Amino acid dipepetide frequency for Neisseria shayeganii 871

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.729AlaAla: 18.729 ± 0.293
1.456AlaCys: 1.456 ± 0.054
7.29AlaAsp: 7.29 ± 0.115
8.416AlaGlu: 8.416 ± 0.149
4.115AlaPhe: 4.115 ± 0.085
9.137AlaGly: 9.137 ± 0.136
2.534AlaHis: 2.534 ± 0.065
4.051AlaIle: 4.051 ± 0.077
4.455AlaLys: 4.455 ± 0.089
12.488AlaLeu: 12.488 ± 0.181
2.807AlaMet: 2.807 ± 0.069
2.894AlaAsn: 2.894 ± 0.064
4.541AlaPro: 4.541 ± 0.111
5.375AlaGln: 5.375 ± 0.114
6.399AlaArg: 6.399 ± 0.097
4.405AlaSer: 4.405 ± 0.086
4.133AlaThr: 4.133 ± 0.089
9.437AlaVal: 9.437 ± 0.13
1.693AlaTrp: 1.693 ± 0.061
3.064AlaTyr: 3.064 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
1.197CysAla: 1.197 ± 0.049
0.204CysCys: 0.204 ± 0.019
0.52CysAsp: 0.52 ± 0.026
0.543CysGlu: 0.543 ± 0.035
0.421CysPhe: 0.421 ± 0.026
1.246CysGly: 1.246 ± 0.044
0.34CysHis: 0.34 ± 0.025
0.502CysIle: 0.502 ± 0.03
0.349CysLys: 0.349 ± 0.025
1.227CysLeu: 1.227 ± 0.046
0.184CysMet: 0.184 ± 0.017
0.327CysAsn: 0.327 ± 0.02
0.607CysPro: 0.607 ± 0.032
0.382CysGln: 0.382 ± 0.025
0.976CysArg: 0.976 ± 0.046
0.579CysSer: 0.579 ± 0.032
0.484CysThr: 0.484 ± 0.027
0.672CysVal: 0.672 ± 0.035
0.136CysTrp: 0.136 ± 0.014
0.328CysTyr: 0.328 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
5.514AspAla: 5.514 ± 0.095
0.576AspCys: 0.576 ± 0.033
2.599AspAsp: 2.599 ± 0.066
3.164AspGlu: 3.164 ± 0.08
2.288AspPhe: 2.288 ± 0.063
4.193AspGly: 4.193 ± 0.087
1.0AspHis: 1.0 ± 0.04
3.331AspIle: 3.331 ± 0.076
2.185AspLys: 2.185 ± 0.064
5.024AspLeu: 5.024 ± 0.089
1.344AspMet: 1.344 ± 0.043
1.717AspAsn: 1.717 ± 0.062
2.007AspPro: 2.007 ± 0.057
1.509AspGln: 1.509 ± 0.048
2.474AspArg: 2.474 ± 0.069
2.657AspSer: 2.657 ± 0.064
2.722AspThr: 2.722 ± 0.072
3.389AspVal: 3.389 ± 0.07
0.924AspTrp: 0.924 ± 0.036
1.848AspTyr: 1.848 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
7.072GluAla: 7.072 ± 0.129
0.48GluCys: 0.48 ± 0.031
2.374GluAsp: 2.374 ± 0.07
3.229GluGlu: 3.229 ± 0.09
1.869GluPhe: 1.869 ± 0.062
3.544GluGly: 3.544 ± 0.076
1.648GluHis: 1.648 ± 0.05
3.194GluIle: 3.194 ± 0.066
2.752GluLys: 2.752 ± 0.073
5.498GluLeu: 5.498 ± 0.098
1.567GluMet: 1.567 ± 0.047
2.318GluAsn: 2.318 ± 0.064
2.049GluPro: 2.049 ± 0.062
3.478GluGln: 3.478 ± 0.078
4.052GluArg: 4.052 ± 0.09
2.726GluSer: 2.726 ± 0.071
3.151GluThr: 3.151 ± 0.069
3.727GluVal: 3.727 ± 0.088
0.837GluTrp: 0.837 ± 0.034
1.546GluTyr: 1.546 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
4.511PheAla: 4.511 ± 0.09
0.616PheCys: 0.616 ± 0.026
2.435PheAsp: 2.435 ± 0.07
1.972PheGlu: 1.972 ± 0.061
1.656PhePhe: 1.656 ± 0.057
3.487PheGly: 3.487 ± 0.08
0.844PheHis: 0.844 ± 0.035
1.834PheIle: 1.834 ± 0.056
1.461PheLys: 1.461 ± 0.052
3.5PheLeu: 3.5 ± 0.081
0.841PheMet: 0.841 ± 0.04
1.42PheAsn: 1.42 ± 0.045
1.635PhePro: 1.635 ± 0.055
1.405PheGln: 1.405 ± 0.046
2.107PheArg: 2.107 ± 0.053
2.566PheSer: 2.566 ± 0.059
1.927PheThr: 1.927 ± 0.048
2.515PheVal: 2.515 ± 0.064
0.598PheTrp: 0.598 ± 0.03
1.189PheTyr: 1.189 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
6.243GlyAla: 6.243 ± 0.12
0.952GlyCys: 0.952 ± 0.04
3.455GlyAsp: 3.455 ± 0.092
4.44GlyGlu: 4.44 ± 0.085
3.497GlyPhe: 3.497 ± 0.073
6.455GlyGly: 6.455 ± 0.127
1.869GlyHis: 1.869 ± 0.056
4.494GlyIle: 4.494 ± 0.1
4.132GlyLys: 4.132 ± 0.082
8.332GlyLeu: 8.332 ± 0.141
2.187GlyMet: 2.187 ± 0.062
2.492GlyAsn: 2.492 ± 0.073
1.545GlyPro: 1.545 ± 0.048
3.278GlyGln: 3.278 ± 0.076
5.355GlyArg: 5.355 ± 0.104
4.866GlySer: 4.866 ± 0.108
3.346GlyThr: 3.346 ± 0.071
5.352GlyVal: 5.352 ± 0.089
1.264GlyTrp: 1.264 ± 0.046
2.551GlyTyr: 2.551 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
2.455HisAla: 2.455 ± 0.053
0.31HisCys: 0.31 ± 0.022
1.129HisAsp: 1.129 ± 0.039
1.221HisGlu: 1.221 ± 0.042
1.059HisPhe: 1.059 ± 0.046
2.124HisGly: 2.124 ± 0.049
0.87HisHis: 0.87 ± 0.04
1.642HisIle: 1.642 ± 0.049
0.819HisLys: 0.819 ± 0.04
2.725HisLeu: 2.725 ± 0.071
0.523HisMet: 0.523 ± 0.028
0.879HisAsn: 0.879 ± 0.039
1.783HisPro: 1.783 ± 0.057
1.081HisGln: 1.081 ± 0.046
1.582HisArg: 1.582 ± 0.049
1.41HisSer: 1.41 ± 0.042
1.603HisThr: 1.603 ± 0.056
1.141HisVal: 1.141 ± 0.044
0.39HisTrp: 0.39 ± 0.025
0.904HisTyr: 0.904 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.415IleAla: 5.415 ± 0.098
0.564IleCys: 0.564 ± 0.033
3.107IleAsp: 3.107 ± 0.072
3.305IleGlu: 3.305 ± 0.078
1.591IlePhe: 1.591 ± 0.058
4.469IleGly: 4.469 ± 0.11
1.225IleHis: 1.225 ± 0.041
2.455IleIle: 2.455 ± 0.073
1.887IleLys: 1.887 ± 0.061
4.452IleLeu: 4.452 ± 0.081
1.155IleMet: 1.155 ± 0.043
1.876IleAsn: 1.876 ± 0.055
2.222IlePro: 2.222 ± 0.06
1.701IleGln: 1.701 ± 0.055
3.418IleArg: 3.418 ± 0.078
2.815IleSer: 2.815 ± 0.057
2.558IleThr: 2.558 ± 0.069
3.211IleVal: 3.211 ± 0.077
0.568IleTrp: 0.568 ± 0.027
1.198IleTyr: 1.198 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
4.229LysAla: 4.229 ± 0.091
0.232LysCys: 0.232 ± 0.019
1.894LysAsp: 1.894 ± 0.063
2.21LysGlu: 2.21 ± 0.072
1.108LysPhe: 1.108 ± 0.042
2.693LysGly: 2.693 ± 0.071
1.026LysHis: 1.026 ± 0.036
2.249LysIle: 2.249 ± 0.061
1.932LysLys: 1.932 ± 0.061
4.115LysLeu: 4.115 ± 0.081
1.12LysMet: 1.12 ± 0.049
1.695LysAsn: 1.695 ± 0.057
2.196LysPro: 2.196 ± 0.06
2.261LysGln: 2.261 ± 0.068
2.573LysArg: 2.573 ± 0.066
1.953LysSer: 1.953 ± 0.057
2.486LysThr: 2.486 ± 0.054
2.512LysVal: 2.512 ± 0.073
0.438LysTrp: 0.438 ± 0.023
0.961LysTyr: 0.961 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
13.587LeuAla: 13.587 ± 0.188
1.347LeuCys: 1.347 ± 0.049
5.096LeuAsp: 5.096 ± 0.085
4.994LeuGlu: 4.994 ± 0.103
4.039LeuPhe: 4.039 ± 0.078
7.473LeuGly: 7.473 ± 0.131
2.782LeuHis: 2.782 ± 0.066
4.881LeuIle: 4.881 ± 0.087
4.635LeuLys: 4.635 ± 0.076
12.405LeuLeu: 12.405 ± 0.238
2.641LeuMet: 2.641 ± 0.072
4.064LeuAsn: 4.064 ± 0.069
7.197LeuPro: 7.197 ± 0.122
4.881LeuGln: 4.881 ± 0.096
6.372LeuArg: 6.372 ± 0.105
6.819LeuSer: 6.819 ± 0.105
4.898LeuThr: 4.898 ± 0.109
6.119LeuVal: 6.119 ± 0.109
1.47LeuTrp: 1.47 ± 0.06
2.708LeuTyr: 2.708 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.725MetAla: 2.725 ± 0.072
0.231MetCys: 0.231 ± 0.017
1.026MetAsp: 1.026 ± 0.039
1.083MetGlu: 1.083 ± 0.039
0.742MetPhe: 0.742 ± 0.033
1.831MetGly: 1.831 ± 0.054
0.532MetHis: 0.532 ± 0.027
1.123MetIle: 1.123 ± 0.046
1.246MetLys: 1.246 ± 0.043
2.72MetLeu: 2.72 ± 0.069
0.837MetMet: 0.837 ± 0.036
1.135MetAsn: 1.135 ± 0.04
1.428MetPro: 1.428 ± 0.049
1.429MetGln: 1.429 ± 0.045
1.593MetArg: 1.593 ± 0.058
1.705MetSer: 1.705 ± 0.05
1.263MetThr: 1.263 ± 0.043
1.626MetVal: 1.626 ± 0.052
0.289MetTrp: 0.289 ± 0.023
0.468MetTyr: 0.468 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.202AsnAla: 3.202 ± 0.068
0.324AsnCys: 0.324 ± 0.025
1.462AsnAsp: 1.462 ± 0.053
1.824AsnGlu: 1.824 ± 0.073
1.164AsnPhe: 1.164 ± 0.043
3.124AsnGly: 3.124 ± 0.077
0.897AsnHis: 0.897 ± 0.039
2.092AsnIle: 2.092 ± 0.062
1.311AsnLys: 1.311 ± 0.039
3.173AsnLeu: 3.173 ± 0.077
0.841AsnMet: 0.841 ± 0.03
1.185AsnAsn: 1.185 ± 0.056
2.202AsnPro: 2.202 ± 0.061
1.441AsnGln: 1.441 ± 0.048
2.522AsnArg: 2.522 ± 0.067
1.62AsnSer: 1.62 ± 0.051
1.738AsnThr: 1.738 ± 0.06
1.992AsnVal: 1.992 ± 0.059
0.499AsnTrp: 0.499 ± 0.03
0.868AsnTyr: 0.868 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
6.275ProAla: 6.275 ± 0.138
0.403ProCys: 0.403 ± 0.029
3.052ProAsp: 3.052 ± 0.069
4.091ProGlu: 4.091 ± 0.084
1.981ProPhe: 1.981 ± 0.048
2.63ProGly: 2.63 ± 0.07
1.473ProHis: 1.473 ± 0.048
1.824ProIle: 1.824 ± 0.053
1.851ProLys: 1.851 ± 0.065
5.046ProLeu: 5.046 ± 0.102
1.105ProMet: 1.105 ± 0.041
1.528ProAsn: 1.528 ± 0.045
2.557ProPro: 2.557 ± 0.073
2.569ProGln: 2.569 ± 0.057
2.082ProArg: 2.082 ± 0.055
2.119ProSer: 2.119 ± 0.068
1.896ProThr: 1.896 ± 0.057
3.595ProVal: 3.595 ± 0.08
0.564ProTrp: 0.564 ± 0.031
1.377ProTyr: 1.377 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
6.606GlnAla: 6.606 ± 0.123
0.355GlnCys: 0.355 ± 0.025
1.993GlnAsp: 1.993 ± 0.053
2.305GlnGlu: 2.305 ± 0.064
1.381GlnPhe: 1.381 ± 0.044
3.148GlnGly: 3.148 ± 0.071
1.377GlnHis: 1.377 ± 0.042
2.383GlnIle: 2.383 ± 0.058
1.792GlnLys: 1.792 ± 0.06
4.127GlnLeu: 4.127 ± 0.101
1.185GlnMet: 1.185 ± 0.041
1.887GlnAsn: 1.887 ± 0.058
2.315GlnPro: 2.315 ± 0.07
3.041GlnGln: 3.041 ± 0.098
2.96GlnArg: 2.96 ± 0.067
2.396GlnSer: 2.396 ± 0.058
2.831GlnThr: 2.831 ± 0.064
2.957GlnVal: 2.957 ± 0.071
0.663GlnTrp: 0.663 ± 0.031
1.219GlnTyr: 1.219 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
5.682ArgAla: 5.682 ± 0.1
0.672ArgCys: 0.672 ± 0.034
2.845ArgAsp: 2.845 ± 0.066
3.652ArgGlu: 3.652 ± 0.073
3.017ArgPhe: 3.017 ± 0.077
3.565ArgGly: 3.565 ± 0.073
2.246ArgHis: 2.246 ± 0.066
3.64ArgIle: 3.64 ± 0.071
2.218ArgLys: 2.218 ± 0.056
7.872ArgLeu: 7.872 ± 0.128
1.665ArgMet: 1.665 ± 0.053
2.064ArgAsn: 2.064 ± 0.058
3.062ArgPro: 3.062 ± 0.078
3.83ArgGln: 3.83 ± 0.087
5.132ArgArg: 5.132 ± 0.11
3.392ArgSer: 3.392 ± 0.077
2.647ArgThr: 2.647 ± 0.074
3.556ArgVal: 3.556 ± 0.078
0.943ArgTrp: 0.943 ± 0.042
2.242ArgTyr: 2.242 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
5.982SerAla: 5.982 ± 0.108
0.514SerCys: 0.514 ± 0.025
2.588SerAsp: 2.588 ± 0.063
2.786SerGlu: 2.786 ± 0.062
1.99SerPhe: 1.99 ± 0.056
5.445SerGly: 5.445 ± 0.098
1.27SerHis: 1.27 ± 0.047
2.363SerIle: 2.363 ± 0.058
1.821SerLys: 1.821 ± 0.057
5.903SerLeu: 5.903 ± 0.098
1.219SerMet: 1.219 ± 0.041
1.554SerAsn: 1.554 ± 0.054
2.611SerPro: 2.611 ± 0.062
2.131SerGln: 2.131 ± 0.064
3.724SerArg: 3.724 ± 0.08
2.777SerSer: 2.777 ± 0.074
2.152SerThr: 2.152 ± 0.061
3.773SerVal: 3.773 ± 0.072
0.687SerTrp: 0.687 ± 0.03
1.356SerTyr: 1.356 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
6.033ThrAla: 6.033 ± 0.097
0.411ThrCys: 0.411 ± 0.027
2.531ThrAsp: 2.531 ± 0.06
2.582ThrGlu: 2.582 ± 0.066
1.675ThrPhe: 1.675 ± 0.045
3.746ThrGly: 3.746 ± 0.085
1.149ThrHis: 1.149 ± 0.044
2.097ThrIle: 2.097 ± 0.06
1.191ThrLys: 1.191 ± 0.044
5.742ThrLeu: 5.742 ± 0.09
1.011ThrMet: 1.011 ± 0.042
1.215ThrAsn: 1.215 ± 0.058
3.016ThrPro: 3.016 ± 0.067
1.756ThrGln: 1.756 ± 0.049
2.734ThrArg: 2.734 ± 0.072
1.891ThrSer: 1.891 ± 0.061
1.995ThrThr: 1.995 ± 0.053
4.132ThrVal: 4.132 ± 0.083
0.522ThrTrp: 0.522 ± 0.028
1.09ThrTyr: 1.09 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
7.755ValAla: 7.755 ± 0.133
1.047ValCys: 1.047 ± 0.042
3.085ValAsp: 3.085 ± 0.069
3.473ValGlu: 3.473 ± 0.081
3.01ValPhe: 3.01 ± 0.073
4.643ValGly: 4.643 ± 0.093
1.425ValHis: 1.425 ± 0.05
3.233ValIle: 3.233 ± 0.073
2.722ValLys: 2.722 ± 0.079
8.127ValLeu: 8.127 ± 0.126
1.93ValMet: 1.93 ± 0.062
2.157ValAsn: 2.157 ± 0.062
3.005ValPro: 3.005 ± 0.063
2.635ValGln: 2.635 ± 0.065
4.358ValArg: 4.358 ± 0.08
4.012ValSer: 4.012 ± 0.084
2.723ValThr: 2.723 ± 0.069
4.943ValVal: 4.943 ± 0.097
1.069ValTrp: 1.069 ± 0.039
1.873ValTyr: 1.873 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.288TrpAla: 1.288 ± 0.049
0.192TrpCys: 0.192 ± 0.016
0.519TrpAsp: 0.519 ± 0.028
0.534TrpGlu: 0.534 ± 0.028
0.613TrpPhe: 0.613 ± 0.034
0.898TrpGly: 0.898 ± 0.042
0.444TrpHis: 0.444 ± 0.022
0.607TrpIle: 0.607 ± 0.028
0.379TrpLys: 0.379 ± 0.028
2.432TrpLeu: 2.432 ± 0.076
0.381TrpMet: 0.381 ± 0.025
0.345TrpAsn: 0.345 ± 0.024
0.648TrpPro: 0.648 ± 0.032
1.398TrpGln: 1.398 ± 0.049
1.102TrpArg: 1.102 ± 0.047
0.574TrpSer: 0.574 ± 0.026
0.439TrpThr: 0.439 ± 0.031
0.876TrpVal: 0.876 ± 0.036
0.256TrpTrp: 0.256 ± 0.024
0.348TrpTyr: 0.348 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.92TyrAla: 2.92 ± 0.08
0.34TyrCys: 0.34 ± 0.024
1.464TyrAsp: 1.464 ± 0.05
1.285TyrGlu: 1.285 ± 0.04
1.303TyrPhe: 1.303 ± 0.049
2.255TyrGly: 2.255 ± 0.058
0.699TyrHis: 0.699 ± 0.032
1.197TyrIle: 1.197 ± 0.042
0.748TyrLys: 0.748 ± 0.037
3.499TyrLeu: 3.499 ± 0.069
0.487TyrMet: 0.487 ± 0.025
0.729TyrAsn: 0.729 ± 0.035
1.392TyrPro: 1.392 ± 0.05
1.341TyrGln: 1.341 ± 0.053
2.426TyrArg: 2.426 ± 0.065
1.365TyrSer: 1.365 ± 0.047
1.525TyrThr: 1.525 ± 0.05
1.701TyrVal: 1.701 ± 0.054
0.463TyrTrp: 0.463 ± 0.027
0.819TyrTyr: 0.819 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2530 proteins (666819 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski