Amino acid dipepetide frequency for Kabuto mountain virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.65AlaAla: 4.65 ± 0.762
1.368AlaCys: 1.368 ± 0.621
2.462AlaAsp: 2.462 ± 0.966
3.282AlaGlu: 3.282 ± 0.878
2.735AlaPhe: 2.735 ± 1.469
3.282AlaGly: 3.282 ± 0.93
0.821AlaHis: 0.821 ± 0.236
4.65AlaIle: 4.65 ± 0.854
3.009AlaLys: 3.009 ± 1.324
4.376AlaLeu: 4.376 ± 1.255
1.641AlaMet: 1.641 ± 1.177
1.368AlaAsn: 1.368 ± 0.963
2.188AlaPro: 2.188 ± 0.807
1.641AlaGln: 1.641 ± 0.58
2.462AlaArg: 2.462 ± 1.124
4.923AlaSer: 4.923 ± 0.553
3.829AlaThr: 3.829 ± 0.627
3.829AlaVal: 3.829 ± 1.172
0.821AlaTrp: 0.821 ± 0.236
0.821AlaTyr: 0.821 ± 1.083
0.0AlaXaa: 0.0 ± 0.0
Cys
1.368CysAla: 1.368 ± 0.4
0.547CysCys: 0.547 ± 0.193
1.368CysAsp: 1.368 ± 0.494
1.368CysGlu: 1.368 ± 1.335
2.735CysPhe: 2.735 ± 1.571
1.368CysGly: 1.368 ± 0.4
0.821CysHis: 0.821 ± 0.771
1.641CysIle: 1.641 ± 0.875
1.641CysLys: 1.641 ± 0.875
4.103CysLeu: 4.103 ± 1.2
0.0CysMet: 0.0 ± 0.0
0.821CysAsn: 0.821 ± 0.236
1.915CysPro: 1.915 ± 1.134
1.368CysGln: 1.368 ± 0.824
0.0CysArg: 0.0 ± 0.0
2.735CysSer: 2.735 ± 1.597
1.094CysThr: 1.094 ± 0.698
0.547CysVal: 0.547 ± 0.534
0.274CysTrp: 0.274 ± 0.576
0.821CysTyr: 0.821 ± 0.801
0.0CysXaa: 0.0 ± 0.0
Asp
1.641AspAla: 1.641 ± 1.228
1.641AspCys: 1.641 ± 1.228
3.556AspAsp: 3.556 ± 0.564
3.829AspGlu: 3.829 ± 1.571
4.376AspPhe: 4.376 ± 1.065
3.556AspGly: 3.556 ± 0.617
1.368AspHis: 1.368 ± 0.655
3.282AspIle: 3.282 ± 0.93
3.829AspLys: 3.829 ± 1.807
5.197AspLeu: 5.197 ± 1.28
0.547AspMet: 0.547 ± 0.193
1.641AspAsn: 1.641 ± 0.687
3.282AspPro: 3.282 ± 0.733
1.368AspGln: 1.368 ± 0.352
1.915AspArg: 1.915 ± 1.452
3.829AspSer: 3.829 ± 0.731
4.103AspThr: 4.103 ± 0.172
3.282AspVal: 3.282 ± 0.746
2.188AspTrp: 2.188 ± 0.571
0.547AspTyr: 0.547 ± 0.505
0.0AspXaa: 0.0 ± 0.0
Glu
5.47GluAla: 5.47 ± 1.288
0.821GluCys: 0.821 ± 0.771
4.65GluAsp: 4.65 ± 1.649
5.47GluGlu: 5.47 ± 1.317
3.009GluPhe: 3.009 ± 0.96
2.735GluGly: 2.735 ± 0.568
2.188GluHis: 2.188 ± 0.331
3.829GluIle: 3.829 ± 0.366
3.829GluLys: 3.829 ± 0.644
3.556GluLeu: 3.556 ± 0.795
1.641GluMet: 1.641 ± 0.668
1.368GluAsn: 1.368 ± 0.4
1.641GluPro: 1.641 ± 0.685
2.188GluGln: 2.188 ± 0.965
4.65GluArg: 4.65 ± 1.284
5.744GluSer: 5.744 ± 0.958
3.009GluThr: 3.009 ± 0.919
6.291GluVal: 6.291 ± 1.17
1.641GluTrp: 1.641 ± 0.472
2.462GluTyr: 2.462 ± 0.562
0.0GluXaa: 0.0 ± 0.0
Phe
3.556PheAla: 3.556 ± 1.677
1.094PheCys: 1.094 ± 0.698
1.641PheAsp: 1.641 ± 0.373
1.641PheGlu: 1.641 ± 0.456
3.282PhePhe: 3.282 ± 0.746
3.829PheGly: 3.829 ± 0.819
2.462PheHis: 2.462 ± 0.562
2.735PheIle: 2.735 ± 0.8
2.735PheLys: 2.735 ± 0.953
6.018PheLeu: 6.018 ± 1.265
1.641PheMet: 1.641 ± 0.939
2.462PheAsn: 2.462 ± 0.411
3.009PhePro: 3.009 ± 0.753
1.094PheGln: 1.094 ± 0.494
3.009PheArg: 3.009 ± 0.78
3.829PheSer: 3.829 ± 1.619
2.735PheThr: 2.735 ± 0.643
2.188PheVal: 2.188 ± 1.161
0.821PheTrp: 0.821 ± 0.485
3.009PheTyr: 3.009 ± 0.454
0.0PheXaa: 0.0 ± 0.0
Gly
1.915GlyAla: 1.915 ± 0.809
0.274GlyCys: 0.274 ± 0.267
4.65GlyAsp: 4.65 ± 0.875
2.188GlyGlu: 2.188 ± 1.252
3.009GlyPhe: 3.009 ± 1.419
2.735GlyGly: 2.735 ± 0.643
1.094GlyHis: 1.094 ± 0.355
3.829GlyIle: 3.829 ± 0.793
4.376GlyLys: 4.376 ± 0.433
5.47GlyLeu: 5.47 ± 1.686
2.462GlyMet: 2.462 ± 0.801
1.641GlyAsn: 1.641 ± 0.373
2.188GlyPro: 2.188 ± 0.728
1.368GlyGln: 1.368 ± 0.621
3.829GlyArg: 3.829 ± 0.366
2.735GlySer: 2.735 ± 0.393
1.641GlyThr: 1.641 ± 0.685
4.65GlyVal: 4.65 ± 1.302
1.641GlyTrp: 1.641 ± 0.875
0.821GlyTyr: 0.821 ± 0.485
0.0GlyXaa: 0.0 ± 0.0
His
0.547HisAla: 0.547 ± 0.193
1.368HisCys: 1.368 ± 0.4
0.821HisAsp: 0.821 ± 0.236
1.368HisGlu: 1.368 ± 0.499
1.094HisPhe: 1.094 ± 0.627
1.915HisGly: 1.915 ± 0.792
1.094HisHis: 1.094 ± 0.355
0.274HisIle: 0.274 ± 0.549
0.821HisLys: 0.821 ± 0.236
3.829HisLeu: 3.829 ± 1.099
1.094HisMet: 1.094 ± 0.355
0.547HisAsn: 0.547 ± 0.323
1.641HisPro: 1.641 ± 0.97
0.0HisGln: 0.0 ± 0.0
1.641HisArg: 1.641 ± 0.652
1.641HisSer: 1.641 ± 0.89
1.368HisThr: 1.368 ± 0.621
3.009HisVal: 3.009 ± 0.545
0.274HisTrp: 0.274 ± 0.162
1.641HisTyr: 1.641 ± 0.58
0.0HisXaa: 0.0 ± 0.0
Ile
3.009IleAla: 3.009 ± 1.115
2.462IleCys: 2.462 ± 0.77
2.462IleAsp: 2.462 ± 0.82
4.65IleGlu: 4.65 ± 0.94
3.829IlePhe: 3.829 ± 0.909
1.915IleGly: 1.915 ± 1.425
1.641IleHis: 1.641 ± 0.472
5.197IleIle: 5.197 ± 1.591
3.829IleLys: 3.829 ± 1.189
7.932IleLeu: 7.932 ± 0.551
1.641IleMet: 1.641 ± 0.58
1.915IleAsn: 1.915 ± 0.523
3.009IlePro: 3.009 ± 0.454
1.641IleGln: 1.641 ± 0.58
1.915IleArg: 1.915 ± 0.455
5.744IleSer: 5.744 ± 0.566
4.103IleThr: 4.103 ± 0.635
2.462IleVal: 2.462 ± 0.97
0.274IleTrp: 0.274 ± 0.162
1.368IleTyr: 1.368 ± 0.499
0.0IleXaa: 0.0 ± 0.0
Lys
3.556LysAla: 3.556 ± 1.769
1.641LysCys: 1.641 ± 1.228
2.188LysAsp: 2.188 ± 1.391
3.009LysGlu: 3.009 ± 1.008
3.009LysPhe: 3.009 ± 0.783
2.188LysGly: 2.188 ± 0.628
1.094LysHis: 1.094 ± 0.4
5.47LysIle: 5.47 ± 1.069
4.376LysLys: 4.376 ± 1.395
5.197LysLeu: 5.197 ± 0.461
1.915LysMet: 1.915 ± 0.523
1.915LysAsn: 1.915 ± 0.36
1.368LysPro: 1.368 ± 0.565
1.915LysGln: 1.915 ± 1.296
4.376LysArg: 4.376 ± 0.588
5.47LysSer: 5.47 ± 0.935
3.829LysThr: 3.829 ± 0.731
3.282LysVal: 3.282 ± 0.644
1.915LysTrp: 1.915 ± 0.36
2.462LysTyr: 2.462 ± 0.411
0.0LysXaa: 0.0 ± 0.0
Leu
6.018LeuAla: 6.018 ± 1.751
2.735LeuCys: 2.735 ± 0.585
6.565LeuAsp: 6.565 ± 2.339
6.291LeuGlu: 6.291 ± 1.2
5.47LeuPhe: 5.47 ± 1.267
5.197LeuGly: 5.197 ± 1.083
1.915LeuHis: 1.915 ± 1.132
3.829LeuIle: 3.829 ± 1.027
6.838LeuLys: 6.838 ± 1.093
7.112LeuLeu: 7.112 ± 1.361
2.735LeuMet: 2.735 ± 0.574
3.009LeuAsn: 3.009 ± 0.686
3.829LeuPro: 3.829 ± 1.154
5.197LeuGln: 5.197 ± 0.991
7.659LeuArg: 7.659 ± 1.785
7.112LeuSer: 7.112 ± 0.969
7.932LeuThr: 7.932 ± 2.984
6.565LeuVal: 6.565 ± 1.139
1.368LeuTrp: 1.368 ± 0.664
2.188LeuTyr: 2.188 ± 0.894
0.0LeuXaa: 0.0 ± 0.0
Met
1.368MetAla: 1.368 ± 0.664
0.547MetCys: 0.547 ± 0.193
1.915MetAsp: 1.915 ± 1.103
2.188MetGlu: 2.188 ± 0.807
0.547MetPhe: 0.547 ± 1.151
1.641MetGly: 1.641 ± 0.472
0.821MetHis: 0.821 ± 0.809
1.915MetIle: 1.915 ± 1.141
1.094MetLys: 1.094 ± 0.562
1.915MetLeu: 1.915 ± 0.581
1.915MetMet: 1.915 ± 0.85
0.821MetAsn: 0.821 ± 0.236
0.0MetPro: 0.0 ± 0.0
0.821MetGln: 0.821 ± 0.485
1.368MetArg: 1.368 ± 0.565
1.368MetSer: 1.368 ± 0.499
2.462MetThr: 2.462 ± 0.706
1.641MetVal: 1.641 ± 0.575
0.821MetTrp: 0.821 ± 0.236
1.094MetTyr: 1.094 ± 0.494
0.0MetXaa: 0.0 ± 0.0
Asn
1.094AsnAla: 1.094 ± 0.355
1.915AsnCys: 1.915 ± 0.809
0.821AsnAsp: 0.821 ± 0.904
0.821AsnGlu: 0.821 ± 0.809
2.188AsnPhe: 2.188 ± 0.44
0.821AsnGly: 0.821 ± 0.236
1.094AsnHis: 1.094 ± 0.355
1.641AsnIle: 1.641 ± 0.472
2.735AsnLys: 2.735 ± 0.459
4.65AsnLeu: 4.65 ± 0.484
1.368AsnMet: 1.368 ± 0.494
0.547AsnAsn: 0.547 ± 0.323
1.641AsnPro: 1.641 ± 0.373
1.641AsnGln: 1.641 ± 0.652
3.009AsnArg: 3.009 ± 1.219
1.915AsnSer: 1.915 ± 0.36
1.094AsnThr: 1.094 ± 0.647
0.821AsnVal: 0.821 ± 0.47
0.821AsnTrp: 0.821 ± 0.236
0.274AsnTyr: 0.274 ± 0.267
0.0AsnXaa: 0.0 ± 0.0
Pro
2.188ProAla: 2.188 ± 1.001
0.547ProCys: 0.547 ± 0.626
1.915ProAsp: 1.915 ± 1.132
5.47ProGlu: 5.47 ± 0.845
2.462ProPhe: 2.462 ± 0.737
3.009ProGly: 3.009 ± 1.164
0.821ProHis: 0.821 ± 0.695
1.915ProIle: 1.915 ± 0.455
1.641ProLys: 1.641 ± 0.472
3.829ProLeu: 3.829 ± 1.119
0.821ProMet: 0.821 ± 0.5
0.547ProAsn: 0.547 ± 0.505
1.641ProPro: 1.641 ± 0.685
1.094ProGln: 1.094 ± 0.564
2.462ProArg: 2.462 ± 0.393
4.65ProSer: 4.65 ± 1.611
2.735ProThr: 2.735 ± 0.659
2.735ProVal: 2.735 ± 0.585
0.547ProTrp: 0.547 ± 0.5
1.094ProTyr: 1.094 ± 1.01
0.0ProXaa: 0.0 ± 0.0
Gln
2.188GlnAla: 2.188 ± 0.891
0.547GlnCys: 0.547 ± 0.534
1.641GlnAsp: 1.641 ± 1.168
3.009GlnGlu: 3.009 ± 1.115
1.368GlnPhe: 1.368 ± 0.4
2.188GlnGly: 2.188 ± 1.001
0.547GlnHis: 0.547 ± 0.323
0.821GlnIle: 0.821 ± 0.47
3.556GlnLys: 3.556 ± 1.206
3.009GlnLeu: 3.009 ± 0.545
0.547GlnMet: 0.547 ± 0.534
0.547GlnAsn: 0.547 ± 0.505
1.094GlnPro: 1.094 ± 0.698
1.094GlnGln: 1.094 ± 0.494
3.009GlnArg: 3.009 ± 0.454
2.188GlnSer: 2.188 ± 0.711
1.915GlnThr: 1.915 ± 0.455
3.009GlnVal: 3.009 ± 0.96
1.094GlnTrp: 1.094 ± 0.401
0.274GlnTyr: 0.274 ± 0.162
0.0GlnXaa: 0.0 ± 0.0
Arg
4.103ArgAla: 4.103 ± 1.25
1.368ArgCys: 1.368 ± 0.963
3.009ArgAsp: 3.009 ± 1.946
4.923ArgGlu: 4.923 ± 1.502
3.009ArgPhe: 3.009 ± 0.199
3.009ArgGly: 3.009 ± 0.81
1.094ArgHis: 1.094 ± 0.698
4.103ArgIle: 4.103 ± 0.909
1.915ArgLys: 1.915 ± 0.915
6.565ArgLeu: 6.565 ± 1.555
1.641ArgMet: 1.641 ± 0.575
1.915ArgAsn: 1.915 ± 0.807
2.462ArgPro: 2.462 ± 0.345
2.462ArgGln: 2.462 ± 0.706
4.103ArgArg: 4.103 ± 1.125
3.829ArgSer: 3.829 ± 0.678
4.65ArgThr: 4.65 ± 1.275
3.556ArgVal: 3.556 ± 1.112
1.641ArgTrp: 1.641 ± 0.886
1.641ArgTyr: 1.641 ± 0.668
0.0ArgXaa: 0.0 ± 0.0
Ser
3.829SerAla: 3.829 ± 1.244
1.641SerCys: 1.641 ± 1.602
4.376SerAsp: 4.376 ± 1.255
4.65SerGlu: 4.65 ± 0.79
1.915SerPhe: 1.915 ± 0.36
3.829SerGly: 3.829 ± 1.588
3.009SerHis: 3.009 ± 0.86
3.556SerIle: 3.556 ± 0.224
3.556SerLys: 3.556 ± 0.724
9.3SerLeu: 9.3 ± 1.577
0.821SerMet: 0.821 ± 0.463
2.462SerAsn: 2.462 ± 0.943
4.103SerPro: 4.103 ± 1.289
3.009SerGln: 3.009 ± 0.381
5.47SerArg: 5.47 ± 0.961
8.206SerSer: 8.206 ± 1.968
4.923SerThr: 4.923 ± 0.977
5.197SerVal: 5.197 ± 1.768
1.641SerTrp: 1.641 ± 0.685
1.368SerTyr: 1.368 ± 0.4
0.0SerXaa: 0.0 ± 0.0
Thr
3.282ThrAla: 3.282 ± 0.34
1.915ThrCys: 1.915 ± 0.844
3.282ThrAsp: 3.282 ± 0.814
4.103ThrGlu: 4.103 ± 0.52
3.282ThrPhe: 3.282 ± 0.878
3.282ThrGly: 3.282 ± 0.487
1.641ThrHis: 1.641 ± 0.58
4.103ThrIle: 4.103 ± 1.275
4.103ThrLys: 4.103 ± 0.943
7.112ThrLeu: 7.112 ± 1.926
0.821ThrMet: 0.821 ± 0.485
2.735ThrAsn: 2.735 ± 1.284
3.556ThrPro: 3.556 ± 0.724
0.821ThrGln: 0.821 ± 0.511
3.829ThrArg: 3.829 ± 1.046
4.103ThrSer: 4.103 ± 1.007
4.103ThrThr: 4.103 ± 0.847
3.009ThrVal: 3.009 ± 0.545
1.641ThrTrp: 1.641 ± 0.685
2.188ThrTyr: 2.188 ± 0.429
0.0ThrXaa: 0.0 ± 0.0
Val
2.735ValAla: 2.735 ± 1.39
3.009ValCys: 3.009 ± 0.96
4.65ValAsp: 4.65 ± 0.79
4.923ValGlu: 4.923 ± 1.258
3.556ValPhe: 3.556 ± 0.683
3.829ValGly: 3.829 ± 1.027
1.368ValHis: 1.368 ± 0.397
4.376ValIle: 4.376 ± 0.859
4.376ValLys: 4.376 ± 1.492
6.018ValLeu: 6.018 ± 0.397
1.368ValMet: 1.368 ± 0.499
1.641ValAsn: 1.641 ± 0.875
1.915ValPro: 1.915 ± 0.915
2.735ValGln: 2.735 ± 0.866
3.282ValArg: 3.282 ± 0.487
3.009ValSer: 3.009 ± 0.723
3.282ValThr: 3.282 ± 0.766
4.376ValVal: 4.376 ± 0.865
1.094ValTrp: 1.094 ± 0.387
2.462ValTyr: 2.462 ± 0.708
0.0ValXaa: 0.0 ± 0.0
Trp
0.547TrpAla: 0.547 ± 0.534
0.547TrpCys: 0.547 ± 0.5
1.368TrpAsp: 1.368 ± 0.449
0.274TrpGlu: 0.274 ± 0.162
1.641TrpPhe: 1.641 ± 0.373
2.188TrpGly: 2.188 ± 0.981
0.274TrpHis: 0.274 ± 0.162
2.462TrpIle: 2.462 ± 0.708
0.821TrpLys: 0.821 ± 0.236
1.915TrpLeu: 1.915 ± 0.832
0.821TrpMet: 0.821 ± 0.485
0.274TrpAsn: 0.274 ± 0.162
1.094TrpPro: 1.094 ± 1.738
0.274TrpGln: 0.274 ± 0.162
0.274TrpArg: 0.274 ± 0.162
1.641TrpSer: 1.641 ± 0.875
2.188TrpThr: 2.188 ± 0.927
1.915TrpVal: 1.915 ± 1.134
0.274TrpTrp: 0.274 ± 0.267
0.274TrpTyr: 0.274 ± 0.162
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.094TyrAla: 1.094 ± 1.588
0.547TyrCys: 0.547 ± 0.534
1.641TyrAsp: 1.641 ± 0.383
2.735TyrGlu: 2.735 ± 0.53
0.274TyrPhe: 0.274 ± 0.162
0.274TyrGly: 0.274 ± 0.162
0.821TyrHis: 0.821 ± 0.485
1.368TyrIle: 1.368 ± 0.352
1.094TyrLys: 1.094 ± 0.355
2.462TyrLeu: 2.462 ± 0.966
0.547TyrMet: 0.547 ± 0.5
2.735TyrAsn: 2.735 ± 0.585
0.547TyrPro: 0.547 ± 0.505
1.915TyrGln: 1.915 ± 0.898
2.735TyrArg: 2.735 ± 0.459
2.188TyrSer: 2.188 ± 0.628
1.915TyrThr: 1.915 ± 0.36
1.641TyrVal: 1.641 ± 0.652
0.274TyrTrp: 0.274 ± 0.267
0.547TyrTyr: 0.547 ± 0.505
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3657 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski