Amino acid dipepetide frequency for Bacteroides coprophilus CAG:333

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.17AlaAla: 6.17 ± 0.104	1.292AlaCys: 1.292 ± 0.04	4.549AlaAsp: 4.549 ± 0.073	5.04AlaGlu: 5.04 ± 0.077	3.303AlaPhe: 3.303 ± 0.063	5.869AlaGly: 5.869 ± 0.098	1.298AlaHis: 1.298 ± 0.04	4.363AlaIle: 4.363 ± 0.083	3.578AlaLys: 3.578 ± 0.086	7.229AlaLeu: 7.229 ± 0.114	1.978AlaMet: 1.978 ± 0.053	2.796AlaAsn: 2.796 ± 0.055	2.516AlaPro: 2.516 ± 0.065	2.832AlaGln: 2.832 ± 0.062	3.664AlaArg: 3.664 ± 0.065	4.653AlaSer: 4.653 ± 0.069	3.646AlaThr: 3.646 ± 0.069	5.25AlaVal: 5.25 ± 0.085	0.899AlaTrp: 0.899 ± 0.034	3.115AlaTyr: 3.115 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.815CysAla: 0.815 ± 0.033	0.24CysCys: 0.24 ± 0.019	0.647CysAsp: 0.647 ± 0.029	0.696CysGlu: 0.696 ± 0.031	0.669CysPhe: 0.669 ± 0.027	1.175CysGly: 1.175 ± 0.047	0.338CysHis: 0.338 ± 0.019	0.991CysIle: 0.991 ± 0.036	0.623CysLys: 0.623 ± 0.022	1.354CysLeu: 1.354 ± 0.041	0.405CysMet: 0.405 ± 0.022	0.569CysAsn: 0.569 ± 0.029	0.626CysPro: 0.626 ± 0.028	0.452CysGln: 0.452 ± 0.023	0.769CysArg: 0.769 ± 0.033	0.834CysSer: 0.834 ± 0.034	0.711CysThr: 0.711 ± 0.029	0.783CysVal: 0.783 ± 0.032	0.178CysTrp: 0.178 ± 0.015	0.558CysTyr: 0.558 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	3.884AspAla: 3.884 ± 0.064	0.682AspCys: 0.682 ± 0.033	2.338AspAsp: 2.338 ± 0.06	3.813AspGlu: 3.813 ± 0.074	2.951AspPhe: 2.951 ± 0.063	4.08AspGly: 4.08 ± 0.083	0.919AspHis: 0.919 ± 0.034	3.748AspIle: 3.748 ± 0.065	3.381AspLys: 3.381 ± 0.074	4.908AspLeu: 4.908 ± 0.071	1.55AspMet: 1.55 ± 0.042	2.319AspAsn: 2.319 ± 0.045	2.035AspPro: 2.035 ± 0.048	1.485AspGln: 1.485 ± 0.04	2.717AspArg: 2.717 ± 0.059	3.038AspSer: 3.038 ± 0.069	2.789AspThr: 2.789 ± 0.056	3.341AspVal: 3.341 ± 0.064	0.878AspTrp: 0.878 ± 0.034	2.742AspTyr: 2.742 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.368GluAla: 5.368 ± 0.099	0.647GluCys: 0.647 ± 0.028	3.314GluAsp: 3.314 ± 0.064	5.452GluGlu: 5.452 ± 0.101	2.365GluPhe: 2.365 ± 0.055	4.569GluGly: 4.569 ± 0.088	1.328GluHis: 1.328 ± 0.039	4.495GluIle: 4.495 ± 0.081	5.115GluLys: 5.115 ± 0.094	6.226GluLeu: 6.226 ± 0.107	2.061GluMet: 2.061 ± 0.052	3.325GluAsn: 3.325 ± 0.069	1.83GluPro: 1.83 ± 0.052	2.741GluGln: 2.741 ± 0.068	3.458GluArg: 3.458 ± 0.069	3.048GluSer: 3.048 ± 0.063	3.629GluThr: 3.629 ± 0.067	4.543GluVal: 4.543 ± 0.083	0.859GluTrp: 0.859 ± 0.034	2.589GluTyr: 2.589 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.021PheAla: 3.021 ± 0.062	0.705PheCys: 0.705 ± 0.028	2.75PheAsp: 2.75 ± 0.056	2.324PheGlu: 2.324 ± 0.056	2.175PhePhe: 2.175 ± 0.067	3.247PheGly: 3.247 ± 0.08	1.016PheHis: 1.016 ± 0.037	3.042PheIle: 3.042 ± 0.072	2.034PheLys: 2.034 ± 0.055	4.204PheLeu: 4.204 ± 0.085	1.256PheMet: 1.256 ± 0.041	2.05PheAsn: 2.05 ± 0.061	1.85PhePro: 1.85 ± 0.048	1.535PheGln: 1.535 ± 0.043	2.509PheArg: 2.509 ± 0.064	3.289PheSer: 3.289 ± 0.073	2.739PheThr: 2.739 ± 0.059	2.911PheVal: 2.911 ± 0.055	0.563PheTrp: 0.563 ± 0.029	1.892PheTyr: 1.892 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.571GlyAla: 4.571 ± 0.085	1.073GlyCys: 1.073 ± 0.035	3.478GlyAsp: 3.478 ± 0.068	4.396GlyGlu: 4.396 ± 0.073	3.259GlyPhe: 3.259 ± 0.075	4.861GlyGly: 4.861 ± 0.097	1.412GlyHis: 1.412 ± 0.048	5.367GlyIle: 5.367 ± 0.092	5.299GlyLys: 5.299 ± 0.09	6.273GlyLeu: 6.273 ± 0.103	2.471GlyMet: 2.471 ± 0.058	3.584GlyAsn: 3.584 ± 0.076	1.575GlyPro: 1.575 ± 0.048	2.328GlyGln: 2.328 ± 0.054	3.17GlyArg: 3.17 ± 0.064	3.941GlySer: 3.941 ± 0.073	4.086GlyThr: 4.086 ± 0.08	4.833GlyVal: 4.833 ± 0.09	1.083GlyTrp: 1.083 ± 0.04	3.372GlyTyr: 3.372 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	1.406HisAla: 1.406 ± 0.047	0.334HisCys: 0.334 ± 0.017	0.978HisAsp: 0.978 ± 0.033	1.158HisGlu: 1.158 ± 0.037	1.123HisPhe: 1.123 ± 0.035	1.29HisGly: 1.29 ± 0.047	0.573HisHis: 0.573 ± 0.028	1.428HisIle: 1.428 ± 0.043	0.946HisLys: 0.946 ± 0.037	2.014HisLeu: 2.014 ± 0.054	0.344HisMet: 0.344 ± 0.021	0.884HisAsn: 0.884 ± 0.03	1.275HisPro: 1.275 ± 0.042	0.724HisGln: 0.724 ± 0.028	0.988HisArg: 0.988 ± 0.039	1.093HisSer: 1.093 ± 0.037	1.205HisThr: 1.205 ± 0.037	1.211HisVal: 1.211 ± 0.037	0.273HisTrp: 0.273 ± 0.017	0.914HisTyr: 0.914 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	5.041IleAla: 5.041 ± 0.093	1.016IleCys: 1.016 ± 0.034	3.742IleAsp: 3.742 ± 0.076	3.954IleGlu: 3.954 ± 0.083	2.706IlePhe: 2.706 ± 0.058	4.473IleGly: 4.473 ± 0.077	1.47IleHis: 1.47 ± 0.038	3.943IleIle: 3.943 ± 0.084	3.232IleLys: 3.232 ± 0.069	5.993IleLeu: 5.993 ± 0.104	1.452IleMet: 1.452 ± 0.044	3.017IleAsn: 3.017 ± 0.067	3.24IlePro: 3.24 ± 0.064	2.331IleGln: 2.331 ± 0.056	3.874IleArg: 3.874 ± 0.066	4.203IleSer: 4.203 ± 0.074	3.644IleThr: 3.644 ± 0.07	4.195IleVal: 4.195 ± 0.08	0.669IleTrp: 0.669 ± 0.032	2.566IleTyr: 2.566 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	4.745LysAla: 4.745 ± 0.078	0.52LysCys: 0.52 ± 0.027	3.692LysAsp: 3.692 ± 0.066	5.363LysGlu: 5.363 ± 0.086	1.862LysPhe: 1.862 ± 0.046	4.392LysGly: 4.392 ± 0.075	1.158LysHis: 1.158 ± 0.032	3.441LysIle: 3.441 ± 0.072	4.306LysLys: 4.306 ± 0.07	4.97LysLeu: 4.97 ± 0.083	1.859LysMet: 1.859 ± 0.053	2.997LysAsn: 2.997 ± 0.064	2.037LysPro: 2.037 ± 0.047	2.465LysGln: 2.465 ± 0.068	3.005LysArg: 3.005 ± 0.057	2.791LysSer: 2.791 ± 0.059	3.107LysThr: 3.107 ± 0.062	4.071LysVal: 4.071 ± 0.074	0.675LysTrp: 0.675 ± 0.029	2.601LysTyr: 2.601 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	7.206LeuAla: 7.206 ± 0.115	1.446LeuCys: 1.446 ± 0.044	4.736LeuAsp: 4.736 ± 0.073	5.572LeuGlu: 5.572 ± 0.095	4.568LeuPhe: 4.568 ± 0.087	6.083LeuGly: 6.083 ± 0.105	1.936LeuHis: 1.936 ± 0.043	5.695LeuIle: 5.695 ± 0.083	6.309LeuLys: 6.309 ± 0.096	9.562LeuLeu: 9.562 ± 0.165	2.788LeuMet: 2.788 ± 0.053	4.526LeuAsn: 4.526 ± 0.074	4.451LeuPro: 4.451 ± 0.079	3.836LeuGln: 3.836 ± 0.075	4.482LeuArg: 4.482 ± 0.079	6.548LeuSer: 6.548 ± 0.1	5.679LeuThr: 5.679 ± 0.088	5.507LeuVal: 5.507 ± 0.095	1.028LeuTrp: 1.028 ± 0.038	3.608LeuTyr: 3.608 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.234MetAla: 2.234 ± 0.058	0.254MetCys: 0.254 ± 0.019	1.552MetAsp: 1.552 ± 0.047	1.94MetGlu: 1.94 ± 0.048	1.043MetPhe: 1.043 ± 0.042	1.999MetGly: 1.999 ± 0.049	0.493MetHis: 0.493 ± 0.026	1.623MetIle: 1.623 ± 0.047	2.581MetLys: 2.581 ± 0.047	2.651MetLeu: 2.651 ± 0.065	0.8MetMet: 0.8 ± 0.038	1.639MetAsn: 1.639 ± 0.045	1.23MetPro: 1.23 ± 0.036	1.159MetGln: 1.159 ± 0.036	1.337MetArg: 1.337 ± 0.038	1.457MetSer: 1.457 ± 0.043	1.505MetThr: 1.505 ± 0.04	1.603MetVal: 1.603 ± 0.043	0.233MetTrp: 0.233 ± 0.017	0.869MetTyr: 0.869 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.128AsnAla: 3.128 ± 0.072	0.471AsnCys: 0.471 ± 0.024	2.287AsnAsp: 2.287 ± 0.056	2.881AsnGlu: 2.881 ± 0.055	2.071AsnPhe: 2.071 ± 0.058	3.605AsnGly: 3.605 ± 0.077	0.999AsnHis: 0.999 ± 0.032	3.286AsnIle: 3.286 ± 0.071	2.435AsnLys: 2.435 ± 0.066	4.246AsnLeu: 4.246 ± 0.081	1.257AsnMet: 1.257 ± 0.037	2.208AsnAsn: 2.208 ± 0.059	2.385AsnPro: 2.385 ± 0.046	1.636AsnGln: 1.636 ± 0.047	2.589AsnArg: 2.589 ± 0.062	2.457AsnSer: 2.457 ± 0.06	2.392AsnThr: 2.392 ± 0.064	2.955AsnVal: 2.955 ± 0.069	0.666AsnTrp: 0.666 ± 0.029	2.182AsnTyr: 2.182 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	3.194ProAla: 3.194 ± 0.068	0.436ProCys: 0.436 ± 0.024	2.756ProAsp: 2.756 ± 0.055	3.95ProGlu: 3.95 ± 0.067	1.979ProPhe: 1.979 ± 0.041	2.679ProGly: 2.679 ± 0.049	0.807ProHis: 0.807 ± 0.033	1.994ProIle: 1.994 ± 0.054	1.796ProLys: 1.796 ± 0.047	3.617ProLeu: 3.617 ± 0.075	0.976ProMet: 0.976 ± 0.032	1.559ProAsn: 1.559 ± 0.042	0.807ProPro: 0.807 ± 0.038	1.576ProGln: 1.576 ± 0.043	1.477ProArg: 1.477 ± 0.049	2.372ProSer: 2.372 ± 0.054	1.818ProThr: 1.818 ± 0.047	3.434ProVal: 3.434 ± 0.069	0.478ProTrp: 0.478 ± 0.025	1.825ProTyr: 1.825 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.088GlnAla: 3.088 ± 0.063	0.341GlnCys: 0.341 ± 0.024	1.602GlnAsp: 1.602 ± 0.049	2.722GlnGlu: 2.722 ± 0.061	1.369GlnPhe: 1.369 ± 0.044	2.352GlnGly: 2.352 ± 0.056	0.692GlnHis: 0.692 ± 0.027	2.391GlnIle: 2.391 ± 0.058	2.435GlnLys: 2.435 ± 0.063	3.771GlnLeu: 3.771 ± 0.07	1.157GlnMet: 1.157 ± 0.032	1.634GlnAsn: 1.634 ± 0.048	1.381GlnPro: 1.381 ± 0.042	1.768GlnGln: 1.768 ± 0.054	1.707GlnArg: 1.707 ± 0.049	1.959GlnSer: 1.959 ± 0.052	2.237GlnThr: 2.237 ± 0.047	2.497GlnVal: 2.497 ± 0.055	0.507GlnTrp: 0.507 ± 0.023	1.491GlnTyr: 1.491 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.975ArgAla: 2.975 ± 0.066	0.534ArgCys: 0.534 ± 0.025	2.158ArgAsp: 2.158 ± 0.048	3.462ArgGlu: 3.462 ± 0.066	2.523ArgPhe: 2.523 ± 0.057	2.566ArgGly: 2.566 ± 0.053	1.088ArgHis: 1.088 ± 0.032	3.987ArgIle: 3.987 ± 0.082	3.739ArgLys: 3.739 ± 0.075	5.058ArgLeu: 5.058 ± 0.098	1.797ArgMet: 1.797 ± 0.051	2.552ArgAsn: 2.552 ± 0.066	1.955ArgPro: 1.955 ± 0.05	2.28ArgGln: 2.28 ± 0.053	2.676ArgArg: 2.676 ± 0.069	2.599ArgSer: 2.599 ± 0.062	2.575ArgThr: 2.575 ± 0.061	2.835ArgVal: 2.835 ± 0.061	0.719ArgTrp: 0.719 ± 0.033	2.227ArgTyr: 2.227 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	4.203SerAla: 4.203 ± 0.083	0.905SerCys: 0.905 ± 0.032	3.038SerAsp: 3.038 ± 0.067	3.439SerGlu: 3.439 ± 0.066	3.187SerPhe: 3.187 ± 0.069	4.617SerGly: 4.617 ± 0.084	1.221SerHis: 1.221 ± 0.035	3.693SerIle: 3.693 ± 0.074	2.755SerLys: 2.755 ± 0.052	6.371SerLeu: 6.371 ± 0.12	1.561SerMet: 1.561 ± 0.048	2.282SerAsn: 2.282 ± 0.057	2.377SerPro: 2.377 ± 0.052	2.008SerGln: 2.008 ± 0.048	3.011SerArg: 3.011 ± 0.062	3.764SerSer: 3.764 ± 0.082	2.731SerThr: 2.731 ± 0.06	4.326SerVal: 4.326 ± 0.074	0.868SerTrp: 0.868 ± 0.034	2.58SerTyr: 2.58 ± 0.073	0.0SerXaa: 0.0 ± 0.0
Thr	4.175ThrAla: 4.175 ± 0.066	0.675ThrCys: 0.675 ± 0.029	3.393ThrAsp: 3.393 ± 0.064	3.438ThrGlu: 3.438 ± 0.065	2.549ThrPhe: 2.549 ± 0.066	4.508ThrGly: 4.508 ± 0.07	1.054ThrHis: 1.054 ± 0.037	3.486ThrIle: 3.486 ± 0.068	2.15ThrLys: 2.15 ± 0.056	5.84ThrLeu: 5.84 ± 0.089	1.095ThrMet: 1.095 ± 0.038	2.078ThrAsn: 2.078 ± 0.059	2.854ThrPro: 2.854 ± 0.064	1.745ThrGln: 1.745 ± 0.049	2.467ThrArg: 2.467 ± 0.053	3.221ThrSer: 3.221 ± 0.06	2.738ThrThr: 2.738 ± 0.059	3.888ThrVal: 3.888 ± 0.073	0.679ThrTrp: 0.679 ± 0.034	2.304ThrTyr: 2.304 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	4.858ValAla: 4.858 ± 0.091	1.134ValCys: 1.134 ± 0.04	3.532ValAsp: 3.532 ± 0.066	4.111ValGlu: 4.111 ± 0.073	2.88ValPhe: 2.88 ± 0.051	4.126ValGly: 4.126 ± 0.08	1.172ValHis: 1.172 ± 0.044	4.371ValIle: 4.371 ± 0.076	4.07ValLys: 4.07 ± 0.078	5.953ValLeu: 5.953 ± 0.107	1.842ValMet: 1.842 ± 0.051	3.181ValAsn: 3.181 ± 0.075	2.794ValPro: 2.794 ± 0.058	1.993ValGln: 1.993 ± 0.043	3.458ValArg: 3.458 ± 0.065	4.519ValSer: 4.519 ± 0.078	3.884ValThr: 3.884 ± 0.075	4.379ValVal: 4.379 ± 0.089	0.771ValTrp: 0.771 ± 0.03	2.797ValTyr: 2.797 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.787TrpAla: 0.787 ± 0.032	0.182TrpCys: 0.182 ± 0.017	0.698TrpAsp: 0.698 ± 0.032	0.799TrpGlu: 0.799 ± 0.032	0.561TrpPhe: 0.561 ± 0.029	0.992TrpGly: 0.992 ± 0.036	0.289TrpHis: 0.289 ± 0.018	0.784TrpIle: 0.784 ± 0.034	1.027TrpLys: 1.027 ± 0.042	1.292TrpLeu: 1.292 ± 0.049	0.471TrpMet: 0.471 ± 0.023	0.814TrpAsn: 0.814 ± 0.033	0.297TrpPro: 0.297 ± 0.02	0.533TrpGln: 0.533 ± 0.025	0.545TrpArg: 0.545 ± 0.026	0.705TrpSer: 0.705 ± 0.031	0.633TrpThr: 0.633 ± 0.031	0.715TrpVal: 0.715 ± 0.031	0.175TrpTrp: 0.175 ± 0.015	0.481TrpTyr: 0.481 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.173TyrAla: 3.173 ± 0.065	0.547TyrCys: 0.547 ± 0.027	2.358TyrAsp: 2.358 ± 0.059	2.454TyrGlu: 2.454 ± 0.054	1.968TyrPhe: 1.968 ± 0.055	2.946TyrGly: 2.946 ± 0.057	0.898TyrHis: 0.898 ± 0.033	2.631TyrIle: 2.631 ± 0.058	2.247TyrLys: 2.247 ± 0.054	4.034TyrLeu: 4.034 ± 0.077	1.081TyrMet: 1.081 ± 0.032	2.124TyrAsn: 2.124 ± 0.067	2.017TyrPro: 2.017 ± 0.048	1.674TyrGln: 1.674 ± 0.043	2.404TyrArg: 2.404 ± 0.05	2.447TyrSer: 2.447 ± 0.067	2.586TyrThr: 2.586 ± 0.063	2.548TyrVal: 2.548 ± 0.054	0.578TyrTrp: 0.578 ± 0.027	2.009TyrTyr: 2.009 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2352 proteins (846506 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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