Amino acid dipepetide frequency for Rachiplusia ou multiple nucleopolyhedrovirus (strain R1) (RoMNPV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.27AlaAla: 3.27 ± 0.369
1.235AlaCys: 1.235 ± 0.181
2.858AlaAsp: 2.858 ± 0.242
2.809AlaGlu: 2.809 ± 0.294
2.567AlaPhe: 2.567 ± 0.242
1.453AlaGly: 1.453 ± 0.195
1.187AlaHis: 1.187 ± 0.178
3.391AlaIle: 3.391 ± 0.345
3.076AlaLys: 3.076 ± 0.269
4.674AlaLeu: 4.674 ± 0.38
1.041AlaMet: 1.041 ± 0.152
3.584AlaAsn: 3.584 ± 0.317
2.64AlaPro: 2.64 ± 0.332
2.107AlaGln: 2.107 ± 0.226
2.083AlaArg: 2.083 ± 0.257
3.342AlaSer: 3.342 ± 0.288
3.052AlaThr: 3.052 ± 0.297
3.221AlaVal: 3.221 ± 0.276
0.266AlaTrp: 0.266 ± 0.108
2.495AlaTyr: 2.495 ± 0.236
0.0AlaXaa: 0.0 ± 0.0
Cys
1.502CysAla: 1.502 ± 0.184
0.654CysCys: 0.654 ± 0.148
1.502CysAsp: 1.502 ± 0.212
1.114CysGlu: 1.114 ± 0.15
1.259CysPhe: 1.259 ± 0.185
0.92CysGly: 0.92 ± 0.151
0.654CysHis: 0.654 ± 0.107
2.107CysIle: 2.107 ± 0.243
1.962CysLys: 1.962 ± 0.243
2.204CysLeu: 2.204 ± 0.254
0.605CysMet: 0.605 ± 0.117
2.18CysAsn: 2.18 ± 0.228
1.114CysPro: 1.114 ± 0.18
0.678CysGln: 0.678 ± 0.122
1.405CysArg: 1.405 ± 0.214
1.332CysSer: 1.332 ± 0.166
1.066CysThr: 1.066 ± 0.156
1.986CysVal: 1.986 ± 0.282
0.242CysTrp: 0.242 ± 0.085
1.114CysTyr: 1.114 ± 0.187
0.0CysXaa: 0.0 ± 0.0
Asp
3.536AspAla: 3.536 ± 0.362
1.284AspCys: 1.284 ± 0.198
5.328AspAsp: 5.328 ± 0.498
3.73AspGlu: 3.73 ± 0.317
2.809AspPhe: 2.809 ± 0.243
2.543AspGly: 2.543 ± 0.289
1.041AspHis: 1.041 ± 0.147
3.221AspIle: 3.221 ± 0.258
4.093AspLys: 4.093 ± 0.36
5.304AspLeu: 5.304 ± 0.338
1.841AspMet: 1.841 ± 0.207
4.65AspAsn: 4.65 ± 0.378
1.647AspPro: 1.647 ± 0.217
1.526AspGln: 1.526 ± 0.198
2.422AspArg: 2.422 ± 0.221
3.391AspSer: 3.391 ± 0.318
3.173AspThr: 3.173 ± 0.293
3.778AspVal: 3.778 ± 0.295
0.533AspTrp: 0.533 ± 0.134
3.609AspTyr: 3.609 ± 0.268
0.0AspXaa: 0.0 ± 0.0
Glu
2.398GluAla: 2.398 ± 0.249
1.356GluCys: 1.356 ± 0.201
2.785GluAsp: 2.785 ± 0.302
2.543GluGlu: 2.543 ± 0.295
2.664GluPhe: 2.664 ± 0.24
1.453GluGly: 1.453 ± 0.221
1.332GluHis: 1.332 ± 0.173
3.899GluIle: 3.899 ± 0.298
3.488GluLys: 3.488 ± 0.273
5.183GluLeu: 5.183 ± 0.4
1.574GluMet: 1.574 ± 0.177
4.626GluAsn: 4.626 ± 0.325
1.841GluPro: 1.841 ± 0.353
2.349GluGln: 2.349 ± 0.291
2.47GluArg: 2.47 ± 0.223
3.827GluSer: 3.827 ± 0.327
3.488GluThr: 3.488 ± 0.289
1.841GluVal: 1.841 ± 0.237
0.46GluTrp: 0.46 ± 0.098
2.955GluTyr: 2.955 ± 0.279
0.0GluXaa: 0.0 ± 0.0
Phe
2.567PheAla: 2.567 ± 0.231
1.647PheCys: 1.647 ± 0.198
4.19PheAsp: 4.19 ± 0.336
3.609PheGlu: 3.609 ± 0.301
1.841PhePhe: 1.841 ± 0.194
1.72PheGly: 1.72 ± 0.207
0.775PheHis: 0.775 ± 0.136
3.366PheIle: 3.366 ± 0.277
4.214PheLys: 4.214 ± 0.338
4.287PheLeu: 4.287 ± 0.313
1.453PheMet: 1.453 ± 0.154
4.553PheAsn: 4.553 ± 0.296
1.55PhePro: 1.55 ± 0.189
1.235PheGln: 1.235 ± 0.19
1.55PheArg: 1.55 ± 0.184
2.543PheSer: 2.543 ± 0.263
2.325PheThr: 2.325 ± 0.222
4.166PheVal: 4.166 ± 0.349
0.17PheTrp: 0.17 ± 0.067
2.616PheTyr: 2.616 ± 0.225
0.0PheXaa: 0.0 ± 0.0
Gly
1.477GlyAla: 1.477 ± 0.19
0.654GlyCys: 0.654 ± 0.127
2.398GlyAsp: 2.398 ± 0.299
1.841GlyGlu: 1.841 ± 0.193
1.647GlyPhe: 1.647 ± 0.206
2.131GlyGly: 2.131 ± 0.348
0.92GlyHis: 0.92 ± 0.146
1.695GlyIle: 1.695 ± 0.21
2.131GlyLys: 2.131 ± 0.221
2.495GlyLeu: 2.495 ± 0.248
0.654GlyMet: 0.654 ± 0.131
2.01GlyAsn: 2.01 ± 0.239
0.872GlyPro: 0.872 ± 0.152
1.211GlyGln: 1.211 ± 0.224
1.671GlyArg: 1.671 ± 0.221
1.816GlySer: 1.816 ± 0.182
2.059GlyThr: 2.059 ± 0.224
2.737GlyVal: 2.737 ± 0.245
0.363GlyTrp: 0.363 ± 0.1
1.598GlyTyr: 1.598 ± 0.191
0.0GlyXaa: 0.0 ± 0.0
His
1.259HisAla: 1.259 ± 0.178
0.436HisCys: 0.436 ± 0.11
1.356HisAsp: 1.356 ± 0.201
1.066HisGlu: 1.066 ± 0.202
1.187HisPhe: 1.187 ± 0.169
0.654HisGly: 0.654 ± 0.135
0.654HisHis: 0.654 ± 0.13
1.526HisIle: 1.526 ± 0.186
1.502HisLys: 1.502 ± 0.21
2.155HisLeu: 2.155 ± 0.247
0.605HisMet: 0.605 ± 0.134
1.841HisAsn: 1.841 ± 0.233
0.945HisPro: 0.945 ± 0.152
0.727HisGln: 0.727 ± 0.134
0.92HisArg: 0.92 ± 0.145
1.259HisSer: 1.259 ± 0.169
1.09HisThr: 1.09 ± 0.169
1.526HisVal: 1.526 ± 0.214
0.291HisTrp: 0.291 ± 0.097
1.308HisTyr: 1.308 ± 0.164
0.0HisXaa: 0.0 ± 0.0
Ile
3.1IleAla: 3.1 ± 0.247
1.841IleCys: 1.841 ± 0.244
4.577IleAsp: 4.577 ± 0.365
3.778IleGlu: 3.778 ± 0.289
3.294IlePhe: 3.294 ± 0.287
1.695IleGly: 1.695 ± 0.217
1.041IleHis: 1.041 ± 0.154
5.57IleIle: 5.57 ± 0.456
6.951IleLys: 6.951 ± 0.441
5.74IleLeu: 5.74 ± 0.402
1.938IleMet: 1.938 ± 0.193
6.297IleAsn: 6.297 ± 0.414
2.01IlePro: 2.01 ± 0.24
2.252IleGln: 2.252 ± 0.255
2.373IleArg: 2.373 ± 0.291
3.415IleSer: 3.415 ± 0.337
3.512IleThr: 3.512 ± 0.273
5.473IleVal: 5.473 ± 0.395
0.291IleTrp: 0.291 ± 0.071
2.737IleTyr: 2.737 ± 0.281
0.0IleXaa: 0.0 ± 0.0
Lys
2.131LysAla: 2.131 ± 0.273
2.325LysCys: 2.325 ± 0.234
2.688LysAsp: 2.688 ± 0.291
3.245LysGlu: 3.245 ± 0.287
3.681LysPhe: 3.681 ± 0.286
1.671LysGly: 1.671 ± 0.247
2.422LysHis: 2.422 ± 0.279
6.2LysIle: 6.2 ± 0.46
4.965LysLys: 4.965 ± 0.394
7.871LysLeu: 7.871 ± 0.541
2.785LysMet: 2.785 ± 0.315
6.37LysAsn: 6.37 ± 0.405
2.519LysPro: 2.519 ± 0.288
3.052LysGln: 3.052 ± 0.306
4.166LysArg: 4.166 ± 0.351
4.795LysSer: 4.795 ± 0.378
4.141LysThr: 4.141 ± 0.298
3.391LysVal: 3.391 ± 0.314
0.581LysTrp: 0.581 ± 0.118
4.141LysTyr: 4.141 ± 0.298
0.0LysXaa: 0.0 ± 0.0
Leu
4.311LeuAla: 4.311 ± 0.308
2.349LeuCys: 2.349 ± 0.262
4.65LeuAsp: 4.65 ± 0.335
5.086LeuGlu: 5.086 ± 0.412
5.11LeuPhe: 5.11 ± 0.344
2.422LeuGly: 2.422 ± 0.271
1.938LeuHis: 1.938 ± 0.212
7.241LeuIle: 7.241 ± 0.403
7.581LeuLys: 7.581 ± 0.507
9.324LeuLeu: 9.324 ± 0.573
2.543LeuMet: 2.543 ± 0.271
8.38LeuAsn: 8.38 ± 0.524
3.463LeuPro: 3.463 ± 0.342
5.28LeuGln: 5.28 ± 0.387
3.633LeuArg: 3.633 ± 0.302
5.57LeuSer: 5.57 ± 0.308
4.941LeuThr: 4.941 ± 0.308
4.65LeuVal: 4.65 ± 0.39
0.63LeuTrp: 0.63 ± 0.128
4.868LeuTyr: 4.868 ± 0.374
0.0LeuXaa: 0.0 ± 0.0
Met
1.526MetAla: 1.526 ± 0.204
1.09MetCys: 1.09 ± 0.183
1.187MetAsp: 1.187 ± 0.166
0.993MetGlu: 0.993 ± 0.152
1.695MetPhe: 1.695 ± 0.213
0.751MetGly: 0.751 ± 0.163
0.799MetHis: 0.799 ± 0.143
1.526MetIle: 1.526 ± 0.194
1.38MetLys: 1.38 ± 0.205
3.197MetLeu: 3.197 ± 0.305
0.581MetMet: 0.581 ± 0.101
2.01MetAsn: 2.01 ± 0.206
1.017MetPro: 1.017 ± 0.143
1.187MetGln: 1.187 ± 0.211
1.453MetArg: 1.453 ± 0.187
2.18MetSer: 2.18 ± 0.223
1.405MetThr: 1.405 ± 0.173
1.259MetVal: 1.259 ± 0.162
0.412MetTrp: 0.412 ± 0.117
1.574MetTyr: 1.574 ± 0.187
0.0MetXaa: 0.0 ± 0.0
Asn
5.038AsnAla: 5.038 ± 0.418
2.083AsnCys: 2.083 ± 0.228
3.899AsnAsp: 3.899 ± 0.263
4.868AsnGlu: 4.868 ± 0.297
4.238AsnPhe: 4.238 ± 0.314
3.27AsnGly: 3.27 ± 0.299
1.356AsnHis: 1.356 ± 0.164
5.256AsnIle: 5.256 ± 0.374
6.418AsnLys: 6.418 ± 0.419
6.563AsnLeu: 6.563 ± 0.416
2.083AsnMet: 2.083 ± 0.201
7.072AsnAsn: 7.072 ± 0.498
2.034AsnPro: 2.034 ± 0.207
2.349AsnGln: 2.349 ± 0.224
3.318AsnArg: 3.318 ± 0.285
5.183AsnSer: 5.183 ± 0.38
4.529AsnThr: 4.529 ± 0.308
6.733AsnVal: 6.733 ± 0.399
0.63AsnTrp: 0.63 ± 0.123
4.868AsnTyr: 4.868 ± 0.346
0.0AsnXaa: 0.0 ± 0.0
Pro
2.301ProAla: 2.301 ± 0.337
0.702ProCys: 0.702 ± 0.14
2.398ProAsp: 2.398 ± 0.216
1.574ProGlu: 1.574 ± 0.358
1.816ProPhe: 1.816 ± 0.175
1.38ProGly: 1.38 ± 0.194
0.92ProHis: 0.92 ± 0.14
2.252ProIle: 2.252 ± 0.29
1.962ProLys: 1.962 ± 0.236
3.584ProLeu: 3.584 ± 0.265
0.533ProMet: 0.533 ± 0.113
2.64ProAsn: 2.64 ± 0.276
3.584ProPro: 3.584 ± 0.995
1.066ProGln: 1.066 ± 0.206
1.816ProArg: 1.816 ± 0.255
2.785ProSer: 2.785 ± 0.324
2.906ProThr: 2.906 ± 0.525
2.422ProVal: 2.422 ± 0.282
0.291ProTrp: 0.291 ± 0.092
1.574ProTyr: 1.574 ± 0.203
0.0ProXaa: 0.0 ± 0.0
Gln
1.453GlnAla: 1.453 ± 0.192
1.066GlnCys: 1.066 ± 0.177
1.574GlnAsp: 1.574 ± 0.183
2.083GlnGlu: 2.083 ± 0.261
2.18GlnPhe: 2.18 ± 0.238
0.702GlnGly: 0.702 ± 0.131
0.896GlnHis: 0.896 ± 0.14
2.737GlnIle: 2.737 ± 0.217
2.688GlnLys: 2.688 ± 0.287
4.287GlnLeu: 4.287 ± 0.366
1.041GlnMet: 1.041 ± 0.179
2.761GlnAsn: 2.761 ± 0.264
1.429GlnPro: 1.429 ± 0.222
2.277GlnGln: 2.277 ± 0.278
1.841GlnArg: 1.841 ± 0.219
2.785GlnSer: 2.785 ± 0.286
2.277GlnThr: 2.277 ± 0.257
1.574GlnVal: 1.574 ± 0.207
0.339GlnTrp: 0.339 ± 0.077
1.695GlnTyr: 1.695 ± 0.206
0.0GlnXaa: 0.0 ± 0.0
Arg
2.422ArgAla: 2.422 ± 0.271
1.138ArgCys: 1.138 ± 0.151
2.591ArgAsp: 2.591 ± 0.288
2.01ArgGlu: 2.01 ± 0.226
2.277ArgPhe: 2.277 ± 0.253
1.453ArgGly: 1.453 ± 0.192
1.332ArgHis: 1.332 ± 0.198
3.124ArgIle: 3.124 ± 0.281
2.93ArgLys: 2.93 ± 0.348
4.214ArgLeu: 4.214 ± 0.357
0.969ArgMet: 0.969 ± 0.159
3.148ArgAsn: 3.148 ± 0.267
1.962ArgPro: 1.962 ± 0.243
2.204ArgGln: 2.204 ± 0.254
3.1ArgArg: 3.1 ± 0.454
3.27ArgSer: 3.27 ± 0.512
1.913ArgThr: 1.913 ± 0.195
2.616ArgVal: 2.616 ± 0.278
0.484ArgTrp: 0.484 ± 0.112
1.647ArgTyr: 1.647 ± 0.189
0.0ArgXaa: 0.0 ± 0.0
Ser
3.294SerAla: 3.294 ± 0.32
1.429SerCys: 1.429 ± 0.201
4.432SerAsp: 4.432 ± 0.35
3.536SerGlu: 3.536 ± 0.365
3.003SerPhe: 3.003 ± 0.26
2.398SerGly: 2.398 ± 0.294
1.09SerHis: 1.09 ± 0.175
3.609SerIle: 3.609 ± 0.291
4.045SerLys: 4.045 ± 0.33
6.055SerLeu: 6.055 ± 0.363
1.574SerMet: 1.574 ± 0.166
4.892SerAsn: 4.892 ± 0.339
2.422SerPro: 2.422 ± 0.323
1.865SerGln: 1.865 ± 0.198
2.906SerArg: 2.906 ± 0.398
4.844SerSer: 4.844 ± 0.491
4.214SerThr: 4.214 ± 0.342
4.916SerVal: 4.916 ± 0.31
0.363SerTrp: 0.363 ± 0.103
1.962SerTyr: 1.962 ± 0.215
0.0SerXaa: 0.0 ± 0.0
Thr
3.1ThrAla: 3.1 ± 0.26
1.163ThrCys: 1.163 ± 0.155
3.318ThrAsp: 3.318 ± 0.359
2.785ThrGlu: 2.785 ± 0.274
2.93ThrPhe: 2.93 ± 0.258
2.18ThrGly: 2.18 ± 0.248
1.138ThrHis: 1.138 ± 0.142
3.851ThrIle: 3.851 ± 0.293
3.221ThrLys: 3.221 ± 0.315
5.667ThrLeu: 5.667 ± 0.401
1.502ThrMet: 1.502 ± 0.21
4.263ThrAsn: 4.263 ± 0.365
2.93ThrPro: 2.93 ± 0.527
2.01ThrGln: 2.01 ± 0.234
2.882ThrArg: 2.882 ± 0.268
3.536ThrSer: 3.536 ± 0.341
3.705ThrThr: 3.705 ± 0.403
3.754ThrVal: 3.754 ± 0.331
0.388ThrTrp: 0.388 ± 0.102
2.301ThrTyr: 2.301 ± 0.251
0.0ThrXaa: 0.0 ± 0.0
Val
3.1ValAla: 3.1 ± 0.285
1.792ValCys: 1.792 ± 0.241
4.505ValAsp: 4.505 ± 0.384
3.221ValGlu: 3.221 ± 0.289
3.197ValPhe: 3.197 ± 0.253
1.816ValGly: 1.816 ± 0.205
1.356ValHis: 1.356 ± 0.19
3.996ValIle: 3.996 ± 0.321
4.747ValLys: 4.747 ± 0.326
6.37ValLeu: 6.37 ± 0.446
1.938ValMet: 1.938 ± 0.199
5.231ValAsn: 5.231 ± 0.361
2.882ValPro: 2.882 ± 0.295
2.543ValGln: 2.543 ± 0.252
2.446ValArg: 2.446 ± 0.248
3.802ValSer: 3.802 ± 0.336
3.366ValThr: 3.366 ± 0.286
4.529ValVal: 4.529 ± 0.345
0.436ValTrp: 0.436 ± 0.13
3.609ValTyr: 3.609 ± 0.317
0.0ValXaa: 0.0 ± 0.0
Trp
0.17TrpAla: 0.17 ± 0.076
0.17TrpCys: 0.17 ± 0.064
0.363TrpAsp: 0.363 ± 0.095
0.412TrpGlu: 0.412 ± 0.114
0.339TrpPhe: 0.339 ± 0.082
0.218TrpGly: 0.218 ± 0.071
0.291TrpHis: 0.291 ± 0.092
0.436TrpIle: 0.436 ± 0.103
0.775TrpLys: 0.775 ± 0.169
0.678TrpLeu: 0.678 ± 0.113
0.194TrpMet: 0.194 ± 0.08
0.678TrpAsn: 0.678 ± 0.16
0.388TrpPro: 0.388 ± 0.099
0.339TrpGln: 0.339 ± 0.098
0.46TrpArg: 0.46 ± 0.114
0.484TrpSer: 0.484 ± 0.117
0.581TrpThr: 0.581 ± 0.111
0.339TrpVal: 0.339 ± 0.099
0.097TrpTrp: 0.097 ± 0.046
0.291TrpTyr: 0.291 ± 0.081
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.398TyrAla: 2.398 ± 0.243
1.187TyrCys: 1.187 ± 0.157
2.858TyrAsp: 2.858 ± 0.315
2.228TyrGlu: 2.228 ± 0.232
2.64TyrPhe: 2.64 ± 0.258
1.55TyrGly: 1.55 ± 0.186
1.163TyrHis: 1.163 ± 0.145
2.882TyrIle: 2.882 ± 0.276
5.013TyrLys: 5.013 ± 0.365
4.141TyrLeu: 4.141 ± 0.358
1.744TyrMet: 1.744 ± 0.193
4.602TyrAsn: 4.602 ± 0.324
1.259TyrPro: 1.259 ± 0.181
1.429TyrGln: 1.429 ± 0.176
1.889TyrArg: 1.889 ± 0.256
2.688TyrSer: 2.688 ± 0.252
2.882TyrThr: 2.882 ± 0.239
3.972TyrVal: 3.972 ± 0.241
0.436TyrTrp: 0.436 ± 0.085
2.979TyrTyr: 2.979 ± 0.298
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 149 proteins (41291 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski