Amino acid dipepetide frequency for Physostegia chlorotic mottle virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.519AlaAla: 3.519 ± 2.478
0.503AlaCys: 0.503 ± 0.292
3.771AlaAsp: 3.771 ± 0.65
3.268AlaGlu: 3.268 ± 1.232
2.262AlaPhe: 2.262 ± 0.42
1.508AlaGly: 1.508 ± 1.072
1.257AlaHis: 1.257 ± 0.578
3.017AlaIle: 3.017 ± 0.717
4.022AlaLys: 4.022 ± 1.842
4.525AlaLeu: 4.525 ± 1.522
0.754AlaMet: 0.754 ± 0.331
2.262AlaAsn: 2.262 ± 1.11
3.017AlaPro: 3.017 ± 1.645
1.257AlaGln: 1.257 ± 0.516
1.257AlaArg: 1.257 ± 0.458
5.782AlaSer: 5.782 ± 0.813
1.508AlaThr: 1.508 ± 0.505
4.274AlaVal: 4.274 ± 1.319
0.251AlaTrp: 0.251 ± 0.271
1.76AlaTyr: 1.76 ± 0.847
0.0AlaXaa: 0.0 ± 0.0
Cys
0.754CysAla: 0.754 ± 0.287
0.251CysCys: 0.251 ± 0.147
1.006CysAsp: 1.006 ± 0.389
0.0CysGlu: 0.0 ± 0.0
0.754CysPhe: 0.754 ± 0.442
0.251CysGly: 0.251 ± 0.271
0.503CysHis: 0.503 ± 0.295
1.508CysIle: 1.508 ± 0.503
0.503CysLys: 0.503 ± 0.237
2.011CysLeu: 2.011 ± 0.746
1.257CysMet: 1.257 ± 0.315
1.257CysAsn: 1.257 ± 0.812
1.508CysPro: 1.508 ± 0.689
0.0CysGln: 0.0 ± 0.0
1.508CysArg: 1.508 ± 0.739
1.508CysSer: 1.508 ± 0.649
0.251CysThr: 0.251 ± 0.147
1.006CysVal: 1.006 ± 0.389
0.0CysTrp: 0.0 ± 0.0
0.251CysTyr: 0.251 ± 0.147
0.0CysXaa: 0.0 ± 0.0
Asp
3.519AspAla: 3.519 ± 0.601
1.006AspCys: 1.006 ± 0.473
3.017AspAsp: 3.017 ± 1.17
3.017AspGlu: 3.017 ± 1.555
1.508AspPhe: 1.508 ± 0.328
2.765AspGly: 2.765 ± 0.67
1.257AspHis: 1.257 ± 0.624
5.782AspIle: 5.782 ± 0.949
4.525AspLys: 4.525 ± 1.208
5.53AspLeu: 5.53 ± 1.063
3.519AspMet: 3.519 ± 1.259
2.514AspAsn: 2.514 ± 0.896
3.519AspPro: 3.519 ± 0.627
2.011AspGln: 2.011 ± 0.36
3.017AspArg: 3.017 ± 0.743
4.274AspSer: 4.274 ± 0.803
4.525AspThr: 4.525 ± 2.699
3.268AspVal: 3.268 ± 1.175
1.006AspTrp: 1.006 ± 0.389
1.76AspTyr: 1.76 ± 0.527
0.0AspXaa: 0.0 ± 0.0
Glu
1.508GluAla: 1.508 ± 0.414
0.754GluCys: 0.754 ± 0.396
5.279GluAsp: 5.279 ± 1.115
2.765GluGlu: 2.765 ± 0.669
1.76GluPhe: 1.76 ± 0.757
4.776GluGly: 4.776 ± 1.498
1.257GluHis: 1.257 ± 0.538
4.776GluIle: 4.776 ± 1.316
4.525GluLys: 4.525 ± 2.154
3.268GluLeu: 3.268 ± 1.054
2.011GluMet: 2.011 ± 0.804
2.514GluAsn: 2.514 ± 0.648
1.257GluPro: 1.257 ± 0.436
0.503GluGln: 0.503 ± 0.487
3.268GluArg: 3.268 ± 1.048
5.279GluSer: 5.279 ± 1.34
4.022GluThr: 4.022 ± 0.629
2.262GluVal: 2.262 ± 0.785
1.508GluTrp: 1.508 ± 0.335
1.257GluTyr: 1.257 ± 0.315
0.0GluXaa: 0.0 ± 0.0
Phe
1.76PheAla: 1.76 ± 0.865
0.754PheCys: 0.754 ± 0.435
1.257PheAsp: 1.257 ± 0.582
2.011PheGlu: 2.011 ± 0.639
0.754PhePhe: 0.754 ± 0.287
1.508PheGly: 1.508 ± 0.667
0.251PheHis: 0.251 ± 0.322
3.017PheIle: 3.017 ± 0.451
0.754PheLys: 0.754 ± 0.442
3.017PheLeu: 3.017 ± 0.657
2.514PheMet: 2.514 ± 0.24
2.011PheAsn: 2.011 ± 0.507
1.76PhePro: 1.76 ± 0.788
1.508PheGln: 1.508 ± 0.582
1.76PheArg: 1.76 ± 0.35
3.771PheSer: 3.771 ± 1.12
1.508PheThr: 1.508 ± 0.751
1.508PheVal: 1.508 ± 0.421
0.754PheTrp: 0.754 ± 0.487
2.011PheTyr: 2.011 ± 0.703
0.0PheXaa: 0.0 ± 0.0
Gly
0.251GlyAla: 0.251 ± 0.271
0.251GlyCys: 0.251 ± 0.147
3.519GlyAsp: 3.519 ± 1.006
4.022GlyGlu: 4.022 ± 1.336
2.011GlyPhe: 2.011 ± 0.623
3.519GlyGly: 3.519 ± 1.244
1.508GlyHis: 1.508 ± 0.498
4.274GlyIle: 4.274 ± 1.285
3.268GlyLys: 3.268 ± 0.459
5.279GlyLeu: 5.279 ± 1.274
2.262GlyMet: 2.262 ± 1.057
2.514GlyAsn: 2.514 ± 1.025
2.262GlyPro: 2.262 ± 0.649
1.508GlyGln: 1.508 ± 0.511
2.514GlyArg: 2.514 ± 0.802
4.274GlySer: 4.274 ± 0.791
2.765GlyThr: 2.765 ± 0.757
5.279GlyVal: 5.279 ± 1.187
1.006GlyTrp: 1.006 ± 0.59
2.765GlyTyr: 2.765 ± 0.51
0.0GlyXaa: 0.0 ± 0.0
His
1.76HisAla: 1.76 ± 0.657
0.251HisCys: 0.251 ± 0.271
1.508HisAsp: 1.508 ± 0.685
1.508HisGlu: 1.508 ± 0.884
1.257HisPhe: 1.257 ± 0.737
1.76HisGly: 1.76 ± 0.6
0.754HisHis: 0.754 ± 0.442
2.011HisIle: 2.011 ± 0.669
0.503HisLys: 0.503 ± 0.433
2.262HisLeu: 2.262 ± 0.926
0.754HisMet: 0.754 ± 0.331
0.754HisAsn: 0.754 ± 0.344
1.257HisPro: 1.257 ± 0.581
0.503HisGln: 0.503 ± 0.295
0.754HisArg: 0.754 ± 0.473
1.257HisSer: 1.257 ± 0.465
1.257HisThr: 1.257 ± 0.473
2.262HisVal: 2.262 ± 0.574
0.251HisTrp: 0.251 ± 0.322
0.503HisTyr: 0.503 ± 0.95
0.0HisXaa: 0.0 ± 0.0
Ile
3.771IleAla: 3.771 ± 1.484
2.011IleCys: 2.011 ± 0.475
4.022IleAsp: 4.022 ± 1.363
3.771IleGlu: 3.771 ± 0.813
3.017IlePhe: 3.017 ± 0.633
3.771IleGly: 3.771 ± 0.798
1.76IleHis: 1.76 ± 0.853
5.279IleIle: 5.279 ± 1.995
4.525IleLys: 4.525 ± 1.007
6.285IleLeu: 6.285 ± 1.483
3.017IleMet: 3.017 ± 0.427
3.519IleAsn: 3.519 ± 1.154
4.022IlePro: 4.022 ± 1.08
3.771IleGln: 3.771 ± 0.961
2.262IleArg: 2.262 ± 0.725
5.279IleSer: 5.279 ± 1.087
5.53IleThr: 5.53 ± 1.052
4.525IleVal: 4.525 ± 0.927
1.006IleTrp: 1.006 ± 0.371
3.268IleTyr: 3.268 ± 0.749
0.0IleXaa: 0.0 ± 0.0
Lys
3.268LysAla: 3.268 ± 0.709
0.503LysCys: 0.503 ± 0.237
2.011LysAsp: 2.011 ± 1.083
4.525LysGlu: 4.525 ± 0.889
2.011LysPhe: 2.011 ± 0.878
2.011LysGly: 2.011 ± 0.764
1.76LysHis: 1.76 ± 0.658
3.519LysIle: 3.519 ± 1.109
2.262LysLys: 2.262 ± 0.98
4.274LysLeu: 4.274 ± 1.105
2.514LysMet: 2.514 ± 0.831
4.274LysAsn: 4.274 ± 0.929
2.765LysPro: 2.765 ± 1.008
1.508LysGln: 1.508 ± 0.604
3.519LysArg: 3.519 ± 0.803
4.525LysSer: 4.525 ± 1.36
4.022LysThr: 4.022 ± 0.774
3.519LysVal: 3.519 ± 0.726
1.006LysTrp: 1.006 ± 0.473
2.262LysTyr: 2.262 ± 0.882
0.0LysXaa: 0.0 ± 0.0
Leu
3.771LeuAla: 3.771 ± 0.762
2.011LeuCys: 2.011 ± 0.93
4.022LeuAsp: 4.022 ± 0.974
3.519LeuGlu: 3.519 ± 0.528
2.011LeuPhe: 2.011 ± 0.527
5.279LeuGly: 5.279 ± 1.172
2.262LeuHis: 2.262 ± 0.884
4.022LeuIle: 4.022 ± 0.954
6.787LeuLys: 6.787 ± 1.998
7.039LeuLeu: 7.039 ± 0.992
3.771LeuMet: 3.771 ± 0.686
5.028LeuAsn: 5.028 ± 1.169
4.274LeuPro: 4.274 ± 0.506
3.268LeuGln: 3.268 ± 0.943
3.771LeuArg: 3.771 ± 1.316
10.055LeuSer: 10.055 ± 1.498
3.268LeuThr: 3.268 ± 0.583
5.028LeuVal: 5.028 ± 1.437
1.257LeuTrp: 1.257 ± 0.387
4.022LeuTyr: 4.022 ± 1.168
0.0LeuXaa: 0.0 ± 0.0
Met
1.006MetAla: 1.006 ± 0.686
1.006MetCys: 1.006 ± 0.376
3.519MetAsp: 3.519 ± 0.865
1.508MetGlu: 1.508 ± 0.505
0.503MetPhe: 0.503 ± 0.237
2.011MetGly: 2.011 ± 0.742
0.503MetHis: 0.503 ± 0.295
3.268MetIle: 3.268 ± 0.523
2.514MetLys: 2.514 ± 0.517
2.262MetLeu: 2.262 ± 0.837
2.011MetMet: 2.011 ± 0.514
1.508MetAsn: 1.508 ± 0.328
1.257MetPro: 1.257 ± 0.406
1.006MetGln: 1.006 ± 0.703
3.268MetArg: 3.268 ± 1.104
4.776MetSer: 4.776 ± 1.485
2.514MetThr: 2.514 ± 0.506
2.514MetVal: 2.514 ± 1.442
0.0MetTrp: 0.0 ± 0.0
2.765MetTyr: 2.765 ± 0.604
0.0MetXaa: 0.0 ± 0.0
Asn
2.011AsnAla: 2.011 ± 1.477
1.006AsnCys: 1.006 ± 0.452
2.765AsnAsp: 2.765 ± 1.13
2.011AsnGlu: 2.011 ± 0.941
2.514AsnPhe: 2.514 ± 0.68
2.765AsnGly: 2.765 ± 0.874
0.754AsnHis: 0.754 ± 0.473
6.033AsnIle: 6.033 ± 0.943
3.017AsnLys: 3.017 ± 1.024
3.771AsnLeu: 3.771 ± 0.892
1.76AsnMet: 1.76 ± 0.654
1.508AsnAsn: 1.508 ± 0.606
3.268AsnPro: 3.268 ± 1.541
3.017AsnGln: 3.017 ± 1.204
0.754AsnArg: 0.754 ± 0.344
2.262AsnSer: 2.262 ± 0.799
3.771AsnThr: 3.771 ± 0.879
3.519AsnVal: 3.519 ± 1.169
0.251AsnTrp: 0.251 ± 0.271
1.76AsnTyr: 1.76 ± 0.623
0.0AsnXaa: 0.0 ± 0.0
Pro
3.017ProAla: 3.017 ± 1.995
0.754ProCys: 0.754 ± 0.287
3.771ProAsp: 3.771 ± 0.78
3.017ProGlu: 3.017 ± 0.652
0.503ProPhe: 0.503 ± 0.357
2.765ProGly: 2.765 ± 1.254
1.508ProHis: 1.508 ± 0.463
3.519ProIle: 3.519 ± 0.899
1.257ProLys: 1.257 ± 0.436
4.022ProLeu: 4.022 ± 1.325
2.011ProMet: 2.011 ± 0.602
2.262ProAsn: 2.262 ± 0.552
3.771ProPro: 3.771 ± 1.771
1.508ProGln: 1.508 ± 0.897
2.514ProArg: 2.514 ± 0.557
4.525ProSer: 4.525 ± 1.893
3.519ProThr: 3.519 ± 2.029
3.268ProVal: 3.268 ± 1.1
0.251ProTrp: 0.251 ± 0.271
3.017ProTyr: 3.017 ± 1.149
0.0ProXaa: 0.0 ± 0.0
Gln
2.011GlnAla: 2.011 ± 1.237
0.503GlnCys: 0.503 ± 0.237
2.765GlnAsp: 2.765 ± 1.022
1.76GlnGlu: 1.76 ± 0.594
1.257GlnPhe: 1.257 ± 0.453
1.508GlnGly: 1.508 ± 0.744
0.251GlnHis: 0.251 ± 0.322
3.268GlnIle: 3.268 ± 1.045
2.514GlnLys: 2.514 ± 0.521
2.011GlnLeu: 2.011 ± 0.808
0.754GlnMet: 0.754 ± 0.287
2.011GlnAsn: 2.011 ± 0.771
1.257GlnPro: 1.257 ± 0.871
1.006GlnGln: 1.006 ± 0.389
1.257GlnArg: 1.257 ± 0.476
3.771GlnSer: 3.771 ± 0.95
1.76GlnThr: 1.76 ± 0.747
1.508GlnVal: 1.508 ± 0.663
0.251GlnTrp: 0.251 ± 0.271
0.503GlnTyr: 0.503 ± 0.377
0.0GlnXaa: 0.0 ± 0.0
Arg
2.514ArgAla: 2.514 ± 1.151
0.503ArgCys: 0.503 ± 0.295
1.76ArgAsp: 1.76 ± 1.032
2.765ArgGlu: 2.765 ± 0.791
2.514ArgPhe: 2.514 ± 0.813
2.514ArgGly: 2.514 ± 0.685
0.251ArgHis: 0.251 ± 0.271
3.771ArgIle: 3.771 ± 0.674
2.765ArgLys: 2.765 ± 0.734
5.028ArgLeu: 5.028 ± 1.029
1.508ArgMet: 1.508 ± 0.506
2.011ArgAsn: 2.011 ± 0.85
2.011ArgPro: 2.011 ± 0.798
2.514ArgGln: 2.514 ± 0.576
3.268ArgArg: 3.268 ± 1.374
5.028ArgSer: 5.028 ± 0.784
1.508ArgThr: 1.508 ± 0.527
3.519ArgVal: 3.519 ± 1.132
0.0ArgTrp: 0.0 ± 0.0
2.011ArgTyr: 2.011 ± 0.703
0.0ArgXaa: 0.0 ± 0.0
Ser
5.53SerAla: 5.53 ± 2.115
1.76SerCys: 1.76 ± 0.788
6.536SerAsp: 6.536 ± 2.19
4.022SerGlu: 4.022 ± 0.732
4.274SerPhe: 4.274 ± 0.616
6.285SerGly: 6.285 ± 0.506
2.514SerHis: 2.514 ± 0.819
7.793SerIle: 7.793 ± 1.17
4.022SerLys: 4.022 ± 0.552
6.536SerLeu: 6.536 ± 1.22
2.262SerMet: 2.262 ± 0.874
3.771SerAsn: 3.771 ± 0.911
5.782SerPro: 5.782 ± 1.972
3.017SerGln: 3.017 ± 1.059
3.771SerArg: 3.771 ± 1.272
8.044SerSer: 8.044 ± 2.266
6.285SerThr: 6.285 ± 0.424
6.285SerVal: 6.285 ± 1.328
1.006SerTrp: 1.006 ± 0.437
3.771SerTyr: 3.771 ± 1.544
0.0SerXaa: 0.0 ± 0.0
Thr
4.022ThrAla: 4.022 ± 0.929
1.257ThrCys: 1.257 ± 0.527
3.519ThrAsp: 3.519 ± 0.507
2.765ThrGlu: 2.765 ± 0.91
1.76ThrPhe: 1.76 ± 0.752
4.525ThrGly: 4.525 ± 1.695
1.508ThrHis: 1.508 ± 0.716
4.274ThrIle: 4.274 ± 1.263
2.011ThrLys: 2.011 ± 0.527
6.285ThrLeu: 6.285 ± 1.396
2.262ThrMet: 2.262 ± 0.677
2.514ThrAsn: 2.514 ± 1.468
2.262ThrPro: 2.262 ± 1.04
1.006ThrGln: 1.006 ± 0.439
3.771ThrArg: 3.771 ± 1.202
5.782ThrSer: 5.782 ± 0.761
4.022ThrThr: 4.022 ± 1.743
3.771ThrVal: 3.771 ± 0.771
1.257ThrTrp: 1.257 ± 0.398
1.508ThrTyr: 1.508 ± 0.737
0.0ThrXaa: 0.0 ± 0.0
Val
3.017ValAla: 3.017 ± 1.018
0.503ValCys: 0.503 ± 0.295
4.022ValAsp: 4.022 ± 0.667
4.022ValGlu: 4.022 ± 0.762
1.508ValPhe: 1.508 ± 0.431
3.268ValGly: 3.268 ± 1.146
1.006ValHis: 1.006 ± 0.59
2.765ValIle: 2.765 ± 0.841
3.771ValLys: 3.771 ± 1.624
6.536ValLeu: 6.536 ± 1.746
3.017ValMet: 3.017 ± 0.812
3.519ValAsn: 3.519 ± 1.419
2.514ValPro: 2.514 ± 0.575
2.011ValGln: 2.011 ± 0.89
4.022ValArg: 4.022 ± 1.303
8.296ValSer: 8.296 ± 2.135
4.022ValThr: 4.022 ± 0.951
5.53ValVal: 5.53 ± 0.775
0.503ValTrp: 0.503 ± 0.237
3.017ValTyr: 3.017 ± 1.313
0.0ValXaa: 0.0 ± 0.0
Trp
1.508TrpAla: 1.508 ± 0.884
0.0TrpCys: 0.0 ± 0.0
0.251TrpAsp: 0.251 ± 0.322
1.257TrpGlu: 1.257 ± 0.514
0.503TrpPhe: 0.503 ± 0.237
1.006TrpGly: 1.006 ± 0.376
0.503TrpHis: 0.503 ± 0.476
0.0TrpIle: 0.0 ± 0.0
0.503TrpLys: 0.503 ± 0.512
0.503TrpLeu: 0.503 ± 0.237
0.503TrpMet: 0.503 ± 0.377
1.006TrpAsn: 1.006 ± 0.473
0.251TrpPro: 0.251 ± 0.271
0.0TrpGln: 0.0 ± 0.0
0.503TrpArg: 0.503 ± 0.237
0.754TrpSer: 0.754 ± 0.487
1.257TrpThr: 1.257 ± 0.392
1.006TrpVal: 1.006 ± 0.389
0.251TrpTrp: 0.251 ± 0.271
0.503TrpTyr: 0.503 ± 0.365
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.257TyrAla: 1.257 ± 0.798
0.503TyrCys: 0.503 ± 0.542
3.017TyrAsp: 3.017 ± 0.763
3.017TyrGlu: 3.017 ± 1.604
1.508TyrPhe: 1.508 ± 0.505
1.257TyrGly: 1.257 ± 0.421
1.76TyrHis: 1.76 ± 0.817
2.514TyrIle: 2.514 ± 0.673
2.011TyrLys: 2.011 ± 0.401
4.022TyrLeu: 4.022 ± 1.085
1.006TyrMet: 1.006 ± 0.757
1.76TyrAsn: 1.76 ± 0.512
2.765TyrPro: 2.765 ± 1.118
1.006TyrGln: 1.006 ± 0.701
1.006TyrArg: 1.006 ± 0.452
4.022TyrSer: 4.022 ± 1.591
3.017TyrThr: 3.017 ± 0.687
3.017TyrVal: 3.017 ± 0.418
0.251TyrTrp: 0.251 ± 0.271
1.257TyrTyr: 1.257 ± 1.315
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (3979 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski