Amino acid dipepetide frequency for Methylovulum psychrotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.118AlaAla: 12.118 ± 0.143	1.19AlaCys: 1.19 ± 0.036	6.434AlaAsp: 6.434 ± 0.079	6.407AlaGlu: 6.407 ± 0.101	3.816AlaPhe: 3.816 ± 0.056	7.331AlaGly: 7.331 ± 0.129	2.126AlaHis: 2.126 ± 0.043	6.067AlaIle: 6.067 ± 0.072	5.013AlaLys: 5.013 ± 0.086	11.99AlaLeu: 11.99 ± 0.123	2.516AlaMet: 2.516 ± 0.048	3.898AlaAsn: 3.898 ± 0.058	3.585AlaPro: 3.585 ± 0.071	4.95AlaGln: 4.95 ± 0.076	4.285AlaArg: 4.285 ± 0.071	5.278AlaSer: 5.278 ± 0.07	5.267AlaThr: 5.267 ± 0.08	7.457AlaVal: 7.457 ± 0.094	1.405AlaTrp: 1.405 ± 0.036	3.053AlaTyr: 3.053 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.031CysAla: 1.031 ± 0.03	0.171CysCys: 0.171 ± 0.011	0.498CysAsp: 0.498 ± 0.024	0.483CysGlu: 0.483 ± 0.021	0.441CysPhe: 0.441 ± 0.017	0.963CysGly: 0.963 ± 0.032	0.356CysHis: 0.356 ± 0.017	0.495CysIle: 0.495 ± 0.02	0.387CysLys: 0.387 ± 0.019	1.258CysLeu: 1.258 ± 0.033	0.2CysMet: 0.2 ± 0.012	0.324CysAsn: 0.324 ± 0.015	0.587CysPro: 0.587 ± 0.024	0.579CysGln: 0.579 ± 0.022	0.611CysArg: 0.611 ± 0.022	0.565CysSer: 0.565 ± 0.021	0.55CysThr: 0.55 ± 0.02	0.656CysVal: 0.656 ± 0.019	0.151CysTrp: 0.151 ± 0.011	0.393CysTyr: 0.393 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.929AspAla: 4.929 ± 0.062	0.599AspCys: 0.599 ± 0.021	3.041AspAsp: 3.041 ± 0.07	2.946AspGlu: 2.946 ± 0.05	2.557AspPhe: 2.557 ± 0.044	4.382AspGly: 4.382 ± 0.081	1.111AspHis: 1.111 ± 0.029	3.791AspIle: 3.791 ± 0.068	2.979AspLys: 2.979 ± 0.05	5.461AspLeu: 5.461 ± 0.074	1.275AspMet: 1.275 ± 0.032	2.381AspAsn: 2.381 ± 0.042	2.412AspPro: 2.412 ± 0.042	1.819AspGln: 1.819 ± 0.038	2.365AspArg: 2.365 ± 0.045	3.304AspSer: 3.304 ± 0.056	3.425AspThr: 3.425 ± 0.095	3.481AspVal: 3.481 ± 0.065	0.898AspTrp: 0.898 ± 0.028	2.238AspTyr: 2.238 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.684GluAla: 5.684 ± 0.088	0.472GluCys: 0.472 ± 0.019	2.333GluAsp: 2.333 ± 0.05	2.846GluGlu: 2.846 ± 0.061	1.948GluPhe: 1.948 ± 0.043	3.052GluGly: 3.052 ± 0.053	1.329GluHis: 1.329 ± 0.033	3.218GluIle: 3.218 ± 0.061	2.879GluLys: 2.879 ± 0.066	6.246GluLeu: 6.246 ± 0.085	1.227GluMet: 1.227 ± 0.036	2.093GluAsn: 2.093 ± 0.043	2.059GluPro: 2.059 ± 0.045	3.458GluGln: 3.458 ± 0.064	3.141GluArg: 3.141 ± 0.051	2.485GluSer: 2.485 ± 0.051	2.889GluThr: 2.889 ± 0.046	3.259GluVal: 3.259 ± 0.059	0.655GluTrp: 0.655 ± 0.025	1.363GluTyr: 1.363 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.976PheAla: 3.976 ± 0.054	0.525PheCys: 0.525 ± 0.02	2.453PheAsp: 2.453 ± 0.048	1.847PheGlu: 1.847 ± 0.039	1.716PhePhe: 1.716 ± 0.04	2.981PheGly: 2.981 ± 0.054	0.774PheHis: 0.774 ± 0.022	2.498PheIle: 2.498 ± 0.043	1.809PheLys: 1.809 ± 0.042	3.756PheLeu: 3.756 ± 0.058	0.905PheMet: 0.905 ± 0.028	1.779PheAsn: 1.779 ± 0.039	1.561PhePro: 1.561 ± 0.035	1.389PheGln: 1.389 ± 0.033	1.785PheArg: 1.785 ± 0.038	2.862PheSer: 2.862 ± 0.047	2.29PheThr: 2.29 ± 0.042	2.525PheVal: 2.525 ± 0.045	0.536PheTrp: 0.536 ± 0.021	1.427PheTyr: 1.427 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	5.748GlyAla: 5.748 ± 0.096	0.928GlyCys: 0.928 ± 0.028	3.922GlyAsp: 3.922 ± 0.075	3.668GlyGlu: 3.668 ± 0.055	3.365GlyPhe: 3.365 ± 0.053	5.835GlyGly: 5.835 ± 0.147	1.793GlyHis: 1.793 ± 0.039	4.608GlyIle: 4.608 ± 0.07	4.026GlyLys: 4.026 ± 0.06	8.191GlyLeu: 8.191 ± 0.088	1.831GlyMet: 1.831 ± 0.041	3.173GlyAsn: 3.173 ± 0.111	1.585GlyPro: 1.585 ± 0.037	3.612GlyGln: 3.612 ± 0.066	3.458GlyArg: 3.458 ± 0.053	4.306GlySer: 4.306 ± 0.089	3.927GlyThr: 3.927 ± 0.094	4.981GlyVal: 4.981 ± 0.077	1.095GlyTrp: 1.095 ± 0.032	2.601GlyTyr: 2.601 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.005HisAla: 2.005 ± 0.044	0.358HisCys: 0.358 ± 0.016	1.259HisAsp: 1.259 ± 0.025	1.15HisGlu: 1.15 ± 0.032	1.159HisPhe: 1.159 ± 0.035	1.613HisGly: 1.613 ± 0.035	0.699HisHis: 0.699 ± 0.027	1.597HisIle: 1.597 ± 0.036	0.967HisLys: 0.967 ± 0.025	2.672HisLeu: 2.672 ± 0.051	0.29HisMet: 0.29 ± 0.016	0.897HisAsn: 0.897 ± 0.024	1.397HisPro: 1.397 ± 0.037	1.079HisGln: 1.079 ± 0.029	1.181HisArg: 1.181 ± 0.033	1.462HisSer: 1.462 ± 0.03	1.197HisThr: 1.197 ± 0.031	1.137HisVal: 1.137 ± 0.032	0.457HisTrp: 0.457 ± 0.018	1.066HisTyr: 1.066 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.389IleAla: 6.389 ± 0.071	0.596IleCys: 0.596 ± 0.022	3.791IleAsp: 3.791 ± 0.058	3.383IleGlu: 3.383 ± 0.066	1.975IlePhe: 1.975 ± 0.041	4.61IleGly: 4.61 ± 0.063	1.23IleHis: 1.23 ± 0.034	3.44IleIle: 3.44 ± 0.063	2.975IleLys: 2.975 ± 0.063	5.067IleLeu: 5.067 ± 0.063	1.078IleMet: 1.078 ± 0.03	2.654IleAsn: 2.654 ± 0.053	2.707IlePro: 2.707 ± 0.043	1.934IleGln: 1.934 ± 0.038	2.948IleArg: 2.948 ± 0.04	3.707IleSer: 3.707 ± 0.058	3.333IleThr: 3.333 ± 0.053	3.564IleVal: 3.564 ± 0.053	0.564IleTrp: 0.564 ± 0.023	1.655IleTyr: 1.655 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	5.03LysAla: 5.03 ± 0.091	0.314LysCys: 0.314 ± 0.019	2.427LysAsp: 2.427 ± 0.053	2.361LysGlu: 2.361 ± 0.057	1.27LysPhe: 1.27 ± 0.034	2.803LysGly: 2.803 ± 0.044	1.093LysHis: 1.093 ± 0.032	2.991LysIle: 2.991 ± 0.056	2.581LysLys: 2.581 ± 0.056	4.836LysLeu: 4.836 ± 0.064	1.061LysMet: 1.061 ± 0.031	2.175LysAsn: 2.175 ± 0.047	2.625LysPro: 2.625 ± 0.053	2.474LysGln: 2.474 ± 0.047	2.295LysArg: 2.295 ± 0.045	2.48LysSer: 2.48 ± 0.048	3.061LysThr: 3.061 ± 0.054	2.847LysVal: 2.847 ± 0.05	0.468LysTrp: 0.468 ± 0.017	1.142LysTyr: 1.142 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	13.342LeuAla: 13.342 ± 0.13	1.242LeuCys: 1.242 ± 0.033	5.942LeuAsp: 5.942 ± 0.076	5.482LeuGlu: 5.482 ± 0.088	4.247LeuPhe: 4.247 ± 0.061	7.634LeuGly: 7.634 ± 0.092	2.545LeuHis: 2.545 ± 0.046	5.54LeuIle: 5.54 ± 0.075	5.149LeuLys: 5.149 ± 0.072	12.668LeuLeu: 12.668 ± 0.138	2.404LeuMet: 2.404 ± 0.04	4.385LeuAsn: 4.385 ± 0.068	6.05LeuPro: 6.05 ± 0.089	4.861LeuGln: 4.861 ± 0.077	5.489LeuArg: 5.489 ± 0.074	7.339LeuSer: 7.339 ± 0.077	6.288LeuThr: 6.288 ± 0.075	6.812LeuVal: 6.812 ± 0.08	1.344LeuTrp: 1.344 ± 0.038	2.979LeuTyr: 2.979 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.637MetAla: 2.637 ± 0.047	0.142MetCys: 0.142 ± 0.011	1.085MetAsp: 1.085 ± 0.029	1.033MetGlu: 1.033 ± 0.032	0.596MetPhe: 0.596 ± 0.024	1.487MetGly: 1.487 ± 0.034	0.424MetHis: 0.424 ± 0.017	1.072MetIle: 1.072 ± 0.029	1.063MetLys: 1.063 ± 0.029	2.313MetLeu: 2.313 ± 0.047	0.527MetMet: 0.527 ± 0.022	0.882MetAsn: 0.882 ± 0.028	1.227MetPro: 1.227 ± 0.028	1.078MetGln: 1.078 ± 0.027	1.045MetArg: 1.045 ± 0.03	1.337MetSer: 1.337 ± 0.034	1.417MetThr: 1.417 ± 0.037	1.516MetVal: 1.516 ± 0.035	0.136MetTrp: 0.136 ± 0.01	0.439MetTyr: 0.439 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.976AsnAla: 3.976 ± 0.066	0.371AsnCys: 0.371 ± 0.016	2.232AsnAsp: 2.232 ± 0.103	1.753AsnGlu: 1.753 ± 0.039	1.41AsnPhe: 1.41 ± 0.033	3.413AsnGly: 3.413 ± 0.086	0.899AsnHis: 0.899 ± 0.027	2.251AsnIle: 2.251 ± 0.052	1.811AsnLys: 1.811 ± 0.041	3.841AsnLeu: 3.841 ± 0.057	0.76AsnMet: 0.76 ± 0.026	1.822AsnAsn: 1.822 ± 0.052	2.414AsnPro: 2.414 ± 0.047	1.693AsnGln: 1.693 ± 0.04	2.047AsnArg: 2.047 ± 0.041	2.33AsnSer: 2.33 ± 0.052	2.384AsnThr: 2.384 ± 0.051	2.239AsnVal: 2.239 ± 0.053	0.513AsnTrp: 0.513 ± 0.02	1.294AsnTyr: 1.294 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.656ProAla: 4.656 ± 0.074	0.455ProCys: 0.455 ± 0.016	3.233ProAsp: 3.233 ± 0.061	3.292ProGlu: 3.292 ± 0.06	1.808ProPhe: 1.808 ± 0.035	2.865ProGly: 2.865 ± 0.055	1.007ProHis: 1.007 ± 0.029	2.497ProIle: 2.497 ± 0.048	2.017ProLys: 2.017 ± 0.048	5.057ProLeu: 5.057 ± 0.076	0.97ProMet: 0.97 ± 0.027	1.668ProAsn: 1.668 ± 0.035	2.348ProPro: 2.348 ± 0.062	1.916ProGln: 1.916 ± 0.041	1.631ProArg: 1.631 ± 0.038	2.664ProSer: 2.664 ± 0.046	2.471ProThr: 2.471 ± 0.039	3.286ProVal: 3.286 ± 0.061	0.585ProTrp: 0.585 ± 0.022	1.356ProTyr: 1.356 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.984GlnAla: 5.984 ± 0.087	0.408GlnCys: 0.408 ± 0.018	2.173GlnAsp: 2.173 ± 0.041	2.237GlnGlu: 2.237 ± 0.052	1.646GlnPhe: 1.646 ± 0.037	3.299GlnGly: 3.299 ± 0.057	1.42GlnHis: 1.42 ± 0.032	2.492GlnIle: 2.492 ± 0.043	1.876GlnLys: 1.876 ± 0.035	5.346GlnLeu: 5.346 ± 0.069	0.959GlnMet: 0.959 ± 0.027	1.573GlnAsn: 1.573 ± 0.031	2.243GlnPro: 2.243 ± 0.051	3.216GlnGln: 3.216 ± 0.067	2.74GlnArg: 2.74 ± 0.049	2.116GlnSer: 2.116 ± 0.036	2.735GlnThr: 2.735 ± 0.047	2.941GlnVal: 2.941 ± 0.053	0.72GlnTrp: 0.72 ± 0.024	1.286GlnTyr: 1.286 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	3.831ArgAla: 3.831 ± 0.061	0.555ArgCys: 0.555 ± 0.024	2.388ArgAsp: 2.388 ± 0.047	2.639ArgGlu: 2.639 ± 0.06	2.248ArgPhe: 2.248 ± 0.039	2.727ArgGly: 2.727 ± 0.048	1.585ArgHis: 1.585 ± 0.034	3.058ArgIle: 3.058 ± 0.054	2.192ArgLys: 2.192 ± 0.043	6.337ArgLeu: 6.337 ± 0.084	1.105ArgMet: 1.105 ± 0.03	1.735ArgAsn: 1.735 ± 0.035	2.12ArgPro: 2.12 ± 0.041	2.971ArgGln: 2.971 ± 0.059	2.753ArgArg: 2.753 ± 0.055	2.391ArgSer: 2.391 ± 0.045	2.274ArgThr: 2.274 ± 0.038	3.092ArgVal: 3.092 ± 0.05	0.834ArgTrp: 0.834 ± 0.028	1.995ArgTyr: 1.995 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.645SerAla: 5.645 ± 0.072	0.588SerCys: 0.588 ± 0.023	3.052SerAsp: 3.052 ± 0.045	2.888SerGlu: 2.888 ± 0.054	2.341SerPhe: 2.341 ± 0.048	5.153SerGly: 5.153 ± 0.088	1.491SerHis: 1.491 ± 0.036	3.086SerIle: 3.086 ± 0.05	2.29SerLys: 2.29 ± 0.04	6.388SerLeu: 6.388 ± 0.072	1.116SerMet: 1.116 ± 0.029	2.092SerAsn: 2.092 ± 0.05	2.809SerPro: 2.809 ± 0.048	2.576SerGln: 2.576 ± 0.045	2.746SerArg: 2.746 ± 0.05	3.281SerSer: 3.281 ± 0.071	3.079SerThr: 3.079 ± 0.067	4.172SerVal: 4.172 ± 0.069	0.691SerTrp: 0.691 ± 0.024	1.812SerTyr: 1.812 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.379ThrAla: 6.379 ± 0.085	0.451ThrCys: 0.451 ± 0.019	3.413ThrAsp: 3.413 ± 0.068	2.807ThrGlu: 2.807 ± 0.053	1.959ThrPhe: 1.959 ± 0.049	4.63ThrGly: 4.63 ± 0.107	1.299ThrHis: 1.299 ± 0.033	2.987ThrIle: 2.987 ± 0.05	1.756ThrLys: 1.756 ± 0.039	7.056ThrLeu: 7.056 ± 0.103	0.928ThrMet: 0.928 ± 0.027	1.74ThrAsn: 1.74 ± 0.038	3.125ThrPro: 3.125 ± 0.053	2.24ThrGln: 2.24 ± 0.043	2.352ThrArg: 2.352 ± 0.043	2.71ThrSer: 2.71 ± 0.054	2.943ThrThr: 2.943 ± 0.057	4.592ThrVal: 4.592 ± 0.072	0.647ThrTrp: 0.647 ± 0.023	1.522ThrTyr: 1.522 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	6.933ValAla: 6.933 ± 0.087	0.777ValCys: 0.777 ± 0.025	3.484ValAsp: 3.484 ± 0.057	3.319ValGlu: 3.319 ± 0.054	2.949ValPhe: 2.949 ± 0.051	4.518ValGly: 4.518 ± 0.061	1.229ValHis: 1.229 ± 0.031	3.927ValIle: 3.927 ± 0.059	2.964ValLys: 2.964 ± 0.052	7.544ValLeu: 7.544 ± 0.083	1.574ValMet: 1.574 ± 0.031	2.668ValAsn: 2.668 ± 0.053	2.716ValPro: 2.716 ± 0.054	2.514ValGln: 2.514 ± 0.042	3.104ValArg: 3.104 ± 0.056	4.158ValSer: 4.158 ± 0.06	3.849ValThr: 3.849 ± 0.06	4.69ValVal: 4.69 ± 0.07	0.89ValTrp: 0.89 ± 0.028	1.898ValTyr: 1.898 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.102TrpAla: 1.102 ± 0.029	0.146TrpCys: 0.146 ± 0.009	0.61TrpAsp: 0.61 ± 0.023	0.61TrpGlu: 0.61 ± 0.023	0.551TrpPhe: 0.551 ± 0.019	0.858TrpGly: 0.858 ± 0.033	0.412TrpHis: 0.412 ± 0.019	0.518TrpIle: 0.518 ± 0.021	0.384TrpLys: 0.384 ± 0.018	2.152TrpLeu: 2.152 ± 0.049	0.242TrpMet: 0.242 ± 0.013	0.4TrpAsn: 0.4 ± 0.018	0.571TrpPro: 0.571 ± 0.024	1.173TrpGln: 1.173 ± 0.037	0.866TrpArg: 0.866 ± 0.028	0.663TrpSer: 0.663 ± 0.023	0.563TrpThr: 0.563 ± 0.02	0.868TrpVal: 0.868 ± 0.025	0.213TrpTrp: 0.213 ± 0.012	0.4TrpTyr: 0.4 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.791TyrAla: 2.791 ± 0.057	0.41TyrCys: 0.41 ± 0.017	1.625TyrAsp: 1.625 ± 0.043	1.482TyrGlu: 1.482 ± 0.029	1.395TyrPhe: 1.395 ± 0.035	2.498TyrGly: 2.498 ± 0.056	0.818TyrHis: 0.818 ± 0.025	1.468TyrIle: 1.468 ± 0.031	1.217TyrLys: 1.217 ± 0.035	3.562TyrLeu: 3.562 ± 0.047	0.486TyrMet: 0.486 ± 0.019	1.111TyrAsn: 1.111 ± 0.034	1.641TyrPro: 1.641 ± 0.039	1.881TyrGln: 1.881 ± 0.038	1.989TyrArg: 1.989 ± 0.042	1.861TyrSer: 1.861 ± 0.041	1.594TyrThr: 1.594 ± 0.039	1.587TyrVal: 1.587 ± 0.031	0.5TyrTrp: 0.5 ± 0.022	1.027TyrTyr: 1.027 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4299 proteins (1384159 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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