Amino acid dipepetide frequency for Balaenoptera physalus (Fin whale) (Balaena physalus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.379AlaAla: 6.379 ± 0.041	1.425AlaCys: 1.425 ± 0.015	2.898AlaAsp: 2.898 ± 0.022	4.695AlaGlu: 4.695 ± 0.034	2.579AlaPhe: 2.579 ± 0.018	4.805AlaGly: 4.805 ± 0.035	1.608AlaHis: 1.608 ± 0.015	2.753AlaIle: 2.753 ± 0.022	3.455AlaLys: 3.455 ± 0.026	7.305AlaLeu: 7.305 ± 0.041	1.473AlaMet: 1.473 ± 0.016	1.984AlaAsn: 1.984 ± 0.017	4.107AlaPro: 4.107 ± 0.035	3.224AlaGln: 3.224 ± 0.024	3.704AlaArg: 3.704 ± 0.024	5.723AlaSer: 5.723 ± 0.033	3.57AlaThr: 3.57 ± 0.031	4.82AlaVal: 4.82 ± 0.026	0.876AlaTrp: 0.876 ± 0.011	1.511AlaTyr: 1.511 ± 0.016	0.021AlaXaa: 0.021 ± 0.002
Cys	1.275CysAla: 1.275 ± 0.014	0.655CysCys: 0.655 ± 0.012	0.992CysAsp: 0.992 ± 0.013	1.214CysGlu: 1.214 ± 0.018	0.915CysPhe: 0.915 ± 0.011	1.546CysGly: 1.546 ± 0.018	0.695CysHis: 0.695 ± 0.011	0.962CysIle: 0.962 ± 0.013	1.101CysLys: 1.101 ± 0.012	2.293CysLeu: 2.293 ± 0.02	0.396CysMet: 0.396 ± 0.008	0.735CysAsn: 0.735 ± 0.012	1.54CysPro: 1.54 ± 0.021	1.059CysGln: 1.059 ± 0.014	1.328CysArg: 1.328 ± 0.014	2.004CysSer: 2.004 ± 0.019	1.13CysThr: 1.13 ± 0.011	1.347CysVal: 1.347 ± 0.015	0.325CysTrp: 0.325 ± 0.007	0.591CysTyr: 0.591 ± 0.008	0.004CysXaa: 0.004 ± 0.001
Asp	2.844AspAla: 2.844 ± 0.022	1.011AspCys: 1.011 ± 0.014	2.539AspAsp: 2.539 ± 0.023	3.347AspGlu: 3.347 ± 0.026	2.127AspPhe: 2.127 ± 0.018	3.254AspGly: 3.254 ± 0.031	1.161AspHis: 1.161 ± 0.013	2.553AspIle: 2.553 ± 0.022	2.46AspLys: 2.46 ± 0.022	5.015AspLeu: 5.015 ± 0.027	1.06AspMet: 1.06 ± 0.012	1.603AspAsn: 1.603 ± 0.016	2.936AspPro: 2.936 ± 0.024	1.84AspGln: 1.84 ± 0.014	2.417AspArg: 2.417 ± 0.019	4.034AspSer: 4.034 ± 0.025	2.462AspThr: 2.462 ± 0.018	3.065AspVal: 3.065 ± 0.033	0.643AspTrp: 0.643 ± 0.01	1.392AspTyr: 1.392 ± 0.014	0.006AspXaa: 0.006 ± 0.001
Glu	5.288GluAla: 5.288 ± 0.034	1.16GluCys: 1.16 ± 0.017	4.326GluAsp: 4.326 ± 0.028	7.736GluGlu: 7.736 ± 0.06	2.043GluPhe: 2.043 ± 0.017	4.343GluGly: 4.343 ± 0.032	1.491GluHis: 1.491 ± 0.014	3.097GluIle: 3.097 ± 0.025	5.218GluLys: 5.218 ± 0.048	6.342GluLeu: 6.342 ± 0.039	1.653GluMet: 1.653 ± 0.017	3.046GluAsn: 3.046 ± 0.026	3.196GluPro: 3.196 ± 0.029	3.068GluGln: 3.068 ± 0.028	3.938GluArg: 3.938 ± 0.03	4.315GluSer: 4.315 ± 0.03	3.472GluThr: 3.472 ± 0.026	4.234GluVal: 4.234 ± 0.029	0.706GluTrp: 0.706 ± 0.01	1.515GluTyr: 1.515 ± 0.015	0.011GluXaa: 0.011 ± 0.001
Phe	2.005PheAla: 2.005 ± 0.016	0.973PheCys: 0.973 ± 0.012	1.641PheAsp: 1.641 ± 0.015	1.976PheGlu: 1.976 ± 0.019	1.635PhePhe: 1.635 ± 0.019	2.21PheGly: 2.21 ± 0.021	1.083PheHis: 1.083 ± 0.012	1.833PheIle: 1.833 ± 0.019	1.802PheLys: 1.802 ± 0.017	4.304PheLeu: 4.304 ± 0.028	0.75PheMet: 0.75 ± 0.011	1.304PheAsn: 1.304 ± 0.016	2.114PhePro: 2.114 ± 0.018	1.848PheGln: 1.848 ± 0.014	1.958PheArg: 1.958 ± 0.016	3.441PheSer: 3.441 ± 0.022	2.053PheThr: 2.053 ± 0.017	2.159PheVal: 2.159 ± 0.019	0.522PheTrp: 0.522 ± 0.008	1.205PheTyr: 1.205 ± 0.015	0.007PheXaa: 0.007 ± 0.001
Gly	4.556GlyAla: 4.556 ± 0.038	1.4GlyCys: 1.4 ± 0.015	3.129GlyAsp: 3.129 ± 0.023	4.071GlyGlu: 4.071 ± 0.03	2.436GlyPhe: 2.436 ± 0.021	4.996GlyGly: 4.996 ± 0.044	1.798GlyHis: 1.798 ± 0.017	2.808GlyIle: 2.808 ± 0.024	3.775GlyLys: 3.775 ± 0.025	6.084GlyLeu: 6.084 ± 0.04	1.293GlyMet: 1.293 ± 0.014	2.361GlyAsn: 2.361 ± 0.018	4.296GlyPro: 4.296 ± 0.053	2.882GlyGln: 2.882 ± 0.025	3.991GlyArg: 3.991 ± 0.029	5.711GlySer: 5.711 ± 0.042	3.735GlyThr: 3.735 ± 0.037	3.684GlyVal: 3.684 ± 0.027	0.894GlyTrp: 0.894 ± 0.013	1.686GlyTyr: 1.686 ± 0.019	0.017GlyXaa: 0.017 ± 0.001
His	1.366HisAla: 1.366 ± 0.014	0.732HisCys: 0.732 ± 0.011	0.899HisAsp: 0.899 ± 0.01	1.267HisGlu: 1.267 ± 0.013	1.137HisPhe: 1.137 ± 0.012	1.601HisGly: 1.601 ± 0.018	0.858HisHis: 0.858 ± 0.011	1.249HisIle: 1.249 ± 0.012	1.23HisLys: 1.23 ± 0.014	3.029HisLeu: 3.029 ± 0.019	0.566HisMet: 0.566 ± 0.01	0.82HisAsn: 0.82 ± 0.01	1.716HisPro: 1.716 ± 0.017	1.229HisGln: 1.229 ± 0.014	1.623HisArg: 1.623 ± 0.016	2.24HisSer: 2.24 ± 0.018	1.379HisThr: 1.379 ± 0.015	1.57HisVal: 1.57 ± 0.014	0.37HisTrp: 0.37 ± 0.007	0.8HisTyr: 0.8 ± 0.012	0.006HisXaa: 0.006 ± 0.001
Ile	2.531IleAla: 2.531 ± 0.017	1.097IleCys: 1.097 ± 0.014	1.947IleAsp: 1.947 ± 0.019	2.459IleGlu: 2.459 ± 0.022	1.93IlePhe: 1.93 ± 0.02	2.181IleGly: 2.181 ± 0.02	1.265IleHis: 1.265 ± 0.013	2.369IleIle: 2.369 ± 0.023	2.596IleLys: 2.596 ± 0.025	4.626IleLeu: 4.626 ± 0.034	0.981IleMet: 0.981 ± 0.012	1.808IleAsn: 1.808 ± 0.019	2.632IlePro: 2.632 ± 0.021	2.245IleGln: 2.245 ± 0.021	2.355IleArg: 2.355 ± 0.016	3.759IleSer: 3.759 ± 0.027	2.609IleThr: 2.609 ± 0.025	2.451IleVal: 2.451 ± 0.021	0.542IleTrp: 0.542 ± 0.01	1.393IleTyr: 1.393 ± 0.016	0.006IleXaa: 0.006 ± 0.001
Lys	3.999LysAla: 3.999 ± 0.027	1.074LysCys: 1.074 ± 0.012	3.074LysAsp: 3.074 ± 0.026	5.102LysGlu: 5.102 ± 0.046	1.756LysPhe: 1.756 ± 0.015	3.34LysGly: 3.34 ± 0.03	1.411LysHis: 1.411 ± 0.017	2.76LysIle: 2.76 ± 0.023	4.693LysLys: 4.693 ± 0.049	5.185LysLeu: 5.185 ± 0.034	1.466LysMet: 1.466 ± 0.019	2.4LysAsn: 2.4 ± 0.024	2.934LysPro: 2.934 ± 0.021	2.584LysGln: 2.584 ± 0.026	3.322LysArg: 3.322 ± 0.025	3.853LysSer: 3.853 ± 0.034	3.132LysThr: 3.132 ± 0.025	3.507LysVal: 3.507 ± 0.028	0.611LysTrp: 0.611 ± 0.009	1.577LysTyr: 1.577 ± 0.015	0.009LysXaa: 0.009 ± 0.001
Leu	6.883LeuAla: 6.883 ± 0.032	2.332LeuCys: 2.332 ± 0.018	4.726LeuAsp: 4.726 ± 0.028	7.105LeuGlu: 7.105 ± 0.042	3.51LeuPhe: 3.51 ± 0.028	6.273LeuGly: 6.273 ± 0.038	2.744LeuHis: 2.744 ± 0.022	3.888LeuIle: 3.888 ± 0.027	5.865LeuLys: 5.865 ± 0.043	10.816LeuLeu: 10.816 ± 0.059	1.976LeuMet: 1.976 ± 0.016	3.475LeuAsn: 3.475 ± 0.02	6.233LeuPro: 6.233 ± 0.036	5.767LeuGln: 5.767 ± 0.039	5.954LeuArg: 5.954 ± 0.03	8.181LeuSer: 8.181 ± 0.036	5.211LeuThr: 5.211 ± 0.029	5.669LeuVal: 5.669 ± 0.031	1.241LeuTrp: 1.241 ± 0.012	2.528LeuTyr: 2.528 ± 0.022	0.02LeuXaa: 0.02 ± 0.002
Met	1.785MetAla: 1.785 ± 0.017	0.413MetCys: 0.413 ± 0.007	1.183MetAsp: 1.183 ± 0.011	1.77MetGlu: 1.77 ± 0.015	0.729MetPhe: 0.729 ± 0.01	1.31MetGly: 1.31 ± 0.015	0.438MetHis: 0.438 ± 0.007	0.839MetIle: 0.839 ± 0.012	1.426MetLys: 1.426 ± 0.015	1.936MetLeu: 1.936 ± 0.018	0.55MetMet: 0.55 ± 0.01	0.87MetAsn: 0.87 ± 0.01	1.062MetPro: 1.062 ± 0.016	0.898MetGln: 0.898 ± 0.012	1.036MetArg: 1.036 ± 0.011	1.491MetSer: 1.491 ± 0.016	1.119MetThr: 1.119 ± 0.012	1.414MetVal: 1.414 ± 0.013	0.241MetTrp: 0.241 ± 0.005	0.552MetTyr: 0.552 ± 0.008	0.004MetXaa: 0.004 ± 0.001
Asn	1.988AsnAla: 1.988 ± 0.016	0.848AsnCys: 0.848 ± 0.01	1.467AsnAsp: 1.467 ± 0.017	2.113AsnGlu: 2.113 ± 0.021	1.472AsnPhe: 1.472 ± 0.014	2.29AsnGly: 2.29 ± 0.022	0.926AsnHis: 0.926 ± 0.013	2.084AsnIle: 2.084 ± 0.019	2.175AsnLys: 2.175 ± 0.019	3.675AsnLeu: 3.675 ± 0.026	0.872AsnMet: 0.872 ± 0.009	1.476AsnAsn: 1.476 ± 0.015	2.187AsnPro: 2.187 ± 0.016	1.616AsnGln: 1.616 ± 0.018	1.817AsnArg: 1.817 ± 0.018	3.02AsnSer: 3.02 ± 0.025	1.963AsnThr: 1.963 ± 0.018	2.204AsnVal: 2.204 ± 0.017	0.458AsnTrp: 0.458 ± 0.008	1.078AsnTyr: 1.078 ± 0.014	0.005AsnXaa: 0.005 ± 0.001
Pro	4.74ProAla: 4.74 ± 0.039	1.235ProCys: 1.235 ± 0.016	2.786ProAsp: 2.786 ± 0.024	4.514ProGlu: 4.514 ± 0.029	1.96ProPhe: 1.96 ± 0.016	5.19ProGly: 5.19 ± 0.062	1.465ProHis: 1.465 ± 0.014	1.884ProIle: 1.884 ± 0.016	2.826ProLys: 2.826 ± 0.034	5.442ProLeu: 5.442 ± 0.033	1.016ProMet: 1.016 ± 0.013	1.798ProAsn: 1.798 ± 0.016	5.292ProPro: 5.292 ± 0.057	2.829ProGln: 2.829 ± 0.026	3.482ProArg: 3.482 ± 0.029	5.686ProSer: 5.686 ± 0.042	3.181ProThr: 3.181 ± 0.041	3.86ProVal: 3.86 ± 0.026	0.777ProTrp: 0.777 ± 0.011	1.292ProTyr: 1.292 ± 0.016	0.02ProXaa: 0.02 ± 0.002
Gln	3.555GlnAla: 3.555 ± 0.025	0.895GlnCys: 0.895 ± 0.013	2.351GlnAsp: 2.351 ± 0.018	3.903GlnGlu: 3.903 ± 0.032	1.344GlnPhe: 1.344 ± 0.015	3.021GlnGly: 3.021 ± 0.024	1.231GlnHis: 1.231 ± 0.014	1.977GlnIle: 1.977 ± 0.017	2.944GlnLys: 2.944 ± 0.027	4.743GlnLeu: 4.743 ± 0.035	1.083GlnMet: 1.083 ± 0.013	1.818GlnAsn: 1.818 ± 0.017	2.693GlnPro: 2.693 ± 0.027	2.754GlnGln: 2.754 ± 0.035	2.857GlnArg: 2.857 ± 0.019	3.009GlnSer: 3.009 ± 0.023	2.306GlnThr: 2.306 ± 0.018	2.897GlnVal: 2.897 ± 0.023	0.559GlnTrp: 0.559 ± 0.009	1.102GlnTyr: 1.102 ± 0.013	0.006GlnXaa: 0.006 ± 0.001
Arg	4.066ArgAla: 4.066 ± 0.03	1.252ArgCys: 1.252 ± 0.016	2.742ArgAsp: 2.742 ± 0.023	4.006ArgGlu: 4.006 ± 0.025	1.854ArgPhe: 1.854 ± 0.015	3.919ArgGly: 3.919 ± 0.031	1.507ArgHis: 1.507 ± 0.015	2.368ArgIle: 2.368 ± 0.018	3.749ArgLys: 3.749 ± 0.025	5.428ArgLeu: 5.428 ± 0.027	1.151ArgMet: 1.151 ± 0.013	2.086ArgAsn: 2.086 ± 0.016	3.232ArgPro: 3.232 ± 0.028	2.589ArgGln: 2.589 ± 0.019	4.19ArgArg: 4.19 ± 0.031	4.115ArgSer: 4.115 ± 0.031	2.807ArgThr: 2.807 ± 0.016	3.263ArgVal: 3.263 ± 0.022	0.739ArgTrp: 0.739 ± 0.009	1.419ArgTyr: 1.419 ± 0.014	0.016ArgXaa: 0.016 ± 0.001
Ser	5.278SerAla: 5.278 ± 0.034	1.881SerCys: 1.881 ± 0.016	3.735SerAsp: 3.735 ± 0.028	5.128SerGlu: 5.128 ± 0.034	3.084SerPhe: 3.084 ± 0.019	5.72SerGly: 5.72 ± 0.04	2.076SerHis: 2.076 ± 0.017	3.197SerIle: 3.197 ± 0.022	4.089SerLys: 4.089 ± 0.033	8.382SerLeu: 8.382 ± 0.038	1.49SerMet: 1.49 ± 0.016	2.562SerAsn: 2.562 ± 0.02	5.884SerPro: 5.884 ± 0.04	3.783SerGln: 3.783 ± 0.03	4.547SerArg: 4.547 ± 0.033	8.78SerSer: 8.78 ± 0.06	4.468SerThr: 4.468 ± 0.05	4.97SerVal: 4.97 ± 0.024	1.137SerTrp: 1.137 ± 0.013	1.996SerTyr: 1.996 ± 0.015	0.019SerXaa: 0.019 ± 0.001
Thr	3.821ThrAla: 3.821 ± 0.029	1.303ThrCys: 1.303 ± 0.017	2.483ThrAsp: 2.483 ± 0.02	3.538ThrGlu: 3.538 ± 0.026	2.126ThrPhe: 2.126 ± 0.017	3.568ThrGly: 3.568 ± 0.028	1.281ThrHis: 1.281 ± 0.012	2.378ThrIle: 2.378 ± 0.025	2.694ThrLys: 2.694 ± 0.021	5.394ThrLeu: 5.394 ± 0.027	1.109ThrMet: 1.109 ± 0.012	1.751ThrAsn: 1.751 ± 0.016	3.564ThrPro: 3.564 ± 0.037	2.262ThrGln: 2.262 ± 0.02	2.574ThrArg: 2.574 ± 0.019	4.769ThrSer: 4.769 ± 0.051	3.389ThrThr: 3.389 ± 0.127	3.893ThrVal: 3.893 ± 0.026	0.727ThrTrp: 0.727 ± 0.011	1.389ThrTyr: 1.389 ± 0.014	0.013ThrXaa: 0.013 ± 0.001
Val	4.303ValAla: 4.303 ± 0.028	1.492ValCys: 1.492 ± 0.016	2.922ValAsp: 2.922 ± 0.026	3.842ValGlu: 3.842 ± 0.027	2.459ValPhe: 2.459 ± 0.019	3.558ValGly: 3.558 ± 0.023	1.551ValHis: 1.551 ± 0.015	2.902ValIle: 2.902 ± 0.019	3.417ValLys: 3.417 ± 0.027	6.453ValLeu: 6.453 ± 0.034	1.306ValMet: 1.306 ± 0.013	2.232ValAsn: 2.232 ± 0.016	3.739ValPro: 3.739 ± 0.025	2.789ValGln: 2.789 ± 0.016	3.077ValArg: 3.077 ± 0.018	5.031ValSer: 5.031 ± 0.03	3.887ValThr: 3.887 ± 0.028	4.015ValVal: 4.015 ± 0.028	0.753ValTrp: 0.753 ± 0.01	1.624ValTyr: 1.624 ± 0.016	0.011ValXaa: 0.011 ± 0.001
Trp	0.881TrpAla: 0.881 ± 0.012	0.259TrpCys: 0.259 ± 0.006	0.684TrpAsp: 0.684 ± 0.01	0.845TrpGlu: 0.845 ± 0.01	0.464TrpPhe: 0.464 ± 0.007	0.876TrpGly: 0.876 ± 0.012	0.329TrpHis: 0.329 ± 0.007	0.545TrpIle: 0.545 ± 0.009	0.843TrpLys: 0.843 ± 0.011	1.242TrpLeu: 1.242 ± 0.013	0.301TrpMet: 0.301 ± 0.007	0.536TrpAsn: 0.536 ± 0.008	0.613TrpPro: 0.613 ± 0.01	0.551TrpGln: 0.551 ± 0.007	0.788TrpArg: 0.788 ± 0.01	0.905TrpSer: 0.905 ± 0.013	0.703TrpThr: 0.703 ± 0.01	0.776TrpVal: 0.776 ± 0.01	0.197TrpTrp: 0.197 ± 0.006	0.333TrpTyr: 0.333 ± 0.007	0.002TrpXaa: 0.002 ± 0.001
Tyr	1.355TyrAla: 1.355 ± 0.012	0.663TyrCys: 0.663 ± 0.011	1.232TyrAsp: 1.232 ± 0.015	1.554TyrGlu: 1.554 ± 0.016	1.261TyrPhe: 1.261 ± 0.015	1.579TyrGly: 1.579 ± 0.021	0.766TyrHis: 0.766 ± 0.01	1.33TyrIle: 1.33 ± 0.014	1.424TyrLys: 1.424 ± 0.018	2.684TyrLeu: 2.684 ± 0.022	0.568TyrMet: 0.568 ± 0.009	1.065TyrAsn: 1.065 ± 0.013	1.284TyrPro: 1.284 ± 0.013	1.222TyrGln: 1.222 ± 0.012	1.53TyrArg: 1.53 ± 0.017	2.119TyrSer: 2.119 ± 0.02	1.441TyrThr: 1.441 ± 0.015	1.554TyrVal: 1.554 ± 0.015	0.352TyrTrp: 0.352 ± 0.009	0.935TyrTyr: 0.935 ± 0.013	0.004TyrXaa: 0.004 ± 0.001
Xaa	0.019XaaAla: 0.019 ± 0.002	0.006XaaCys: 0.006 ± 0.001	0.009XaaAsp: 0.009 ± 0.001	0.015XaaGlu: 0.015 ± 0.001	0.006XaaPhe: 0.006 ± 0.001	0.021XaaGly: 0.021 ± 0.002	0.006XaaHis: 0.006 ± 0.001	0.006XaaIle: 0.006 ± 0.001	0.007XaaLys: 0.007 ± 0.001	0.018XaaLeu: 0.018 ± 0.001	0.005XaaMet: 0.005 ± 0.001	0.004XaaAsn: 0.004 ± 0.001	0.02XaaPro: 0.02 ± 0.002	0.01XaaGln: 0.01 ± 0.001	0.012XaaArg: 0.012 ± 0.001	0.019XaaSer: 0.019 ± 0.002	0.01XaaThr: 0.01 ± 0.001	0.01XaaVal: 0.01 ± 0.001	0.003XaaTrp: 0.003 ± 0.001	0.002XaaTyr: 0.002 ± 0.001	2.909XaaXaa: 2.909 ± 0.121

Statistics based on 19643 proteins (8174059 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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