Amino acid dipepetide frequency for Rhodopirellula sp. SWK7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.561AlaAla: 10.561 ± 0.096	1.132AlaCys: 1.132 ± 0.024	6.136AlaAsp: 6.136 ± 0.059	6.17AlaGlu: 6.17 ± 0.063	3.328AlaPhe: 3.328 ± 0.038	7.382AlaGly: 7.382 ± 0.077	1.564AlaHis: 1.564 ± 0.028	5.916AlaIle: 5.916 ± 0.064	3.803AlaLys: 3.803 ± 0.053	7.189AlaLeu: 7.189 ± 0.066	2.804AlaMet: 2.804 ± 0.043	3.325AlaAsn: 3.325 ± 0.039	3.85AlaPro: 3.85 ± 0.052	2.767AlaGln: 2.767 ± 0.037	5.261AlaArg: 5.261 ± 0.058	7.25AlaSer: 7.25 ± 0.065	6.026AlaThr: 6.026 ± 0.071	6.615AlaVal: 6.615 ± 0.057	1.265AlaTrp: 1.265 ± 0.027	1.963AlaTyr: 1.963 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	0.721CysAla: 0.721 ± 0.018	0.218CysCys: 0.218 ± 0.01	0.825CysAsp: 0.825 ± 0.019	0.734CysGlu: 0.734 ± 0.019	0.462CysPhe: 0.462 ± 0.014	1.087CysGly: 1.087 ± 0.026	0.426CysHis: 0.426 ± 0.019	0.469CysIle: 0.469 ± 0.013	0.297CysLys: 0.297 ± 0.013	1.087CysLeu: 1.087 ± 0.023	0.229CysMet: 0.229 ± 0.01	0.318CysAsn: 0.318 ± 0.012	0.597CysPro: 0.597 ± 0.017	0.406CysGln: 0.406 ± 0.014	0.828CysArg: 0.828 ± 0.019	0.746CysSer: 0.746 ± 0.02	0.487CysThr: 0.487 ± 0.015	0.94CysVal: 0.94 ± 0.022	0.161CysTrp: 0.161 ± 0.006	0.308CysTyr: 0.308 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.923AspAla: 6.923 ± 0.065	0.651AspCys: 0.651 ± 0.018	4.691AspAsp: 4.691 ± 0.063	4.723AspGlu: 4.723 ± 0.051	2.424AspPhe: 2.424 ± 0.039	5.737AspGly: 5.737 ± 0.089	1.519AspHis: 1.519 ± 0.023	2.618AspIle: 2.618 ± 0.036	1.569AspLys: 1.569 ± 0.032	5.818AspLeu: 5.818 ± 0.066	1.085AspMet: 1.085 ± 0.021	1.935AspAsn: 1.935 ± 0.04	3.674AspPro: 3.674 ± 0.045	2.596AspGln: 2.596 ± 0.033	4.46AspArg: 4.46 ± 0.044	4.386AspSer: 4.386 ± 0.057	3.019AspThr: 3.019 ± 0.053	4.862AspVal: 4.862 ± 0.063	1.134AspTrp: 1.134 ± 0.022	1.601AspTyr: 1.601 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	5.361GluAla: 5.361 ± 0.052	0.54GluCys: 0.54 ± 0.014	3.057GluAsp: 3.057 ± 0.042	3.4GluGlu: 3.4 ± 0.048	2.422GluPhe: 2.422 ± 0.032	3.727GluGly: 3.727 ± 0.039	1.413GluHis: 1.413 ± 0.027	3.772GluIle: 3.772 ± 0.041	2.486GluLys: 2.486 ± 0.046	6.423GluLeu: 6.423 ± 0.054	1.712GluMet: 1.712 ± 0.03	2.408GluAsn: 2.408 ± 0.032	2.829GluPro: 2.829 ± 0.037	2.779GluGln: 2.779 ± 0.032	4.118GluArg: 4.118 ± 0.053	4.949GluSer: 4.949 ± 0.053	4.089GluThr: 4.089 ± 0.042	4.047GluVal: 4.047 ± 0.044	0.726GluTrp: 0.726 ± 0.018	1.362GluTyr: 1.362 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.868PheAla: 3.868 ± 0.043	0.503PheCys: 0.503 ± 0.016	3.046PheAsp: 3.046 ± 0.045	2.369PheGlu: 2.369 ± 0.036	1.399PhePhe: 1.399 ± 0.028	3.294PheGly: 3.294 ± 0.05	0.835PheHis: 0.835 ± 0.018	1.486PheIle: 1.486 ± 0.025	0.914PheLys: 0.914 ± 0.021	3.215PheLeu: 3.215 ± 0.043	0.684PheMet: 0.684 ± 0.016	1.2PheAsn: 1.2 ± 0.025	1.577PhePro: 1.577 ± 0.026	1.222PheGln: 1.222 ± 0.021	2.385PheArg: 2.385 ± 0.032	2.515PheSer: 2.515 ± 0.037	2.057PheThr: 2.057 ± 0.037	2.882PheVal: 2.882 ± 0.035	0.558PheTrp: 0.558 ± 0.015	0.968PheTyr: 0.968 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	5.645GlyAla: 5.645 ± 0.066	1.021GlyCys: 1.021 ± 0.024	5.249GlyAsp: 5.249 ± 0.082	4.823GlyGlu: 4.823 ± 0.046	3.089GlyPhe: 3.089 ± 0.042	6.949GlyGly: 6.949 ± 0.134	1.67GlyHis: 1.67 ± 0.029	4.045GlyIle: 4.045 ± 0.049	3.402GlyLys: 3.402 ± 0.047	6.594GlyLeu: 6.594 ± 0.059	1.973GlyMet: 1.973 ± 0.035	2.995GlyAsn: 2.995 ± 0.065	3.031GlyPro: 3.031 ± 0.041	2.773GlyGln: 2.773 ± 0.035	4.995GlyArg: 4.995 ± 0.059	5.173GlySer: 5.173 ± 0.092	4.695GlyThr: 4.695 ± 0.075	5.683GlyVal: 5.683 ± 0.062	1.269GlyTrp: 1.269 ± 0.025	2.137GlyTyr: 2.137 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.156HisAla: 2.156 ± 0.03	0.327HisCys: 0.327 ± 0.012	1.439HisAsp: 1.439 ± 0.027	1.313HisGlu: 1.313 ± 0.027	0.911HisPhe: 0.911 ± 0.022	1.817HisGly: 1.817 ± 0.029	0.754HisHis: 0.754 ± 0.019	0.776HisIle: 0.776 ± 0.019	0.467HisLys: 0.467 ± 0.016	2.102HisLeu: 2.102 ± 0.036	0.371HisMet: 0.371 ± 0.012	0.644HisAsn: 0.644 ± 0.017	1.444HisPro: 1.444 ± 0.03	0.911HisGln: 0.911 ± 0.021	1.724HisArg: 1.724 ± 0.032	1.412HisSer: 1.412 ± 0.023	0.963HisThr: 0.963 ± 0.021	1.648HisVal: 1.648 ± 0.026	0.434HisTrp: 0.434 ± 0.014	0.62HisTyr: 0.62 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.337IleAla: 6.337 ± 0.064	0.602IleCys: 0.602 ± 0.018	4.376IleAsp: 4.376 ± 0.054	4.229IleGlu: 4.229 ± 0.04	1.396IlePhe: 1.396 ± 0.026	4.507IleGly: 4.507 ± 0.046	1.116IleHis: 1.116 ± 0.021	1.894IleIle: 1.894 ± 0.033	1.422IleLys: 1.422 ± 0.026	3.797IleLeu: 3.797 ± 0.041	0.755IleMet: 0.755 ± 0.02	1.699IleAsn: 1.699 ± 0.04	2.468IlePro: 2.468 ± 0.032	1.695IleGln: 1.695 ± 0.026	3.566IleArg: 3.566 ± 0.044	3.29IleSer: 3.29 ± 0.044	2.919IleThr: 2.919 ± 0.048	4.02IleVal: 4.02 ± 0.044	0.596IleTrp: 0.596 ± 0.015	1.122IleTyr: 1.122 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.738LysAla: 2.738 ± 0.045	0.296LysCys: 0.296 ± 0.012	1.692LysAsp: 1.692 ± 0.028	1.868LysGlu: 1.868 ± 0.035	1.122LysPhe: 1.122 ± 0.018	1.987LysGly: 1.987 ± 0.035	0.821LysHis: 0.821 ± 0.018	1.841LysIle: 1.841 ± 0.032	1.616LysLys: 1.616 ± 0.038	3.337LysLeu: 3.337 ± 0.048	0.895LysMet: 0.895 ± 0.02	1.223LysAsn: 1.223 ± 0.024	2.135LysPro: 2.135 ± 0.036	1.499LysGln: 1.499 ± 0.027	2.491LysArg: 2.491 ± 0.038	2.352LysSer: 2.352 ± 0.039	2.33LysThr: 2.33 ± 0.034	2.147LysVal: 2.147 ± 0.041	0.572LysTrp: 0.572 ± 0.015	0.837LysTyr: 0.837 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	9.645LeuAla: 9.645 ± 0.075	1.048LeuCys: 1.048 ± 0.025	5.919LeuAsp: 5.919 ± 0.065	4.939LeuGlu: 4.939 ± 0.055	3.218LeuPhe: 3.218 ± 0.044	6.554LeuGly: 6.554 ± 0.061	1.914LeuHis: 1.914 ± 0.033	4.786LeuIle: 4.786 ± 0.045	3.178LeuLys: 3.178 ± 0.048	8.617LeuLeu: 8.617 ± 0.091	2.09LeuMet: 2.09 ± 0.037	2.93LeuAsn: 2.93 ± 0.04	5.266LeuPro: 5.266 ± 0.057	3.345LeuGln: 3.345 ± 0.043	6.156LeuArg: 6.156 ± 0.056	6.586LeuSer: 6.586 ± 0.066	5.419LeuThr: 5.419 ± 0.053	6.649LeuVal: 6.649 ± 0.062	1.162LeuTrp: 1.162 ± 0.027	1.894LeuTyr: 1.894 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.09MetAla: 2.09 ± 0.037	0.23MetCys: 0.23 ± 0.01	1.107MetAsp: 1.107 ± 0.021	1.079MetGlu: 1.079 ± 0.021	0.797MetPhe: 0.797 ± 0.018	1.555MetGly: 1.555 ± 0.031	0.547MetHis: 0.547 ± 0.019	1.389MetIle: 1.389 ± 0.027	1.044MetLys: 1.044 ± 0.024	2.415MetLeu: 2.415 ± 0.034	0.664MetMet: 0.664 ± 0.019	0.98MetAsn: 0.98 ± 0.022	1.426MetPro: 1.426 ± 0.026	0.995MetGln: 0.995 ± 0.018	1.597MetArg: 1.597 ± 0.027	1.748MetSer: 1.748 ± 0.029	1.632MetThr: 1.632 ± 0.029	1.531MetVal: 1.531 ± 0.026	0.26MetTrp: 0.26 ± 0.01	0.378MetTyr: 0.378 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.463AsnAla: 3.463 ± 0.041	0.345AsnCys: 0.345 ± 0.013	2.44AsnAsp: 2.44 ± 0.048	2.256AsnGlu: 2.256 ± 0.032	1.141AsnPhe: 1.141 ± 0.024	2.946AsnGly: 2.946 ± 0.06	0.829AsnHis: 0.829 ± 0.02	1.379AsnIle: 1.379 ± 0.03	0.822AsnLys: 0.822 ± 0.018	3.0AsnLeu: 3.0 ± 0.033	0.582AsnMet: 0.582 ± 0.016	1.232AsnAsn: 1.232 ± 0.037	2.1AsnPro: 2.1 ± 0.032	1.443AsnGln: 1.443 ± 0.025	2.494AsnArg: 2.494 ± 0.035	2.22AsnSer: 2.22 ± 0.04	1.845AsnThr: 1.845 ± 0.041	2.632AsnVal: 2.632 ± 0.035	0.531AsnTrp: 0.531 ± 0.014	0.901AsnTyr: 0.901 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	4.879ProAla: 4.879 ± 0.06	0.396ProCys: 0.396 ± 0.013	3.507ProAsp: 3.507 ± 0.042	3.665ProGlu: 3.665 ± 0.046	1.847ProPhe: 1.847 ± 0.027	3.838ProGly: 3.838 ± 0.051	1.154ProHis: 1.154 ± 0.024	2.814ProIle: 2.814 ± 0.04	1.805ProLys: 1.805 ± 0.035	4.194ProLeu: 4.194 ± 0.05	1.289ProMet: 1.289 ± 0.024	2.061ProAsn: 2.061 ± 0.034	2.74ProPro: 2.74 ± 0.045	1.736ProGln: 1.736 ± 0.027	2.743ProArg: 2.743 ± 0.04	3.859ProSer: 3.859 ± 0.041	3.363ProThr: 3.363 ± 0.046	3.748ProVal: 3.748 ± 0.043	0.74ProTrp: 0.74 ± 0.018	1.103ProTyr: 1.103 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.131GlnAla: 3.131 ± 0.038	0.413GlnCys: 0.413 ± 0.014	1.63GlnAsp: 1.63 ± 0.027	1.678GlnGlu: 1.678 ± 0.029	1.575GlnPhe: 1.575 ± 0.025	2.104GlnGly: 2.104 ± 0.034	0.862GlnHis: 0.862 ± 0.018	2.244GlnIle: 2.244 ± 0.032	1.301GlnLys: 1.301 ± 0.021	3.839GlnLeu: 3.839 ± 0.044	0.948GlnMet: 0.948 ± 0.018	1.264GlnAsn: 1.264 ± 0.02	2.107GlnPro: 2.107 ± 0.033	1.721GlnGln: 1.721 ± 0.03	2.86GlnArg: 2.86 ± 0.035	3.06GlnSer: 3.06 ± 0.042	2.665GlnThr: 2.665 ± 0.036	2.257GlnVal: 2.257 ± 0.033	0.766GlnTrp: 0.766 ± 0.018	0.937GlnTyr: 0.937 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	4.731ArgAla: 4.731 ± 0.053	0.894ArgCys: 0.894 ± 0.017	4.218ArgAsp: 4.218 ± 0.047	4.219ArgGlu: 4.219 ± 0.053	3.024ArgPhe: 3.024 ± 0.035	4.531ArgGly: 4.531 ± 0.05	1.518ArgHis: 1.518 ± 0.026	3.634ArgIle: 3.634 ± 0.041	2.281ArgLys: 2.281 ± 0.042	6.816ArgLeu: 6.816 ± 0.071	1.843ArgMet: 1.843 ± 0.03	2.155ArgAsn: 2.155 ± 0.031	3.09ArgPro: 3.09 ± 0.04	2.592ArgGln: 2.592 ± 0.036	5.307ArgArg: 5.307 ± 0.068	4.571ArgSer: 4.571 ± 0.053	3.376ArgThr: 3.376 ± 0.037	4.878ArgVal: 4.878 ± 0.047	1.245ArgTrp: 1.245 ± 0.023	1.908ArgTyr: 1.908 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	5.966SerAla: 5.966 ± 0.065	0.697SerCys: 0.697 ± 0.019	4.911SerAsp: 4.911 ± 0.057	4.315SerGlu: 4.315 ± 0.049	2.443SerPhe: 2.443 ± 0.036	6.169SerGly: 6.169 ± 0.091	1.52SerHis: 1.52 ± 0.026	3.745SerIle: 3.745 ± 0.046	2.245SerLys: 2.245 ± 0.035	6.716SerLeu: 6.716 ± 0.067	1.703SerMet: 1.703 ± 0.029	2.506SerAsn: 2.506 ± 0.037	3.967SerPro: 3.967 ± 0.048	2.626SerGln: 2.626 ± 0.036	4.546SerArg: 4.546 ± 0.049	4.93SerSer: 4.93 ± 0.064	3.989SerThr: 3.989 ± 0.05	5.187SerVal: 5.187 ± 0.053	0.923SerTrp: 0.923 ± 0.019	1.442SerTyr: 1.442 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.533ThrAla: 5.533 ± 0.063	0.535ThrCys: 0.535 ± 0.016	3.751ThrAsp: 3.751 ± 0.058	3.249ThrGlu: 3.249 ± 0.04	2.174ThrPhe: 2.174 ± 0.038	4.794ThrGly: 4.794 ± 0.06	1.253ThrHis: 1.253 ± 0.024	3.412ThrIle: 3.412 ± 0.055	1.827ThrLys: 1.827 ± 0.03	5.765ThrLeu: 5.765 ± 0.054	1.272ThrMet: 1.272 ± 0.023	2.02ThrAsn: 2.02 ± 0.036	3.826ThrPro: 3.826 ± 0.047	2.1ThrGln: 2.1 ± 0.025	3.524ThrArg: 3.524 ± 0.039	3.939ThrSer: 3.939 ± 0.056	3.691ThrThr: 3.691 ± 0.063	4.238ThrVal: 4.238 ± 0.065	0.788ThrTrp: 0.788 ± 0.018	1.381ThrTyr: 1.381 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.374ValAla: 7.374 ± 0.061	0.956ValCys: 0.956 ± 0.025	5.03ValAsp: 5.03 ± 0.06	4.403ValGlu: 4.403 ± 0.04	2.592ValPhe: 2.592 ± 0.032	5.326ValGly: 5.326 ± 0.058	1.464ValHis: 1.464 ± 0.026	3.901ValIle: 3.901 ± 0.033	2.056ValLys: 2.056 ± 0.035	6.568ValLeu: 6.568 ± 0.06	1.697ValMet: 1.697 ± 0.027	2.354ValAsn: 2.354 ± 0.037	3.476ValPro: 3.476 ± 0.041	2.311ValGln: 2.311 ± 0.028	4.733ValArg: 4.733 ± 0.048	5.148ValSer: 5.148 ± 0.052	4.452ValThr: 4.452 ± 0.069	5.694ValVal: 5.694 ± 0.056	1.014ValTrp: 1.014 ± 0.024	1.62ValTyr: 1.62 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.089TrpAla: 1.089 ± 0.022	0.211TrpCys: 0.211 ± 0.008	0.834TrpAsp: 0.834 ± 0.018	0.739TrpGlu: 0.739 ± 0.019	0.587TrpPhe: 0.587 ± 0.017	0.971TrpGly: 0.971 ± 0.019	0.418TrpHis: 0.418 ± 0.015	0.887TrpIle: 0.887 ± 0.023	0.684TrpLys: 0.684 ± 0.018	1.536TrpLeu: 1.536 ± 0.028	0.471TrpMet: 0.471 ± 0.014	0.613TrpAsn: 0.613 ± 0.016	0.666TrpPro: 0.666 ± 0.016	0.714TrpGln: 0.714 ± 0.018	0.981TrpArg: 0.981 ± 0.023	0.98TrpSer: 0.98 ± 0.021	0.873TrpThr: 0.873 ± 0.02	0.935TrpVal: 0.935 ± 0.019	0.294TrpTrp: 0.294 ± 0.012	0.363TrpTyr: 0.363 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.097TyrAla: 2.097 ± 0.029	0.33TyrCys: 0.33 ± 0.012	1.568TyrAsp: 1.568 ± 0.039	1.448TyrGlu: 1.448 ± 0.024	1.027TyrPhe: 1.027 ± 0.023	1.937TyrGly: 1.937 ± 0.033	0.637TyrHis: 0.637 ± 0.017	0.794TyrIle: 0.794 ± 0.017	0.58TyrLys: 0.58 ± 0.018	2.286TyrLeu: 2.286 ± 0.036	0.398TyrMet: 0.398 ± 0.013	0.74TyrAsn: 0.74 ± 0.019	1.211TyrPro: 1.211 ± 0.023	1.132TyrGln: 1.132 ± 0.022	2.063TyrArg: 2.063 ± 0.027	1.432TyrSer: 1.432 ± 0.025	1.182TyrThr: 1.182 ± 0.027	1.577TyrVal: 1.577 ± 0.028	0.409TyrTrp: 0.409 ± 0.014	0.733TyrTyr: 0.733 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7238 proteins (2568549 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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