Amino acid dipepetide frequency for Brockia lithotrophica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.628AlaAla: 12.628 ± 0.219	0.561AlaCys: 0.561 ± 0.037	4.751AlaAsp: 4.751 ± 0.1	9.042AlaGlu: 9.042 ± 0.163	5.069AlaPhe: 5.069 ± 0.117	8.311AlaGly: 8.311 ± 0.129	2.289AlaHis: 2.289 ± 0.07	3.937AlaIle: 3.937 ± 0.097	3.111AlaLys: 3.111 ± 0.074	14.121AlaLeu: 14.121 ± 0.211	1.956AlaMet: 1.956 ± 0.069	1.789AlaAsn: 1.789 ± 0.053	4.902AlaPro: 4.902 ± 0.097	2.964AlaGln: 2.964 ± 0.081	10.133AlaArg: 10.133 ± 0.163	5.163AlaSer: 5.163 ± 0.107	4.074AlaThr: 4.074 ± 0.081	9.677AlaVal: 9.677 ± 0.151	1.447AlaTrp: 1.447 ± 0.058	3.709AlaTyr: 3.709 ± 0.097	0.0AlaXaa: 0.0 ± 0.0
Cys	0.487CysAla: 0.487 ± 0.035	0.039CysCys: 0.039 ± 0.007	0.206CysAsp: 0.206 ± 0.018	0.245CysGlu: 0.245 ± 0.021	0.131CysPhe: 0.131 ± 0.016	0.621CysGly: 0.621 ± 0.039	0.092CysHis: 0.092 ± 0.017	0.129CysIle: 0.129 ± 0.016	0.116CysLys: 0.116 ± 0.016	0.371CysLeu: 0.371 ± 0.027	0.064CysMet: 0.064 ± 0.012	0.079CysAsn: 0.079 ± 0.012	0.522CysPro: 0.522 ± 0.037	0.072CysGln: 0.072 ± 0.012	0.37CysArg: 0.37 ± 0.031	0.208CysSer: 0.208 ± 0.02	0.268CysThr: 0.268 ± 0.02	0.307CysVal: 0.307 ± 0.025	0.029CysTrp: 0.029 ± 0.007	0.094CysTyr: 0.094 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	5.417AspAla: 5.417 ± 0.113	0.143AspCys: 0.143 ± 0.018	2.068AspAsp: 2.068 ± 0.081	3.736AspGlu: 3.736 ± 0.114	1.923AspPhe: 1.923 ± 0.063	4.056AspGly: 4.056 ± 0.104	0.724AspHis: 0.724 ± 0.04	1.859AspIle: 1.859 ± 0.06	1.015AspLys: 1.015 ± 0.051	5.959AspLeu: 5.959 ± 0.102	0.618AspMet: 0.618 ± 0.03	0.673AspAsn: 0.673 ± 0.039	3.716AspPro: 3.716 ± 0.081	0.68AspGln: 0.68 ± 0.036	3.754AspArg: 3.754 ± 0.1	1.327AspSer: 1.327 ± 0.05	1.649AspThr: 1.649 ± 0.055	5.645AspVal: 5.645 ± 0.115	0.487AspTrp: 0.487 ± 0.033	1.063AspTyr: 1.063 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	10.138GluAla: 10.138 ± 0.167	0.221GluCys: 0.221 ± 0.023	4.085GluAsp: 4.085 ± 0.11	8.607GluGlu: 8.607 ± 0.168	2.403GluPhe: 2.403 ± 0.067	7.787GluGly: 7.787 ± 0.129	1.489GluHis: 1.489 ± 0.048	4.19GluIle: 4.19 ± 0.093	2.751GluLys: 2.751 ± 0.077	7.919GluLeu: 7.919 ± 0.14	1.353GluMet: 1.353 ± 0.044	1.476GluAsn: 1.476 ± 0.064	2.9GluPro: 2.9 ± 0.085	1.427GluGln: 1.427 ± 0.059	8.493GluArg: 8.493 ± 0.156	2.523GluSer: 2.523 ± 0.06	3.446GluThr: 3.446 ± 0.081	7.215GluVal: 7.215 ± 0.131	0.759GluTrp: 0.759 ± 0.037	1.416GluTyr: 1.416 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	5.196PheAla: 5.196 ± 0.108	0.219PheCys: 0.219 ± 0.023	1.822PheAsp: 1.822 ± 0.063	1.846PheGlu: 1.846 ± 0.061	2.304PhePhe: 2.304 ± 0.086	3.617PheGly: 3.617 ± 0.098	0.732PheHis: 0.732 ± 0.036	1.052PheIle: 1.052 ± 0.044	0.539PheLys: 0.539 ± 0.037	6.014PheLeu: 6.014 ± 0.133	0.473PheMet: 0.473 ± 0.032	0.535PheAsn: 0.535 ± 0.033	2.694PhePro: 2.694 ± 0.072	0.778PheGln: 0.778 ± 0.037	3.828PheArg: 3.828 ± 0.096	2.502PheSer: 2.502 ± 0.078	1.999PheThr: 1.999 ± 0.062	4.032PheVal: 4.032 ± 0.087	0.59PheTrp: 0.59 ± 0.034	1.024PheTyr: 1.024 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	8.134GlyAla: 8.134 ± 0.156	0.463GlyCys: 0.463 ± 0.03	4.045GlyAsp: 4.045 ± 0.082	7.551GlyGlu: 7.551 ± 0.13	3.519GlyPhe: 3.519 ± 0.08	7.768GlyGly: 7.768 ± 0.168	1.493GlyHis: 1.493 ± 0.058	4.848GlyIle: 4.848 ± 0.087	3.959GlyLys: 3.959 ± 0.095	8.105GlyLeu: 8.105 ± 0.127	1.914GlyMet: 1.914 ± 0.059	1.765GlyAsn: 1.765 ± 0.07	3.433GlyPro: 3.433 ± 0.086	1.89GlyGln: 1.89 ± 0.063	7.513GlyArg: 7.513 ± 0.145	4.22GlySer: 4.22 ± 0.087	4.782GlyThr: 4.782 ± 0.1	7.312GlyVal: 7.312 ± 0.135	0.974GlyTrp: 0.974 ± 0.045	2.543GlyTyr: 2.543 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	2.091HisAla: 2.091 ± 0.064	0.079HisCys: 0.079 ± 0.013	0.785HisAsp: 0.785 ± 0.042	1.208HisGlu: 1.208 ± 0.044	0.763HisPhe: 0.763 ± 0.039	1.618HisGly: 1.618 ± 0.057	0.43HisHis: 0.43 ± 0.029	0.824HisIle: 0.824 ± 0.04	0.393HisLys: 0.393 ± 0.024	2.464HisLeu: 2.464 ± 0.066	0.305HisMet: 0.305 ± 0.022	0.353HisAsn: 0.353 ± 0.029	1.693HisPro: 1.693 ± 0.064	0.256HisGln: 0.256 ± 0.025	1.603HisArg: 1.603 ± 0.055	0.632HisSer: 0.632 ± 0.037	1.0HisThr: 1.0 ± 0.048	1.953HisVal: 1.953 ± 0.063	0.173HisTrp: 0.173 ± 0.017	0.52HisTyr: 0.52 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	4.742IleAla: 4.742 ± 0.1	0.222IleCys: 0.222 ± 0.023	1.999IleAsp: 1.999 ± 0.06	2.535IleGlu: 2.535 ± 0.079	1.622IlePhe: 1.622 ± 0.063	3.234IleGly: 3.234 ± 0.087	0.741IleHis: 0.741 ± 0.04	0.934IleIle: 0.934 ± 0.05	0.82IleLys: 0.82 ± 0.05	5.279IleLeu: 5.279 ± 0.097	0.416IleMet: 0.416 ± 0.031	0.673IleAsn: 0.673 ± 0.035	2.721IlePro: 2.721 ± 0.07	0.851IleGln: 0.851 ± 0.045	3.585IleArg: 3.585 ± 0.093	1.953IleSer: 1.953 ± 0.063	1.616IleThr: 1.616 ± 0.062	3.959IleVal: 3.959 ± 0.102	0.43IleTrp: 0.43 ± 0.028	1.011IleTyr: 1.011 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	2.907LysAla: 2.907 ± 0.084	0.108LysCys: 0.108 ± 0.015	1.625LysAsp: 1.625 ± 0.065	2.565LysGlu: 2.565 ± 0.081	0.802LysPhe: 0.802 ± 0.042	2.642LysGly: 2.642 ± 0.081	0.46LysHis: 0.46 ± 0.029	1.55LysIle: 1.55 ± 0.059	1.401LysLys: 1.401 ± 0.059	2.776LysLeu: 2.776 ± 0.083	0.518LysMet: 0.518 ± 0.031	0.759LysAsn: 0.759 ± 0.038	1.581LysPro: 1.581 ± 0.055	0.601LysGln: 0.601 ± 0.034	2.486LysArg: 2.486 ± 0.072	1.377LysSer: 1.377 ± 0.054	1.541LysThr: 1.541 ± 0.06	2.471LysVal: 2.471 ± 0.077	0.296LysTrp: 0.296 ± 0.029	0.688LysTyr: 0.688 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	14.65LeuAla: 14.65 ± 0.197	0.412LeuCys: 0.412 ± 0.027	5.06LeuAsp: 5.06 ± 0.101	8.252LeuGlu: 8.252 ± 0.14	5.26LeuPhe: 5.26 ± 0.123	9.886LeuGly: 9.886 ± 0.145	2.063LeuHis: 2.063 ± 0.073	3.376LeuIle: 3.376 ± 0.088	3.019LeuLys: 3.019 ± 0.08	14.496LeuLeu: 14.496 ± 0.236	1.519LeuMet: 1.519 ± 0.055	1.69LeuAsn: 1.69 ± 0.06	7.132LeuPro: 7.132 ± 0.115	2.089LeuGln: 2.089 ± 0.056	11.493LeuArg: 11.493 ± 0.17	6.213LeuSer: 6.213 ± 0.107	5.367LeuThr: 5.367 ± 0.106	10.175LeuVal: 10.175 ± 0.141	1.511LeuTrp: 1.511 ± 0.057	3.286LeuTyr: 3.286 ± 0.084	0.0LeuXaa: 0.0 ± 0.0
Met	1.671MetAla: 1.671 ± 0.057	0.097MetCys: 0.097 ± 0.013	0.765MetAsp: 0.765 ± 0.037	1.07MetGlu: 1.07 ± 0.047	0.541MetPhe: 0.541 ± 0.03	1.552MetGly: 1.552 ± 0.055	0.329MetHis: 0.329 ± 0.023	0.616MetIle: 0.616 ± 0.034	0.555MetLys: 0.555 ± 0.032	1.482MetLeu: 1.482 ± 0.058	0.189MetMet: 0.189 ± 0.023	0.46MetAsn: 0.46 ± 0.03	0.877MetPro: 0.877 ± 0.036	0.423MetGln: 0.423 ± 0.027	1.704MetArg: 1.704 ± 0.05	0.963MetSer: 0.963 ± 0.039	0.816MetThr: 0.816 ± 0.042	1.103MetVal: 1.103 ± 0.046	0.213MetTrp: 0.213 ± 0.018	0.417MetTyr: 0.417 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.087AsnAla: 2.087 ± 0.065	0.083AsnCys: 0.083 ± 0.014	0.697AsnAsp: 0.697 ± 0.042	0.986AsnGlu: 0.986 ± 0.047	0.827AsnPhe: 0.827 ± 0.04	1.377AsnGly: 1.377 ± 0.057	0.34AsnHis: 0.34 ± 0.022	0.781AsnIle: 0.781 ± 0.043	0.517AsnLys: 0.517 ± 0.034	2.293AsnLeu: 2.293 ± 0.067	0.296AsnMet: 0.296 ± 0.023	0.403AsnAsn: 0.403 ± 0.032	1.66AsnPro: 1.66 ± 0.057	0.316AsnGln: 0.316 ± 0.023	1.421AsnArg: 1.421 ± 0.051	0.724AsnSer: 0.724 ± 0.042	0.838AsnThr: 0.838 ± 0.04	1.798AsnVal: 1.798 ± 0.066	0.199AsnTrp: 0.199 ± 0.021	0.471AsnTyr: 0.471 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.786ProAla: 4.786 ± 0.094	0.252ProCys: 0.252 ± 0.024	3.048ProAsp: 3.048 ± 0.08	6.27ProGlu: 6.27 ± 0.112	2.569ProPhe: 2.569 ± 0.081	4.782ProGly: 4.782 ± 0.107	1.392ProHis: 1.392 ± 0.051	1.857ProIle: 1.857 ± 0.053	1.767ProLys: 1.767 ± 0.069	6.161ProLeu: 6.161 ± 0.119	0.929ProMet: 0.929 ± 0.041	1.217ProAsn: 1.217 ± 0.053	4.367ProPro: 4.367 ± 0.134	1.456ProGln: 1.456 ± 0.054	4.253ProArg: 4.253 ± 0.101	3.363ProSer: 3.363 ± 0.094	2.616ProThr: 2.616 ± 0.066	4.7ProVal: 4.7 ± 0.09	0.838ProTrp: 0.838 ± 0.038	1.896ProTyr: 1.896 ± 0.061	0.0ProXaa: 0.0 ± 0.0
Gln	2.512GlnAla: 2.512 ± 0.074	0.063GlnCys: 0.063 ± 0.01	0.995GlnAsp: 0.995 ± 0.038	1.995GlnGlu: 1.995 ± 0.059	0.588GlnPhe: 0.588 ± 0.033	2.127GlnGly: 2.127 ± 0.065	0.311GlnHis: 0.311 ± 0.023	1.16GlnIle: 1.16 ± 0.049	1.011GlnLys: 1.011 ± 0.045	1.765GlnLeu: 1.765 ± 0.059	0.416GlnMet: 0.416 ± 0.027	0.605GlnAsn: 0.605 ± 0.035	0.936GlnPro: 0.936 ± 0.053	0.393GlnGln: 0.393 ± 0.03	1.548GlnArg: 1.548 ± 0.057	0.932GlnSer: 0.932 ± 0.046	1.12GlnThr: 1.12 ± 0.04	1.688GlnVal: 1.688 ± 0.058	0.184GlnTrp: 0.184 ± 0.022	0.432GlnTyr: 0.432 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	9.276ArgAla: 9.276 ± 0.165	0.364ArgCys: 0.364 ± 0.027	4.098ArgAsp: 4.098 ± 0.084	9.322ArgGlu: 9.322 ± 0.15	3.545ArgPhe: 3.545 ± 0.071	7.121ArgGly: 7.121 ± 0.126	1.669ArgHis: 1.669 ± 0.065	4.499ArgIle: 4.499 ± 0.101	3.012ArgLys: 3.012 ± 0.076	10.342ArgLeu: 10.342 ± 0.17	1.844ArgMet: 1.844 ± 0.056	1.578ArgAsn: 1.578 ± 0.058	4.858ArgPro: 4.858 ± 0.093	1.863ArgGln: 1.863 ± 0.062	9.557ArgArg: 9.557 ± 0.171	3.782ArgSer: 3.782 ± 0.073	4.385ArgThr: 4.385 ± 0.081	7.206ArgVal: 7.206 ± 0.15	1.105ArgTrp: 1.105 ± 0.047	2.508ArgTyr: 2.508 ± 0.071	0.0ArgXaa: 0.0 ± 0.0
Ser	4.837SerAla: 4.837 ± 0.116	0.239SerCys: 0.239 ± 0.022	1.923SerAsp: 1.923 ± 0.062	3.293SerGlu: 3.293 ± 0.083	2.438SerPhe: 2.438 ± 0.068	4.766SerGly: 4.766 ± 0.095	0.818SerHis: 0.818 ± 0.043	1.377SerIle: 1.377 ± 0.055	0.949SerLys: 0.949 ± 0.047	6.106SerLeu: 6.106 ± 0.125	0.769SerMet: 0.769 ± 0.042	0.61SerAsn: 0.61 ± 0.035	3.854SerPro: 3.854 ± 0.101	1.033SerGln: 1.033 ± 0.043	3.786SerArg: 3.786 ± 0.087	2.6SerSer: 2.6 ± 0.078	1.977SerThr: 1.977 ± 0.065	3.758SerVal: 3.758 ± 0.081	0.605SerTrp: 0.605 ± 0.037	1.079SerTyr: 1.079 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.593ThrAla: 4.593 ± 0.088	0.234ThrCys: 0.234 ± 0.02	1.857ThrAsp: 1.857 ± 0.066	2.596ThrGlu: 2.596 ± 0.073	2.219ThrPhe: 2.219 ± 0.062	4.1ThrGly: 4.1 ± 0.089	1.015ThrHis: 1.015 ± 0.043	1.907ThrIle: 1.907 ± 0.069	1.201ThrLys: 1.201 ± 0.051	5.488ThrLeu: 5.488 ± 0.102	0.682ThrMet: 0.682 ± 0.038	0.967ThrAsn: 0.967 ± 0.044	3.348ThrPro: 3.348 ± 0.082	0.888ThrGln: 0.888 ± 0.043	3.203ThrArg: 3.203 ± 0.084	2.58ThrSer: 2.58 ± 0.069	2.201ThrThr: 2.201 ± 0.071	3.891ThrVal: 3.891 ± 0.091	0.656ThrTrp: 0.656 ± 0.036	1.638ThrTyr: 1.638 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	8.941ValAla: 8.941 ± 0.141	0.48ValCys: 0.48 ± 0.036	4.6ValAsp: 4.6 ± 0.093	6.466ValGlu: 6.466 ± 0.114	3.758ValPhe: 3.758 ± 0.106	7.242ValGly: 7.242 ± 0.118	2.03ValHis: 2.03 ± 0.067	2.944ValIle: 2.944 ± 0.081	2.05ValLys: 2.05 ± 0.069	11.14ValLeu: 11.14 ± 0.142	0.995ValMet: 0.995 ± 0.04	1.598ValAsn: 1.598 ± 0.063	5.224ValPro: 5.224 ± 0.105	1.997ValGln: 1.997 ± 0.057	9.428ValArg: 9.428 ± 0.14	4.249ValSer: 4.249 ± 0.09	3.646ValThr: 3.646 ± 0.075	8.546ValVal: 8.546 ± 0.151	1.096ValTrp: 1.096 ± 0.05	2.83ValTyr: 2.83 ± 0.075	0.0ValXaa: 0.0 ± 0.0
Trp	1.145TrpAla: 1.145 ± 0.042	0.046TrpCys: 0.046 ± 0.01	0.645TrpAsp: 0.645 ± 0.035	1.263TrpGlu: 1.263 ± 0.045	0.443TrpPhe: 0.443 ± 0.03	1.039TrpGly: 1.039 ± 0.046	0.219TrpHis: 0.219 ± 0.023	0.561TrpIle: 0.561 ± 0.035	0.434TrpLys: 0.434 ± 0.032	1.19TrpLeu: 1.19 ± 0.048	0.259TrpMet: 0.259 ± 0.019	0.318TrpAsn: 0.318 ± 0.027	0.561TrpPro: 0.561 ± 0.036	0.278TrpGln: 0.278 ± 0.022	1.041TrpArg: 1.041 ± 0.042	0.601TrpSer: 0.601 ± 0.036	0.603TrpThr: 0.603 ± 0.033	0.929TrpVal: 0.929 ± 0.044	0.217TrpTrp: 0.217 ± 0.02	0.278TrpTyr: 0.278 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.394TyrAla: 3.394 ± 0.074	0.125TyrCys: 0.125 ± 0.018	1.438TyrAsp: 1.438 ± 0.062	1.75TyrGlu: 1.75 ± 0.061	1.07TyrPhe: 1.07 ± 0.045	2.585TyrGly: 2.585 ± 0.072	0.507TyrHis: 0.507 ± 0.033	0.943TyrIle: 0.943 ± 0.046	0.537TyrLys: 0.537 ± 0.04	3.477TyrLeu: 3.477 ± 0.094	0.329TyrMet: 0.329 ± 0.027	0.566TyrAsn: 0.566 ± 0.036	1.541TyrPro: 1.541 ± 0.058	0.526TyrGln: 0.526 ± 0.035	2.734TyrArg: 2.734 ± 0.076	0.905TyrSer: 0.905 ± 0.04	1.318TyrThr: 1.318 ± 0.051	2.898TyrVal: 2.898 ± 0.07	0.257TyrTrp: 0.257 ± 0.022	0.691TyrTyr: 0.691 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1680 proteins (543884 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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