Amino acid dipepetide frequency for Chitinophaga extrema

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.662AlaAla: 10.662 ± 0.119	0.879AlaCys: 0.879 ± 0.024	5.037AlaAsp: 5.037 ± 0.046	4.125AlaGlu: 4.125 ± 0.045	3.683AlaPhe: 3.683 ± 0.041	7.793AlaGly: 7.793 ± 0.078	1.497AlaHis: 1.497 ± 0.027	5.0AlaIle: 5.0 ± 0.054	3.343AlaLys: 3.343 ± 0.055	8.071AlaLeu: 8.071 ± 0.075	2.024AlaMet: 2.024 ± 0.036	3.209AlaAsn: 3.209 ± 0.045	3.308AlaPro: 3.308 ± 0.053	3.21AlaGln: 3.21 ± 0.038	3.669AlaArg: 3.669 ± 0.039	4.626AlaSer: 4.626 ± 0.043	5.075AlaThr: 5.075 ± 0.093	6.193AlaVal: 6.193 ± 0.067	1.055AlaTrp: 1.055 ± 0.023	3.347AlaTyr: 3.347 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.575CysAla: 0.575 ± 0.02	0.183CysCys: 0.183 ± 0.008	0.375CysAsp: 0.375 ± 0.021	0.371CysGlu: 0.371 ± 0.013	0.414CysPhe: 0.414 ± 0.013	0.675CysGly: 0.675 ± 0.022	0.213CysHis: 0.213 ± 0.01	0.654CysIle: 0.654 ± 0.016	0.411CysLys: 0.411 ± 0.014	0.883CysLeu: 0.883 ± 0.023	0.268CysMet: 0.268 ± 0.012	0.432CysAsn: 0.432 ± 0.021	0.352CysPro: 0.352 ± 0.013	0.26CysGln: 0.26 ± 0.012	0.507CysArg: 0.507 ± 0.015	0.579CysSer: 0.579 ± 0.018	0.538CysThr: 0.538 ± 0.018	0.484CysVal: 0.484 ± 0.018	0.147CysTrp: 0.147 ± 0.007	0.395CysTyr: 0.395 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.292AspAla: 4.292 ± 0.05	0.369AspCys: 0.369 ± 0.012	2.239AspAsp: 2.239 ± 0.034	2.741AspGlu: 2.741 ± 0.043	2.598AspPhe: 2.598 ± 0.039	3.653AspGly: 3.653 ± 0.046	0.967AspHis: 0.967 ± 0.023	3.972AspIle: 3.972 ± 0.051	3.305AspLys: 3.305 ± 0.045	4.369AspLeu: 4.369 ± 0.053	1.33AspMet: 1.33 ± 0.026	2.741AspAsn: 2.741 ± 0.041	2.32AspPro: 2.32 ± 0.037	1.713AspGln: 1.713 ± 0.03	2.286AspArg: 2.286 ± 0.038	2.948AspSer: 2.948 ± 0.058	3.161AspThr: 3.161 ± 0.048	3.159AspVal: 3.159 ± 0.045	0.696AspTrp: 0.696 ± 0.017	2.52AspTyr: 2.52 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	4.4GluAla: 4.4 ± 0.049	0.331GluCys: 0.331 ± 0.013	2.586GluAsp: 2.586 ± 0.04	3.586GluGlu: 3.586 ± 0.059	1.858GluPhe: 1.858 ± 0.033	3.131GluGly: 3.131 ± 0.036	1.172GluHis: 1.172 ± 0.024	3.685GluIle: 3.685 ± 0.041	4.27GluLys: 4.27 ± 0.055	5.235GluLeu: 5.235 ± 0.057	1.499GluMet: 1.499 ± 0.026	2.783GluAsn: 2.783 ± 0.041	1.585GluPro: 1.585 ± 0.027	2.752GluGln: 2.752 ± 0.044	2.51GluArg: 2.51 ± 0.036	2.421GluSer: 2.421 ± 0.032	2.806GluThr: 2.806 ± 0.037	3.48GluVal: 3.48 ± 0.042	0.673GluTrp: 0.673 ± 0.016	1.909GluTyr: 1.909 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.075PheAla: 3.075 ± 0.041	0.433PheCys: 0.433 ± 0.014	2.588PheAsp: 2.588 ± 0.038	2.308PheGlu: 2.308 ± 0.034	2.254PhePhe: 2.254 ± 0.039	2.905PheGly: 2.905 ± 0.044	0.914PheHis: 0.914 ± 0.021	3.026PheIle: 3.026 ± 0.038	2.118PheLys: 2.118 ± 0.038	4.101PheLeu: 4.101 ± 0.054	1.129PheMet: 1.129 ± 0.024	2.6PheAsn: 2.6 ± 0.033	1.863PhePro: 1.863 ± 0.031	1.32PheGln: 1.32 ± 0.024	2.599PheArg: 2.599 ± 0.034	3.532PheSer: 3.532 ± 0.044	3.185PheThr: 3.185 ± 0.044	2.482PheVal: 2.482 ± 0.037	0.509PheTrp: 0.509 ± 0.017	1.871PheTyr: 1.871 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.443GlyAla: 5.443 ± 0.06	0.696GlyCys: 0.696 ± 0.019	3.348GlyAsp: 3.348 ± 0.04	3.482GlyGlu: 3.482 ± 0.048	3.269GlyPhe: 3.269 ± 0.049	5.178GlyGly: 5.178 ± 0.074	1.387GlyHis: 1.387 ± 0.025	5.386GlyIle: 5.386 ± 0.054	4.878GlyLys: 4.878 ± 0.05	5.955GlyLeu: 5.955 ± 0.057	1.906GlyMet: 1.906 ± 0.032	3.997GlyAsn: 3.997 ± 0.057	1.874GlyPro: 1.874 ± 0.041	2.438GlyGln: 2.438 ± 0.034	3.327GlyArg: 3.327 ± 0.047	4.496GlySer: 4.496 ± 0.053	4.422GlyThr: 4.422 ± 0.065	4.672GlyVal: 4.672 ± 0.068	1.065GlyTrp: 1.065 ± 0.026	3.339GlyTyr: 3.339 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.521HisAla: 1.521 ± 0.032	0.253HisCys: 0.253 ± 0.019	0.926HisAsp: 0.926 ± 0.022	1.023HisGlu: 1.023 ± 0.023	1.242HisPhe: 1.242 ± 0.025	1.198HisGly: 1.198 ± 0.026	0.783HisHis: 0.783 ± 0.025	1.6HisIle: 1.6 ± 0.03	0.909HisLys: 0.909 ± 0.023	2.107HisLeu: 2.107 ± 0.035	0.466HisMet: 0.466 ± 0.013	0.906HisAsn: 0.906 ± 0.02	1.267HisPro: 1.267 ± 0.026	0.917HisGln: 0.917 ± 0.021	1.043HisArg: 1.043 ± 0.024	1.109HisSer: 1.109 ± 0.023	1.391HisThr: 1.391 ± 0.029	1.079HisVal: 1.079 ± 0.022	0.282HisTrp: 0.282 ± 0.014	1.028HisTyr: 1.028 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.722IleAla: 5.722 ± 0.057	0.719IleCys: 0.719 ± 0.02	3.35IleAsp: 3.35 ± 0.042	2.911IleGlu: 2.911 ± 0.04	2.755IlePhe: 2.755 ± 0.04	4.239IleGly: 4.239 ± 0.048	1.378IleHis: 1.378 ± 0.027	4.239IleIle: 4.239 ± 0.056	3.153IleLys: 3.153 ± 0.049	5.598IleLeu: 5.598 ± 0.059	1.377IleMet: 1.377 ± 0.026	3.292IleAsn: 3.292 ± 0.044	3.344IlePro: 3.344 ± 0.037	2.335IleGln: 2.335 ± 0.037	3.926IleArg: 3.926 ± 0.045	4.927IleSer: 4.927 ± 0.05	4.907IleThr: 4.907 ± 0.069	3.703IleVal: 3.703 ± 0.052	0.745IleTrp: 0.745 ± 0.02	2.468IleTyr: 2.468 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.579LysAla: 4.579 ± 0.055	0.285LysCys: 0.285 ± 0.012	3.513LysAsp: 3.513 ± 0.044	3.68LysGlu: 3.68 ± 0.055	1.804LysPhe: 1.804 ± 0.03	4.014LysGly: 4.014 ± 0.051	1.045LysHis: 1.045 ± 0.025	3.652LysIle: 3.652 ± 0.048	3.92LysLys: 3.92 ± 0.058	4.58LysLeu: 4.58 ± 0.048	1.589LysMet: 1.589 ± 0.031	2.779LysAsn: 2.779 ± 0.047	2.347LysPro: 2.347 ± 0.036	2.316LysGln: 2.316 ± 0.031	2.34LysArg: 2.34 ± 0.038	2.907LysSer: 2.907 ± 0.042	3.328LysThr: 3.328 ± 0.036	3.658LysVal: 3.658 ± 0.056	0.679LysTrp: 0.679 ± 0.017	2.178LysTyr: 2.178 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	7.343LeuAla: 7.343 ± 0.073	0.916LeuCys: 0.916 ± 0.022	4.47LeuAsp: 4.47 ± 0.054	5.083LeuGlu: 5.083 ± 0.052	4.336LeuPhe: 4.336 ± 0.044	5.595LeuGly: 5.595 ± 0.057	2.341LeuHis: 2.341 ± 0.035	5.477LeuIle: 5.477 ± 0.06	5.671LeuLys: 5.671 ± 0.061	11.083LeuLeu: 11.083 ± 0.116	2.219LeuMet: 2.219 ± 0.034	4.427LeuAsn: 4.427 ± 0.051	5.092LeuPro: 5.092 ± 0.068	5.571LeuGln: 5.571 ± 0.074	4.743LeuArg: 4.743 ± 0.049	6.824LeuSer: 6.824 ± 0.069	5.915LeuThr: 5.915 ± 0.061	5.294LeuVal: 5.294 ± 0.047	0.952LeuTrp: 0.952 ± 0.022	3.501LeuTyr: 3.501 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.987MetAla: 1.987 ± 0.036	0.166MetCys: 0.166 ± 0.008	1.263MetAsp: 1.263 ± 0.025	1.543MetGlu: 1.543 ± 0.032	0.771MetPhe: 0.771 ± 0.023	1.499MetGly: 1.499 ± 0.028	0.563MetHis: 0.563 ± 0.015	1.483MetIle: 1.483 ± 0.032	1.873MetLys: 1.873 ± 0.027	2.532MetLeu: 2.532 ± 0.042	0.72MetMet: 0.72 ± 0.018	1.222MetAsn: 1.222 ± 0.024	1.279MetPro: 1.279 ± 0.027	1.34MetGln: 1.34 ± 0.022	1.109MetArg: 1.109 ± 0.024	1.308MetSer: 1.308 ± 0.027	1.26MetThr: 1.26 ± 0.024	1.424MetVal: 1.424 ± 0.026	0.2MetTrp: 0.2 ± 0.009	0.786MetTyr: 0.786 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.914AsnAla: 3.914 ± 0.053	0.372AsnCys: 0.372 ± 0.014	2.426AsnAsp: 2.426 ± 0.044	2.312AsnGlu: 2.312 ± 0.033	2.094AsnPhe: 2.094 ± 0.038	4.039AsnGly: 4.039 ± 0.054	0.815AsnHis: 0.815 ± 0.02	3.77AsnIle: 3.77 ± 0.055	2.649AsnLys: 2.649 ± 0.04	3.88AsnLeu: 3.88 ± 0.054	1.158AsnMet: 1.158 ± 0.021	2.987AsnAsn: 2.987 ± 0.054	2.524AsnPro: 2.524 ± 0.046	1.599AsnGln: 1.599 ± 0.031	2.475AsnArg: 2.475 ± 0.038	2.765AsnSer: 2.765 ± 0.047	3.412AsnThr: 3.412 ± 0.056	2.844AsnVal: 2.844 ± 0.044	0.628AsnTrp: 0.628 ± 0.018	2.225AsnTyr: 2.225 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	5.395ProAla: 5.395 ± 0.088	0.269ProCys: 0.269 ± 0.011	3.158ProAsp: 3.158 ± 0.044	3.162ProGlu: 3.162 ± 0.046	2.089ProPhe: 2.089 ± 0.031	3.787ProGly: 3.787 ± 0.047	0.808ProHis: 0.808 ± 0.021	1.637ProIle: 1.637 ± 0.031	1.569ProLys: 1.569 ± 0.029	4.223ProLeu: 4.223 ± 0.05	0.842ProMet: 0.842 ± 0.018	1.447ProAsn: 1.447 ± 0.03	1.541ProPro: 1.541 ± 0.029	1.727ProGln: 1.727 ± 0.029	1.522ProArg: 1.522 ± 0.024	2.263ProSer: 2.263 ± 0.035	1.646ProThr: 1.646 ± 0.033	4.58ProVal: 4.58 ± 0.063	0.499ProTrp: 0.499 ± 0.017	1.636ProTyr: 1.636 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.328GlnAla: 3.328 ± 0.043	0.254GlnCys: 0.254 ± 0.012	1.823GlnAsp: 1.823 ± 0.029	2.733GlnGlu: 2.733 ± 0.043	1.638GlnPhe: 1.638 ± 0.031	2.273GlnGly: 2.273 ± 0.036	1.306GlnHis: 1.306 ± 0.027	2.109GlnIle: 2.109 ± 0.03	1.841GlnLys: 1.841 ± 0.033	5.439GlnLeu: 5.439 ± 0.073	0.905GlnMet: 0.905 ± 0.021	1.385GlnAsn: 1.385 ± 0.029	2.21GlnPro: 2.21 ± 0.032	3.747GlnGln: 3.747 ± 0.064	2.118GlnArg: 2.118 ± 0.029	2.079GlnSer: 2.079 ± 0.03	2.122GlnThr: 2.122 ± 0.026	2.877GlnVal: 2.877 ± 0.047	0.601GlnTrp: 0.601 ± 0.016	1.842GlnTyr: 1.842 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.951ArgAla: 2.951 ± 0.036	0.328ArgCys: 0.328 ± 0.013	2.255ArgAsp: 2.255 ± 0.036	3.021ArgGlu: 3.021 ± 0.045	2.412ArgPhe: 2.412 ± 0.034	2.47ArgGly: 2.47 ± 0.033	1.163ArgHis: 1.163 ± 0.02	3.716ArgIle: 3.716 ± 0.039	3.197ArgLys: 3.197 ± 0.049	4.938ArgLeu: 4.938 ± 0.052	1.375ArgMet: 1.375 ± 0.023	2.69ArgAsn: 2.69 ± 0.038	1.787ArgPro: 1.787 ± 0.028	2.531ArgGln: 2.531 ± 0.041	2.309ArgArg: 2.309 ± 0.04	2.598ArgSer: 2.598 ± 0.039	2.583ArgThr: 2.583 ± 0.036	2.639ArgVal: 2.639 ± 0.037	0.801ArgTrp: 0.801 ± 0.021	2.342ArgTyr: 2.342 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.198SerAla: 5.198 ± 0.058	0.659SerCys: 0.659 ± 0.017	2.698SerAsp: 2.698 ± 0.039	2.349SerGlu: 2.349 ± 0.032	3.291SerPhe: 3.291 ± 0.042	5.441SerGly: 5.441 ± 0.072	1.134SerHis: 1.134 ± 0.023	3.884SerIle: 3.884 ± 0.042	2.676SerLys: 2.676 ± 0.038	6.285SerLeu: 6.285 ± 0.061	1.378SerMet: 1.378 ± 0.027	2.826SerAsn: 2.826 ± 0.049	2.577SerPro: 2.577 ± 0.039	1.968SerGln: 1.968 ± 0.03	3.197SerArg: 3.197 ± 0.038	3.841SerSer: 3.841 ± 0.059	3.257SerThr: 3.257 ± 0.048	4.02SerVal: 4.02 ± 0.045	0.963SerTrp: 0.963 ± 0.025	2.771SerTyr: 2.771 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.374ThrAla: 6.374 ± 0.081	0.46ThrCys: 0.46 ± 0.017	3.639ThrAsp: 3.639 ± 0.044	2.71ThrGlu: 2.71 ± 0.038	2.698ThrPhe: 2.698 ± 0.033	5.908ThrGly: 5.908 ± 0.064	1.125ThrHis: 1.125 ± 0.023	3.993ThrIle: 3.993 ± 0.064	2.209ThrLys: 2.209 ± 0.034	5.829ThrLeu: 5.829 ± 0.053	1.106ThrMet: 1.106 ± 0.025	2.406ThrAsn: 2.406 ± 0.044	3.222ThrPro: 3.222 ± 0.049	1.919ThrGln: 1.919 ± 0.032	2.7ThrArg: 2.7 ± 0.039	3.448ThrSer: 3.448 ± 0.048	3.961ThrThr: 3.961 ± 0.074	4.365ThrVal: 4.365 ± 0.076	0.812ThrTrp: 0.812 ± 0.039	2.36ThrTyr: 2.36 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	5.115ValAla: 5.115 ± 0.055	0.623ValCys: 0.623 ± 0.024	2.766ValAsp: 2.766 ± 0.04	2.792ValGlu: 2.792 ± 0.034	2.985ValPhe: 2.985 ± 0.043	3.172ValGly: 3.172 ± 0.061	1.183ValHis: 1.183 ± 0.025	4.589ValIle: 4.589 ± 0.047	4.2ValLys: 4.2 ± 0.047	6.381ValLeu: 6.381 ± 0.064	1.724ValMet: 1.724 ± 0.028	3.603ValAsn: 3.603 ± 0.055	2.968ValPro: 2.968 ± 0.065	2.449ValGln: 2.449 ± 0.03	2.779ValArg: 2.779 ± 0.036	4.52ValSer: 4.52 ± 0.051	4.721ValThr: 4.721 ± 0.083	4.157ValVal: 4.157 ± 0.047	0.744ValTrp: 0.744 ± 0.018	2.551ValTyr: 2.551 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.777TrpAla: 0.777 ± 0.02	0.138TrpCys: 0.138 ± 0.009	0.635TrpAsp: 0.635 ± 0.016	0.765TrpGlu: 0.765 ± 0.02	0.559TrpPhe: 0.559 ± 0.016	0.817TrpGly: 0.817 ± 0.023	0.308TrpHis: 0.308 ± 0.013	0.755TrpIle: 0.755 ± 0.021	0.899TrpLys: 0.899 ± 0.026	1.432TrpLeu: 1.432 ± 0.028	0.402TrpMet: 0.402 ± 0.015	0.722TrpAsn: 0.722 ± 0.022	0.387TrpPro: 0.387 ± 0.016	0.799TrpGln: 0.799 ± 0.019	0.604TrpArg: 0.604 ± 0.016	0.75TrpSer: 0.75 ± 0.027	0.685TrpThr: 0.685 ± 0.02	0.668TrpVal: 0.668 ± 0.016	0.258TrpTrp: 0.258 ± 0.012	0.542TrpTyr: 0.542 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.157TyrAla: 3.157 ± 0.038	0.381TyrCys: 0.381 ± 0.014	2.284TyrAsp: 2.284 ± 0.042	1.973TyrGlu: 1.973 ± 0.032	2.065TyrPhe: 2.065 ± 0.037	2.771TyrGly: 2.771 ± 0.041	0.951TyrHis: 0.951 ± 0.023	2.462TyrIle: 2.462 ± 0.034	2.103TyrLys: 2.103 ± 0.036	3.931TyrLeu: 3.931 ± 0.048	0.909TyrMet: 0.909 ± 0.019	2.434TyrAsn: 2.434 ± 0.043	1.952TyrPro: 1.952 ± 0.033	1.722TyrGln: 1.722 ± 0.026	2.341TyrArg: 2.341 ± 0.036	2.472TyrSer: 2.472 ± 0.041	2.87TyrThr: 2.87 ± 0.043	2.242TyrVal: 2.242 ± 0.038	0.592TyrTrp: 0.592 ± 0.019	1.928TyrTyr: 1.928 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5973 proteins (2372467 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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