Amino acid dipepetide frequency for Trichinella zimbabwensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.581AlaAla: 5.581 ± 0.053
1.473AlaCys: 1.473 ± 0.016
3.551AlaAsp: 3.551 ± 0.023
4.639AlaGlu: 4.639 ± 0.04
2.776AlaPhe: 2.776 ± 0.019
3.337AlaGly: 3.337 ± 0.024
1.327AlaHis: 1.327 ± 0.013
3.505AlaIle: 3.505 ± 0.022
3.581AlaLys: 3.581 ± 0.024
6.197AlaLeu: 6.197 ± 0.037
1.59AlaMet: 1.59 ± 0.015
2.992AlaAsn: 2.992 ± 0.025
2.321AlaPro: 2.321 ± 0.023
2.291AlaGln: 2.291 ± 0.02
2.918AlaArg: 2.918 ± 0.024
5.32AlaSer: 5.32 ± 0.034
3.557AlaThr: 3.557 ± 0.025
4.956AlaVal: 4.956 ± 0.03
0.674AlaTrp: 0.674 ± 0.009
1.822AlaTyr: 1.822 ± 0.016
0.002AlaXaa: 0.002 ± 0.001
Cys
1.443CysAla: 1.443 ± 0.018
0.895CysCys: 0.895 ± 0.013
1.329CysAsp: 1.329 ± 0.022
1.534CysGlu: 1.534 ± 0.02
1.293CysPhe: 1.293 ± 0.014
1.392CysGly: 1.392 ± 0.018
0.674CysHis: 0.674 ± 0.01
1.53CysIle: 1.53 ± 0.02
1.527CysLys: 1.527 ± 0.022
2.55CysLeu: 2.55 ± 0.021
0.567CysMet: 0.567 ± 0.008
1.242CysAsn: 1.242 ± 0.016
1.18CysPro: 1.18 ± 0.021
1.147CysGln: 1.147 ± 0.017
1.541CysArg: 1.541 ± 0.019
2.383CysSer: 2.383 ± 0.022
1.36CysThr: 1.36 ± 0.015
1.473CysVal: 1.473 ± 0.016
0.349CysTrp: 0.349 ± 0.007
0.76CysTyr: 0.76 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
3.336AspAla: 3.336 ± 0.023
1.37AspCys: 1.37 ± 0.017
3.975AspAsp: 3.975 ± 0.042
4.229AspGlu: 4.229 ± 0.033
2.426AspPhe: 2.426 ± 0.022
3.035AspGly: 3.035 ± 0.028
1.204AspHis: 1.204 ± 0.012
2.826AspIle: 2.826 ± 0.022
2.584AspLys: 2.584 ± 0.018
4.702AspLeu: 4.702 ± 0.032
1.159AspMet: 1.159 ± 0.011
2.341AspAsn: 2.341 ± 0.019
2.058AspPro: 2.058 ± 0.019
2.078AspGln: 2.078 ± 0.018
2.654AspArg: 2.654 ± 0.021
4.255AspSer: 4.255 ± 0.032
2.18AspThr: 2.18 ± 0.018
3.697AspVal: 3.697 ± 0.025
0.655AspTrp: 0.655 ± 0.009
1.606AspTyr: 1.606 ± 0.016
0.001AspXaa: 0.001 ± 0.0
Glu
3.941GluAla: 3.941 ± 0.04
1.401GluCys: 1.401 ± 0.024
3.246GluAsp: 3.246 ± 0.028
5.766GluGlu: 5.766 ± 0.056
2.463GluPhe: 2.463 ± 0.017
2.336GluGly: 2.336 ± 0.024
1.52GluHis: 1.52 ± 0.015
4.052GluIle: 4.052 ± 0.029
5.097GluLys: 5.097 ± 0.038
5.911GluLeu: 5.911 ± 0.037
1.946GluMet: 1.946 ± 0.017
4.172GluAsn: 4.172 ± 0.029
2.203GluPro: 2.203 ± 0.029
3.2GluGln: 3.2 ± 0.035
3.571GluArg: 3.571 ± 0.029
4.574GluSer: 4.574 ± 0.034
3.352GluThr: 3.352 ± 0.024
3.504GluVal: 3.504 ± 0.026
0.679GluTrp: 0.679 ± 0.009
1.751GluTyr: 1.751 ± 0.018
0.001GluXaa: 0.001 ± 0.0
Phe
2.757PheAla: 2.757 ± 0.019
1.377PheCys: 1.377 ± 0.017
2.558PheAsp: 2.558 ± 0.017
2.718PheGlu: 2.718 ± 0.019
2.247PhePhe: 2.247 ± 0.023
2.546PheGly: 2.546 ± 0.021
1.241PheHis: 1.241 ± 0.014
2.582PheIle: 2.582 ± 0.022
2.271PheLys: 2.271 ± 0.021
4.344PheLeu: 4.344 ± 0.035
0.933PheMet: 0.933 ± 0.011
2.131PheAsn: 2.131 ± 0.02
1.927PhePro: 1.927 ± 0.018
1.928PheGln: 1.928 ± 0.015
2.27PheArg: 2.27 ± 0.022
3.971PheSer: 3.971 ± 0.025
2.475PheThr: 2.475 ± 0.02
3.073PheVal: 3.073 ± 0.02
0.592PheTrp: 0.592 ± 0.01
1.719PheTyr: 1.719 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
2.709GlyAla: 2.709 ± 0.025
1.266GlyCys: 1.266 ± 0.015
2.529GlyAsp: 2.529 ± 0.02
2.91GlyGlu: 2.91 ± 0.027
2.209GlyPhe: 2.209 ± 0.023
3.266GlyGly: 3.266 ± 0.035
1.22GlyHis: 1.22 ± 0.015
2.888GlyIle: 2.888 ± 0.02
3.331GlyLys: 3.331 ± 0.025
3.972GlyLeu: 3.972 ± 0.028
1.168GlyMet: 1.168 ± 0.013
2.498GlyAsn: 2.498 ± 0.022
1.791GlyPro: 1.791 ± 0.027
2.066GlyGln: 2.066 ± 0.02
3.08GlyArg: 3.08 ± 0.03
4.164GlySer: 4.164 ± 0.028
2.555GlyThr: 2.555 ± 0.021
2.973GlyVal: 2.973 ± 0.021
0.632GlyTrp: 0.632 ± 0.01
1.745GlyTyr: 1.745 ± 0.017
0.001GlyXaa: 0.001 ± 0.0
His
1.417HisAla: 1.417 ± 0.013
0.888HisCys: 0.888 ± 0.013
1.018HisAsp: 1.018 ± 0.011
1.312HisGlu: 1.312 ± 0.015
1.386HisPhe: 1.386 ± 0.015
1.327HisGly: 1.327 ± 0.013
0.925HisHis: 0.925 ± 0.017
1.279HisIle: 1.279 ± 0.012
0.996HisLys: 0.996 ± 0.012
2.672HisLeu: 2.672 ± 0.019
0.536HisMet: 0.536 ± 0.008
0.993HisAsn: 0.993 ± 0.012
1.212HisPro: 1.212 ± 0.014
1.112HisGln: 1.112 ± 0.013
1.497HisArg: 1.497 ± 0.015
2.066HisSer: 2.066 ± 0.017
1.088HisThr: 1.088 ± 0.011
1.572HisVal: 1.572 ± 0.016
0.349HisTrp: 0.349 ± 0.007
0.903HisTyr: 0.903 ± 0.01
0.0HisXaa: 0.0 ± 0.0
Ile
3.749IleAla: 3.749 ± 0.023
1.676IleCys: 1.676 ± 0.018
3.003IleAsp: 3.003 ± 0.021
3.417IleGlu: 3.417 ± 0.028
2.806IlePhe: 2.806 ± 0.026
2.789IleGly: 2.789 ± 0.024
1.308IleHis: 1.308 ± 0.013
3.133IleIle: 3.133 ± 0.027
2.949IleLys: 2.949 ± 0.024
5.37IleLeu: 5.37 ± 0.032
1.205IleMet: 1.205 ± 0.015
2.512IleAsn: 2.512 ± 0.021
2.492IlePro: 2.492 ± 0.02
2.235IleGln: 2.235 ± 0.019
3.08IleArg: 3.08 ± 0.02
4.813IleSer: 4.813 ± 0.035
2.969IleThr: 2.969 ± 0.03
3.649IleVal: 3.649 ± 0.025
0.661IleTrp: 0.661 ± 0.009
1.906IleTyr: 1.906 ± 0.018
0.001IleXaa: 0.001 ± 0.0
Lys
3.664LysAla: 3.664 ± 0.023
1.498LysCys: 1.498 ± 0.019
2.71LysAsp: 2.71 ± 0.023
4.044LysGlu: 4.044 ± 0.036
2.551LysPhe: 2.551 ± 0.02
2.212LysGly: 2.212 ± 0.019
1.548LysHis: 1.548 ± 0.015
3.63LysIle: 3.63 ± 0.024
4.599LysLys: 4.599 ± 0.044
6.196LysLeu: 6.196 ± 0.036
1.79LysMet: 1.79 ± 0.015
3.271LysAsn: 3.271 ± 0.027
2.51LysPro: 2.51 ± 0.022
3.006LysGln: 3.006 ± 0.021
3.787LysArg: 3.787 ± 0.03
4.584LysSer: 4.584 ± 0.03
3.064LysThr: 3.064 ± 0.023
3.358LysVal: 3.358 ± 0.021
0.714LysTrp: 0.714 ± 0.01
1.836LysTyr: 1.836 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
5.97LeuAla: 5.97 ± 0.036
2.446LeuCys: 2.446 ± 0.021
4.591LeuAsp: 4.591 ± 0.031
5.922LeuGlu: 5.922 ± 0.045
4.582LeuPhe: 4.582 ± 0.036
3.778LeuGly: 3.778 ± 0.023
2.711LeuHis: 2.711 ± 0.019
5.464LeuIle: 5.464 ± 0.032
6.749LeuLys: 6.749 ± 0.044
10.767LeuLeu: 10.767 ± 0.062
2.286LeuMet: 2.286 ± 0.018
5.008LeuAsn: 5.008 ± 0.028
4.761LeuPro: 4.761 ± 0.03
4.636LeuGln: 4.636 ± 0.031
5.436LeuArg: 5.436 ± 0.029
7.739LeuSer: 7.739 ± 0.035
5.021LeuThr: 5.021 ± 0.028
5.318LeuVal: 5.318 ± 0.023
1.082LeuTrp: 1.082 ± 0.011
2.921LeuTyr: 2.921 ± 0.023
0.002LeuXaa: 0.002 ± 0.001
Met
1.604MetAla: 1.604 ± 0.014
0.497MetCys: 0.497 ± 0.008
1.289MetAsp: 1.289 ± 0.013
1.672MetGlu: 1.672 ± 0.015
0.991MetPhe: 0.991 ± 0.013
0.905MetGly: 0.905 ± 0.012
0.675MetHis: 0.675 ± 0.008
1.348MetIle: 1.348 ± 0.014
1.768MetLys: 1.768 ± 0.015
2.487MetLeu: 2.487 ± 0.021
0.71MetMet: 0.71 ± 0.011
1.367MetAsn: 1.367 ± 0.014
1.161MetPro: 1.161 ± 0.012
1.192MetGln: 1.192 ± 0.012
1.251MetArg: 1.251 ± 0.013
1.77MetSer: 1.77 ± 0.016
1.286MetThr: 1.286 ± 0.014
1.381MetVal: 1.381 ± 0.013
0.23MetTrp: 0.23 ± 0.005
0.639MetTyr: 0.639 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
3.336AsnAla: 3.336 ± 0.02
1.441AsnCys: 1.441 ± 0.016
2.844AsnAsp: 2.844 ± 0.022
3.287AsnGlu: 3.287 ± 0.023
2.581AsnPhe: 2.581 ± 0.019
2.944AsnGly: 2.944 ± 0.024
1.05AsnHis: 1.05 ± 0.012
2.757AsnIle: 2.757 ± 0.023
2.596AsnLys: 2.596 ± 0.023
4.611AsnLeu: 4.611 ± 0.026
1.156AsnMet: 1.156 ± 0.013
3.111AsnAsn: 3.111 ± 0.035
1.84AsnPro: 1.84 ± 0.02
1.849AsnGln: 1.849 ± 0.016
2.556AsnArg: 2.556 ± 0.015
4.338AsnSer: 4.338 ± 0.03
2.307AsnThr: 2.307 ± 0.018
3.49AsnVal: 3.49 ± 0.022
0.582AsnTrp: 0.582 ± 0.009
1.705AsnTyr: 1.705 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
2.829ProAla: 2.829 ± 0.022
0.935ProCys: 0.935 ± 0.016
2.249ProAsp: 2.249 ± 0.02
2.646ProGlu: 2.646 ± 0.024
1.908ProPhe: 1.908 ± 0.018
2.353ProGly: 2.353 ± 0.045
0.884ProHis: 0.884 ± 0.011
2.144ProIle: 2.144 ± 0.018
2.318ProLys: 2.318 ± 0.021
4.018ProLeu: 4.018 ± 0.025
0.936ProMet: 0.936 ± 0.011
2.048ProAsn: 2.048 ± 0.018
2.936ProPro: 2.936 ± 0.04
1.53ProGln: 1.53 ± 0.016
1.849ProArg: 1.849 ± 0.017
3.821ProSer: 3.821 ± 0.028
2.573ProThr: 2.573 ± 0.023
3.177ProVal: 3.177 ± 0.025
0.471ProTrp: 0.471 ± 0.01
1.379ProTyr: 1.379 ± 0.015
0.001ProXaa: 0.001 ± 0.0
Gln
2.696GlnAla: 2.696 ± 0.018
1.16GlnCys: 1.16 ± 0.019
1.536GlnAsp: 1.536 ± 0.015
2.315GlnGlu: 2.315 ± 0.023
1.976GlnPhe: 1.976 ± 0.015
1.469GlnGly: 1.469 ± 0.016
1.268GlnHis: 1.268 ± 0.016
2.407GlnIle: 2.407 ± 0.018
2.569GlnLys: 2.569 ± 0.023
4.956GlnLeu: 4.956 ± 0.035
1.206GlnMet: 1.206 ± 0.013
2.118GlnAsn: 2.118 ± 0.016
1.928GlnPro: 1.928 ± 0.023
3.916GlnGln: 3.916 ± 0.069
2.672GlnArg: 2.672 ± 0.022
3.387GlnSer: 3.387 ± 0.025
2.166GlnThr: 2.166 ± 0.017
2.11GlnVal: 2.11 ± 0.014
0.597GlnTrp: 0.597 ± 0.009
1.315GlnTyr: 1.315 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
2.997ArgAla: 2.997 ± 0.025
1.578ArgCys: 1.578 ± 0.019
2.405ArgAsp: 2.405 ± 0.021
2.962ArgGlu: 2.962 ± 0.024
2.539ArgPhe: 2.539 ± 0.018
2.411ArgGly: 2.411 ± 0.025
1.502ArgHis: 1.502 ± 0.016
3.191ArgIle: 3.191 ± 0.02
3.726ArgLys: 3.726 ± 0.023
5.781ArgLeu: 5.781 ± 0.034
1.413ArgMet: 1.413 ± 0.016
2.633ArgAsn: 2.633 ± 0.018
2.313ArgPro: 2.313 ± 0.021
2.567ArgGln: 2.567 ± 0.021
4.412ArgArg: 4.412 ± 0.046
4.297ArgSer: 4.297 ± 0.034
2.691ArgThr: 2.691 ± 0.021
2.91ArgVal: 2.91 ± 0.022
0.775ArgTrp: 0.775 ± 0.013
1.689ArgTyr: 1.689 ± 0.013
0.0ArgXaa: 0.0 ± 0.0
Ser
5.622SerAla: 5.622 ± 0.033
2.101SerCys: 2.101 ± 0.02
4.464SerAsp: 4.464 ± 0.028
5.034SerGlu: 5.034 ± 0.036
3.614SerPhe: 3.614 ± 0.023
4.559SerGly: 4.559 ± 0.029
1.656SerHis: 1.656 ± 0.017
4.176SerIle: 4.176 ± 0.027
4.734SerLys: 4.734 ± 0.032
7.56SerLeu: 7.56 ± 0.032
1.869SerMet: 1.869 ± 0.016
4.193SerAsn: 4.193 ± 0.027
3.507SerPro: 3.507 ± 0.032
2.919SerGln: 2.919 ± 0.024
4.292SerArg: 4.292 ± 0.03
9.582SerSer: 9.582 ± 0.073
5.253SerThr: 5.253 ± 0.03
5.604SerVal: 5.604 ± 0.03
0.921SerTrp: 0.921 ± 0.011
2.237SerTyr: 2.237 ± 0.018
0.001SerXaa: 0.001 ± 0.0
Thr
4.149ThrAla: 4.149 ± 0.028
1.288ThrCys: 1.288 ± 0.019
2.843ThrAsp: 2.843 ± 0.022
3.219ThrGlu: 3.219 ± 0.028
2.442ThrPhe: 2.442 ± 0.018
2.828ThrGly: 2.828 ± 0.026
0.97ThrHis: 0.97 ± 0.012
2.887ThrIle: 2.887 ± 0.02
2.746ThrLys: 2.746 ± 0.018
5.088ThrLeu: 5.088 ± 0.029
1.277ThrMet: 1.277 ± 0.013
2.467ThrAsn: 2.467 ± 0.019
2.407ThrPro: 2.407 ± 0.024
1.571ThrGln: 1.571 ± 0.015
2.2ThrArg: 2.2 ± 0.018
4.58ThrSer: 4.58 ± 0.029
3.925ThrThr: 3.925 ± 0.039
4.404ThrVal: 4.404 ± 0.027
0.573ThrTrp: 0.573 ± 0.01
1.411ThrTyr: 1.411 ± 0.012
0.001ThrXaa: 0.001 ± 0.0
Val
4.185ValAla: 4.185 ± 0.028
1.619ValCys: 1.619 ± 0.017
4.047ValAsp: 4.047 ± 0.03
4.64ValGlu: 4.64 ± 0.031
2.588ValPhe: 2.588 ± 0.023
3.295ValGly: 3.295 ± 0.021
1.731ValHis: 1.731 ± 0.015
3.503ValIle: 3.503 ± 0.023
3.827ValLys: 3.827 ± 0.023
5.703ValLeu: 5.703 ± 0.031
1.417ValMet: 1.417 ± 0.013
3.061ValAsn: 3.061 ± 0.02
2.646ValPro: 2.646 ± 0.023
2.812ValGln: 2.812 ± 0.021
3.245ValArg: 3.245 ± 0.021
4.815ValSer: 4.815 ± 0.031
3.274ValThr: 3.274 ± 0.022
4.584ValVal: 4.584 ± 0.028
0.723ValTrp: 0.723 ± 0.01
1.879ValTyr: 1.879 ± 0.017
0.001ValXaa: 0.001 ± 0.0
Trp
0.565TrpAla: 0.565 ± 0.01
0.27TrpCys: 0.27 ± 0.006
0.543TrpAsp: 0.543 ± 0.01
0.568TrpGlu: 0.568 ± 0.009
0.566TrpPhe: 0.566 ± 0.01
0.4TrpGly: 0.4 ± 0.009
0.328TrpHis: 0.328 ± 0.007
0.786TrpIle: 0.786 ± 0.011
0.919TrpLys: 0.919 ± 0.012
1.306TrpLeu: 1.306 ± 0.015
0.343TrpMet: 0.343 ± 0.006
0.737TrpAsn: 0.737 ± 0.009
0.491TrpPro: 0.491 ± 0.008
0.533TrpGln: 0.533 ± 0.007
0.716TrpArg: 0.716 ± 0.01
0.996TrpSer: 0.996 ± 0.013
0.687TrpThr: 0.687 ± 0.009
0.504TrpVal: 0.504 ± 0.009
0.173TrpTrp: 0.173 ± 0.005
0.424TrpTyr: 0.424 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.858TyrAla: 1.858 ± 0.017
0.99TyrCys: 0.99 ± 0.014
1.639TyrAsp: 1.639 ± 0.015
1.852TyrGlu: 1.852 ± 0.016
1.716TyrPhe: 1.716 ± 0.017
1.793TyrGly: 1.793 ± 0.02
0.808TyrHis: 0.808 ± 0.011
1.637TyrIle: 1.637 ± 0.016
1.682TyrLys: 1.682 ± 0.014
2.996TyrLeu: 2.996 ± 0.021
0.716TyrMet: 0.716 ± 0.008
1.488TyrAsn: 1.488 ± 0.016
1.32TyrPro: 1.32 ± 0.015
1.179TyrGln: 1.179 ± 0.012
1.761TyrArg: 1.761 ± 0.015
2.441TyrSer: 2.441 ± 0.017
1.49TyrThr: 1.49 ± 0.015
1.859TyrVal: 1.859 ± 0.016
0.423TyrTrp: 0.423 ± 0.009
1.204TyrTyr: 1.204 ± 0.014
0.001TyrXaa: 0.001 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.001XaaAsp: 0.001 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.0
0.001XaaLys: 0.001 ± 0.0
0.001XaaLeu: 0.001 ± 0.0
0.001XaaMet: 0.001 ± 0.0
0.001XaaAsn: 0.001 ± 0.0
0.001XaaPro: 0.001 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.001XaaArg: 0.001 ± 0.0
0.001XaaSer: 0.001 ± 0.0
0.001XaaThr: 0.001 ± 0.0
0.001XaaVal: 0.001 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.041XaaXaa: 0.041 ± 0.007
Statistics based on 18195 proteins (8458498 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski