Amino acid dipepetide frequency for Lactococcus termiticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.378AlaAla: 6.378 ± 0.173
0.44AlaCys: 0.44 ± 0.027
5.025AlaAsp: 5.025 ± 0.096
6.731AlaGlu: 6.731 ± 0.154
3.91AlaPhe: 3.91 ± 0.095
7.287AlaGly: 7.287 ± 0.144
1.343AlaHis: 1.343 ± 0.055
6.156AlaIle: 6.156 ± 0.12
5.817AlaLys: 5.817 ± 0.137
8.463AlaLeu: 8.463 ± 0.145
2.406AlaMet: 2.406 ± 0.063
3.246AlaAsn: 3.246 ± 0.088
2.452AlaPro: 2.452 ± 0.079
3.375AlaGln: 3.375 ± 0.096
3.257AlaArg: 3.257 ± 0.09
6.384AlaSer: 6.384 ± 0.2
4.597AlaThr: 4.597 ± 0.133
6.321AlaVal: 6.321 ± 0.133
0.879AlaTrp: 0.879 ± 0.043
2.942AlaTyr: 2.942 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.288CysAla: 0.288 ± 0.025
0.058CysCys: 0.058 ± 0.014
0.242CysAsp: 0.242 ± 0.023
0.284CysGlu: 0.284 ± 0.028
0.192CysPhe: 0.192 ± 0.021
0.403CysGly: 0.403 ± 0.032
0.103CysHis: 0.103 ± 0.016
0.244CysIle: 0.244 ± 0.021
0.167CysLys: 0.167 ± 0.019
0.436CysLeu: 0.436 ± 0.03
0.077CysMet: 0.077 ± 0.014
0.143CysAsn: 0.143 ± 0.018
0.232CysPro: 0.232 ± 0.025
0.198CysGln: 0.198 ± 0.022
0.163CysArg: 0.163 ± 0.02
0.276CysSer: 0.276 ± 0.027
0.165CysThr: 0.165 ± 0.02
0.272CysVal: 0.272 ± 0.03
0.046CysTrp: 0.046 ± 0.009
0.157CysTyr: 0.157 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.097AspAla: 4.097 ± 0.1
0.272AspCys: 0.272 ± 0.021
2.926AspAsp: 2.926 ± 0.088
4.825AspGlu: 4.825 ± 0.119
3.759AspPhe: 3.759 ± 0.114
3.876AspGly: 3.876 ± 0.101
0.964AspHis: 0.964 ± 0.048
3.622AspIle: 3.622 ± 0.096
3.906AspLys: 3.906 ± 0.1
5.448AspLeu: 5.448 ± 0.108
1.48AspMet: 1.48 ± 0.057
2.313AspAsn: 2.313 ± 0.073
1.688AspPro: 1.688 ± 0.059
1.966AspGln: 1.966 ± 0.072
2.22AspArg: 2.22 ± 0.076
3.712AspSer: 3.712 ± 0.217
2.295AspThr: 2.295 ± 0.07
3.579AspVal: 3.579 ± 0.095
0.853AspTrp: 0.853 ± 0.049
2.692AspTyr: 2.692 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
7.509GluAla: 7.509 ± 0.176
0.173GluCys: 0.173 ± 0.021
3.66GluAsp: 3.66 ± 0.101
5.799GluGlu: 5.799 ± 0.155
2.268GluPhe: 2.268 ± 0.083
4.087GluGly: 4.087 ± 0.105
1.323GluHis: 1.323 ± 0.053
5.245GluIle: 5.245 ± 0.135
5.656GluLys: 5.656 ± 0.115
7.842GluLeu: 7.842 ± 0.187
1.978GluMet: 1.978 ± 0.075
3.482GluAsn: 3.482 ± 0.09
1.847GluPro: 1.847 ± 0.077
2.811GluGln: 2.811 ± 0.084
3.307GluArg: 3.307 ± 0.102
3.958GluSer: 3.958 ± 0.196
3.311GluThr: 3.311 ± 0.083
5.063GluVal: 5.063 ± 0.123
0.464GluTrp: 0.464 ± 0.031
1.633GluTyr: 1.633 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.628PheAla: 3.628 ± 0.083
0.192PheCys: 0.192 ± 0.022
3.25PheAsp: 3.25 ± 0.094
3.404PheGlu: 3.404 ± 0.092
2.143PhePhe: 2.143 ± 0.087
3.331PheGly: 3.331 ± 0.091
0.794PheHis: 0.794 ± 0.041
3.263PheIle: 3.263 ± 0.083
2.313PheLys: 2.313 ± 0.067
4.491PheLeu: 4.491 ± 0.117
1.107PheMet: 1.107 ± 0.044
1.918PheAsn: 1.918 ± 0.055
1.565PhePro: 1.565 ± 0.061
1.444PheGln: 1.444 ± 0.053
1.534PheArg: 1.534 ± 0.064
3.222PheSer: 3.222 ± 0.097
2.266PheThr: 2.266 ± 0.074
3.067PheVal: 3.067 ± 0.076
0.565PheTrp: 0.565 ± 0.035
1.647PheTyr: 1.647 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
5.297GlyAla: 5.297 ± 0.128
0.347GlyCys: 0.347 ± 0.028
3.424GlyAsp: 3.424 ± 0.088
4.065GlyGlu: 4.065 ± 0.101
3.573GlyPhe: 3.573 ± 0.094
4.595GlyGly: 4.595 ± 0.125
1.44GlyHis: 1.44 ± 0.059
5.182GlyIle: 5.182 ± 0.113
4.716GlyLys: 4.716 ± 0.094
7.935GlyLeu: 7.935 ± 0.156
1.944GlyMet: 1.944 ± 0.06
2.843GlyAsn: 2.843 ± 0.083
1.647GlyPro: 1.647 ± 0.055
3.152GlyGln: 3.152 ± 0.082
3.041GlyArg: 3.041 ± 0.084
4.277GlySer: 4.277 ± 0.127
3.809GlyThr: 3.809 ± 0.115
4.559GlyVal: 4.559 ± 0.104
0.794GlyTrp: 0.794 ± 0.047
2.494GlyTyr: 2.494 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.291HisAla: 1.291 ± 0.052
0.131HisCys: 0.131 ± 0.016
1.006HisAsp: 1.006 ± 0.05
1.186HisGlu: 1.186 ± 0.05
1.036HisPhe: 1.036 ± 0.048
1.331HisGly: 1.331 ± 0.053
0.393HisHis: 0.393 ± 0.027
1.151HisIle: 1.151 ± 0.05
0.954HisLys: 0.954 ± 0.044
1.891HisLeu: 1.891 ± 0.064
0.43HisMet: 0.43 ± 0.031
0.637HisAsn: 0.637 ± 0.037
0.98HisPro: 0.98 ± 0.049
0.758HisGln: 0.758 ± 0.037
0.784HisArg: 0.784 ± 0.039
1.002HisSer: 1.002 ± 0.041
0.76HisThr: 0.76 ± 0.047
1.075HisVal: 1.075 ± 0.047
0.206HisTrp: 0.206 ± 0.022
0.843HisTyr: 0.843 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
6.563IleAla: 6.563 ± 0.128
0.343IleCys: 0.343 ± 0.026
4.232IleAsp: 4.232 ± 0.105
4.418IleGlu: 4.418 ± 0.108
3.418IlePhe: 3.418 ± 0.093
4.975IleGly: 4.975 ± 0.112
1.204IleHis: 1.204 ± 0.049
4.843IleIle: 4.843 ± 0.125
4.263IleLys: 4.263 ± 0.104
6.941IleLeu: 6.941 ± 0.144
1.672IleMet: 1.672 ± 0.054
2.843IleAsn: 2.843 ± 0.068
2.787IlePro: 2.787 ± 0.078
2.42IleGln: 2.42 ± 0.068
2.569IleArg: 2.569 ± 0.075
4.886IleSer: 4.886 ± 0.139
3.375IleThr: 3.375 ± 0.092
4.616IleVal: 4.616 ± 0.1
0.561IleTrp: 0.561 ± 0.035
2.202IleTyr: 2.202 ± 0.065
0.0IleXaa: 0.0 ± 0.0
Lys
6.622LysAla: 6.622 ± 0.137
0.149LysCys: 0.149 ± 0.016
3.462LysAsp: 3.462 ± 0.091
4.827LysGlu: 4.827 ± 0.113
2.16LysPhe: 2.16 ± 0.071
3.557LysGly: 3.557 ± 0.1
1.097LysHis: 1.097 ± 0.049
4.791LysIle: 4.791 ± 0.105
5.341LysLys: 5.341 ± 0.121
6.301LysLeu: 6.301 ± 0.13
2.026LysMet: 2.026 ± 0.054
3.254LysAsn: 3.254 ± 0.087
2.218LysPro: 2.218 ± 0.074
2.474LysGln: 2.474 ± 0.077
2.829LysArg: 2.829 ± 0.076
4.176LysSer: 4.176 ± 0.123
3.805LysThr: 3.805 ± 0.085
4.101LysVal: 4.101 ± 0.097
0.516LysTrp: 0.516 ± 0.029
1.912LysTyr: 1.912 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
9.766LeuAla: 9.766 ± 0.156
0.361LeuCys: 0.361 ± 0.028
6.15LeuAsp: 6.15 ± 0.131
6.969LeuGlu: 6.969 ± 0.171
4.172LeuPhe: 4.172 ± 0.118
6.699LeuGly: 6.699 ± 0.139
1.559LeuHis: 1.559 ± 0.057
7.187LeuIle: 7.187 ± 0.152
6.303LeuLys: 6.303 ± 0.14
10.37LeuLeu: 10.37 ± 0.254
2.825LeuMet: 2.825 ± 0.084
3.763LeuAsn: 3.763 ± 0.085
4.245LeuPro: 4.245 ± 0.096
3.19LeuGln: 3.19 ± 0.089
3.785LeuArg: 3.785 ± 0.101
8.296LeuSer: 8.296 ± 0.251
6.126LeuThr: 6.126 ± 0.109
6.842LeuVal: 6.842 ± 0.142
0.827LeuTrp: 0.827 ± 0.044
3.099LeuTyr: 3.099 ± 0.094
0.0LeuXaa: 0.0 ± 0.0
Met
2.583MetAla: 2.583 ± 0.076
0.071MetCys: 0.071 ± 0.013
1.381MetAsp: 1.381 ± 0.059
1.603MetGlu: 1.603 ± 0.063
0.811MetPhe: 0.811 ± 0.04
1.698MetGly: 1.698 ± 0.06
0.407MetHis: 0.407 ± 0.031
1.879MetIle: 1.879 ± 0.065
2.053MetLys: 2.053 ± 0.067
2.472MetLeu: 2.472 ± 0.07
0.831MetMet: 0.831 ± 0.05
1.347MetAsn: 1.347 ± 0.049
1.075MetPro: 1.075 ± 0.043
0.924MetGln: 0.924 ± 0.035
1.036MetArg: 1.036 ± 0.047
1.829MetSer: 1.829 ± 0.063
2.093MetThr: 2.093 ± 0.064
1.643MetVal: 1.643 ± 0.061
0.127MetTrp: 0.127 ± 0.014
0.486MetTyr: 0.486 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.39AsnAla: 3.39 ± 0.084
0.222AsnCys: 0.222 ± 0.022
2.087AsnAsp: 2.087 ± 0.07
2.529AsnGlu: 2.529 ± 0.089
2.19AsnPhe: 2.19 ± 0.08
3.033AsnGly: 3.033 ± 0.081
0.801AsnHis: 0.801 ± 0.048
3.168AsnIle: 3.168 ± 0.082
2.488AsnLys: 2.488 ± 0.071
3.908AsnLeu: 3.908 ± 0.078
1.107AsnMet: 1.107 ± 0.044
1.793AsnAsn: 1.793 ± 0.078
2.363AsnPro: 2.363 ± 0.068
1.845AsnGln: 1.845 ± 0.074
1.704AsnArg: 1.704 ± 0.064
2.611AsnSer: 2.611 ± 0.11
2.041AsnThr: 2.041 ± 0.076
2.714AsnVal: 2.714 ± 0.084
0.546AsnTrp: 0.546 ± 0.036
1.639AsnTyr: 1.639 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
3.19ProAla: 3.19 ± 0.094
0.131ProCys: 0.131 ± 0.017
2.281ProAsp: 2.281 ± 0.064
3.515ProGlu: 3.515 ± 0.105
1.674ProPhe: 1.674 ± 0.061
2.371ProGly: 2.371 ± 0.064
0.635ProHis: 0.635 ± 0.039
2.115ProIle: 2.115 ± 0.058
2.085ProLys: 2.085 ± 0.066
3.061ProLeu: 3.061 ± 0.086
0.833ProMet: 0.833 ± 0.042
1.484ProAsn: 1.484 ± 0.056
0.55ProPro: 0.55 ± 0.036
1.135ProGln: 1.135 ± 0.05
1.141ProArg: 1.141 ± 0.05
2.268ProSer: 2.268 ± 0.08
2.071ProThr: 2.071 ± 0.073
2.611ProVal: 2.611 ± 0.079
0.381ProTrp: 0.381 ± 0.026
1.25ProTyr: 1.25 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
4.146GlnAla: 4.146 ± 0.111
0.075GlnCys: 0.075 ± 0.012
1.829GlnAsp: 1.829 ± 0.067
2.95GlnGlu: 2.95 ± 0.092
1.401GlnPhe: 1.401 ± 0.053
2.389GlnGly: 2.389 ± 0.071
0.684GlnHis: 0.684 ± 0.04
2.523GlnIle: 2.523 ± 0.077
2.758GlnLys: 2.758 ± 0.088
3.96GlnLeu: 3.96 ± 0.097
1.024GlnMet: 1.024 ± 0.042
1.615GlnAsn: 1.615 ± 0.062
1.315GlnPro: 1.315 ± 0.057
1.444GlnGln: 1.444 ± 0.065
1.369GlnArg: 1.369 ± 0.059
2.25GlnSer: 2.25 ± 0.114
2.055GlnThr: 2.055 ± 0.075
2.74GlnVal: 2.74 ± 0.074
0.294GlnTrp: 0.294 ± 0.027
1.063GlnTyr: 1.063 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
3.055ArgAla: 3.055 ± 0.073
0.139ArgCys: 0.139 ± 0.018
2.252ArgAsp: 2.252 ± 0.07
3.039ArgGlu: 3.039 ± 0.099
1.873ArgPhe: 1.873 ± 0.07
2.525ArgGly: 2.525 ± 0.094
0.847ArgHis: 0.847 ± 0.039
2.549ArgIle: 2.549 ± 0.08
2.756ArgLys: 2.756 ± 0.078
4.704ArgLeu: 4.704 ± 0.128
1.103ArgMet: 1.103 ± 0.048
1.593ArgAsn: 1.593 ± 0.063
1.464ArgPro: 1.464 ± 0.064
1.742ArgGln: 1.742 ± 0.068
2.123ArgArg: 2.123 ± 0.081
2.037ArgSer: 2.037 ± 0.071
1.819ArgThr: 1.819 ± 0.061
2.547ArgVal: 2.547 ± 0.081
0.343ArgTrp: 0.343 ± 0.026
1.286ArgTyr: 1.286 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
4.761SerAla: 4.761 ± 0.165
0.262SerCys: 0.262 ± 0.031
3.823SerAsp: 3.823 ± 0.135
4.549SerGlu: 4.549 ± 0.224
3.252SerPhe: 3.252 ± 0.095
5.035SerGly: 5.035 ± 0.117
1.373SerHis: 1.373 ± 0.056
4.317SerIle: 4.317 ± 0.117
4.033SerLys: 4.033 ± 0.119
7.929SerLeu: 7.929 ± 0.242
1.526SerMet: 1.526 ± 0.055
2.867SerAsn: 2.867 ± 0.117
2.174SerPro: 2.174 ± 0.072
2.956SerGln: 2.956 ± 0.125
2.714SerArg: 2.714 ± 0.074
5.144SerSer: 5.144 ± 0.311
3.44SerThr: 3.44 ± 0.199
3.813SerVal: 3.813 ± 0.105
0.792SerTrp: 0.792 ± 0.044
2.406SerTyr: 2.406 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
5.341ThrAla: 5.341 ± 0.121
0.2ThrCys: 0.2 ± 0.024
3.125ThrAsp: 3.125 ± 0.083
3.48ThrGlu: 3.48 ± 0.102
2.206ThrPhe: 2.206 ± 0.071
4.636ThrGly: 4.636 ± 0.139
0.833ThrHis: 0.833 ± 0.035
3.621ThrIle: 3.621 ± 0.091
2.906ThrLys: 2.906 ± 0.079
4.759ThrLeu: 4.759 ± 0.097
1.182ThrMet: 1.182 ± 0.045
2.022ThrAsn: 2.022 ± 0.086
2.248ThrPro: 2.248 ± 0.068
1.686ThrGln: 1.686 ± 0.068
1.795ThrArg: 1.795 ± 0.061
3.773ThrSer: 3.773 ± 0.153
3.246ThrThr: 3.246 ± 0.129
4.005ThrVal: 4.005 ± 0.106
0.421ThrTrp: 0.421 ± 0.03
1.831ThrTyr: 1.831 ± 0.064
0.0ThrXaa: 0.0 ± 0.0
Val
6.096ValAla: 6.096 ± 0.127
0.367ValCys: 0.367 ± 0.031
3.857ValAsp: 3.857 ± 0.106
4.416ValGlu: 4.416 ± 0.112
2.894ValPhe: 2.894 ± 0.078
4.43ValGly: 4.43 ± 0.107
1.089ValHis: 1.089 ± 0.048
4.801ValIle: 4.801 ± 0.116
4.606ValLys: 4.606 ± 0.105
6.828ValLeu: 6.828 ± 0.133
1.754ValMet: 1.754 ± 0.064
3.004ValAsn: 3.004 ± 0.089
2.367ValPro: 2.367 ± 0.062
2.083ValGln: 2.083 ± 0.067
2.394ValArg: 2.394 ± 0.079
4.392ValSer: 4.392 ± 0.101
3.853ValThr: 3.853 ± 0.099
4.571ValVal: 4.571 ± 0.1
0.52ValTrp: 0.52 ± 0.032
2.262ValTyr: 2.262 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.698TrpAla: 0.698 ± 0.039
0.046TrpCys: 0.046 ± 0.009
0.498TrpAsp: 0.498 ± 0.032
0.609TrpGlu: 0.609 ± 0.038
0.432TrpPhe: 0.432 ± 0.032
0.627TrpGly: 0.627 ± 0.033
0.22TrpHis: 0.22 ± 0.021
0.589TrpIle: 0.589 ± 0.034
0.661TrpLys: 0.661 ± 0.035
1.284TrpLeu: 1.284 ± 0.059
0.29TrpMet: 0.29 ± 0.028
0.456TrpAsn: 0.456 ± 0.031
0.226TrpPro: 0.226 ± 0.02
0.488TrpGln: 0.488 ± 0.031
0.423TrpArg: 0.423 ± 0.024
0.593TrpSer: 0.593 ± 0.039
0.544TrpThr: 0.544 ± 0.032
0.492TrpVal: 0.492 ± 0.031
0.109TrpTrp: 0.109 ± 0.015
0.331TrpTyr: 0.331 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.708TyrAla: 2.708 ± 0.083
0.165TyrCys: 0.165 ± 0.017
1.986TyrAsp: 1.986 ± 0.068
2.216TyrGlu: 2.216 ± 0.078
1.78TyrPhe: 1.78 ± 0.064
2.248TyrGly: 2.248 ± 0.066
0.734TyrHis: 0.734 ± 0.041
1.887TyrIle: 1.887 ± 0.062
1.837TyrLys: 1.837 ± 0.072
3.513TyrLeu: 3.513 ± 0.08
0.752TyrMet: 0.752 ± 0.041
1.559TyrAsn: 1.559 ± 0.06
1.337TyrPro: 1.337 ± 0.047
1.791TyrGln: 1.791 ± 0.062
1.609TyrArg: 1.609 ± 0.062
2.079TyrSer: 2.079 ± 0.078
1.647TyrThr: 1.647 ± 0.071
1.954TyrVal: 1.954 ± 0.059
0.373TyrTrp: 0.373 ± 0.026
1.288TyrTyr: 1.288 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1667 proteins (504073 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski