Amino acid dipepetide frequency for Anaerotruncus sp. CAG:528

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.841AlaAla: 9.841 ± 0.183	1.458AlaCys: 1.458 ± 0.051	5.566AlaAsp: 5.566 ± 0.096	6.375AlaGlu: 6.375 ± 0.135	3.817AlaPhe: 3.817 ± 0.092	6.137AlaGly: 6.137 ± 0.109	1.184AlaHis: 1.184 ± 0.041	5.401AlaIle: 5.401 ± 0.102	6.314AlaLys: 6.314 ± 0.112	7.621AlaLeu: 7.621 ± 0.133	2.126AlaMet: 2.126 ± 0.062	3.546AlaAsn: 3.546 ± 0.083	2.4AlaPro: 2.4 ± 0.075	2.74AlaGln: 2.74 ± 0.073	2.79AlaArg: 2.79 ± 0.08	4.697AlaSer: 4.697 ± 0.106	3.568AlaThr: 3.568 ± 0.102	8.001AlaVal: 8.001 ± 0.148	0.52AlaTrp: 0.52 ± 0.034	2.96AlaTyr: 2.96 ± 0.083	0.002AlaXaa: 0.002 ± 0.002
Cys	1.711CysAla: 1.711 ± 0.061	0.355CysCys: 0.355 ± 0.028	1.24CysAsp: 1.24 ± 0.051	1.277CysGlu: 1.277 ± 0.046	0.746CysPhe: 0.746 ± 0.039	2.008CysGly: 2.008 ± 0.07	0.269CysHis: 0.269 ± 0.024	1.157CysIle: 1.157 ± 0.046	1.131CysLys: 1.131 ± 0.05	1.189CysLeu: 1.189 ± 0.048	0.376CysMet: 0.376 ± 0.025	0.762CysAsn: 0.762 ± 0.045	0.756CysPro: 0.756 ± 0.046	0.329CysGln: 0.329 ± 0.025	0.756CysArg: 0.756 ± 0.036	1.153CysSer: 1.153 ± 0.049	0.884CysThr: 0.884 ± 0.044	1.342CysVal: 1.342 ± 0.047	0.14CysTrp: 0.14 ± 0.018	0.591CysTyr: 0.591 ± 0.036	0.0CysXaa: 0.0 ± 0.0
Asp	4.339AspAla: 4.339 ± 0.102	1.186AspCys: 1.186 ± 0.049	3.364AspAsp: 3.364 ± 0.084	4.833AspGlu: 4.833 ± 0.115	3.359AspPhe: 3.359 ± 0.084	4.25AspGly: 4.25 ± 0.105	0.626AspHis: 0.626 ± 0.035	4.924AspIle: 4.924 ± 0.086	4.455AspLys: 4.455 ± 0.11	4.428AspLeu: 4.428 ± 0.1	1.824AspMet: 1.824 ± 0.059	2.637AspAsn: 2.637 ± 0.068	1.578AspPro: 1.578 ± 0.055	0.795AspGln: 0.795 ± 0.037	1.662AspArg: 1.662 ± 0.053	3.306AspSer: 3.306 ± 0.091	2.533AspThr: 2.533 ± 0.067	4.192AspVal: 4.192 ± 0.088	0.507AspTrp: 0.507 ± 0.035	3.182AspTyr: 3.182 ± 0.081	0.0AspXaa: 0.0 ± 0.0
Glu	5.159GluAla: 5.159 ± 0.109	0.997GluCys: 0.997 ± 0.051	3.104GluAsp: 3.104 ± 0.09	4.337GluGlu: 4.337 ± 0.13	2.955GluPhe: 2.955 ± 0.084	3.273GluGly: 3.273 ± 0.076	1.04GluHis: 1.04 ± 0.052	5.914GluIle: 5.914 ± 0.12	6.594GluLys: 6.594 ± 0.123	5.684GluLeu: 5.684 ± 0.114	2.142GluMet: 2.142 ± 0.068	4.892GluAsn: 4.892 ± 0.114	1.757GluPro: 1.757 ± 0.065	2.013GluGln: 2.013 ± 0.071	2.715GluArg: 2.715 ± 0.078	3.899GluSer: 3.899 ± 0.098	3.381GluThr: 3.381 ± 0.093	3.381GluVal: 3.381 ± 0.086	0.533GluTrp: 0.533 ± 0.033	3.22GluTyr: 3.22 ± 0.078	0.0GluXaa: 0.0 ± 0.0
Phe	4.11PheAla: 4.11 ± 0.085	0.858PheCys: 0.858 ± 0.041	3.028PheAsp: 3.028 ± 0.079	3.053PheGlu: 3.053 ± 0.065	1.886PhePhe: 1.886 ± 0.068	3.719PheGly: 3.719 ± 0.074	0.573PheHis: 0.573 ± 0.028	3.088PheIle: 3.088 ± 0.077	3.044PheLys: 3.044 ± 0.073	3.337PheLeu: 3.337 ± 0.077	1.044PheMet: 1.044 ± 0.039	2.106PheAsn: 2.106 ± 0.064	1.318PhePro: 1.318 ± 0.04	0.833PheGln: 0.833 ± 0.044	1.364PheArg: 1.364 ± 0.053	3.155PheSer: 3.155 ± 0.079	2.549PheThr: 2.549 ± 0.068	3.175PheVal: 3.175 ± 0.078	0.38PheTrp: 0.38 ± 0.03	1.689PheTyr: 1.689 ± 0.058	0.0PheXaa: 0.0 ± 0.0
Gly	5.985GlyAla: 5.985 ± 0.097	1.382GlyCys: 1.382 ± 0.051	4.053GlyAsp: 4.053 ± 0.084	4.833GlyGlu: 4.833 ± 0.098	3.31GlyPhe: 3.31 ± 0.075	5.546GlyGly: 5.546 ± 0.122	1.02GlyHis: 1.02 ± 0.044	5.721GlyIle: 5.721 ± 0.111	5.93GlyLys: 5.93 ± 0.093	5.277GlyLeu: 5.277 ± 0.108	1.946GlyMet: 1.946 ± 0.065	3.453GlyAsn: 3.453 ± 0.097	1.266GlyPro: 1.266 ± 0.056	1.444GlyGln: 1.444 ± 0.054	2.833GlyArg: 2.833 ± 0.09	4.464GlySer: 4.464 ± 0.099	4.379GlyThr: 4.379 ± 0.116	5.419GlyVal: 5.419 ± 0.114	0.571GlyTrp: 0.571 ± 0.035	2.924GlyTyr: 2.924 ± 0.083	0.002GlyXaa: 0.002 ± 0.002
His	1.037HisAla: 1.037 ± 0.047	0.316HisCys: 0.316 ± 0.025	0.824HisAsp: 0.824 ± 0.04	0.836HisGlu: 0.836 ± 0.045	0.742HisPhe: 0.742 ± 0.037	1.275HisGly: 1.275 ± 0.051	0.324HisHis: 0.324 ± 0.038	1.169HisIle: 1.169 ± 0.044	0.984HisLys: 0.984 ± 0.044	1.062HisLeu: 1.062 ± 0.045	0.366HisMet: 0.366 ± 0.027	0.771HisAsn: 0.771 ± 0.037	0.793HisPro: 0.793 ± 0.04	0.346HisGln: 0.346 ± 0.023	0.656HisArg: 0.656 ± 0.034	1.087HisSer: 1.087 ± 0.041	0.798HisThr: 0.798 ± 0.034	0.658HisVal: 0.658 ± 0.038	0.144HisTrp: 0.144 ± 0.018	0.622HisTyr: 0.622 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.463IleAla: 6.463 ± 0.125	1.66IleCys: 1.66 ± 0.054	4.448IleAsp: 4.448 ± 0.094	5.001IleGlu: 5.001 ± 0.111	2.879IlePhe: 2.879 ± 0.081	5.201IleGly: 5.201 ± 0.123	0.977IleHis: 0.977 ± 0.043	5.928IleIle: 5.928 ± 0.127	5.979IleLys: 5.979 ± 0.118	5.33IleLeu: 5.33 ± 0.116	1.911IleMet: 1.911 ± 0.063	3.797IleAsn: 3.797 ± 0.079	2.595IlePro: 2.595 ± 0.077	1.367IleGln: 1.367 ± 0.052	2.548IleArg: 2.548 ± 0.087	5.335IleSer: 5.335 ± 0.104	4.701IleThr: 4.701 ± 0.09	4.901IleVal: 4.901 ± 0.097	0.484IleTrp: 0.484 ± 0.027	2.786IleTyr: 2.786 ± 0.059	0.002IleXaa: 0.002 ± 0.002
Lys	6.574LysAla: 6.574 ± 0.134	1.109LysCys: 1.109 ± 0.043	3.611LysAsp: 3.611 ± 0.086	5.404LysGlu: 5.404 ± 0.118	2.713LysPhe: 2.713 ± 0.07	4.257LysGly: 4.257 ± 0.097	1.089LysHis: 1.089 ± 0.047	6.295LysIle: 6.295 ± 0.112	6.901LysLys: 6.901 ± 0.134	5.841LysLeu: 5.841 ± 0.107	2.315LysMet: 2.315 ± 0.06	4.759LysAsn: 4.759 ± 0.096	2.419LysPro: 2.419 ± 0.074	2.077LysGln: 2.077 ± 0.062	2.99LysArg: 2.99 ± 0.083	5.228LysSer: 5.228 ± 0.099	4.352LysThr: 4.352 ± 0.093	3.946LysVal: 3.946 ± 0.092	0.589LysTrp: 0.589 ± 0.034	3.451LysTyr: 3.451 ± 0.082	0.0LysXaa: 0.0 ± 0.0
Leu	7.168LeuAla: 7.168 ± 0.134	1.706LeuCys: 1.706 ± 0.062	4.893LeuAsp: 4.893 ± 0.108	4.866LeuGlu: 4.866 ± 0.099	3.779LeuPhe: 3.779 ± 0.092	5.935LeuGly: 5.935 ± 0.111	1.202LeuHis: 1.202 ± 0.045	5.643LeuIle: 5.643 ± 0.107	6.025LeuLys: 6.025 ± 0.126	7.085LeuLeu: 7.085 ± 0.148	2.157LeuMet: 2.157 ± 0.056	4.006LeuAsn: 4.006 ± 0.092	3.381LeuPro: 3.381 ± 0.077	2.262LeuGln: 2.262 ± 0.063	3.093LeuArg: 3.093 ± 0.093	6.065LeuSer: 6.065 ± 0.109	4.366LeuThr: 4.366 ± 0.104	4.966LeuVal: 4.966 ± 0.101	0.615LeuTrp: 0.615 ± 0.036	2.888LeuTyr: 2.888 ± 0.092	0.0LeuXaa: 0.0 ± 0.0
Met	2.18MetAla: 2.18 ± 0.065	0.387MetCys: 0.387 ± 0.027	1.297MetAsp: 1.297 ± 0.057	1.353MetGlu: 1.353 ± 0.053	1.037MetPhe: 1.037 ± 0.044	1.733MetGly: 1.733 ± 0.064	0.444MetHis: 0.444 ± 0.026	1.917MetIle: 1.917 ± 0.061	2.22MetLys: 2.22 ± 0.063	2.695MetLeu: 2.695 ± 0.063	0.736MetMet: 0.736 ± 0.042	1.491MetAsn: 1.491 ± 0.05	1.342MetPro: 1.342 ± 0.046	0.926MetGln: 0.926 ± 0.041	1.171MetArg: 1.171 ± 0.046	1.549MetSer: 1.549 ± 0.06	1.246MetThr: 1.246 ± 0.059	1.397MetVal: 1.397 ± 0.05	0.176MetTrp: 0.176 ± 0.018	0.775MetTyr: 0.775 ± 0.043	0.0MetXaa: 0.0 ± 0.0
Asn	4.379AsnAla: 4.379 ± 0.095	0.927AsnCys: 0.927 ± 0.041	2.87AsnAsp: 2.87 ± 0.068	3.55AsnGlu: 3.55 ± 0.088	1.873AsnPhe: 1.873 ± 0.068	4.761AsnGly: 4.761 ± 0.122	0.709AsnHis: 0.709 ± 0.039	3.993AsnIle: 3.993 ± 0.085	3.524AsnLys: 3.524 ± 0.093	3.806AsnLeu: 3.806 ± 0.101	1.342AsnMet: 1.342 ± 0.048	2.4AsnAsn: 2.4 ± 0.085	2.189AsnPro: 2.189 ± 0.058	1.217AsnGln: 1.217 ± 0.052	1.802AsnArg: 1.802 ± 0.06	3.339AsnSer: 3.339 ± 0.089	2.559AsnThr: 2.559 ± 0.091	3.16AsnVal: 3.16 ± 0.078	0.418AsnTrp: 0.418 ± 0.029	2.006AsnTyr: 2.006 ± 0.072	0.0AsnXaa: 0.0 ± 0.0
Pro	2.928ProAla: 2.928 ± 0.08	0.595ProCys: 0.595 ± 0.038	2.044ProAsp: 2.044 ± 0.069	2.691ProGlu: 2.691 ± 0.083	1.657ProPhe: 1.657 ± 0.054	2.182ProGly: 2.182 ± 0.063	0.56ProHis: 0.56 ± 0.032	2.139ProIle: 2.139 ± 0.066	2.124ProLys: 2.124 ± 0.072	2.764ProLeu: 2.764 ± 0.073	0.727ProMet: 0.727 ± 0.033	1.546ProAsn: 1.546 ± 0.055	0.904ProPro: 0.904 ± 0.046	1.471ProGln: 1.471 ± 0.057	1.022ProArg: 1.022 ± 0.043	1.851ProSer: 1.851 ± 0.059	1.629ProThr: 1.629 ± 0.062	2.702ProVal: 2.702 ± 0.058	0.313ProTrp: 0.313 ± 0.024	1.326ProTyr: 1.326 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.035GlnAla: 2.035 ± 0.056	0.375GlnCys: 0.375 ± 0.026	1.106GlnAsp: 1.106 ± 0.043	1.326GlnGlu: 1.326 ± 0.058	1.035GlnPhe: 1.035 ± 0.037	1.622GlnGly: 1.622 ± 0.066	0.418GlnHis: 0.418 ± 0.028	2.326GlnIle: 2.326 ± 0.074	2.322GlnLys: 2.322 ± 0.065	2.149GlnLeu: 2.149 ± 0.066	0.838GlnMet: 0.838 ± 0.037	1.72GlnAsn: 1.72 ± 0.051	0.855GlnPro: 0.855 ± 0.044	0.813GlnGln: 0.813 ± 0.046	1.115GlnArg: 1.115 ± 0.043	1.822GlnSer: 1.822 ± 0.057	1.438GlnThr: 1.438 ± 0.048	1.337GlnVal: 1.337 ± 0.055	0.211GlnTrp: 0.211 ± 0.023	1.106GlnTyr: 1.106 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.729ArgAla: 2.729 ± 0.071	0.615ArgCys: 0.615 ± 0.035	1.966ArgAsp: 1.966 ± 0.071	2.862ArgGlu: 2.862 ± 0.073	1.838ArgPhe: 1.838 ± 0.063	2.313ArgGly: 2.313 ± 0.068	0.678ArgHis: 0.678 ± 0.03	2.886ArgIle: 2.886 ± 0.072	2.75ArgLys: 2.75 ± 0.081	3.624ArgLeu: 3.624 ± 0.088	0.96ArgMet: 0.96 ± 0.042	1.722ArgAsn: 1.722 ± 0.056	1.18ArgPro: 1.18 ± 0.044	1.227ArgGln: 1.227 ± 0.044	1.955ArgArg: 1.955 ± 0.071	1.926ArgSer: 1.926 ± 0.054	1.706ArgThr: 1.706 ± 0.057	2.388ArgVal: 2.388 ± 0.076	0.282ArgTrp: 0.282 ± 0.022	1.358ArgTyr: 1.358 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.135SerAla: 6.135 ± 0.115	0.975SerCys: 0.975 ± 0.047	4.037SerAsp: 4.037 ± 0.097	4.292SerGlu: 4.292 ± 0.089	2.948SerPhe: 2.948 ± 0.073	5.683SerGly: 5.683 ± 0.114	0.993SerHis: 0.993 ± 0.038	3.881SerIle: 3.881 ± 0.078	4.268SerLys: 4.268 ± 0.098	5.375SerLeu: 5.375 ± 0.112	1.387SerMet: 1.387 ± 0.052	2.851SerAsn: 2.851 ± 0.091	2.002SerPro: 2.002 ± 0.057	1.764SerGln: 1.764 ± 0.059	2.551SerArg: 2.551 ± 0.08	4.022SerSer: 4.022 ± 0.106	3.044SerThr: 3.044 ± 0.086	5.41SerVal: 5.41 ± 0.112	0.489SerTrp: 0.489 ± 0.032	2.444SerTyr: 2.444 ± 0.079	0.0SerXaa: 0.0 ± 0.0
Thr	5.346ThrAla: 5.346 ± 0.119	0.686ThrCys: 0.686 ± 0.037	3.462ThrAsp: 3.462 ± 0.091	3.408ThrGlu: 3.408 ± 0.085	2.062ThrPhe: 2.062 ± 0.065	4.322ThrGly: 4.322 ± 0.108	0.829ThrHis: 0.829 ± 0.042	3.082ThrIle: 3.082 ± 0.07	3.191ThrLys: 3.191 ± 0.078	4.355ThrLeu: 4.355 ± 0.097	1.084ThrMet: 1.084 ± 0.045	2.088ThrAsn: 2.088 ± 0.065	2.148ThrPro: 2.148 ± 0.068	1.395ThrGln: 1.395 ± 0.053	1.666ThrArg: 1.666 ± 0.056	2.835ThrSer: 2.835 ± 0.088	2.739ThrThr: 2.739 ± 0.109	5.206ThrVal: 5.206 ± 0.136	0.338ThrTrp: 0.338 ± 0.027	1.929ThrTyr: 1.929 ± 0.074	0.0ThrXaa: 0.0 ± 0.0
Val	5.477ValAla: 5.477 ± 0.118	1.668ValCys: 1.668 ± 0.066	3.801ValAsp: 3.801 ± 0.088	3.708ValGlu: 3.708 ± 0.093	3.346ValPhe: 3.346 ± 0.106	3.995ValGly: 3.995 ± 0.102	1.064ValHis: 1.064 ± 0.042	5.324ValIle: 5.324 ± 0.104	4.777ValLys: 4.777 ± 0.106	6.663ValLeu: 6.663 ± 0.117	1.689ValMet: 1.689 ± 0.059	3.488ValAsn: 3.488 ± 0.097	2.757ValPro: 2.757 ± 0.071	1.698ValGln: 1.698 ± 0.055	2.542ValArg: 2.542 ± 0.085	5.41ValSer: 5.41 ± 0.107	3.741ValThr: 3.741 ± 0.1	4.628ValVal: 4.628 ± 0.114	0.555ValTrp: 0.555 ± 0.035	2.628ValTyr: 2.628 ± 0.077	0.0ValXaa: 0.0 ± 0.0
Trp	0.487TrpAla: 0.487 ± 0.029	0.16TrpCys: 0.16 ± 0.02	0.453TrpAsp: 0.453 ± 0.031	0.469TrpGlu: 0.469 ± 0.032	0.367TrpPhe: 0.367 ± 0.03	0.615TrpGly: 0.615 ± 0.042	0.2TrpHis: 0.2 ± 0.021	0.506TrpIle: 0.506 ± 0.031	0.522TrpLys: 0.522 ± 0.03	0.726TrpLeu: 0.726 ± 0.036	0.207TrpMet: 0.207 ± 0.021	0.471TrpAsn: 0.471 ± 0.033	0.136TrpPro: 0.136 ± 0.017	0.34TrpGln: 0.34 ± 0.025	0.327TrpArg: 0.327 ± 0.022	0.516TrpSer: 0.516 ± 0.035	0.322TrpThr: 0.322 ± 0.022	0.435TrpVal: 0.435 ± 0.028	0.102TrpTrp: 0.102 ± 0.014	0.327TrpTyr: 0.327 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.98TyrAla: 2.98 ± 0.074	0.758TyrCys: 0.758 ± 0.037	2.813TyrAsp: 2.813 ± 0.088	2.513TyrGlu: 2.513 ± 0.065	1.962TyrPhe: 1.962 ± 0.061	2.931TyrGly: 2.931 ± 0.074	0.611TyrHis: 0.611 ± 0.033	2.999TyrIle: 2.999 ± 0.074	2.866TyrLys: 2.866 ± 0.079	3.088TyrLeu: 3.088 ± 0.085	0.891TyrMet: 0.891 ± 0.038	2.319TyrAsn: 2.319 ± 0.076	1.397TyrPro: 1.397 ± 0.042	0.911TyrGln: 0.911 ± 0.039	1.407TyrArg: 1.407 ± 0.053	2.89TyrSer: 2.89 ± 0.077	2.239TyrThr: 2.239 ± 0.077	2.317TyrVal: 2.317 ± 0.064	0.322TyrTrp: 0.322 ± 0.026	2.008TyrTyr: 2.008 ± 0.071	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.002XaaSer: 0.002 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.011XaaXaa: 0.011 ± 0.006

Statistics based on 1705 proteins (549919 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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