Amino acid dipepetide frequency for Oceanivirga miroungae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.971AlaAla: 2.971 ± 0.145
0.372AlaCys: 0.372 ± 0.032
2.236AlaAsp: 2.236 ± 0.104
2.407AlaGlu: 2.407 ± 0.143
2.216AlaPhe: 2.216 ± 0.096
3.405AlaGly: 3.405 ± 0.166
0.665AlaHis: 0.665 ± 0.044
5.817AlaIle: 5.817 ± 0.178
5.512AlaLys: 5.512 ± 0.157
4.899AlaLeu: 4.899 ± 0.128
1.253AlaMet: 1.253 ± 0.067
3.425AlaAsn: 3.425 ± 0.134
0.903AlaPro: 0.903 ± 0.048
0.97AlaGln: 0.97 ± 0.058
1.755AlaArg: 1.755 ± 0.063
3.524AlaSer: 3.524 ± 0.11
2.938AlaThr: 2.938 ± 0.133
3.348AlaVal: 3.348 ± 0.155
0.246AlaTrp: 0.246 ± 0.026
2.179AlaTyr: 2.179 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.226CysAla: 0.226 ± 0.025
0.05CysCys: 0.05 ± 0.011
0.382CysAsp: 0.382 ± 0.035
0.395CysGlu: 0.395 ± 0.033
0.216CysPhe: 0.216 ± 0.027
0.464CysGly: 0.464 ± 0.038
0.107CysHis: 0.107 ± 0.019
0.62CysIle: 0.62 ± 0.042
0.434CysLys: 0.434 ± 0.037
0.392CysLeu: 0.392 ± 0.034
0.169CysMet: 0.169 ± 0.019
0.385CysAsn: 0.385 ± 0.028
0.169CysPro: 0.169 ± 0.024
0.082CysGln: 0.082 ± 0.013
0.206CysArg: 0.206 ± 0.026
0.501CysSer: 0.501 ± 0.041
0.283CysThr: 0.283 ± 0.034
0.347CysVal: 0.347 ± 0.032
0.037CysTrp: 0.037 ± 0.01
0.285CysTyr: 0.285 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
2.66AspAla: 2.66 ± 0.137
0.191AspCys: 0.191 ± 0.023
3.184AspAsp: 3.184 ± 0.085
5.259AspGlu: 5.259 ± 0.131
2.963AspPhe: 2.963 ± 0.091
3.556AspGly: 3.556 ± 0.338
0.519AspHis: 0.519 ± 0.042
7.09AspIle: 7.09 ± 0.215
7.187AspLys: 7.187 ± 0.179
5.802AspLeu: 5.802 ± 0.145
1.352AspMet: 1.352 ± 0.065
4.045AspAsn: 4.045 ± 0.15
1.251AspPro: 1.251 ± 0.054
0.658AspGln: 0.658 ± 0.04
1.931AspArg: 1.931 ± 0.079
3.298AspSer: 3.298 ± 0.112
2.839AspThr: 2.839 ± 0.125
3.586AspVal: 3.586 ± 0.105
0.258AspTrp: 0.258 ± 0.029
2.817AspTyr: 2.817 ± 0.099
0.0AspXaa: 0.0 ± 0.0
Glu
3.817GluAla: 3.817 ± 0.117
0.367GluCys: 0.367 ± 0.036
4.405GluAsp: 4.405 ± 0.112
6.105GluGlu: 6.105 ± 0.162
3.561GluPhe: 3.561 ± 0.113
3.162GluGly: 3.162 ± 0.142
0.72GluHis: 0.72 ± 0.052
8.537GluIle: 8.537 ± 0.208
10.497GluLys: 10.497 ± 0.207
7.261GluLeu: 7.261 ± 0.176
1.911GluMet: 1.911 ± 0.08
7.37GluAsn: 7.37 ± 0.151
1.129GluPro: 1.129 ± 0.061
1.328GluGln: 1.328 ± 0.063
1.836GluArg: 1.836 ± 0.089
3.338GluSer: 3.338 ± 0.089
2.941GluThr: 2.941 ± 0.109
4.762GluVal: 4.762 ± 0.126
0.352GluTrp: 0.352 ± 0.03
4.278GluTyr: 4.278 ± 0.128
0.0GluXaa: 0.0 ± 0.0
Phe
1.906PheAla: 1.906 ± 0.077
0.335PheCys: 0.335 ± 0.03
2.809PheAsp: 2.809 ± 0.105
3.05PheGlu: 3.05 ± 0.093
2.035PhePhe: 2.035 ± 0.093
2.554PheGly: 2.554 ± 0.088
0.439PheHis: 0.439 ± 0.037
4.147PheIle: 4.147 ± 0.143
4.219PheLys: 4.219 ± 0.122
4.124PheLeu: 4.124 ± 0.142
1.057PheMet: 1.057 ± 0.051
3.402PheAsn: 3.402 ± 0.09
1.015PhePro: 1.015 ± 0.049
0.588PheGln: 0.588 ± 0.039
1.253PheArg: 1.253 ± 0.059
3.76PheSer: 3.76 ± 0.112
2.144PheThr: 2.144 ± 0.073
2.64PheVal: 2.64 ± 0.087
0.208PheTrp: 0.208 ± 0.022
1.998PheTyr: 1.998 ± 0.077
0.0PheXaa: 0.0 ± 0.0
Gly
3.469GlyAla: 3.469 ± 0.147
0.318GlyCys: 0.318 ± 0.031
2.908GlyAsp: 2.908 ± 0.15
3.844GlyGlu: 3.844 ± 0.187
2.521GlyPhe: 2.521 ± 0.089
3.482GlyGly: 3.482 ± 0.143
0.871GlyHis: 0.871 ± 0.049
5.884GlyIle: 5.884 ± 0.139
5.321GlyLys: 5.321 ± 0.205
4.983GlyLeu: 4.983 ± 0.125
1.29GlyMet: 1.29 ± 0.063
3.239GlyAsn: 3.239 ± 0.249
1.03GlyPro: 1.03 ± 0.092
1.218GlyGln: 1.218 ± 0.081
1.898GlyArg: 1.898 ± 0.082
3.286GlySer: 3.286 ± 0.157
3.087GlyThr: 3.087 ± 0.175
4.072GlyVal: 4.072 ± 0.122
0.268GlyTrp: 0.268 ± 0.025
2.578GlyTyr: 2.578 ± 0.091
0.0GlyXaa: 0.0 ± 0.0
His
0.608HisAla: 0.608 ± 0.039
0.077HisCys: 0.077 ± 0.015
0.638HisAsp: 0.638 ± 0.04
0.74HisGlu: 0.74 ± 0.044
0.504HisPhe: 0.504 ± 0.036
0.687HisGly: 0.687 ± 0.052
0.213HisHis: 0.213 ± 0.026
1.107HisIle: 1.107 ± 0.061
1.129HisLys: 1.129 ± 0.055
1.099HisLeu: 1.099 ± 0.053
0.226HisMet: 0.226 ± 0.028
0.779HisAsn: 0.779 ± 0.049
0.467HisPro: 0.467 ± 0.039
0.246HisGln: 0.246 ± 0.027
0.434HisArg: 0.434 ± 0.036
0.836HisSer: 0.836 ± 0.044
0.511HisThr: 0.511 ± 0.034
0.534HisVal: 0.534 ± 0.039
0.062HisTrp: 0.062 ± 0.011
0.504HisTyr: 0.504 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.651IleAla: 5.651 ± 0.14
0.7IleCys: 0.7 ± 0.044
6.604IleAsp: 6.604 ± 0.155
8.13IleGlu: 8.13 ± 0.162
4.276IlePhe: 4.276 ± 0.153
5.256IleGly: 5.256 ± 0.194
1.005IleHis: 1.005 ± 0.055
8.974IleIle: 8.974 ± 0.227
10.733IleLys: 10.733 ± 0.192
10.232IleLeu: 10.232 ± 0.278
1.859IleMet: 1.859 ± 0.075
6.648IleAsn: 6.648 ± 0.177
2.707IlePro: 2.707 ± 0.088
1.774IleGln: 1.774 ± 0.06
2.956IleArg: 2.956 ± 0.102
7.907IleSer: 7.907 ± 0.184
4.807IleThr: 4.807 ± 0.145
6.043IleVal: 6.043 ± 0.127
0.454IleTrp: 0.454 ± 0.04
4.462IleTyr: 4.462 ± 0.138
0.0IleXaa: 0.0 ± 0.0
Lys
4.996LysAla: 4.996 ± 0.153
0.407LysCys: 0.407 ± 0.032
7.437LysAsp: 7.437 ± 0.209
10.743LysGlu: 10.743 ± 0.258
3.745LysPhe: 3.745 ± 0.115
4.998LysGly: 4.998 ± 0.193
0.941LysHis: 0.941 ± 0.048
10.502LysIle: 10.502 ± 0.179
12.143LysLys: 12.143 ± 0.239
10.475LysLeu: 10.475 ± 0.2
2.757LysMet: 2.757 ± 0.093
8.825LysAsn: 8.825 ± 0.177
1.908LysPro: 1.908 ± 0.08
1.777LysGln: 1.777 ± 0.065
3.234LysArg: 3.234 ± 0.101
5.209LysSer: 5.209 ± 0.125
4.765LysThr: 4.765 ± 0.131
6.323LysVal: 6.323 ± 0.143
0.504LysTrp: 0.504 ± 0.04
5.847LysTyr: 5.847 ± 0.161
0.0LysXaa: 0.0 ± 0.0
Leu
5.254LeuAla: 5.254 ± 0.147
0.543LeuCys: 0.543 ± 0.038
6.802LeuAsp: 6.802 ± 0.149
8.353LeuGlu: 8.353 ± 0.186
3.66LeuPhe: 3.66 ± 0.124
5.814LeuGly: 5.814 ± 0.151
1.005LeuHis: 1.005 ± 0.054
8.279LeuIle: 8.279 ± 0.201
9.951LeuLys: 9.951 ± 0.18
7.748LeuLeu: 7.748 ± 0.224
2.008LeuMet: 2.008 ± 0.091
6.986LeuAsn: 6.986 ± 0.159
2.162LeuPro: 2.162 ± 0.095
1.732LeuGln: 1.732 ± 0.07
2.856LeuArg: 2.856 ± 0.102
7.043LeuSer: 7.043 ± 0.178
4.348LeuThr: 4.348 ± 0.126
5.867LeuVal: 5.867 ± 0.142
0.395LeuTrp: 0.395 ± 0.032
3.241LeuTyr: 3.241 ± 0.106
0.0LeuXaa: 0.0 ± 0.0
Met
1.251MetAla: 1.251 ± 0.068
0.122MetCys: 0.122 ± 0.019
1.097MetAsp: 1.097 ± 0.055
1.429MetGlu: 1.429 ± 0.069
0.926MetPhe: 0.926 ± 0.054
1.417MetGly: 1.417 ± 0.068
0.28MetHis: 0.28 ± 0.027
2.077MetIle: 2.077 ± 0.081
2.315MetLys: 2.315 ± 0.087
2.236MetLeu: 2.236 ± 0.079
0.563MetMet: 0.563 ± 0.058
1.231MetAsn: 1.231 ± 0.056
0.854MetPro: 0.854 ± 0.053
0.645MetGln: 0.645 ± 0.041
0.705MetArg: 0.705 ± 0.051
1.534MetSer: 1.534 ± 0.07
1.075MetThr: 1.075 ± 0.062
1.204MetVal: 1.204 ± 0.06
0.099MetTrp: 0.099 ± 0.016
1.156MetTyr: 1.156 ± 0.057
0.0MetXaa: 0.0 ± 0.0
Asn
3.258AsnAla: 3.258 ± 0.146
0.313AsnCys: 0.313 ± 0.029
3.891AsnAsp: 3.891 ± 0.132
5.668AsnGlu: 5.668 ± 0.132
3.062AsnPhe: 3.062 ± 0.099
3.842AsnGly: 3.842 ± 0.216
0.764AsnHis: 0.764 ± 0.041
8.487AsnIle: 8.487 ± 0.19
8.063AsnLys: 8.063 ± 0.181
6.931AsnLeu: 6.931 ± 0.169
1.688AsnMet: 1.688 ± 0.063
5.06AsnAsn: 5.06 ± 0.198
1.941AsnPro: 1.941 ± 0.073
1.206AsnGln: 1.206 ± 0.058
2.3AsnArg: 2.3 ± 0.078
4.514AsnSer: 4.514 ± 0.159
3.378AsnThr: 3.378 ± 0.137
3.953AsnVal: 3.953 ± 0.121
0.33AsnTrp: 0.33 ± 0.033
3.268AsnTyr: 3.268 ± 0.108
0.0AsnXaa: 0.0 ± 0.0
Pro
1.032ProAla: 1.032 ± 0.056
0.179ProCys: 0.179 ± 0.02
1.206ProAsp: 1.206 ± 0.062
1.673ProGlu: 1.673 ± 0.074
1.156ProPhe: 1.156 ± 0.056
1.196ProGly: 1.196 ± 0.086
0.365ProHis: 0.365 ± 0.034
2.139ProIle: 2.139 ± 0.089
2.028ProLys: 2.028 ± 0.07
1.876ProLeu: 1.876 ± 0.067
0.412ProMet: 0.412 ± 0.031
1.606ProAsn: 1.606 ± 0.07
0.34ProPro: 0.34 ± 0.037
0.548ProGln: 0.548 ± 0.043
0.635ProArg: 0.635 ± 0.048
1.648ProSer: 1.648 ± 0.066
1.34ProThr: 1.34 ± 0.061
1.593ProVal: 1.593 ± 0.076
0.149ProTrp: 0.149 ± 0.021
1.318ProTyr: 1.318 ± 0.062
0.0ProXaa: 0.0 ± 0.0
Gln
1.139GlnAla: 1.139 ± 0.067
0.089GlnCys: 0.089 ± 0.014
1.114GlnAsp: 1.114 ± 0.059
1.335GlnGlu: 1.335 ± 0.058
0.715GlnPhe: 0.715 ± 0.046
1.01GlnGly: 1.01 ± 0.068
0.176GlnHis: 0.176 ± 0.019
2.005GlnIle: 2.005 ± 0.059
2.04GlnLys: 2.04 ± 0.071
1.576GlnLeu: 1.576 ± 0.065
0.489GlnMet: 0.489 ± 0.035
1.335GlnAsn: 1.335 ± 0.063
0.323GlnPro: 0.323 ± 0.03
0.347GlnGln: 0.347 ± 0.032
0.645GlnArg: 0.645 ± 0.04
0.923GlnSer: 0.923 ± 0.058
0.844GlnThr: 0.844 ± 0.065
1.241GlnVal: 1.241 ± 0.058
0.087GlnTrp: 0.087 ± 0.015
0.774GlnTyr: 0.774 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
1.707ArgAla: 1.707 ± 0.071
0.191ArgCys: 0.191 ± 0.024
1.603ArgAsp: 1.603 ± 0.07
2.462ArgGlu: 2.462 ± 0.103
1.3ArgPhe: 1.3 ± 0.058
1.544ArgGly: 1.544 ± 0.075
0.499ArgHis: 0.499 ± 0.036
3.07ArgIle: 3.07 ± 0.106
3.311ArgLys: 3.311 ± 0.113
3.03ArgLeu: 3.03 ± 0.104
0.722ArgMet: 0.722 ± 0.052
1.938ArgAsn: 1.938 ± 0.08
0.784ArgPro: 0.784 ± 0.053
0.834ArgGln: 0.834 ± 0.05
1.226ArgArg: 1.226 ± 0.061
1.521ArgSer: 1.521 ± 0.067
1.333ArgThr: 1.333 ± 0.072
2.204ArgVal: 2.204 ± 0.081
0.141ArgTrp: 0.141 ± 0.019
1.601ArgTyr: 1.601 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
2.693SerAla: 2.693 ± 0.104
0.402SerCys: 0.402 ± 0.033
3.616SerAsp: 3.616 ± 0.105
4.201SerGlu: 4.201 ± 0.103
3.385SerPhe: 3.385 ± 0.107
3.747SerGly: 3.747 ± 0.124
0.749SerHis: 0.749 ± 0.045
6.941SerIle: 6.941 ± 0.16
6.71SerLys: 6.71 ± 0.147
6.403SerLeu: 6.403 ± 0.146
1.34SerMet: 1.34 ± 0.06
4.643SerAsn: 4.643 ± 0.134
1.352SerPro: 1.352 ± 0.055
1.315SerGln: 1.315 ± 0.062
1.975SerArg: 1.975 ± 0.07
4.487SerSer: 4.487 ± 0.127
2.978SerThr: 2.978 ± 0.109
3.981SerVal: 3.981 ± 0.11
0.32SerTrp: 0.32 ± 0.031
3.204SerTyr: 3.204 ± 0.105
0.0SerXaa: 0.0 ± 0.0
Thr
2.367ThrAla: 2.367 ± 0.137
0.248ThrCys: 0.248 ± 0.022
2.802ThrAsp: 2.802 ± 0.157
2.717ThrGlu: 2.717 ± 0.099
2.119ThrPhe: 2.119 ± 0.062
3.157ThrGly: 3.157 ± 0.169
0.772ThrHis: 0.772 ± 0.048
4.298ThrIle: 4.298 ± 0.115
5.063ThrLys: 5.063 ± 0.162
4.298ThrLeu: 4.298 ± 0.111
0.896ThrMet: 0.896 ± 0.048
3.432ThrAsn: 3.432 ± 0.159
1.603ThrPro: 1.603 ± 0.112
0.95ThrGln: 0.95 ± 0.058
1.601ThrArg: 1.601 ± 0.075
2.931ThrSer: 2.931 ± 0.109
2.653ThrThr: 2.653 ± 0.143
3.085ThrVal: 3.085 ± 0.116
0.241ThrTrp: 0.241 ± 0.025
2.204ThrTyr: 2.204 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
3.673ValAla: 3.673 ± 0.147
0.529ValCys: 0.529 ± 0.036
4.053ValAsp: 4.053 ± 0.112
4.839ValGlu: 4.839 ± 0.125
2.871ValPhe: 2.871 ± 0.112
3.633ValGly: 3.633 ± 0.131
0.675ValHis: 0.675 ± 0.041
5.869ValIle: 5.869 ± 0.134
5.812ValLys: 5.812 ± 0.153
5.877ValLeu: 5.877 ± 0.148
1.164ValMet: 1.164 ± 0.061
3.993ValAsn: 3.993 ± 0.13
1.382ValPro: 1.382 ± 0.074
0.931ValGln: 0.931 ± 0.041
1.859ValArg: 1.859 ± 0.063
4.931ValSer: 4.931 ± 0.111
2.621ValThr: 2.621 ± 0.116
4.368ValVal: 4.368 ± 0.142
0.278ValTrp: 0.278 ± 0.026
2.913ValTyr: 2.913 ± 0.076
0.0ValXaa: 0.0 ± 0.0
Trp
0.248TrpAla: 0.248 ± 0.025
0.037TrpCys: 0.037 ± 0.01
0.333TrpAsp: 0.333 ± 0.037
0.4TrpGlu: 0.4 ± 0.038
0.251TrpPhe: 0.251 ± 0.025
0.29TrpGly: 0.29 ± 0.027
0.065TrpHis: 0.065 ± 0.012
0.38TrpIle: 0.38 ± 0.037
0.328TrpLys: 0.328 ± 0.03
0.464TrpLeu: 0.464 ± 0.034
0.139TrpMet: 0.139 ± 0.02
0.285TrpAsn: 0.285 ± 0.028
0.072TrpPro: 0.072 ± 0.013
0.151TrpGln: 0.151 ± 0.022
0.146TrpArg: 0.146 ± 0.019
0.285TrpSer: 0.285 ± 0.028
0.213TrpThr: 0.213 ± 0.025
0.31TrpVal: 0.31 ± 0.029
0.072TrpTrp: 0.072 ± 0.013
0.243TrpTyr: 0.243 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.114TyrAla: 2.114 ± 0.071
0.28TyrCys: 0.28 ± 0.029
3.325TyrAsp: 3.325 ± 0.113
3.928TyrGlu: 3.928 ± 0.123
2.201TyrPhe: 2.201 ± 0.086
2.355TyrGly: 2.355 ± 0.085
0.571TyrHis: 0.571 ± 0.042
4.953TyrIle: 4.953 ± 0.153
4.74TyrLys: 4.74 ± 0.124
4.343TyrLeu: 4.343 ± 0.139
0.918TyrMet: 0.918 ± 0.046
3.291TyrAsn: 3.291 ± 0.113
1.047TyrPro: 1.047 ± 0.052
0.906TyrGln: 0.906 ± 0.045
1.568TyrArg: 1.568 ± 0.07
2.968TyrSer: 2.968 ± 0.095
2.34TyrThr: 2.34 ± 0.083
2.809TyrVal: 2.809 ± 0.09
0.211TyrTrp: 0.211 ± 0.023
2.142TyrTyr: 2.142 ± 0.088
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1193 proteins (402960 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski