.027	1.057TyrAsn: 1.057 ± 0.04	1.617TyrPro: 1.617 ± 0.042	1.809TyrGln: 1.809 ± 0.051	2.062TyrArg: 2.062 ± 0.051	1.841TyrSer: 1.841 ± 0.049	1.682TyrThr: 1.682 ± 0.05	2.192TyrVal: 2.192 ± 0.053	0.478TyrTrp: 0.478 ± 0.03	0.993TyrTyr: 0.993 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.011XaaXaa: 0.011 ± 0.011

Statistics based on 3064 proteins (883548 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---