Amino acid dipepetide frequency for Dickeya phage Luksen

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.608AlaAla: 9.608 ± 1.208
0.697AlaCys: 0.697 ± 0.239
5.579AlaAsp: 5.579 ± 0.803
5.579AlaGlu: 5.579 ± 0.822
3.022AlaPhe: 3.022 ± 0.49
6.121AlaGly: 6.121 ± 0.841
1.627AlaHis: 1.627 ± 0.392
4.881AlaIle: 4.881 ± 0.525
6.199AlaLys: 6.199 ± 0.671
8.368AlaLeu: 8.368 ± 0.773
2.712AlaMet: 2.712 ± 0.478
4.107AlaAsn: 4.107 ± 0.613
2.944AlaPro: 2.944 ± 0.457
5.114AlaGln: 5.114 ± 0.78
5.036AlaArg: 5.036 ± 0.546
5.889AlaSer: 5.889 ± 0.85
4.029AlaThr: 4.029 ± 0.582
6.819AlaVal: 6.819 ± 0.705
0.93AlaTrp: 0.93 ± 0.279
2.479AlaTyr: 2.479 ± 0.547
0.0AlaXaa: 0.0 ± 0.0
Cys
1.24CysAla: 1.24 ± 0.302
0.077CysCys: 0.077 ± 0.083
1.007CysAsp: 1.007 ± 0.3
0.93CysGlu: 0.93 ± 0.269
0.465CysPhe: 0.465 ± 0.205
0.697CysGly: 0.697 ± 0.251
0.465CysHis: 0.465 ± 0.181
0.387CysIle: 0.387 ± 0.176
0.31CysLys: 0.31 ± 0.134
0.697CysLeu: 0.697 ± 0.272
0.077CysMet: 0.077 ± 0.079
0.31CysAsn: 0.31 ± 0.164
0.465CysPro: 0.465 ± 0.22
0.465CysGln: 0.465 ± 0.247
0.387CysArg: 0.387 ± 0.164
0.465CysSer: 0.465 ± 0.241
0.31CysThr: 0.31 ± 0.197
0.62CysVal: 0.62 ± 0.23
0.465CysTrp: 0.465 ± 0.205
0.232CysTyr: 0.232 ± 0.153
0.0CysXaa: 0.0 ± 0.0
Asp
6.819AspAla: 6.819 ± 0.771
0.62AspCys: 0.62 ± 0.306
3.177AspAsp: 3.177 ± 0.543
3.487AspGlu: 3.487 ± 0.531
2.944AspPhe: 2.944 ± 0.441
6.431AspGly: 6.431 ± 0.661
1.24AspHis: 1.24 ± 0.329
3.409AspIle: 3.409 ± 0.448
3.487AspLys: 3.487 ± 0.452
4.262AspLeu: 4.262 ± 0.566
1.472AspMet: 1.472 ± 0.281
1.937AspAsn: 1.937 ± 0.335
2.712AspPro: 2.712 ± 0.39
2.325AspGln: 2.325 ± 0.63
2.634AspArg: 2.634 ± 0.54
3.487AspSer: 3.487 ± 0.413
3.177AspThr: 3.177 ± 0.354
4.649AspVal: 4.649 ± 0.745
0.62AspTrp: 0.62 ± 0.181
2.092AspTyr: 2.092 ± 0.417
0.0AspXaa: 0.0 ± 0.0
Glu
8.213GluAla: 8.213 ± 0.995
0.697GluCys: 0.697 ± 0.271
3.719GluAsp: 3.719 ± 0.605
5.269GluGlu: 5.269 ± 0.938
3.797GluPhe: 3.797 ± 0.518
4.339GluGly: 4.339 ± 0.659
1.24GluHis: 1.24 ± 0.235
3.719GluIle: 3.719 ± 0.555
2.634GluLys: 2.634 ± 0.577
4.959GluLeu: 4.959 ± 0.6
2.092GluMet: 2.092 ± 0.44
3.099GluAsn: 3.099 ± 0.449
1.782GluPro: 1.782 ± 0.455
3.719GluGln: 3.719 ± 0.538
3.719GluArg: 3.719 ± 0.557
3.642GluSer: 3.642 ± 0.66
2.944GluThr: 2.944 ± 0.38
3.874GluVal: 3.874 ± 0.557
0.93GluTrp: 0.93 ± 0.283
2.402GluTyr: 2.402 ± 0.453
0.0GluXaa: 0.0 ± 0.0
Phe
2.634PheAla: 2.634 ± 0.48
0.387PheCys: 0.387 ± 0.211
2.867PheAsp: 2.867 ± 0.469
2.092PheGlu: 2.092 ± 0.451
1.55PhePhe: 1.55 ± 0.402
3.332PheGly: 3.332 ± 0.587
0.62PheHis: 0.62 ± 0.189
2.789PheIle: 2.789 ± 0.52
2.712PheLys: 2.712 ± 0.502
3.487PheLeu: 3.487 ± 0.473
1.317PheMet: 1.317 ± 0.308
2.247PheAsn: 2.247 ± 0.389
1.86PhePro: 1.86 ± 0.454
1.472PheGln: 1.472 ± 0.361
1.24PheArg: 1.24 ± 0.336
2.634PheSer: 2.634 ± 0.504
3.332PheThr: 3.332 ± 0.449
2.247PheVal: 2.247 ± 0.349
0.465PheTrp: 0.465 ± 0.158
0.775PheTyr: 0.775 ± 0.245
0.0PheXaa: 0.0 ± 0.0
Gly
6.276GlyAla: 6.276 ± 0.848
1.085GlyCys: 1.085 ± 0.29
5.036GlyAsp: 5.036 ± 0.639
4.649GlyGlu: 4.649 ± 0.751
3.177GlyPhe: 3.177 ± 0.558
5.191GlyGly: 5.191 ± 0.626
1.317GlyHis: 1.317 ± 0.397
3.952GlyIle: 3.952 ± 0.481
6.121GlyLys: 6.121 ± 1.029
6.044GlyLeu: 6.044 ± 0.747
1.705GlyMet: 1.705 ± 0.4
3.719GlyAsn: 3.719 ± 0.795
1.782GlyPro: 1.782 ± 0.363
2.557GlyGln: 2.557 ± 0.626
3.719GlyArg: 3.719 ± 0.625
5.501GlySer: 5.501 ± 0.648
4.184GlyThr: 4.184 ± 0.736
4.184GlyVal: 4.184 ± 0.723
1.24GlyTrp: 1.24 ± 0.374
2.479GlyTyr: 2.479 ± 0.404
0.0GlyXaa: 0.0 ± 0.0
His
0.62HisAla: 0.62 ± 0.202
0.62HisCys: 0.62 ± 0.22
1.007HisAsp: 1.007 ± 0.292
2.015HisGlu: 2.015 ± 0.439
0.775HisPhe: 0.775 ± 0.276
1.472HisGly: 1.472 ± 0.365
0.542HisHis: 0.542 ± 0.243
0.852HisIle: 0.852 ± 0.306
1.007HisLys: 1.007 ± 0.242
1.937HisLeu: 1.937 ± 0.479
0.465HisMet: 0.465 ± 0.153
1.007HisAsn: 1.007 ± 0.265
0.387HisPro: 0.387 ± 0.23
0.697HisGln: 0.697 ± 0.208
0.387HisArg: 0.387 ± 0.197
1.782HisSer: 1.782 ± 0.531
0.775HisThr: 0.775 ± 0.256
1.317HisVal: 1.317 ± 0.357
0.542HisTrp: 0.542 ± 0.196
0.62HisTyr: 0.62 ± 0.21
0.0HisXaa: 0.0 ± 0.0
Ile
4.959IleAla: 4.959 ± 0.585
0.465IleCys: 0.465 ± 0.248
3.332IleAsp: 3.332 ± 0.564
3.177IleGlu: 3.177 ± 0.572
1.317IlePhe: 1.317 ± 0.32
2.944IleGly: 2.944 ± 0.468
1.162IleHis: 1.162 ± 0.276
3.487IleIle: 3.487 ± 0.617
4.029IleLys: 4.029 ± 0.743
4.417IleLeu: 4.417 ± 0.608
1.705IleMet: 1.705 ± 0.396
2.402IleAsn: 2.402 ± 0.585
2.247IlePro: 2.247 ± 0.446
2.247IleGln: 2.247 ± 0.319
3.952IleArg: 3.952 ± 0.592
2.712IleSer: 2.712 ± 0.354
2.557IleThr: 2.557 ± 0.512
3.177IleVal: 3.177 ± 0.436
0.465IleTrp: 0.465 ± 0.184
2.092IleTyr: 2.092 ± 0.386
0.0IleXaa: 0.0 ± 0.0
Lys
7.826LysAla: 7.826 ± 0.974
0.31LysCys: 0.31 ± 0.182
3.874LysAsp: 3.874 ± 0.515
5.036LysGlu: 5.036 ± 0.604
2.479LysPhe: 2.479 ± 0.44
4.572LysGly: 4.572 ± 0.62
1.085LysHis: 1.085 ± 0.245
2.634LysIle: 2.634 ± 0.514
3.564LysLys: 3.564 ± 0.646
4.804LysLeu: 4.804 ± 0.565
2.325LysMet: 2.325 ± 0.401
2.867LysAsn: 2.867 ± 0.599
2.325LysPro: 2.325 ± 0.492
2.557LysGln: 2.557 ± 0.467
3.797LysArg: 3.797 ± 0.565
4.881LysSer: 4.881 ± 0.701
4.726LysThr: 4.726 ± 0.568
3.952LysVal: 3.952 ± 0.55
0.465LysTrp: 0.465 ± 0.15
2.325LysTyr: 2.325 ± 0.378
0.0LysXaa: 0.0 ± 0.0
Leu
6.431LeuAla: 6.431 ± 0.724
0.852LeuCys: 0.852 ± 0.371
5.269LeuAsp: 5.269 ± 0.612
5.966LeuGlu: 5.966 ± 0.73
2.479LeuPhe: 2.479 ± 0.527
5.579LeuGly: 5.579 ± 0.756
1.472LeuHis: 1.472 ± 0.389
3.874LeuIle: 3.874 ± 0.622
8.756LeuLys: 8.756 ± 0.875
4.804LeuLeu: 4.804 ± 0.672
2.634LeuMet: 2.634 ± 0.43
4.184LeuAsn: 4.184 ± 0.473
3.099LeuPro: 3.099 ± 0.557
3.332LeuGln: 3.332 ± 0.646
4.494LeuArg: 4.494 ± 0.494
5.656LeuSer: 5.656 ± 0.845
3.797LeuThr: 3.797 ± 0.604
4.107LeuVal: 4.107 ± 0.514
0.852LeuTrp: 0.852 ± 0.293
2.247LeuTyr: 2.247 ± 0.428
0.0LeuXaa: 0.0 ± 0.0
Met
3.099MetAla: 3.099 ± 0.412
0.232MetCys: 0.232 ± 0.136
1.86MetAsp: 1.86 ± 0.376
1.627MetGlu: 1.627 ± 0.476
1.472MetPhe: 1.472 ± 0.298
2.247MetGly: 2.247 ± 0.594
0.465MetHis: 0.465 ± 0.208
1.395MetIle: 1.395 ± 0.277
1.782MetLys: 1.782 ± 0.366
2.634MetLeu: 2.634 ± 0.436
0.62MetMet: 0.62 ± 0.277
1.395MetAsn: 1.395 ± 0.249
1.472MetPro: 1.472 ± 0.247
0.775MetGln: 0.775 ± 0.192
1.395MetArg: 1.395 ± 0.32
2.634MetSer: 2.634 ± 0.528
1.472MetThr: 1.472 ± 0.303
2.634MetVal: 2.634 ± 0.369
0.155MetTrp: 0.155 ± 0.111
0.542MetTyr: 0.542 ± 0.187
0.0MetXaa: 0.0 ± 0.0
Asn
3.642AsnAla: 3.642 ± 0.526
0.542AsnCys: 0.542 ± 0.173
2.325AsnAsp: 2.325 ± 0.378
2.789AsnGlu: 2.789 ± 0.383
2.325AsnPhe: 2.325 ± 0.363
4.029AsnGly: 4.029 ± 0.633
0.697AsnHis: 0.697 ± 0.233
2.092AsnIle: 2.092 ± 0.299
2.712AsnLys: 2.712 ± 0.478
3.642AsnLeu: 3.642 ± 0.457
1.705AsnMet: 1.705 ± 0.365
2.247AsnAsn: 2.247 ± 0.445
2.867AsnPro: 2.867 ± 0.473
1.782AsnGln: 1.782 ± 0.475
2.402AsnArg: 2.402 ± 0.502
2.479AsnSer: 2.479 ± 0.436
2.247AsnThr: 2.247 ± 0.441
3.332AsnVal: 3.332 ± 0.437
1.162AsnTrp: 1.162 ± 0.415
1.86AsnTyr: 1.86 ± 0.514
0.0AsnXaa: 0.0 ± 0.0
Pro
3.487ProAla: 3.487 ± 0.618
0.465ProCys: 0.465 ± 0.189
2.402ProAsp: 2.402 ± 0.302
4.262ProGlu: 4.262 ± 0.687
1.395ProPhe: 1.395 ± 0.373
1.55ProGly: 1.55 ± 0.333
0.775ProHis: 0.775 ± 0.226
1.782ProIle: 1.782 ± 0.329
2.479ProLys: 2.479 ± 0.514
2.325ProLeu: 2.325 ± 0.415
1.162ProMet: 1.162 ± 0.337
2.325ProAsn: 2.325 ± 0.37
0.852ProPro: 0.852 ± 0.266
1.705ProGln: 1.705 ± 0.383
1.472ProArg: 1.472 ± 0.28
2.092ProSer: 2.092 ± 0.46
2.015ProThr: 2.015 ± 0.34
3.409ProVal: 3.409 ± 0.422
0.62ProTrp: 0.62 ± 0.191
1.24ProTyr: 1.24 ± 0.338
0.0ProXaa: 0.0 ± 0.0
Gln
4.029GlnAla: 4.029 ± 0.663
0.387GlnCys: 0.387 ± 0.171
2.247GlnAsp: 2.247 ± 0.45
2.712GlnGlu: 2.712 ± 0.543
2.015GlnPhe: 2.015 ± 0.344
2.557GlnGly: 2.557 ± 0.38
0.542GlnHis: 0.542 ± 0.239
2.402GlnIle: 2.402 ± 0.434
2.557GlnLys: 2.557 ± 0.563
4.262GlnLeu: 4.262 ± 0.493
1.317GlnMet: 1.317 ± 0.29
1.937GlnAsn: 1.937 ± 0.428
1.472GlnPro: 1.472 ± 0.302
1.782GlnGln: 1.782 ± 0.357
2.17GlnArg: 2.17 ± 0.355
2.789GlnSer: 2.789 ± 0.482
2.247GlnThr: 2.247 ± 0.481
3.409GlnVal: 3.409 ± 0.687
0.93GlnTrp: 0.93 ± 0.299
0.542GlnTyr: 0.542 ± 0.174
0.0GlnXaa: 0.0 ± 0.0
Arg
4.029ArgAla: 4.029 ± 0.723
0.542ArgCys: 0.542 ± 0.193
3.409ArgAsp: 3.409 ± 0.494
4.029ArgGlu: 4.029 ± 0.649
2.402ArgPhe: 2.402 ± 0.436
3.177ArgGly: 3.177 ± 0.51
1.162ArgHis: 1.162 ± 0.381
2.789ArgIle: 2.789 ± 0.358
3.487ArgLys: 3.487 ± 0.543
4.107ArgLeu: 4.107 ± 0.583
1.55ArgMet: 1.55 ± 0.402
2.247ArgAsn: 2.247 ± 0.312
2.247ArgPro: 2.247 ± 0.452
2.479ArgGln: 2.479 ± 0.438
2.325ArgArg: 2.325 ± 0.425
2.712ArgSer: 2.712 ± 0.384
2.944ArgThr: 2.944 ± 0.439
3.409ArgVal: 3.409 ± 0.64
0.465ArgTrp: 0.465 ± 0.209
1.627ArgTyr: 1.627 ± 0.414
0.0ArgXaa: 0.0 ± 0.0
Ser
5.579SerAla: 5.579 ± 1.091
0.775SerCys: 0.775 ± 0.257
4.107SerAsp: 4.107 ± 0.692
4.184SerGlu: 4.184 ± 0.597
3.254SerPhe: 3.254 ± 0.496
6.431SerGly: 6.431 ± 0.722
1.317SerHis: 1.317 ± 0.323
2.402SerIle: 2.402 ± 0.397
3.487SerLys: 3.487 ± 0.543
5.114SerLeu: 5.114 ± 0.576
1.86SerMet: 1.86 ± 0.324
2.634SerAsn: 2.634 ± 0.475
2.634SerPro: 2.634 ± 0.638
2.712SerGln: 2.712 ± 0.486
3.099SerArg: 3.099 ± 0.466
4.184SerSer: 4.184 ± 0.628
2.402SerThr: 2.402 ± 0.482
3.797SerVal: 3.797 ± 0.529
1.55SerTrp: 1.55 ± 0.352
2.402SerTyr: 2.402 ± 0.413
0.0SerXaa: 0.0 ± 0.0
Thr
3.952ThrAla: 3.952 ± 0.567
0.31ThrCys: 0.31 ± 0.141
3.099ThrAsp: 3.099 ± 0.451
3.409ThrGlu: 3.409 ± 0.5
2.015ThrPhe: 2.015 ± 0.419
5.269ThrGly: 5.269 ± 0.532
0.852ThrHis: 0.852 ± 0.258
4.184ThrIle: 4.184 ± 0.663
3.254ThrLys: 3.254 ± 0.533
4.881ThrLeu: 4.881 ± 0.682
1.86ThrMet: 1.86 ± 0.355
2.325ThrAsn: 2.325 ± 0.372
2.402ThrPro: 2.402 ± 0.392
1.937ThrGln: 1.937 ± 0.375
1.627ThrArg: 1.627 ± 0.336
2.634ThrSer: 2.634 ± 0.42
3.332ThrThr: 3.332 ± 0.522
4.649ThrVal: 4.649 ± 0.535
0.62ThrTrp: 0.62 ± 0.211
1.317ThrTyr: 1.317 ± 0.293
0.0ThrXaa: 0.0 ± 0.0
Val
5.269ValAla: 5.269 ± 0.662
0.465ValCys: 0.465 ± 0.184
3.487ValAsp: 3.487 ± 0.424
3.177ValGlu: 3.177 ± 0.414
1.86ValPhe: 1.86 ± 0.323
5.191ValGly: 5.191 ± 0.634
0.93ValHis: 0.93 ± 0.248
3.874ValIle: 3.874 ± 0.627
4.959ValLys: 4.959 ± 0.611
5.501ValLeu: 5.501 ± 0.587
1.705ValMet: 1.705 ± 0.487
3.642ValAsn: 3.642 ± 0.493
3.022ValPro: 3.022 ± 0.444
2.789ValGln: 2.789 ± 0.512
4.107ValArg: 4.107 ± 0.515
4.881ValSer: 4.881 ± 0.556
5.036ValThr: 5.036 ± 0.73
5.114ValVal: 5.114 ± 0.928
1.162ValTrp: 1.162 ± 0.3
1.937ValTyr: 1.937 ± 0.365
0.0ValXaa: 0.0 ± 0.0
Trp
1.085TrpAla: 1.085 ± 0.262
0.387TrpCys: 0.387 ± 0.162
1.162TrpAsp: 1.162 ± 0.274
0.542TrpGlu: 0.542 ± 0.194
0.465TrpPhe: 0.465 ± 0.191
0.465TrpGly: 0.465 ± 0.247
0.465TrpHis: 0.465 ± 0.225
0.775TrpIle: 0.775 ± 0.267
1.085TrpLys: 1.085 ± 0.301
1.085TrpLeu: 1.085 ± 0.237
0.775TrpMet: 0.775 ± 0.214
0.62TrpAsn: 0.62 ± 0.171
0.31TrpPro: 0.31 ± 0.148
0.387TrpGln: 0.387 ± 0.181
1.085TrpArg: 1.085 ± 0.298
1.162TrpSer: 1.162 ± 0.344
0.697TrpThr: 0.697 ± 0.27
1.162TrpVal: 1.162 ± 0.365
0.31TrpTrp: 0.31 ± 0.13
0.232TrpTyr: 0.232 ± 0.168
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.944TyrAla: 2.944 ± 0.485
0.155TyrCys: 0.155 ± 0.169
2.015TyrAsp: 2.015 ± 0.399
1.86TyrGlu: 1.86 ± 0.347
0.852TyrPhe: 0.852 ± 0.239
2.325TyrGly: 2.325 ± 0.415
0.852TyrHis: 0.852 ± 0.277
1.162TyrIle: 1.162 ± 0.418
1.782TyrLys: 1.782 ± 0.294
2.557TyrLeu: 2.557 ± 0.483
0.775TyrMet: 0.775 ± 0.238
1.627TyrAsn: 1.627 ± 0.309
1.007TyrPro: 1.007 ± 0.31
1.472TyrGln: 1.472 ± 0.315
2.092TyrArg: 2.092 ± 0.55
1.705TyrSer: 1.705 ± 0.386
1.705TyrThr: 1.705 ± 0.373
2.247TyrVal: 2.247 ± 0.414
0.31TyrTrp: 0.31 ± 0.172
0.775TyrTyr: 0.775 ± 0.298
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 53 proteins (12907 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski