Amino acid dipepetide frequency for Bulleidia extructa W1219

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.583AlaAla: 3.583 ± 0.115
0.984AlaCys: 0.984 ± 0.052
3.026AlaAsp: 3.026 ± 0.085
3.324AlaGlu: 3.324 ± 0.108
2.762AlaPhe: 2.762 ± 0.084
4.101AlaGly: 4.101 ± 0.125
1.255AlaHis: 1.255 ± 0.053
5.529AlaIle: 5.529 ± 0.136
5.781AlaLys: 5.781 ± 0.151
6.877AlaLeu: 6.877 ± 0.138
2.081AlaMet: 2.081 ± 0.069
2.918AlaAsn: 2.918 ± 0.094
1.33AlaPro: 1.33 ± 0.062
2.244AlaGln: 2.244 ± 0.082
2.429AlaArg: 2.429 ± 0.069
3.828AlaSer: 3.828 ± 0.094
3.14AlaThr: 3.14 ± 0.097
3.901AlaVal: 3.901 ± 0.104
0.569AlaTrp: 0.569 ± 0.041
2.788AlaTyr: 2.788 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
0.737CysAla: 0.737 ± 0.042
0.128CysCys: 0.128 ± 0.018
0.588CysAsp: 0.588 ± 0.039
0.635CysGlu: 0.635 ± 0.041
0.56CysPhe: 0.56 ± 0.033
0.893CysGly: 0.893 ± 0.048
0.343CysHis: 0.343 ± 0.024
0.742CysIle: 0.742 ± 0.046
0.469CysLys: 0.469 ± 0.029
1.197CysLeu: 1.197 ± 0.064
0.278CysMet: 0.278 ± 0.028
0.301CysAsn: 0.301 ± 0.026
0.46CysPro: 0.46 ± 0.038
0.471CysGln: 0.471 ± 0.039
0.42CysArg: 0.42 ± 0.034
0.723CysSer: 0.723 ± 0.041
0.52CysThr: 0.52 ± 0.033
0.672CysVal: 0.672 ± 0.042
0.093CysTrp: 0.093 ± 0.012
0.394CysTyr: 0.394 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
2.704AspAla: 2.704 ± 0.074
0.614AspCys: 0.614 ± 0.035
2.412AspAsp: 2.412 ± 0.086
4.16AspGlu: 4.16 ± 0.125
2.832AspPhe: 2.832 ± 0.068
3.684AspGly: 3.684 ± 0.103
1.535AspHis: 1.535 ± 0.064
4.05AspIle: 4.05 ± 0.098
3.476AspLys: 3.476 ± 0.099
5.333AspLeu: 5.333 ± 0.131
1.421AspMet: 1.421 ± 0.061
1.715AspAsn: 1.715 ± 0.075
1.834AspPro: 1.834 ± 0.072
2.326AspGln: 2.326 ± 0.083
2.354AspArg: 2.354 ± 0.077
2.804AspSer: 2.804 ± 0.071
2.31AspThr: 2.31 ± 0.081
3.628AspVal: 3.628 ± 0.085
0.588AspTrp: 0.588 ± 0.041
2.475AspTyr: 2.475 ± 0.077
0.0AspXaa: 0.0 ± 0.0
Glu
5.186GluAla: 5.186 ± 0.145
0.495GluCys: 0.495 ± 0.035
3.961GluAsp: 3.961 ± 0.114
6.966GluGlu: 6.966 ± 0.192
2.51GluPhe: 2.51 ± 0.077
3.859GluGly: 3.859 ± 0.09
1.25GluHis: 1.25 ± 0.053
5.893GluIle: 5.893 ± 0.133
7.736GluLys: 7.736 ± 0.163
6.588GluLeu: 6.588 ± 0.141
2.373GluMet: 2.373 ± 0.079
3.933GluAsn: 3.933 ± 0.095
1.521GluPro: 1.521 ± 0.061
2.562GluGln: 2.562 ± 0.086
2.874GluArg: 2.874 ± 0.107
3.334GluSer: 3.334 ± 0.088
3.761GluThr: 3.761 ± 0.098
5.48GluVal: 5.48 ± 0.133
0.693GluTrp: 0.693 ± 0.04
2.715GluTyr: 2.715 ± 0.088
0.0GluXaa: 0.0 ± 0.0
Phe
2.536PheAla: 2.536 ± 0.085
0.525PheCys: 0.525 ± 0.038
2.543PheAsp: 2.543 ± 0.08
2.998PheGlu: 2.998 ± 0.076
2.242PhePhe: 2.242 ± 0.095
3.014PheGly: 3.014 ± 0.1
1.141PheHis: 1.141 ± 0.055
3.112PheIle: 3.112 ± 0.094
2.715PheLys: 2.715 ± 0.071
4.743PheLeu: 4.743 ± 0.12
1.318PheMet: 1.318 ± 0.061
1.836PheAsn: 1.836 ± 0.071
1.421PhePro: 1.421 ± 0.059
2.002PheGln: 2.002 ± 0.072
1.635PheArg: 1.635 ± 0.052
3.415PheSer: 3.415 ± 0.086
1.974PheThr: 1.974 ± 0.066
3.04PheVal: 3.04 ± 0.083
0.448PheTrp: 0.448 ± 0.035
1.971PheTyr: 1.971 ± 0.08
0.0PheXaa: 0.0 ± 0.0
Gly
3.674GlyAla: 3.674 ± 0.103
0.789GlyCys: 0.789 ± 0.04
3.168GlyAsp: 3.168 ± 0.098
3.649GlyGlu: 3.649 ± 0.094
3.196GlyPhe: 3.196 ± 0.104
3.856GlyGly: 3.856 ± 0.124
1.558GlyHis: 1.558 ± 0.067
5.625GlyIle: 5.625 ± 0.122
5.515GlyLys: 5.515 ± 0.114
6.044GlyLeu: 6.044 ± 0.14
1.978GlyMet: 1.978 ± 0.074
2.93GlyAsn: 2.93 ± 0.091
1.131GlyPro: 1.131 ± 0.054
2.34GlyGln: 2.34 ± 0.074
2.496GlyArg: 2.496 ± 0.083
3.989GlySer: 3.989 ± 0.109
3.436GlyThr: 3.436 ± 0.093
4.362GlyVal: 4.362 ± 0.1
0.576GlyTrp: 0.576 ± 0.054
3.25GlyTyr: 3.25 ± 0.096
0.0GlyXaa: 0.0 ± 0.0
His
1.045HisAla: 1.045 ± 0.046
0.345HisCys: 0.345 ± 0.032
1.085HisAsp: 1.085 ± 0.055
1.281HisGlu: 1.281 ± 0.058
1.376HisPhe: 1.376 ± 0.061
1.43HisGly: 1.43 ± 0.065
0.877HisHis: 0.877 ± 0.066
1.544HisIle: 1.544 ± 0.06
1.234HisLys: 1.234 ± 0.056
2.45HisLeu: 2.45 ± 0.076
0.509HisMet: 0.509 ± 0.036
0.73HisAsn: 0.73 ± 0.039
1.092HisPro: 1.092 ± 0.054
1.241HisGln: 1.241 ± 0.051
0.994HisArg: 0.994 ± 0.05
1.439HisSer: 1.439 ± 0.065
1.029HisThr: 1.029 ± 0.046
1.346HisVal: 1.346 ± 0.064
0.245HisTrp: 0.245 ± 0.028
1.045HisTyr: 1.045 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
5.149IleAla: 5.149 ± 0.126
0.893IleCys: 0.893 ± 0.05
3.947IleAsp: 3.947 ± 0.111
5.382IleGlu: 5.382 ± 0.128
3.145IlePhe: 3.145 ± 0.104
5.228IleGly: 5.228 ± 0.129
2.205IleHis: 2.205 ± 0.072
4.633IleIle: 4.633 ± 0.121
4.528IleLys: 4.528 ± 0.107
7.782IleLeu: 7.782 ± 0.172
1.642IleMet: 1.642 ± 0.074
2.921IleAsn: 2.921 ± 0.096
3.175IlePro: 3.175 ± 0.084
4.327IleGln: 4.327 ± 0.113
3.583IleArg: 3.583 ± 0.087
5.361IleSer: 5.361 ± 0.11
3.476IleThr: 3.476 ± 0.075
5.135IleVal: 5.135 ± 0.117
0.688IleTrp: 0.688 ± 0.044
2.837IleTyr: 2.837 ± 0.09
0.0IleXaa: 0.0 ± 0.0
Lys
5.72LysAla: 5.72 ± 0.141
0.462LysCys: 0.462 ± 0.034
4.74LysAsp: 4.74 ± 0.116
8.711LysGlu: 8.711 ± 0.172
2.041LysPhe: 2.041 ± 0.067
5.081LysGly: 5.081 ± 0.12
1.29LysHis: 1.29 ± 0.053
5.529LysIle: 5.529 ± 0.123
8.744LysLys: 8.744 ± 0.19
5.744LysLeu: 5.744 ± 0.118
2.704LysMet: 2.704 ± 0.089
4.661LysAsn: 4.661 ± 0.143
2.09LysPro: 2.09 ± 0.071
3.159LysGln: 3.159 ± 0.093
3.345LysArg: 3.345 ± 0.097
4.136LysSer: 4.136 ± 0.092
4.332LysThr: 4.332 ± 0.104
5.485LysVal: 5.485 ± 0.127
0.754LysTrp: 0.754 ± 0.045
2.746LysTyr: 2.746 ± 0.093
0.0LysXaa: 0.0 ± 0.0
Leu
6.604LeuAla: 6.604 ± 0.158
1.043LeuCys: 1.043 ± 0.049
5.303LeuAsp: 5.303 ± 0.124
7.524LeuGlu: 7.524 ± 0.173
4.593LeuPhe: 4.593 ± 0.126
5.816LeuGly: 5.816 ± 0.149
1.752LeuHis: 1.752 ± 0.068
6.518LeuIle: 6.518 ± 0.148
8.594LeuLys: 8.594 ± 0.16
8.907LeuLeu: 8.907 ± 0.176
2.874LeuMet: 2.874 ± 0.096
4.414LeuAsn: 4.414 ± 0.108
3.397LeuPro: 3.397 ± 0.092
3.483LeuGln: 3.483 ± 0.095
3.8LeuArg: 3.8 ± 0.095
7.146LeuSer: 7.146 ± 0.121
4.544LeuThr: 4.544 ± 0.099
6.877LeuVal: 6.877 ± 0.146
0.977LeuTrp: 0.977 ± 0.05
3.364LeuTyr: 3.364 ± 0.096
0.0LeuXaa: 0.0 ± 0.0
Met
2.279MetAla: 2.279 ± 0.073
0.219MetCys: 0.219 ± 0.021
1.792MetAsp: 1.792 ± 0.066
2.093MetGlu: 2.093 ± 0.08
0.919MetPhe: 0.919 ± 0.046
1.754MetGly: 1.754 ± 0.074
0.308MetHis: 0.308 ± 0.031
2.517MetIle: 2.517 ± 0.083
2.902MetLys: 2.902 ± 0.085
2.053MetLeu: 2.053 ± 0.067
1.064MetMet: 1.064 ± 0.055
1.81MetAsn: 1.81 ± 0.068
0.924MetPro: 0.924 ± 0.048
0.761MetGln: 0.761 ± 0.041
1.11MetArg: 1.11 ± 0.044
1.717MetSer: 1.717 ± 0.061
1.493MetThr: 1.493 ± 0.059
2.305MetVal: 2.305 ± 0.078
0.189MetTrp: 0.189 ± 0.022
0.793MetTyr: 0.793 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
2.834AsnAla: 2.834 ± 0.09
0.485AsnCys: 0.485 ± 0.031
2.247AsnAsp: 2.247 ± 0.073
3.142AsnGlu: 3.142 ± 0.094
1.873AsnPhe: 1.873 ± 0.068
3.334AsnGly: 3.334 ± 0.105
1.456AsnHis: 1.456 ± 0.066
3.154AsnIle: 3.154 ± 0.086
3.117AsnLys: 3.117 ± 0.091
4.206AsnLeu: 4.206 ± 0.096
1.141AsnMet: 1.141 ± 0.054
1.631AsnAsn: 1.631 ± 0.056
1.95AsnPro: 1.95 ± 0.071
2.58AsnGln: 2.58 ± 0.08
2.228AsnArg: 2.228 ± 0.075
2.352AsnSer: 2.352 ± 0.075
2.237AsnThr: 2.237 ± 0.082
2.818AsnVal: 2.818 ± 0.083
0.513AsnTrp: 0.513 ± 0.037
1.915AsnTyr: 1.915 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
1.586ProAla: 1.586 ± 0.063
0.322ProCys: 0.322 ± 0.027
1.526ProAsp: 1.526 ± 0.057
2.426ProGlu: 2.426 ± 0.08
1.631ProPhe: 1.631 ± 0.066
1.645ProGly: 1.645 ± 0.063
0.574ProHis: 0.574 ± 0.037
2.503ProIle: 2.503 ± 0.097
2.627ProLys: 2.627 ± 0.074
3.0ProLeu: 3.0 ± 0.086
0.917ProMet: 0.917 ± 0.045
1.691ProAsn: 1.691 ± 0.068
0.469ProPro: 0.469 ± 0.036
0.949ProGln: 0.949 ± 0.046
0.81ProArg: 0.81 ± 0.052
2.107ProSer: 2.107 ± 0.071
1.668ProThr: 1.668 ± 0.066
2.177ProVal: 2.177 ± 0.066
0.303ProTrp: 0.303 ± 0.026
1.442ProTyr: 1.442 ± 0.065
0.0ProXaa: 0.0 ± 0.0
Gln
2.883GlnAla: 2.883 ± 0.098
0.287GlnCys: 0.287 ± 0.027
2.137GlnAsp: 2.137 ± 0.076
4.062GlnGlu: 4.062 ± 0.128
1.621GlnPhe: 1.621 ± 0.061
2.433GlnGly: 2.433 ± 0.071
0.639GlnHis: 0.639 ± 0.04
2.921GlnIle: 2.921 ± 0.087
4.02GlnLys: 4.02 ± 0.122
3.94GlnLeu: 3.94 ± 0.098
1.148GlnMet: 1.148 ± 0.053
1.955GlnAsn: 1.955 ± 0.068
1.059GlnPro: 1.059 ± 0.046
1.607GlnGln: 1.607 ± 0.081
1.754GlnArg: 1.754 ± 0.064
2.326GlnSer: 2.326 ± 0.077
1.743GlnThr: 1.743 ± 0.056
2.522GlnVal: 2.522 ± 0.088
0.406GlnTrp: 0.406 ± 0.031
1.656GlnTyr: 1.656 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
2.186ArgAla: 2.186 ± 0.068
0.404ArgCys: 0.404 ± 0.033
1.901ArgAsp: 1.901 ± 0.072
2.958ArgGlu: 2.958 ± 0.079
2.048ArgPhe: 2.048 ± 0.077
2.123ArgGly: 2.123 ± 0.073
0.938ArgHis: 0.938 ± 0.052
3.369ArgIle: 3.369 ± 0.085
3.614ArgLys: 3.614 ± 0.109
4.188ArgLeu: 4.188 ± 0.097
1.379ArgMet: 1.379 ± 0.06
1.999ArgAsn: 1.999 ± 0.066
1.085ArgPro: 1.085 ± 0.051
1.766ArgGln: 1.766 ± 0.072
1.876ArgArg: 1.876 ± 0.073
2.293ArgSer: 2.293 ± 0.079
1.764ArgThr: 1.764 ± 0.061
2.489ArgVal: 2.489 ± 0.093
0.441ArgTrp: 0.441 ± 0.033
2.016ArgTyr: 2.016 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
3.45SerAla: 3.45 ± 0.086
0.679SerCys: 0.679 ± 0.043
2.939SerAsp: 2.939 ± 0.092
3.674SerGlu: 3.674 ± 0.086
3.583SerPhe: 3.583 ± 0.099
4.29SerGly: 4.29 ± 0.103
1.47SerHis: 1.47 ± 0.057
4.929SerIle: 4.929 ± 0.112
4.451SerLys: 4.451 ± 0.118
7.055SerLeu: 7.055 ± 0.14
1.626SerMet: 1.626 ± 0.06
2.552SerAsn: 2.552 ± 0.078
1.533SerPro: 1.533 ± 0.054
2.377SerGln: 2.377 ± 0.081
2.198SerArg: 2.198 ± 0.079
4.181SerSer: 4.181 ± 0.125
2.921SerThr: 2.921 ± 0.082
4.122SerVal: 4.122 ± 0.105
0.555SerTrp: 0.555 ± 0.033
2.876SerTyr: 2.876 ± 0.087
0.0SerXaa: 0.0 ± 0.0
Thr
3.056ThrAla: 3.056 ± 0.098
0.527ThrCys: 0.527 ± 0.035
2.291ThrAsp: 2.291 ± 0.076
2.562ThrGlu: 2.562 ± 0.072
2.237ThrPhe: 2.237 ± 0.077
3.506ThrGly: 3.506 ± 0.096
0.896ThrHis: 0.896 ± 0.048
4.565ThrIle: 4.565 ± 0.097
3.866ThrLys: 3.866 ± 0.097
4.918ThrLeu: 4.918 ± 0.099
1.39ThrMet: 1.39 ± 0.056
2.209ThrAsn: 2.209 ± 0.083
1.787ThrPro: 1.787 ± 0.078
1.479ThrGln: 1.479 ± 0.07
1.813ThrArg: 1.813 ± 0.065
3.005ThrSer: 3.005 ± 0.086
2.457ThrThr: 2.457 ± 0.09
3.623ThrVal: 3.623 ± 0.101
0.518ThrTrp: 0.518 ± 0.038
1.957ThrTyr: 1.957 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
4.188ValAla: 4.188 ± 0.107
0.835ValCys: 0.835 ± 0.049
3.835ValAsp: 3.835 ± 0.103
4.67ValGlu: 4.67 ± 0.115
2.883ValPhe: 2.883 ± 0.071
4.358ValGly: 4.358 ± 0.127
1.351ValHis: 1.351 ± 0.059
5.314ValIle: 5.314 ± 0.134
5.051ValLys: 5.051 ± 0.141
7.225ValLeu: 7.225 ± 0.146
1.908ValMet: 1.908 ± 0.068
3.082ValAsn: 3.082 ± 0.101
2.144ValPro: 2.144 ± 0.077
2.767ValGln: 2.767 ± 0.081
2.578ValArg: 2.578 ± 0.083
4.47ValSer: 4.47 ± 0.106
3.296ValThr: 3.296 ± 0.093
4.817ValVal: 4.817 ± 0.136
0.679ValTrp: 0.679 ± 0.037
2.624ValTyr: 2.624 ± 0.079
0.0ValXaa: 0.0 ± 0.0
Trp
0.509TrpAla: 0.509 ± 0.036
0.1TrpCys: 0.1 ± 0.014
0.497TrpAsp: 0.497 ± 0.032
0.509TrpGlu: 0.509 ± 0.039
0.551TrpPhe: 0.551 ± 0.049
0.502TrpGly: 0.502 ± 0.034
0.194TrpHis: 0.194 ± 0.023
0.963TrpIle: 0.963 ± 0.048
0.868TrpLys: 0.868 ± 0.045
1.136TrpLeu: 1.136 ± 0.055
0.394TrpMet: 0.394 ± 0.031
0.539TrpAsn: 0.539 ± 0.032
0.243TrpPro: 0.243 ± 0.024
0.383TrpGln: 0.383 ± 0.033
0.343TrpArg: 0.343 ± 0.028
0.457TrpSer: 0.457 ± 0.035
0.401TrpThr: 0.401 ± 0.033
0.632TrpVal: 0.632 ± 0.032
0.096TrpTrp: 0.096 ± 0.016
0.406TrpTyr: 0.406 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.541TyrAla: 2.541 ± 0.082
0.488TyrCys: 0.488 ± 0.028
2.314TyrAsp: 2.314 ± 0.071
2.965TyrGlu: 2.965 ± 0.08
2.023TyrPhe: 2.023 ± 0.062
2.657TyrGly: 2.657 ± 0.089
1.306TyrHis: 1.306 ± 0.063
2.627TyrIle: 2.627 ± 0.078
2.17TyrLys: 2.17 ± 0.085
4.146TyrLeu: 4.146 ± 0.102
0.856TyrMet: 0.856 ± 0.046
1.386TyrAsn: 1.386 ± 0.067
1.729TyrPro: 1.729 ± 0.063
2.296TyrGln: 2.296 ± 0.08
2.195TyrArg: 2.195 ± 0.075
2.38TyrSer: 2.38 ± 0.089
2.16TyrThr: 2.16 ± 0.072
2.645TyrVal: 2.645 ± 0.076
0.39TyrTrp: 0.39 ± 0.03
1.68TyrTyr: 1.68 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1415 proteins (428656 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski