Amino acid dipepetide frequency for Zoo ranavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.537AlaAla: 10.537 ± 0.917
1.9AlaCys: 1.9 ± 0.257
4.158AlaAsp: 4.158 ± 0.433
5.484AlaGlu: 5.484 ± 0.549
2.867AlaPhe: 2.867 ± 0.402
7.455AlaGly: 7.455 ± 0.638
1.864AlaHis: 1.864 ± 0.25
2.437AlaIle: 2.437 ± 0.247
4.588AlaLys: 4.588 ± 0.407
7.562AlaLeu: 7.562 ± 0.609
3.154AlaMet: 3.154 ± 0.312
1.792AlaAsn: 1.792 ± 0.257
4.48AlaPro: 4.48 ± 0.42
2.724AlaGln: 2.724 ± 0.325
5.161AlaArg: 5.161 ± 0.495
6.308AlaSer: 6.308 ± 0.566
4.373AlaThr: 4.373 ± 0.399
8.745AlaVal: 8.745 ± 0.618
1.362AlaTrp: 1.362 ± 0.252
2.76AlaTyr: 2.76 ± 0.304
0.0AlaXaa: 0.0 ± 0.0
Cys
1.9CysAla: 1.9 ± 0.259
0.717CysCys: 0.717 ± 0.166
1.29CysAsp: 1.29 ± 0.193
1.183CysGlu: 1.183 ± 0.219
0.609CysPhe: 0.609 ± 0.165
1.756CysGly: 1.756 ± 0.254
0.466CysHis: 0.466 ± 0.15
0.645CysIle: 0.645 ± 0.194
1.434CysLys: 1.434 ± 0.247
1.649CysLeu: 1.649 ± 0.299
0.681CysMet: 0.681 ± 0.16
0.502CysAsn: 0.502 ± 0.141
1.685CysPro: 1.685 ± 0.287
0.573CysGln: 0.573 ± 0.151
1.613CysArg: 1.613 ± 0.263
1.541CysSer: 1.541 ± 0.211
0.753CysThr: 0.753 ± 0.169
1.541CysVal: 1.541 ± 0.245
0.538CysTrp: 0.538 ± 0.129
0.681CysTyr: 0.681 ± 0.157
0.0CysXaa: 0.0 ± 0.0
Asp
5.304AspAla: 5.304 ± 0.462
1.434AspCys: 1.434 ± 0.198
3.226AspAsp: 3.226 ± 0.372
2.903AspGlu: 2.903 ± 0.428
1.756AspPhe: 1.756 ± 0.306
4.803AspGly: 4.803 ± 0.495
1.039AspHis: 1.039 ± 0.189
2.366AspIle: 2.366 ± 0.281
2.652AspLys: 2.652 ± 0.289
5.412AspLeu: 5.412 ± 0.439
2.115AspMet: 2.115 ± 0.256
1.756AspAsn: 1.756 ± 0.304
4.265AspPro: 4.265 ± 0.487
1.398AspGln: 1.398 ± 0.261
4.158AspArg: 4.158 ± 0.422
4.301AspSer: 4.301 ± 0.401
2.616AspThr: 2.616 ± 0.371
4.982AspVal: 4.982 ± 0.406
1.004AspTrp: 1.004 ± 0.219
2.222AspTyr: 2.222 ± 0.316
0.0AspXaa: 0.0 ± 0.0
Glu
5.806GluAla: 5.806 ± 0.455
1.541GluCys: 1.541 ± 0.272
3.584GluAsp: 3.584 ± 0.43
3.548GluGlu: 3.548 ± 0.536
1.756GluPhe: 1.756 ± 0.24
3.656GluGly: 3.656 ± 0.435
0.824GluHis: 0.824 ± 0.165
1.756GluIle: 1.756 ± 0.224
3.441GluLys: 3.441 ± 0.349
3.477GluLeu: 3.477 ± 0.34
2.043GluMet: 2.043 ± 0.288
1.254GluAsn: 1.254 ± 0.177
2.616GluPro: 2.616 ± 0.28
1.971GluGln: 1.971 ± 0.454
4.05GluArg: 4.05 ± 0.365
3.548GluSer: 3.548 ± 0.458
3.584GluThr: 3.584 ± 0.345
3.584GluVal: 3.584 ± 0.408
1.29GluTrp: 1.29 ± 0.193
2.115GluTyr: 2.115 ± 0.288
0.0GluXaa: 0.0 ± 0.0
Phe
2.975PheAla: 2.975 ± 0.357
0.645PheCys: 0.645 ± 0.178
1.613PheAsp: 1.613 ± 0.23
1.792PheGlu: 1.792 ± 0.221
1.254PhePhe: 1.254 ± 0.225
2.581PheGly: 2.581 ± 0.303
0.753PheHis: 0.753 ± 0.18
1.039PheIle: 1.039 ± 0.178
1.541PheLys: 1.541 ± 0.221
3.046PheLeu: 3.046 ± 0.288
0.932PheMet: 0.932 ± 0.16
1.326PheAsn: 1.326 ± 0.207
1.971PhePro: 1.971 ± 0.249
0.789PheGln: 0.789 ± 0.15
2.366PheArg: 2.366 ± 0.323
2.688PheSer: 2.688 ± 0.29
1.935PheThr: 1.935 ± 0.253
2.903PheVal: 2.903 ± 0.355
0.287PheTrp: 0.287 ± 0.103
1.004PheTyr: 1.004 ± 0.202
0.0PheXaa: 0.0 ± 0.0
Gly
6.272GlyAla: 6.272 ± 0.509
1.72GlyCys: 1.72 ± 0.305
4.516GlyAsp: 4.516 ± 0.512
3.441GlyGlu: 3.441 ± 0.355
2.76GlyPhe: 2.76 ± 0.347
5.77GlyGly: 5.77 ± 0.562
2.007GlyHis: 2.007 ± 0.341
2.15GlyIle: 2.15 ± 0.304
4.48GlyLys: 4.48 ± 0.417
5.735GlyLeu: 5.735 ± 0.445
2.007GlyMet: 2.007 ± 0.268
1.362GlyAsn: 1.362 ± 0.265
4.122GlyPro: 4.122 ± 0.461
1.935GlyGln: 1.935 ± 0.259
5.448GlyArg: 5.448 ± 0.613
5.842GlySer: 5.842 ± 0.415
4.659GlyThr: 4.659 ± 0.446
5.699GlyVal: 5.699 ± 0.543
1.469GlyTrp: 1.469 ± 0.238
2.545GlyTyr: 2.545 ± 0.274
0.0GlyXaa: 0.0 ± 0.0
His
1.649HisAla: 1.649 ± 0.223
0.394HisCys: 0.394 ± 0.101
1.111HisAsp: 1.111 ± 0.174
0.789HisGlu: 0.789 ± 0.195
0.538HisPhe: 0.538 ± 0.151
1.864HisGly: 1.864 ± 0.285
0.609HisHis: 0.609 ± 0.198
1.039HisIle: 1.039 ± 0.222
0.896HisLys: 0.896 ± 0.184
2.079HisLeu: 2.079 ± 0.318
0.645HisMet: 0.645 ± 0.142
0.645HisAsn: 0.645 ± 0.192
1.577HisPro: 1.577 ± 0.303
0.753HisGln: 0.753 ± 0.151
1.254HisArg: 1.254 ± 0.254
1.326HisSer: 1.326 ± 0.239
1.254HisThr: 1.254 ± 0.241
2.079HisVal: 2.079 ± 0.285
0.251HisTrp: 0.251 ± 0.092
0.86HisTyr: 0.86 ± 0.184
0.0HisXaa: 0.0 ± 0.0
Ile
2.15IleAla: 2.15 ± 0.265
0.573IleCys: 0.573 ± 0.121
1.971IleAsp: 1.971 ± 0.265
1.828IleGlu: 1.828 ± 0.273
1.183IlePhe: 1.183 ± 0.19
1.864IleGly: 1.864 ± 0.281
0.86IleHis: 0.86 ± 0.203
1.075IleIle: 1.075 ± 0.171
2.401IleLys: 2.401 ± 0.259
3.477IleLeu: 3.477 ± 0.324
1.219IleMet: 1.219 ± 0.199
0.932IleAsn: 0.932 ± 0.214
2.115IlePro: 2.115 ± 0.247
0.824IleGln: 0.824 ± 0.177
2.903IleArg: 2.903 ± 0.337
2.366IleSer: 2.366 ± 0.259
1.541IleThr: 1.541 ± 0.275
2.939IleVal: 2.939 ± 0.388
0.143IleTrp: 0.143 ± 0.065
1.111IleTyr: 1.111 ± 0.223
0.0IleXaa: 0.0 ± 0.0
Lys
5.089LysAla: 5.089 ± 0.569
0.896LysCys: 0.896 ± 0.203
2.796LysAsp: 2.796 ± 0.33
3.046LysGlu: 3.046 ± 0.281
1.469LysPhe: 1.469 ± 0.202
4.444LysGly: 4.444 ± 0.413
0.717LysHis: 0.717 ± 0.147
2.473LysIle: 2.473 ± 0.268
3.978LysLys: 3.978 ± 0.426
4.122LysLeu: 4.122 ± 0.39
1.971LysMet: 1.971 ± 0.218
1.685LysAsn: 1.685 ± 0.241
3.369LysPro: 3.369 ± 0.486
1.434LysGln: 1.434 ± 0.271
5.627LysArg: 5.627 ± 0.712
3.727LysSer: 3.727 ± 0.584
3.62LysThr: 3.62 ± 0.341
3.441LysVal: 3.441 ± 0.332
0.681LysTrp: 0.681 ± 0.172
1.935LysTyr: 1.935 ± 0.22
0.0LysXaa: 0.0 ± 0.0
Leu
6.81LeuAla: 6.81 ± 0.521
2.15LeuCys: 2.15 ± 0.332
5.269LeuAsp: 5.269 ± 0.416
5.018LeuGlu: 5.018 ± 0.431
2.867LeuPhe: 2.867 ± 0.312
5.52LeuGly: 5.52 ± 0.56
1.756LeuHis: 1.756 ± 0.296
2.724LeuIle: 2.724 ± 0.361
5.018LeuLys: 5.018 ± 0.467
6.738LeuLeu: 6.738 ± 0.634
2.186LeuMet: 2.186 ± 0.255
2.688LeuAsn: 2.688 ± 0.249
4.014LeuPro: 4.014 ± 0.495
1.541LeuGln: 1.541 ± 0.22
6.523LeuArg: 6.523 ± 0.554
6.523LeuSer: 6.523 ± 0.494
4.839LeuThr: 4.839 ± 0.429
6.272LeuVal: 6.272 ± 0.508
1.004LeuTrp: 1.004 ± 0.192
2.258LeuTyr: 2.258 ± 0.205
0.0LeuXaa: 0.0 ± 0.0
Met
3.333MetAla: 3.333 ± 0.382
0.932MetCys: 0.932 ± 0.216
1.971MetAsp: 1.971 ± 0.243
1.971MetGlu: 1.971 ± 0.247
1.219MetPhe: 1.219 ± 0.213
2.401MetGly: 2.401 ± 0.275
0.86MetHis: 0.86 ± 0.22
0.609MetIle: 0.609 ± 0.137
0.86MetLys: 0.86 ± 0.186
2.294MetLeu: 2.294 ± 0.28
0.753MetMet: 0.753 ± 0.17
0.466MetAsn: 0.466 ± 0.138
1.469MetPro: 1.469 ± 0.226
0.609MetGln: 0.609 ± 0.162
2.079MetArg: 2.079 ± 0.273
2.903MetSer: 2.903 ± 0.355
1.971MetThr: 1.971 ± 0.221
2.222MetVal: 2.222 ± 0.3
0.358MetTrp: 0.358 ± 0.116
0.717MetTyr: 0.717 ± 0.17
0.0MetXaa: 0.0 ± 0.0
Asn
2.366AsnAla: 2.366 ± 0.315
0.502AsnCys: 0.502 ± 0.155
1.039AsnAsp: 1.039 ± 0.189
0.968AsnGlu: 0.968 ± 0.161
0.717AsnPhe: 0.717 ± 0.152
1.541AsnGly: 1.541 ± 0.183
0.502AsnHis: 0.502 ± 0.135
1.29AsnIle: 1.29 ± 0.278
1.147AsnLys: 1.147 ± 0.205
2.724AsnLeu: 2.724 ± 0.353
1.004AsnMet: 1.004 ± 0.205
0.86AsnAsn: 0.86 ± 0.244
2.581AsnPro: 2.581 ± 0.432
0.753AsnGln: 0.753 ± 0.134
1.469AsnArg: 1.469 ± 0.221
1.72AsnSer: 1.72 ± 0.222
1.362AsnThr: 1.362 ± 0.289
2.867AsnVal: 2.867 ± 0.285
0.466AsnTrp: 0.466 ± 0.118
0.86AsnTyr: 0.86 ± 0.179
0.0AsnXaa: 0.0 ± 0.0
Pro
5.591ProAla: 5.591 ± 0.562
1.147ProCys: 1.147 ± 0.224
3.763ProAsp: 3.763 ± 0.307
4.588ProGlu: 4.588 ± 0.558
1.971ProPhe: 1.971 ± 0.271
4.265ProGly: 4.265 ± 0.453
1.828ProHis: 1.828 ± 0.275
1.864ProIle: 1.864 ± 0.269
3.082ProLys: 3.082 ± 0.477
4.301ProLeu: 4.301 ± 0.633
1.111ProMet: 1.111 ± 0.202
1.469ProAsn: 1.469 ± 0.279
4.265ProPro: 4.265 ± 0.833
1.9ProGln: 1.9 ± 0.31
3.154ProArg: 3.154 ± 0.453
4.767ProSer: 4.767 ± 0.423
3.118ProThr: 3.118 ± 0.722
6.917ProVal: 6.917 ± 0.812
0.896ProTrp: 0.896 ± 0.184
1.577ProTyr: 1.577 ± 0.312
0.0ProXaa: 0.0 ± 0.0
Gln
2.437GlnAla: 2.437 ± 0.248
0.681GlnCys: 0.681 ± 0.141
2.043GlnAsp: 2.043 ± 0.341
1.864GlnGlu: 1.864 ± 0.268
0.645GlnPhe: 0.645 ± 0.118
1.792GlnGly: 1.792 ± 0.268
0.681GlnHis: 0.681 ± 0.182
1.039GlnIle: 1.039 ± 0.173
1.326GlnLys: 1.326 ± 0.191
1.935GlnLeu: 1.935 ± 0.314
0.681GlnMet: 0.681 ± 0.143
0.645GlnAsn: 0.645 ± 0.13
1.685GlnPro: 1.685 ± 0.381
1.864GlnGln: 1.864 ± 0.741
2.186GlnArg: 2.186 ± 0.379
2.079GlnSer: 2.079 ± 0.284
2.043GlnThr: 2.043 ± 0.312
2.15GlnVal: 2.15 ± 0.36
0.251GlnTrp: 0.251 ± 0.086
0.645GlnTyr: 0.645 ± 0.143
0.0GlnXaa: 0.0 ± 0.0
Arg
5.269ArgAla: 5.269 ± 0.505
1.075ArgCys: 1.075 ± 0.207
4.516ArgAsp: 4.516 ± 0.481
4.301ArgGlu: 4.301 ± 0.399
2.294ArgPhe: 2.294 ± 0.284
5.448ArgGly: 5.448 ± 0.485
1.828ArgHis: 1.828 ± 0.314
2.294ArgIle: 2.294 ± 0.333
4.373ArgLys: 4.373 ± 0.586
6.057ArgLeu: 6.057 ± 0.499
2.15ArgMet: 2.15 ± 0.288
2.258ArgAsn: 2.258 ± 0.365
4.408ArgPro: 4.408 ± 0.526
2.366ArgGln: 2.366 ± 0.349
6.2ArgArg: 6.2 ± 0.687
3.477ArgSer: 3.477 ± 0.322
3.943ArgThr: 3.943 ± 0.427
5.842ArgVal: 5.842 ± 0.497
0.932ArgTrp: 0.932 ± 0.185
2.15ArgTyr: 2.15 ± 0.226
0.0ArgXaa: 0.0 ± 0.0
Ser
6.451SerAla: 6.451 ± 0.665
1.434SerCys: 1.434 ± 0.207
4.91SerAsp: 4.91 ± 0.359
3.727SerGlu: 3.727 ± 0.333
2.939SerPhe: 2.939 ± 0.319
5.448SerGly: 5.448 ± 0.432
1.541SerHis: 1.541 ± 0.265
2.222SerIle: 2.222 ± 0.221
3.477SerLys: 3.477 ± 0.404
6.236SerLeu: 6.236 ± 0.563
1.72SerMet: 1.72 ± 0.242
1.828SerAsn: 1.828 ± 0.262
5.197SerPro: 5.197 ± 0.891
1.971SerGln: 1.971 ± 0.33
4.552SerArg: 4.552 ± 0.498
5.269SerSer: 5.269 ± 0.456
2.975SerThr: 2.975 ± 0.348
6.165SerVal: 6.165 ± 0.577
1.29SerTrp: 1.29 ± 0.199
1.649SerTyr: 1.649 ± 0.227
0.0SerXaa: 0.0 ± 0.0
Thr
5.735ThrAla: 5.735 ± 0.551
1.111ThrCys: 1.111 ± 0.169
3.405ThrAsp: 3.405 ± 0.392
2.33ThrGlu: 2.33 ± 0.302
2.258ThrPhe: 2.258 ± 0.271
4.982ThrGly: 4.982 ± 0.449
0.681ThrHis: 0.681 ± 0.139
2.258ThrIle: 2.258 ± 0.243
2.724ThrLys: 2.724 ± 0.3
4.659ThrLeu: 4.659 ± 0.472
1.72ThrMet: 1.72 ± 0.248
1.039ThrAsn: 1.039 ± 0.169
3.907ThrPro: 3.907 ± 0.541
1.685ThrGln: 1.685 ± 0.267
3.297ThrArg: 3.297 ± 0.341
2.724ThrSer: 2.724 ± 0.397
1.971ThrThr: 1.971 ± 0.381
5.95ThrVal: 5.95 ± 0.436
0.394ThrTrp: 0.394 ± 0.159
1.362ThrTyr: 1.362 ± 0.257
0.0ThrXaa: 0.0 ± 0.0
Val
6.38ValAla: 6.38 ± 0.497
1.828ValCys: 1.828 ± 0.323
5.125ValAsp: 5.125 ± 0.399
4.408ValGlu: 4.408 ± 0.521
2.939ValPhe: 2.939 ± 0.323
5.125ValGly: 5.125 ± 0.589
2.079ValHis: 2.079 ± 0.272
2.401ValIle: 2.401 ± 0.244
6.451ValLys: 6.451 ± 0.671
6.774ValLeu: 6.774 ± 0.575
2.688ValMet: 2.688 ± 0.384
2.545ValAsn: 2.545 ± 0.299
5.304ValPro: 5.304 ± 0.766
2.401ValGln: 2.401 ± 0.32
6.595ValArg: 6.595 ± 0.475
6.666ValSer: 6.666 ± 0.506
4.588ValThr: 4.588 ± 0.536
6.666ValVal: 6.666 ± 0.556
1.326ValTrp: 1.326 ± 0.176
2.437ValTyr: 2.437 ± 0.313
0.0ValXaa: 0.0 ± 0.0
Trp
1.004TrpAla: 1.004 ± 0.248
0.358TrpCys: 0.358 ± 0.107
1.147TrpAsp: 1.147 ± 0.169
0.789TrpGlu: 0.789 ± 0.167
0.538TrpPhe: 0.538 ± 0.146
0.896TrpGly: 0.896 ± 0.178
0.323TrpHis: 0.323 ± 0.117
0.573TrpIle: 0.573 ± 0.163
1.004TrpLys: 1.004 ± 0.167
1.398TrpLeu: 1.398 ± 0.188
0.466TrpMet: 0.466 ± 0.12
0.573TrpAsn: 0.573 ± 0.161
0.609TrpPro: 0.609 ± 0.137
0.215TrpGln: 0.215 ± 0.08
0.789TrpArg: 0.789 ± 0.164
0.824TrpSer: 0.824 ± 0.149
1.469TrpThr: 1.469 ± 0.263
0.824TrpVal: 0.824 ± 0.204
0.179TrpTrp: 0.179 ± 0.074
0.43TrpTyr: 0.43 ± 0.153
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.652TyrAla: 2.652 ± 0.31
0.717TyrCys: 0.717 ± 0.181
2.258TyrAsp: 2.258 ± 0.3
1.469TyrGlu: 1.469 ± 0.211
0.86TyrPhe: 0.86 ± 0.153
2.33TyrGly: 2.33 ± 0.276
0.394TyrHis: 0.394 ± 0.105
1.219TyrIle: 1.219 ± 0.222
1.649TyrLys: 1.649 ± 0.227
2.079TyrLeu: 2.079 ± 0.241
0.717TyrMet: 0.717 ± 0.155
1.111TyrAsn: 1.111 ± 0.23
1.935TyrPro: 1.935 ± 0.215
0.968TyrGln: 0.968 ± 0.182
1.756TyrArg: 1.756 ± 0.192
2.401TyrSer: 2.401 ± 0.257
1.577TyrThr: 1.577 ± 0.227
2.939TyrVal: 2.939 ± 0.36
0.287TyrTrp: 0.287 ± 0.103
0.86TyrTyr: 0.86 ± 0.201
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 95 proteins (27902 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski