Amino acid dipepetide frequency for Streptomyces griseoaurantiacus M045

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.932AlaAla: 21.932 ± 0.157	1.032AlaCys: 1.032 ± 0.024	7.859AlaAsp: 7.859 ± 0.06	9.395AlaGlu: 9.395 ± 0.097	3.342AlaPhe: 3.342 ± 0.043	13.851AlaGly: 13.851 ± 0.107	3.344AlaHis: 3.344 ± 0.042	2.841AlaIle: 2.841 ± 0.039	2.607AlaLys: 2.607 ± 0.046	15.276AlaLeu: 15.276 ± 0.126	2.325AlaMet: 2.325 ± 0.035	1.706AlaAsn: 1.706 ± 0.03	8.15AlaPro: 8.15 ± 0.098	3.476AlaGln: 3.476 ± 0.051	11.602AlaArg: 11.602 ± 0.091	5.868AlaSer: 5.868 ± 0.063	6.953AlaThr: 6.953 ± 0.06	12.287AlaVal: 12.287 ± 0.095	1.811AlaTrp: 1.811 ± 0.033	2.714AlaTyr: 2.714 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.132CysAla: 1.132 ± 0.024	0.089CysCys: 0.089 ± 0.008	0.412CysAsp: 0.412 ± 0.015	0.411CysGlu: 0.411 ± 0.014	0.2CysPhe: 0.2 ± 0.009	0.926CysGly: 0.926 ± 0.019	0.207CysHis: 0.207 ± 0.011	0.128CysIle: 0.128 ± 0.008	0.089CysLys: 0.089 ± 0.007	0.733CysLeu: 0.733 ± 0.017	0.114CysMet: 0.114 ± 0.007	0.114CysAsn: 0.114 ± 0.007	0.48CysPro: 0.48 ± 0.017	0.134CysGln: 0.134 ± 0.007	0.638CysArg: 0.638 ± 0.019	0.374CysSer: 0.374 ± 0.013	0.453CysThr: 0.453 ± 0.016	0.652CysVal: 0.652 ± 0.016	0.101CysTrp: 0.101 ± 0.007	0.127CysTyr: 0.127 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.482AspAla: 7.482 ± 0.055	0.413AspCys: 0.413 ± 0.015	3.134AspAsp: 3.134 ± 0.055	3.683AspGlu: 3.683 ± 0.052	1.573AspPhe: 1.573 ± 0.027	6.188AspGly: 6.188 ± 0.062	1.412AspHis: 1.412 ± 0.028	1.654AspIle: 1.654 ± 0.025	1.115AspLys: 1.115 ± 0.028	6.29AspLeu: 6.29 ± 0.061	0.835AspMet: 0.835 ± 0.019	0.897AspAsn: 0.897 ± 0.022	4.541AspPro: 4.541 ± 0.054	1.289AspGln: 1.289 ± 0.025	5.122AspArg: 5.122 ± 0.07	2.469AspSer: 2.469 ± 0.039	3.438AspThr: 3.438 ± 0.051	4.616AspVal: 4.616 ± 0.042	0.988AspTrp: 0.988 ± 0.027	1.052AspTyr: 1.052 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	8.034GluAla: 8.034 ± 0.087	0.335GluCys: 0.335 ± 0.013	3.45GluAsp: 3.45 ± 0.048	4.336GluGlu: 4.336 ± 0.058	1.379GluPhe: 1.379 ± 0.028	5.122GluGly: 5.122 ± 0.054	1.597GluHis: 1.597 ± 0.027	2.035GluIle: 2.035 ± 0.036	1.396GluLys: 1.396 ± 0.036	6.5GluLeu: 6.5 ± 0.067	0.863GluMet: 0.863 ± 0.019	1.067GluAsn: 1.067 ± 0.024	3.467GluPro: 3.467 ± 0.042	2.044GluGln: 2.044 ± 0.031	5.861GluArg: 5.861 ± 0.073	2.564GluSer: 2.564 ± 0.035	2.914GluThr: 2.914 ± 0.038	4.674GluVal: 4.674 ± 0.052	0.732GluTrp: 0.732 ± 0.017	1.095GluTyr: 1.095 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.547PheAla: 3.547 ± 0.041	0.242PheCys: 0.242 ± 0.01	1.865PheAsp: 1.865 ± 0.032	1.403PheGlu: 1.403 ± 0.027	0.8PhePhe: 0.8 ± 0.02	2.851PheGly: 2.851 ± 0.044	0.614PheHis: 0.614 ± 0.016	0.539PheIle: 0.539 ± 0.017	0.451PheLys: 0.451 ± 0.015	2.661PheLeu: 2.661 ± 0.039	0.37PheMet: 0.37 ± 0.014	0.476PheAsn: 0.476 ± 0.016	1.405PhePro: 1.405 ± 0.026	0.603PheGln: 0.603 ± 0.017	1.878PheArg: 1.878 ± 0.032	1.341PheSer: 1.341 ± 0.029	1.911PheThr: 1.911 ± 0.032	2.117PheVal: 2.117 ± 0.032	0.383PheTrp: 0.383 ± 0.013	0.527PheTyr: 0.527 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.998GlyAla: 11.998 ± 0.099	0.777GlyCys: 0.777 ± 0.019	5.164GlyAsp: 5.164 ± 0.056	5.583GlyGlu: 5.583 ± 0.056	2.774GlyPhe: 2.774 ± 0.036	9.607GlyGly: 9.607 ± 0.09	2.512GlyHis: 2.512 ± 0.035	3.208GlyIle: 3.208 ± 0.042	2.243GlyLys: 2.243 ± 0.04	9.439GlyLeu: 9.439 ± 0.079	1.941GlyMet: 1.941 ± 0.029	1.673GlyAsn: 1.673 ± 0.032	5.758GlyPro: 5.758 ± 0.067	2.495GlyGln: 2.495 ± 0.038	8.646GlyArg: 8.646 ± 0.076	5.387GlySer: 5.387 ± 0.058	6.961GlyThr: 6.961 ± 0.072	7.468GlyVal: 7.468 ± 0.06	1.651GlyTrp: 1.651 ± 0.029	2.176GlyTyr: 2.176 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	2.89HisAla: 2.89 ± 0.037	0.22HisCys: 0.22 ± 0.011	1.37HisAsp: 1.37 ± 0.021	1.382HisGlu: 1.382 ± 0.027	0.659HisPhe: 0.659 ± 0.02	2.606HisGly: 2.606 ± 0.038	0.763HisHis: 0.763 ± 0.022	0.597HisIle: 0.597 ± 0.016	0.342HisLys: 0.342 ± 0.012	2.64HisLeu: 2.64 ± 0.038	0.341HisMet: 0.341 ± 0.014	0.352HisAsn: 0.352 ± 0.013	1.968HisPro: 1.968 ± 0.03	0.621HisGln: 0.621 ± 0.018	2.37HisArg: 2.37 ± 0.036	1.025HisSer: 1.025 ± 0.025	1.448HisThr: 1.448 ± 0.031	1.866HisVal: 1.866 ± 0.029	0.404HisTrp: 0.404 ± 0.014	0.472HisTyr: 0.472 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.014IleAla: 4.014 ± 0.05	0.241IleCys: 0.241 ± 0.011	2.02IleAsp: 2.02 ± 0.036	1.691IleGlu: 1.691 ± 0.034	0.585IlePhe: 0.585 ± 0.021	3.135IleGly: 3.135 ± 0.044	0.557IleHis: 0.557 ± 0.014	0.695IleIle: 0.695 ± 0.023	0.613IleLys: 0.613 ± 0.019	2.173IleLeu: 2.173 ± 0.034	0.397IleMet: 0.397 ± 0.015	0.584IleAsn: 0.584 ± 0.018	1.535IlePro: 1.535 ± 0.027	0.583IleGln: 0.583 ± 0.016	2.048IleArg: 2.048 ± 0.032	1.395IleSer: 1.395 ± 0.025	1.867IleThr: 1.867 ± 0.029	2.406IleVal: 2.406 ± 0.034	0.297IleTrp: 0.297 ± 0.011	0.437IleTyr: 0.437 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.679LysAla: 2.679 ± 0.041	0.106LysCys: 0.106 ± 0.007	1.325LysAsp: 1.325 ± 0.032	1.131LysGlu: 1.131 ± 0.026	0.394LysPhe: 0.394 ± 0.014	1.808LysGly: 1.808 ± 0.036	0.412LysHis: 0.412 ± 0.014	0.737LysIle: 0.737 ± 0.02	0.834LysLys: 0.834 ± 0.027	1.73LysLeu: 1.73 ± 0.033	0.338LysMet: 0.338 ± 0.013	0.498LysAsn: 0.498 ± 0.017	1.151LysPro: 1.151 ± 0.026	0.612LysGln: 0.612 ± 0.019	1.372LysArg: 1.372 ± 0.031	1.082LysSer: 1.082 ± 0.026	1.164LysThr: 1.164 ± 0.029	1.738LysVal: 1.738 ± 0.031	0.233LysTrp: 0.233 ± 0.011	0.419LysTyr: 0.419 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.532LeuAla: 15.532 ± 0.117	0.833LeuCys: 0.833 ± 0.018	6.762LeuAsp: 6.762 ± 0.065	4.794LeuGlu: 4.794 ± 0.058	2.481LeuPhe: 2.481 ± 0.039	9.506LeuGly: 9.506 ± 0.094	2.401LeuHis: 2.401 ± 0.028	2.841LeuIle: 2.841 ± 0.048	1.833LeuLys: 1.833 ± 0.036	11.81LeuLeu: 11.81 ± 0.118	1.569LeuMet: 1.569 ± 0.028	1.536LeuAsn: 1.536 ± 0.03	6.777LeuPro: 6.777 ± 0.074	1.999LeuGln: 1.999 ± 0.029	9.463LeuArg: 9.463 ± 0.086	5.238LeuSer: 5.238 ± 0.051	7.044LeuThr: 7.044 ± 0.071	8.986LeuVal: 8.986 ± 0.082	1.274LeuTrp: 1.274 ± 0.027	1.784LeuTyr: 1.784 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.149MetAla: 2.149 ± 0.035	0.129MetCys: 0.129 ± 0.008	0.854MetAsp: 0.854 ± 0.019	0.736MetGlu: 0.736 ± 0.019	0.447MetPhe: 0.447 ± 0.016	1.24MetGly: 1.24 ± 0.024	0.357MetHis: 0.357 ± 0.013	0.593MetIle: 0.593 ± 0.018	0.386MetLys: 0.386 ± 0.014	1.602MetLeu: 1.602 ± 0.027	0.288MetMet: 0.288 ± 0.012	0.406MetAsn: 0.406 ± 0.013	1.145MetPro: 1.145 ± 0.022	0.379MetGln: 0.379 ± 0.014	1.458MetArg: 1.458 ± 0.026	1.255MetSer: 1.255 ± 0.021	1.49MetThr: 1.49 ± 0.026	1.23MetVal: 1.23 ± 0.028	0.207MetTrp: 0.207 ± 0.009	0.294MetTyr: 0.294 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.069AsnAla: 2.069 ± 0.031	0.138AsnCys: 0.138 ± 0.008	0.898AsnAsp: 0.898 ± 0.026	0.757AsnGlu: 0.757 ± 0.02	0.429AsnPhe: 0.429 ± 0.014	1.744AsnGly: 1.744 ± 0.033	0.366AsnHis: 0.366 ± 0.012	0.551AsnIle: 0.551 ± 0.017	0.381AsnLys: 0.381 ± 0.015	1.505AsnLeu: 1.505 ± 0.027	0.276AsnMet: 0.276 ± 0.01	0.378AsnAsn: 0.378 ± 0.014	1.227AsnPro: 1.227 ± 0.026	0.45AsnGln: 0.45 ± 0.016	1.221AsnArg: 1.221 ± 0.025	0.818AsnSer: 0.818 ± 0.021	1.022AsnThr: 1.022 ± 0.023	1.297AsnVal: 1.297 ± 0.024	0.265AsnTrp: 0.265 ± 0.011	0.367AsnTyr: 0.367 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	9.686ProAla: 9.686 ± 0.104	0.35ProCys: 0.35 ± 0.013	4.337ProAsp: 4.337 ± 0.048	4.821ProGlu: 4.821 ± 0.057	1.508ProPhe: 1.508 ± 0.028	7.519ProGly: 7.519 ± 0.079	1.638ProHis: 1.638 ± 0.034	1.036ProIle: 1.036 ± 0.021	1.083ProLys: 1.083 ± 0.026	5.632ProLeu: 5.632 ± 0.059	0.96ProMet: 0.96 ± 0.024	0.777ProAsn: 0.777 ± 0.019	4.197ProPro: 4.197 ± 0.082	1.561ProGln: 1.561 ± 0.037	4.63ProArg: 4.63 ± 0.055	3.354ProSer: 3.354 ± 0.05	3.156ProThr: 3.156 ± 0.051	5.638ProVal: 5.638 ± 0.059	0.869ProTrp: 0.869 ± 0.02	1.375ProTyr: 1.375 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.315GlnAla: 3.315 ± 0.042	0.151GlnCys: 0.151 ± 0.008	1.332GlnAsp: 1.332 ± 0.025	1.407GlnGlu: 1.407 ± 0.027	0.627GlnPhe: 0.627 ± 0.018	2.134GlnGly: 2.134 ± 0.037	0.608GlnHis: 0.608 ± 0.018	0.926GlnIle: 0.926 ± 0.024	0.555GlnLys: 0.555 ± 0.018	2.629GlnLeu: 2.629 ± 0.04	0.457GlnMet: 0.457 ± 0.015	0.444GlnAsn: 0.444 ± 0.016	1.469GlnPro: 1.469 ± 0.034	1.076GlnGln: 1.076 ± 0.033	2.249GlnArg: 2.249 ± 0.034	1.152GlnSer: 1.152 ± 0.025	1.16GlnThr: 1.16 ± 0.021	2.152GlnVal: 2.152 ± 0.034	0.413GlnTrp: 0.413 ± 0.015	0.57GlnTyr: 0.57 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	11.224ArgAla: 11.224 ± 0.084	0.589ArgCys: 0.589 ± 0.017	4.246ArgAsp: 4.246 ± 0.06	5.509ArgGlu: 5.509 ± 0.067	2.346ArgPhe: 2.346 ± 0.035	6.485ArgGly: 6.485 ± 0.064	2.356ArgHis: 2.356 ± 0.038	3.013ArgIle: 3.013 ± 0.039	1.556ArgLys: 1.556 ± 0.031	9.557ArgLeu: 9.557 ± 0.085	1.822ArgMet: 1.822 ± 0.03	1.315ArgAsn: 1.315 ± 0.028	5.831ArgPro: 5.831 ± 0.069	2.227ArgGln: 2.227 ± 0.036	8.873ArgArg: 8.873 ± 0.088	4.026ArgSer: 4.026 ± 0.05	5.982ArgThr: 5.982 ± 0.065	6.313ArgVal: 6.313 ± 0.059	1.394ArgTrp: 1.394 ± 0.027	1.777ArgTyr: 1.777 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.812SerAla: 6.812 ± 0.057	0.364SerCys: 0.364 ± 0.015	2.533SerAsp: 2.533 ± 0.041	2.389SerGlu: 2.389 ± 0.038	1.47SerPhe: 1.47 ± 0.027	5.976SerGly: 5.976 ± 0.056	1.041SerHis: 1.041 ± 0.022	1.171SerIle: 1.171 ± 0.024	0.902SerLys: 0.902 ± 0.024	4.696SerLeu: 4.696 ± 0.052	0.979SerMet: 0.979 ± 0.023	0.775SerAsn: 0.775 ± 0.019	3.265SerPro: 3.265 ± 0.046	1.085SerGln: 1.085 ± 0.026	3.841SerArg: 3.841 ± 0.046	2.84SerSer: 2.84 ± 0.051	2.953SerThr: 2.953 ± 0.037	4.031SerVal: 4.031 ± 0.047	0.825SerTrp: 0.825 ± 0.019	1.139SerTyr: 1.139 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	9.216ThrAla: 9.216 ± 0.082	0.411ThrCys: 0.411 ± 0.014	3.579ThrAsp: 3.579 ± 0.044	3.305ThrGlu: 3.305 ± 0.043	1.559ThrPhe: 1.559 ± 0.029	7.111ThrGly: 7.111 ± 0.065	1.297ThrHis: 1.297 ± 0.029	1.365ThrIle: 1.365 ± 0.028	1.094ThrLys: 1.094 ± 0.027	5.828ThrLeu: 5.828 ± 0.059	0.903ThrMet: 0.903 ± 0.024	0.87ThrAsn: 0.87 ± 0.02	4.335ThrPro: 4.335 ± 0.053	1.218ThrGln: 1.218 ± 0.026	4.226ThrArg: 4.226 ± 0.044	3.097ThrSer: 3.097 ± 0.038	3.838ThrThr: 3.838 ± 0.055	6.174ThrVal: 6.174 ± 0.063	0.835ThrTrp: 0.835 ± 0.021	1.267ThrTyr: 1.267 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	10.286ValAla: 10.286 ± 0.089	0.773ValCys: 0.773 ± 0.019	4.909ValAsp: 4.909 ± 0.044	4.763ValGlu: 4.763 ± 0.05	2.345ValPhe: 2.345 ± 0.036	6.363ValGly: 6.363 ± 0.062	2.098ValHis: 2.098 ± 0.032	2.406ValIle: 2.406 ± 0.04	1.594ValLys: 1.594 ± 0.031	10.0ValLeu: 10.0 ± 0.093	1.385ValMet: 1.385 ± 0.023	1.563ValAsn: 1.563 ± 0.031	5.673ValPro: 5.673 ± 0.06	1.874ValGln: 1.874 ± 0.032	7.776ValArg: 7.776 ± 0.067	4.089ValSer: 4.089 ± 0.046	5.664ValThr: 5.664 ± 0.057	7.868ValVal: 7.868 ± 0.078	1.119ValTrp: 1.119 ± 0.023	1.506ValTyr: 1.506 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.615TrpAla: 1.615 ± 0.029	0.155TrpCys: 0.155 ± 0.008	0.761TrpAsp: 0.761 ± 0.02	0.729TrpGlu: 0.729 ± 0.019	0.47TrpPhe: 0.47 ± 0.016	1.03TrpGly: 1.03 ± 0.025	0.377TrpHis: 0.377 ± 0.013	0.524TrpIle: 0.524 ± 0.017	0.322TrpLys: 0.322 ± 0.013	1.729TrpLeu: 1.729 ± 0.032	0.259TrpMet: 0.259 ± 0.012	0.379TrpAsn: 0.379 ± 0.014	0.738TrpPro: 0.738 ± 0.018	0.568TrpGln: 0.568 ± 0.017	1.334TrpArg: 1.334 ± 0.024	0.864TrpSer: 0.864 ± 0.023	0.982TrpThr: 0.982 ± 0.022	0.924TrpVal: 0.924 ± 0.021	0.333TrpTrp: 0.333 ± 0.013	0.347TrpTyr: 0.347 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.756TyrAla: 2.756 ± 0.033	0.166TyrCys: 0.166 ± 0.01	1.377TyrAsp: 1.377 ± 0.029	1.242TyrGlu: 1.242 ± 0.028	0.595TyrPhe: 0.595 ± 0.018	2.258TyrGly: 2.258 ± 0.035	0.377TyrHis: 0.377 ± 0.014	0.415TyrIle: 0.415 ± 0.015	0.367TyrLys: 0.367 ± 0.015	2.032TyrLeu: 2.032 ± 0.031	0.226TyrMet: 0.226 ± 0.01	0.348TyrAsn: 0.348 ± 0.014	1.016TyrPro: 1.016 ± 0.022	0.531TyrGln: 0.531 ± 0.016	1.833TyrArg: 1.833 ± 0.029	0.855TyrSer: 0.855 ± 0.019	1.128TyrThr: 1.128 ± 0.024	1.615TyrVal: 1.615 ± 0.029	0.309TyrTrp: 0.309 ± 0.012	0.423TyrTyr: 0.423 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6839 proteins (2225282 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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